Pub Date : 2023-09-28DOI: 10.1186/s42494-023-00134-3
Yingchun Xu, Ge Tan, Deng Chen, Jiao Liu, Zixian Zhou, Ling Liu
Abstract Epilepsy affects all age groups and is one of the most common and disabling neurological disorders worldwide. Drug-resistant epilepsy (DRE), status epilepticus (SE), and sudden unexpected death in epilepsy (SUDEP), which are associated with considerable healthcare costs and mortality, have always been difficult to address and become the focus of clinical research. The rapid identification of seizure onset and accurate localization of epileptic foci are crucial for the treatment and prognosis of people with DRE, SE, or near-SUDEP. However, most of the conventional neuroimaging techniques for assessing cerebral blood flow of people with epilepsy are restricted by time consumption, limited resolution, and ionizing radiation. Arterial spin labeling (ASL) is a newly powerful non-contrast magnetic resonance imaging technique that enables the quantitative evaluation of brain perfusion, characterized by its unique advantages of reproducibility and easy accessibility. Recent studies have demonstrated the potential advantages of ASL for the diagnosis and evaluation of epilepsy. Therefore, in this review, we discussed the complementary value of ASL in evaluating and characterizing the basic substrates underlying refractory epilepsy and epileptic emergencies.
癫痫影响所有年龄组，是世界上最常见和致残的神经系统疾病之一。耐药癫痫(Drug-resistant epilepsy, DRE)、癫痫持续状态(status epilepticus, SE)和癫痫猝死(sudden unexpected death in epilepsy, SUDEP)一直以来都是难以解决的问题，并成为临床研究的重点。快速识别癫痫发作和准确定位癫痫病灶对DRE、SE或近sudep患者的治疗和预后至关重要。然而，大多数用于评估癫痫患者脑血流量的传统神经成像技术受到时间消耗、分辨率有限和电离辐射的限制。动脉自旋标记(ASL)是一种新的强大的非对比磁共振成像技术，能够定量评估脑灌注，具有独特的重复性和易于获取的优点。最近的研究表明，ASL在癫痫的诊断和评估方面具有潜在的优势。因此，在这篇综述中，我们讨论了ASL在评估和表征难治性癫痫和癫痫紧急情况的基本基础方面的补充价值。
{"title":"Arterial spin labeling perfusion MRI applications in drug-resistant epilepsy and epileptic emergency","authors":"Yingchun Xu, Ge Tan, Deng Chen, Jiao Liu, Zixian Zhou, Ling Liu","doi":"10.1186/s42494-023-00134-3","DOIUrl":"https://doi.org/10.1186/s42494-023-00134-3","url":null,"abstract":"Abstract Epilepsy affects all age groups and is one of the most common and disabling neurological disorders worldwide. Drug-resistant epilepsy (DRE), status epilepticus (SE), and sudden unexpected death in epilepsy (SUDEP), which are associated with considerable healthcare costs and mortality, have always been difficult to address and become the focus of clinical research. The rapid identification of seizure onset and accurate localization of epileptic foci are crucial for the treatment and prognosis of people with DRE, SE, or near-SUDEP. However, most of the conventional neuroimaging techniques for assessing cerebral blood flow of people with epilepsy are restricted by time consumption, limited resolution, and ionizing radiation. Arterial spin labeling (ASL) is a newly powerful non-contrast magnetic resonance imaging technique that enables the quantitative evaluation of brain perfusion, characterized by its unique advantages of reproducibility and easy accessibility. Recent studies have demonstrated the potential advantages of ASL for the diagnosis and evaluation of epilepsy. Therefore, in this review, we discussed the complementary value of ASL in evaluating and characterizing the basic substrates underlying refractory epilepsy and epileptic emergencies.","PeriodicalId":33628,"journal":{"name":"Acta Epileptologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135387423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-13DOI: 10.1186/s42494-023-00133-4
Xiaoqin Sun, Miao Wang, Zeng He, Lihong Liu, Xianjun Shi, Chunqing Zhang, Ning An, Meihua Yang, Zhifeng Wu, Ruodan Wang, Li Wang, Zhongke Wang, Hui Yang, Xiaolin Yang, Shiyong Liu
