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Emotional intelligence and its relationship with subjective perception of happiness in patients with mental disorders 精神障碍患者情绪智力及其与主观幸福感的关系
Pub Date : 2021-04-21 DOI: 10.26565/2312-5675-2021-16-06
O. Maruta
The aim of this study was to research emotional intelligence and its relationship with the level of "happiness" in patients with various forms of mental disorders.The study involved 210 patients with mental disorders (70 with organic mental disorders, 70 with endogenous disorders and 70 with neurotic disorders) and 105 healthy people.Patients with mental disorders were characterized by a lower level of emotional intelligence (EQ), which is equal to medium-low normative gradations, which defined patients as less able to adequately understand, guide and express their own emotions and experiences, as well as understand and adequately respond to the emotions of others, compared with individuals. without mental pathology. Patients with endogenous disorders were characterized by a low level of EQ.According to the data obtained, the least satisfied with life, and, accordingly, having a low level of happiness, were patients with neurotic disorders, in which the degree of satisfaction with life (the difference between needs and their realizability) had low values ​​(0.90 ± 0.39), which defined them as less lucky.The level of happiness and, accordingly, the least low indicators of the degree of satisfaction with life among the forms of mental disorders were determined by organic disorders (1.22 ± 0.46), the indicators of which were as close as possible to the results of healthy individuals. The level of dissatisfaction with life in people with endogenous disorders was higher (1.57 ± 0.39) than in healthy people, at p ≤ 0.05, which determined them as less successful.The level of happiness of patients was directly correlate to the severity of emotional intelligence (the higher the level of EQ, the higher the level of happiness is), motivational focus on development and social activity, as well as sthenism in emotional experiences. These emotional and motivational features cause an increase in the level of subjective perception of happiness.
本研究的目的是研究各种精神障碍患者的情绪智力及其与“幸福”水平的关系。该研究涉及210名精神障碍患者(70名器质性精神障碍患者,70名内源性精神障碍患者和70名神经性精神障碍患者)和105名健康人。精神障碍患者的情商(EQ)水平较低,相当于中低的规范等级,与个体相比,患者不能充分理解、引导和表达自己的情绪和经历,也不能理解和充分回应他人的情绪。没有精神疾病。内源性障碍患者的eq水平较低。根据获得的数据,对生活满意度最低,幸福感水平也较低的是神经性障碍患者,其对生活的满意度(需求与其可实现性的差值)较低(0.90±0.39),属于运气较差的人群。各种精神障碍的幸福程度以及相应的生活满意度的最低指标由器质性障碍决定(1.22±0.46),器质性障碍的指标与健康个体的结果尽可能接近。内源性疾病患者对生活的不满意程度(1.57±0.39)高于健康人群(p≤0.05),表明其较不成功。患者的幸福感水平与情绪智力的严重程度(情商越高,幸福感水平越高)、对发展和社会活动的动机关注以及情绪体验的薄弱程度直接相关。这些情感和动机特征会导致主观幸福感水平的提高。
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引用次数: 1
Nootropic drugs for correction of cognitive functions through the focus of evidence-based medicine (literature review) 益智药物对认知功能矫正的循证医学重点(文献综述)
Pub Date : 2021-01-01 DOI: 10.26565/2312-5675-2021-16-02
Relevance. In today's world, the first cause of death is pathology of the cardiovascular system. Vascular disease is influenced by many factors: lack of sleep, physical inertia, poorly balanced diet, obesity, heart disease. The fast pace of life forces a person to be in permanent stress, so as not to miss anything and have time for all the goals. This is why there is a demand for excipients and substances that could improve the peak of human cognitive abilities, maintain psychological stability. Today, the pharmaceutical market offers drugs that, according to pharmaceutical marketers, have solutions to the problems outlined above. These substances are classified to group of nootropic drugs (racetams). Objective. Review of high quality research on the effectiveness of nootropic drugs. Materials and methods. The literature review was performed using such scientometric databases as: PubMed, Cochrane Library, Scopus, BMJ Evidence-Based Medicine, Ingecta, Web of Science, UpToDate. The review included studies of randomized trials, placebo-controlled randomized trials, meta-analyzes, and systematic reviews. Data meet criteria A and B of evidence-based medicine. In the absence of high quality studies, studies with a lower level of evidence were selected. The search was made by topics: improving of cognitive functions, improving ability to work, improving sleep, improving mood, treatment of mental and psychiatric pathologies (Alzheimer's disease, dementia with various etiologies, depression), application in pediatrics. Results. The literature review included more than 40 high quality studies, but no conclusive evidence was found on the effectiveness of any drug. Conclusions. Data on the undeniable efficacy in relation to the cognitive functions of any of these nootropic drugs were not found in any study. In the treatment of Alzheimer's disease, some (Cerebrolysin, Nicergoline) drugs show controversial results of efficacy and safety. They require continued clinical research and they need to be approved by the FDA.
的相关性。在当今世界,死亡的首要原因是心血管系统的病理。影响血管疾病的因素很多:睡眠不足、身体惰性、饮食不均衡、肥胖、心脏病。快节奏的生活迫使一个人永远处于压力之中,这样才不会错过任何事情,才有时间实现所有的目标。这就是为什么对能提高人类认知能力巅峰、保持心理稳定的辅料和物质有需求的原因。今天,药品市场提供的药品,根据药品营销人员,有解决上述问题的办法。这些物质被归为益智药(拉西坦)一类。益智药物有效性的高质量研究综述。材料和方法。文献综述使用如下科学计量数据库:PubMed、Cochrane Library、Scopus、BMJ循证医学、Ingecta、Web of Science、UpToDate。该综述包括随机试验、安慰剂对照随机试验、元分析和系统综述的研究。数据符合循证医学标准A和B。在缺乏高质量研究的情况下,选择了证据水平较低的研究。搜索的主题是:改善认知功能,提高工作能力,改善睡眠,改善情绪,治疗精神和精神疾病(阿尔茨海默病,各种病因的痴呆,抑郁症),在儿科的应用。结果。文献综述包括40多个高质量的研究,但没有发现任何药物有效性的确凿证据。在任何研究中都没有发现任何这些益智药物与认知功能有关的不可否认的功效的数据。在阿尔茨海默病的治疗中,一些药物(脑溶血素、尼麦角林)的疗效和安全性存在争议。它们需要持续的临床研究,并且需要得到FDA的批准。
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引用次数: 0
History of formation of medical psychology of Ukraine 乌克兰医学心理学的形成史
Pub Date : 2021-01-01 DOI: 10.26565/2312-5675-2021-16-09
В. Хрол, Майдан Свободи
The article in the historical aspect considers the problems of formation of medical psychology. The work contains the results of the analysis of the history of the formation of medical psychology in Ukraine, the development of its most promising directions in solving specific problems of medical practice. On the way to the formation of Ukrainian psychology as a science, there were different schools, directions and concepts. They were different in nature, often contradicting each other. Thus, in Soviet psychological science, based on the communist idea, the task was to develop a single, monistic approach to the study and explanation of mental phenomena. It is emphasized that when the connection with practice is lost, the subject of psychology is eroded, the scientific status of this knowledge is lost. On the way to overcoming the crisis of modern medical psychology, it is necessary to theoretically comprehend the practical experience for the development of technologies for solving urgent practical problems of psychological care. Comprehension and generalization of the invaluable experience of the first practical psychologists of our country can serve modern researchers and practitioners, as psychological practice now faces the same problems that arose at the beginning of the last century before the then scientists and practitioners. Traditional in the history of psychology is the general idea that the allocation of medical psychology as an applied field was due to the closure of experimental research to address current issues and practical problems in psychiatry and neurology in the late XX - early XXI century. The methodological basis for the study of the psyche was to be a dialectical-materialist orientation. However, despite ideological pressure, a single approach to the study of the psyche could not be developed. In specific studies of the Soviet period, sometimes directly, and in most cases, the positions of psychologists of various fields and schools were used in disguise, which was evidence of the creative use of the achievements of world psychological science.