Abstract Background In the new International League Against Epilepsy (ILAE) classification of seizure types, generalized seizures such as absence seizures (ASs) may originate from a focal point and rapidly spread to the bilaterally distributed brain network. Increasing evidence from animal and clinical studies has indicated that focal changes may occur prior to ASs; however, the relationship of ASs with epileptogenic lesions remains unclear. Methods We retrospectively collected and analyzed the clinical, imaging, and electrophysiological data of 16 patients who had ASs and structural lesions with seizure-free outcomes after lesion resection. Results In semiology analysis, nine patients displayed focal onset; only two patients showed simple ASs, and seizure types other than ASs were observed in the remaining patients. On ictal electroencephalography (EEG), four patients showed bilateral synchronous symmetric 3 Hz generalized spike-wave discharges (GSWDs), and the remaining patients showed bilateral 1.5–2.5 Hz GSWDs. Moreover, most patients (13/16, 81.3%) exhibited focal features in addition to ASs, while interictal EEG was the same in 12 patients. Furthermore, on stereoelectroencephalogram (SEEG), 2/5 patients showed focal discharges before bilateral burst GSWDs. Additionally, all patients had structural lesions on imaging. In four typical AS patients, the lesions were located in deep brain regions. Notably, in 9 patients (9/16, 56%), the lesions were located in the posterior cortex. All patients underwent lesion resection and had seizure-free outcomes during follow-up, and intelligence quotient (IQ) also improved by 10.71 ± 3.90 one year after surgery. Conclusions Patients with lesion-related epilepsy may present with ASs that have a focal onset and are associated with good surgical outcomes.
{"title":"Absence seizures in lesion-related epilepsy","authors":"Xiaoqin Sun, Miao Wang, Zeng He, Lihong Liu, Xianjun Shi, Chunqing Zhang, Ning An, Meihua Yang, Zhifeng Wu, Ruodan Wang, Li Wang, Zhongke Wang, Hui Yang, Xiaolin Yang, Shiyong Liu","doi":"10.1186/s42494-023-00133-4","DOIUrl":"https://doi.org/10.1186/s42494-023-00133-4","url":null,"abstract":"Abstract Background In the new International League Against Epilepsy (ILAE) classification of seizure types, generalized seizures such as absence seizures (ASs) may originate from a focal point and rapidly spread to the bilaterally distributed brain network. Increasing evidence from animal and clinical studies has indicated that focal changes may occur prior to ASs; however, the relationship of ASs with epileptogenic lesions remains unclear. Methods We retrospectively collected and analyzed the clinical, imaging, and electrophysiological data of 16 patients who had ASs and structural lesions with seizure-free outcomes after lesion resection. Results In semiology analysis, nine patients displayed focal onset; only two patients showed simple ASs, and seizure types other than ASs were observed in the remaining patients. On ictal electroencephalography (EEG), four patients showed bilateral synchronous symmetric 3 Hz generalized spike-wave discharges (GSWDs), and the remaining patients showed bilateral 1.5–2.5 Hz GSWDs. Moreover, most patients (13/16, 81.3%) exhibited focal features in addition to ASs, while interictal EEG was the same in 12 patients. Furthermore, on stereoelectroencephalogram (SEEG), 2/5 patients showed focal discharges before bilateral burst GSWDs. Additionally, all patients had structural lesions on imaging. In four typical AS patients, the lesions were located in deep brain regions. Notably, in 9 patients (9/16, 56%), the lesions were located in the posterior cortex. All patients underwent lesion resection and had seizure-free outcomes during follow-up, and intelligence quotient (IQ) also improved by 10.71 ± 3.90 one year after surgery. Conclusions Patients with lesion-related epilepsy may present with ASs that have a focal onset and are associated with good surgical outcomes.","PeriodicalId":33628,"journal":{"name":"Acta Epileptologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135733688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.1186/s42494-023-00132-5
Emily Yixuan Huang, Hongfeng Gao, N. Zhong