本文从历史的角度考察医学心理学的形成问题。这项工作包括对乌克兰医学心理学形成历史的分析结果,以及在解决医疗实践的具体问题方面最有希望的方向的发展。在乌克兰心理学作为一门科学的形成过程中,有不同的学派、方向和概念。它们性质不同,常常互相矛盾。因此,在苏联的心理科学中,基于共产主义思想,任务是发展一种单一的、一元论的方法来研究和解释心理现象。要强调的是,当与实践的联系消失时,心理学这门学科就会受到侵蚀,这门知识的科学地位就会丧失。在克服现代医学心理学危机的道路上,有必要从理论上理解解决心理护理迫切实际问题的技术发展的实践经验。理解和概括我国第一批实践心理学家的宝贵经验,可以为现代研究人员和实践者服务,因为心理学实践现在面临着上世纪初科学家和实践者之前出现的同样问题。心理学历史上的传统观点是,医学心理学作为一个应用领域的分配是由于在20世纪末至21世纪初,为了解决精神病学和神经病学的当前问题和实际问题而关闭了实验研究。心灵研究的方法论基础是辩证唯物主义取向。然而,尽管意识形态的压力,单一的方法来研究心理不能发展。在对苏联时期的具体研究中,有时直接,但在大多数情况下,伪装地使用了不同领域和学派的心理学家的立场,这是创造性地使用世界心理科学成果的证据。
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引用次数: 0
Resilience-oriented intervention for war veterans with traumatic brain injury in remote period: study protocol and empirical evaluation of methodology 战后退伍军人创伤性脑损伤的远程康复干预:研究方案与方法的实证评价
Pub Date : 2021-01-01 DOI: 10.26565/2312-5675-2021-16-05
Much attention is paid worldwide to the development of interventions that affect veterans' resilience to reduce post-concussion and post-traumatic symptoms. However, today there are a few of them and they have insufficient evidence base for effectiveness in improving the mental state of veterans. This article presents a protocol and results of empirical evaluation of methodology of research aimed at improving the effectiveness of rehabilitation of war veterans with traumatic brain injury in remote period, based on the study of resilience cognitive and emotional components and its recovery by improving the complex of psychocorrection and prognosis. We plan to conduct the study on 2019-2023 with participation a total of 140 demobilized combatants in the ATO/OUF zone. For psychological assessment we plan to use the scale of neurobehavioral symptoms, the posttraumatic stress disorder checklist 5, hospital anxiety and depression scale, Montreal cognitive assessment scale, Chaban quality of life scale, Connor-Davidson resilience scale. To study the variability of dependent variables under the influence of psychocorrection, we plan to use analysis of variance. To study the prognostic value of changes in the cognitive and emotional components of resilience during the process of rehabilitation we plan to use a regression analysis. Based on the results of an empirical assessment, the selected methods make it possible to obtain a detailed characteristic of the resilience of war veterans with traumatic brain injury in remote period, to evaluate the effectiveness of the psychocorrection program and the prognostic value of changes in the cognitive and emotional components of resilience. Taking into account the methodology empirical assessment results, it can be expected that the main group and the comparison group socio-demographic and clinical indicators will be equivalent to each other, which will make it possible to assert their homogeneity and use for comparison. Methods of statistical processing of the data obtained correspond to the nature of the statistical data, make it possible to systematize the data, establish the degree of reliability and confirm the results obtained.
世界范围内对影响退伍军人恢复力的干预措施的发展给予了很大的关注,以减少脑震荡后和创伤后症状。然而,目前已有的研究较少,缺乏有效改善退伍军人心理状态的证据基础。本文提出了一种基于弹性、认知和情绪成分的研究,通过改善心理矫正和预后复核,提高创伤性脑损伤退伍军人远程康复效果的研究方法的方案和结果。我们计划在2019-2023年开展这项研究,共有140名复员战斗人员参加北约/OUF地区。心理评估拟采用神经行为症状量表、创伤后应激障碍清单5、医院焦虑抑郁量表、蒙特利尔认知评估量表、Chaban生活质量量表、Connor-Davidson弹性量表。为了研究因变量在心理矫正影响下的变异性,我们计划使用方差分析。为了研究康复过程中心理弹性的认知和情绪成分变化的预后价值,我们计划使用回归分析。在实证评估结果的基础上,所选择的方法可以获得创伤性脑损伤退伍军人心理弹性的详细特征,评估心理矫正方案的有效性以及心理弹性的认知和情绪成分变化的预测价值。考虑到方法的经验评估结果,可以预期主要组和比较组的社会人口和临床指标将彼此相等,这将有可能断言它们的同质性并用于比较。对所获得的数据进行统计处理的方法与统计数据的性质相对应,使数据系统化,建立可靠度和确认所获得的结果成为可能。
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引用次数: 0
The threshold and semantic characteristics of fast transient visual-perceptive processes in patients with affective disorders 情感性障碍患者快速瞬态视觉知觉过程的阈值和语义特征
Pub Date : 2021-01-01 DOI: 10.26565/2312-5675-2021-16-08
The article is devoted to the currently topical problem of modern medical psychology, namely the study of conscious and unconscious perceptual-information processes in patients with affective disorders. The aim of the work was to determine the thresholds and semantic components of visual perception in patients with various forms of affective disorders. The latest method of ultrafast (tachistoscopic) demonstration of visual verbal stimuli was used to examine 23 patients with depression and anxiety-depressive disorders. The obtained results are compared with similar indicants of the control group, which consisted of 15 mentally healthy individuals, and analyzed using Student's criterion, one-way and multifactor models of analysis of variance. It has been shown that in the presence of an affective disorder, the threshold exposure time required for reliable identification of visual verbal stimuli is on average more than three times higher, i.e. is much worse than a similar perceptual threshold in individuals without mental disorders. Thus, in affective disorders there is inhibition and suppression of not only emotional and psychomotor, but visual-perceptual processes as well. It is proved that the time thresholds of visual perception significantly depend not only on the presence of emotional disorders, but also on their psychopathological structure, as well as on the age factor. In depressed patients, visual-perceptual disorders are much more pronounced than in patients with anxiety-depressive disorders, namely: in depression, the minimal absolute sensory thresholds are significantly higher, more attempts are made to adapt the visual analyzer, and this deficit is significantly increased depending on age. In patients with depressive and anxiety-depressive disorders also revealed significant features of psychosemantic components of the mechanisms of recognition of verbal stimuli, which consists in a kind of unconscious filtering of the latter with a predominant perception of words with negative emotional loading. The obtained results might be meaningful in the process of developing the new diagnostic methods for affective disorders and in creating the personalized psycho-correctional programs based on the methodological principles of subsensory stimulation.
这篇文章致力于现代医学心理学当前的热门问题,即情感障碍患者的有意识和无意识感知信息过程的研究。工作的目的是确定阈值和语义成分的视觉知觉的各种形式的情感障碍的患者。采用最新的超快速视觉言语刺激显示方法对23例抑郁症和焦虑抑郁症患者进行了检查。将所得结果与对照组(15名心理健康者)相似指标进行比较,采用Student标准、单因素和多因素方差分析模型进行分析。研究表明,在存在情感障碍的情况下,可靠识别视觉言语刺激所需的阈值暴露时间平均高出三倍以上,即比没有精神障碍的个体的类似感知阈值差得多。因此,在情感障碍中,不仅存在情绪和精神运动的抑制和抑制,而且也存在视觉感知过程的抑制和抑制。结果表明,视觉知觉的时间阈值不仅与情绪障碍的存在有关,还与情绪障碍的精神病理结构以及年龄因素有关。在抑郁症患者中,视觉知觉障碍比焦虑抑郁症患者更为明显,即:抑郁症患者的最小绝对感觉阈值明显更高,对视觉分析仪的适应尝试更多,并且这种缺陷随着年龄的增长而显著增加。抑郁和焦虑抑郁患者言语刺激识别机制的心理语义成分也显示出显著特征,即对后者进行无意识过滤,对负性情绪负荷词的感知占主导地位。研究结果对建立新的情感性障碍诊断方法和建立基于亚感觉刺激方法原理的个性化心理矫正方案具有重要意义。
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引用次数: 1
Disorders of the psychoemotional sphere of the ATO/JFO military services ATO/JFO军事服务中心理情感领域的障碍
Pub Date : 2021-01-01 DOI: 10.26565/2312-5675-2021-17-01