{"title":"Heterogeneity of clinical features, EEG and brain imaging findings in anti-leucine-rich glioma-inactivated protein 1 autoimmune encephalitis: a retrospective case series study and review of the literature","authors":"Emily Yixuan Huang, Hongfeng Gao, N. Zhong","doi":"10.1186/s42494-023-00132-5","DOIUrl":"https://doi.org/10.1186/s42494-023-00132-5","url":null,"abstract":"","PeriodicalId":33628,"journal":{"name":"Acta Epileptologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42824041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-14DOI: 10.1186/s42494-023-00130-7
L. Cai, Kai Zhang, Wenjing Zhou, Xiaoqiu Shao, Y. Guan, Tao Yu, Ye Wu, Shuhua Chen, Rui Zhao, Shuli Liang, Xun Wu, G. Luan, Yuwu Jiang, Jianguo Zhang, Xiaoyan Liu
{"title":"Consensus on pediatric epilepsy surgery for young children: an investigation by the China Association Against Epilepsy task force on epilepsy surgery","authors":"L. Cai, Kai Zhang, Wenjing Zhou, Xiaoqiu Shao, Y. Guan, Tao Yu, Ye Wu, Shuhua Chen, Rui Zhao, Shuli Liang, Xun Wu, G. Luan, Yuwu Jiang, Jianguo Zhang, Xiaoyan Liu","doi":"10.1186/s42494-023-00130-7","DOIUrl":"https://doi.org/10.1186/s42494-023-00130-7","url":null,"abstract":"","PeriodicalId":33628,"journal":{"name":"Acta Epileptologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44368258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-26DOI: 10.1186/s42494-023-00129-0
Ningxiang Qin, Jing Wang, Xi Peng, Liang-yu Wang
{"title":"Development from recurrent anti-N-methyl-D-aspartate receptor encephalitis with seizures as the first symptom to autoimmune-associated epilepsy: a case report","authors":"Ningxiang Qin, Jing Wang, Xi Peng, Liang-yu Wang","doi":"10.1186/s42494-023-00129-0","DOIUrl":"https://doi.org/10.1186/s42494-023-00129-0","url":null,"abstract":"","PeriodicalId":33628,"journal":{"name":"Acta Epileptologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44280085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-18DOI: 10.1186/s42494-023-00131-6
Sofía S. Sánchez-Boluarte, W. Aguirre-Quispe, Manuel Herrera Aramburú, W. Tatum, Walter F. De La Cruz Ramirez
{"title":"Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case report","authors":"Sofía S. Sánchez-Boluarte, W. Aguirre-Quispe, Manuel Herrera Aramburú, W. Tatum, Walter F. De La Cruz Ramirez","doi":"10.1186/s42494-023-00131-6","DOIUrl":"https://doi.org/10.1186/s42494-023-00131-6","url":null,"abstract":"","PeriodicalId":33628,"journal":{"name":"Acta Epileptologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44063782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.1186/s42494-023-00127-2
J. Agbo, Z. G. Ibrahim, S. Magaji, Y. Mutalub, P. P. Mshelia, Daniel H. Mhyha
{"title":"Therapeutic efficacy of voltage-gated sodium channel inhibitors in epilepsy","authors":"J. Agbo, Z. G. Ibrahim, S. Magaji, Y. Mutalub, P. P. Mshelia, Daniel H. Mhyha","doi":"10.1186/s42494-023-00127-2","DOIUrl":"https://doi.org/10.1186/s42494-023-00127-2","url":null,"abstract":"","PeriodicalId":33628,"journal":{"name":"Acta Epileptologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48686309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of serum copper on the risk of epilepsy: a mendelian randomization study","authors":"Shihao Chen, Wenting Huang, Qi Xu, Tao He, Mulan Zhang, Huiqin Xu","doi":"10.1186/s42494-023-00126-3","DOIUrl":"https://doi.org/10.1186/s42494-023-00126-3","url":null,"abstract":"","PeriodicalId":33628,"journal":{"name":"Acta Epileptologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47056892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Heterogeneity in susceptibility to polycystic ovary syndrome among women with epilepsy","authors":"Leihao Sha, Yiming Wu, Wanlin Lai, Yifei Duan, Yilin Xia, Lei Chen","doi":"10.1186/s42494-023-00125-4","DOIUrl":"https://doi.org/10.1186/s42494-023-00125-4","url":null,"abstract":"","PeriodicalId":33628,"journal":{"name":"Acta Epileptologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47089329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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