In this article, we have presented the results of our own research concerning the state of psychoemotional disorders in the military personnel of the ATO/JFO. It is known that the state of mental health is infl uenced by various external factors, both socio-economic and physical, traumatic, environmental, etc. The professional activity of the ATO/JFO military personnel is carried out in extreme conditions associated with psychophysical overload, an increased level of responsibility, etc. Therefore, the psychoemotional state of this contingent requires signifi cant attention and correction. The aim of this study was to study the psychoemotional state of the ATO/JFO military personnel. The study involved 66 ATO/JFO combatants (31 men and 35 women) with signs of adjustment disorders who were in Clinic of Neurology, Psychiatry and Narcology of Military Medical Clinical Centre of the Northern region (Kharkov, Ukraine). The control group consisted of 29 people (14 men and 15 women) who did not take part in hostilities and also had signs of adjustment disorders. Using the clinicalanamnestic method in the main group, we identifi ed 32 people with prolonged depressive reaction caused by adaptation disorder (F43.21 according to ICD-10) and 34 people with mixed anxiety and depressive reactions (F43.22). In the control group, 15 people had F43.21 and 14 examined had F43.22. The use of the psychodiagnostic methodology «Tsung Scale for Self-Assessment of Depression» (adapted by T.I. Balashova, 2003) made it possible to reveal a subdepressive state in 12,1±1,9% of the surveyed combatants (men 4,5±1,2%, women 7,6±1,5%). Severe depression was diagnosed in 87,9±1,9% military personnel (men 42,4±2,8%, women 45,5±2,9%). In the control group, a state without depression was revealed in 79,3±5,2% of individuals (37,9±6,3% men, 41,4±6,4% women), and mild depression was also identifi ed (10,3±4,1% men, 10,3±4,1% women, there were 20,6±5,2% people in total). It was concluded that it is necessary to take into account the data obtained when developing an algorithm for psychocorrectional measures in this contingent of patients.
在这篇文章中,我们介绍了我们自己对ATO/JFO军事人员心理情绪障碍状态的研究结果。众所周知,心理健康状况受到各种外部因素的影响,包括社会经济因素和身体、创伤、环境等因素。ATO/JFO军事人员的专业活动是在极端条件下进行的,与心理生理负荷、责任水平增加等相关。因此,这一偶然事件的心理情绪状态需要显著的关注和纠正。本研究的目的是研究ATO/JFO军事人员的心理情绪状态。该研究涉及66名ATO/JFO战斗人员(31名男性和35名女性),他们有适应障碍的迹象,在北部地区军事医学临床中心(乌克兰哈尔科夫)的神经病学、精神病学和麻醉学诊所接受治疗。对照组由29人(14男15女)组成,他们没有参与敌对行动,也有适应障碍的迹象。主组采用临床记忆法,鉴定出32例由适应障碍引起的延长性抑郁反应(ICD-10 f43.21)和34例焦虑和抑郁混合反应(F43.22)。在对照组中,15人患有F43.21, 14人患有F43.22。使用精神诊断方法“Tsung抑郁自我评估量表”(由T.I.Balashova改编,2003年),可以在被调查的战斗人员中显示出12,1±1,9%的亚抑郁状态(男性4,5±1,2%,女性7,6±1,5%)。军人重度抑郁症发生率为87,9±1,9%(男性42,4±2,8%,女性45,5±2,9%)。对照组无抑郁状态者为79,3±5,2%(男性37,9±6,3%,女性41,44±6,4%),轻度抑郁者为10,3±4,1%(男性10,3±4,1%,女性10,3±4,1%,共20.6±5,2%)。结论是,在为这类患者制定心理矫正措施的算法时,有必要考虑到所获得的数据。
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引用次数: 0
Psychological health and subjective perception of happiness in mental disorders 心理健康与主观幸福感在精神障碍中的作用
Pub Date : 2021-01-01 DOI: 10.26565/2312-5675-2021-17-07
The aim of the study was to study psychological health (PH) and its relationship with subjective perception of happiness in patients with various types of mental disorders (MD). The set of research methods included the methodology “Individual model of psychological health”, “Semantic diff erential of happiness” (SDH) and methods of statistical processing of the data obtained. The study involved 210 patients with MD (70 with organic disorders, 70 with depressive disorders and 70 with neurotic disorders). It was found that with all variants of MD, a signifi cantly lower level of realizability of the “Prosocial” vector was determined, which refl ects the presence of internal and social coherence of the individual. In neurotic disorders, apart from Prosocial, the “Strategic” and “Family” vectors were also signifi cantly less realizable, which refl ected signifi cantly lower levels of family well-being, the ability for strategic planning, purposeful functioning, and persistence of these patients. In depressive disorders, the “Strategic”, “Intellectual” and “I” vectors were also signifi cantly less realizable, determining the low realizability of patients in this group, primarily in the spheres “I”-Realization, — emotional, intellectual, social and physical. In organic disorders among the components of the PH, the “Intellectual” vector was also less realized in comparison with the healthy group; The data obtained indicate that the subjective perception of happiness by patients with MD is associated primarily with the “Strategic”, “Prosocial”, “Family”, “Intellectual” and “I” vectors of the PH. The “creative”, “Spiritual” and “Humanistic” components of PH did not fi nd a relationship with the level of subjective perception of happiness in patients with MD.
本研究旨在探讨不同类型精神障碍(MD)患者的心理健康状况及其与主观幸福感的关系。研究方法包括“心理健康个体模型”方法论、“幸福语义差异”(SDH)方法论和所得数据的统计处理方法。该研究涉及210名MD患者(70名患有器质性疾病,70名患有抑郁症,70名患有神经性疾病)。研究发现,在所有MD变异中,“亲社会”向量的可实现性水平明显较低,这反映了个体内部和社会一致性的存在。在神经性疾病中,除了亲社会外,“战略”和“家庭”两个载体的可实现性也明显较低,这反映了这些患者的家庭幸福感、战略规划能力、有目的的功能和持久性水平明显较低。在抑郁症中,“战略”、“智力”和“我”的可实现性也明显较低,这决定了该组患者的可实现性较低,主要是在“我”——实现、——情感、智力、社会和身体领域。在有机障碍的PH成分中,与健康组相比,“智力”向量的实现程度也较低;所获得的数据表明,MD患者的主观幸福感主要与PH的“战略”、“亲社会”、“家庭”、“智力”和“我”向量相关。PH的“精神”和“人文”成分与MD患者主观幸福感水平没有关系。
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引用次数: 0
Structural and functional changes of abdominal organs in patients with hepatocerebral degeneration 肝脑变性患者腹部脏器结构与功能的改变
Pub Date : 2021-01-01 DOI: 10.26565/2312-5675-2021-16-04
The paper presents the results of ultrasound diagnostic of 76 patients with neurological forms of hepatocerebral degeneration (HCD) or Wilson’s disease (WD), who were examined and treated at the clinic of the Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine. According to ultrasound diagnostic, all patients had pathological changes in the liver. In 58% of patients these changes corresponded to chronic hepatitis, in 42% - liver cirrhosis, and in 32% of patients were reported for portal hypertension. Background hepatic hemodynamics of patients was within normal limits, but in 82% of them the reaction to food load was negative. Doppler study showed that background hepatic hemodynamics in patients with neurological forms of hepatocerebral degeneration (GCD) was within normal limits. However, the food load showed that 82% of patients had impaired reciprocal autoregulation of liver microcirculation. This indicates a decrease in their compensatory-adaptive capacity of the liver. This position is confirmed by the fact that 70% of these patients have a decrease in vasoactive endothelial function. Our study of the functional state of the vascular endothelium showed that patients with GCD have a significant decrease in vasoactive endothelial function. In general, the group was only 8.12% at a rate of 10% or more. Despite the young average age of our patients (29.7 years), only 30% of patients had a normal vasoactive reaction. These were patients under the age of 25 from the group of chronic hepatitis. The degree of endothelial dysfunction was significantly higher in patients with liver cirrhosis compared with chronic hepatitis. According to ultrasound elastography, in the vast majority of examined patients with GCD (88%) there was increased stiffness of the liver parenchyma. On the average on group of patients it made 10,62 KPA with a range from 4,74 to 20,69 KPA (norm 0,4-6,0 KPA). Thus, patients with neurological forms of GCD, which are observed by a neurologist, it is necessary before each course of treatment, but at least 1-2 times a year, to conduct ultrasound of the abdominal cavity.
本文介绍了在乌克兰国家医学科学院神经病学、精神病学和神经科研究所门诊检查和治疗的76例神经系统形式肝脑变性(HCD)或威尔逊病(WD)患者的超声诊断结果。根据超声诊断,所有患者均有肝脏病理改变。58%的患者表现为慢性肝炎,42%表现为肝硬化,32%表现为门静脉高压症。背景:患者的肝脏血流动力学在正常范围内,但82%的患者对食物负荷的反应为阴性。多普勒研究显示,神经型肝脑变性(GCD)患者的背景肝血流动力学在正常范围内。然而,食物负荷显示82%的患者肝脏微循环的相互自动调节受损。这表明它们的肝脏代偿适应能力有所下降。70%的患者血管活性内皮功能下降,这一事实证实了这一观点。我们对血管内皮功能状态的研究表明,GCD患者血管活性内皮功能明显下降。总体而言,该群体在10%或更高的比率下仅为8.12%。尽管我们的患者平均年龄年轻(29.7岁),但只有30%的患者有正常的血管活性反应。这些患者年龄在25岁以下,属于慢性肝炎组。肝硬化患者的内皮功能障碍程度明显高于慢性肝炎患者。超声弹性图显示,绝大多数GCD患者(88%)肝实质硬度增加。每组患者平均为10,62 KPA,范围为4,74 ~ 20,69 KPA(常模为0,4,6,0 KPA)。因此,由神经科医生观察的神经系统形式的GCD患者,在每个疗程之前都有必要进行腹腔超声检查,但每年至少1-2次。
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引用次数: 0
Influence of comprehensive physical rehabilitation on the restoration of motor deficiency in patients suffered ischemic stroke 综合物理康复对缺血性脑卒中患者运动功能障碍恢复的影响
Pub Date : 2021-01-01 DOI: 10.26565/2312-5675-2021-17-04
The article consideres the issue of restoring lost motor function through comprehensive physical rehabilitation. The results of a study of 84 patients with cerebral ischemic stroke (CIS) are presented. The study of patients was conducted in the recovery period (from 3 to 6 months after the vascular accident). The average age of patients was 64.2±1.7 years. During the study all patients were divided into two groups depending on the type of rehabilitation treatment. The main group consisted of 43 patients who received standard medicines therapy aimed at secondary prevention (antihypertensive, hypocholesterolemic, hypoglycemic and other medicines), as well as therapy aimed at the correction and prevention of neurocognitive and dyscirculatory disorders (medicines with metabolic and vasoactive action) during the entire period of supervision. All patients of the main group underwent a course of comprehensive physical rehabilitation treatment. The latter included classes in kinesiotherapy, occupational therapy, speech therapy classes and, if necessary, patients received psycho-correctional and psychotherapeutic methods of treatment. The second (comparison) group consisted of 41 patients who received only drug treatment: standard basic therapy in the framework of secondary prevention of CIS and therapy aimed at the correction and prevention of neurocognitive, dyscirculatory disorders. The results of our study showed that the use of a comprehensive rehabilitation treatment program consisting of physical and medical methods are signifi cantly more eff ective for patients with motor disorders who have suff ered an ischemic stroke compared with the use of only drug therapy in these patients.
本文探讨了通过综合物理康复恢复运动功能的问题。本文报道了84例缺血性脑卒中(CIS)患者的研究结果。患者的研究在恢复期(血管意外发生后3 ~ 6个月)进行。患者平均年龄64.2±1.7岁。在研究中,根据康复治疗的类型将所有患者分为两组。主要组为43例患者,在整个监测期内接受二级预防(降压、降胆固醇、降血糖等药物)的标准药物治疗,以及纠正和预防神经认知和循环障碍(具有代谢和血管活性作用的药物)的治疗。主组患者均接受1个疗程的综合物理康复治疗。后者包括运动疗法、职业疗法、言语疗法课程,如有需要,病人接受心理矫正和心理治疗方法的治疗。第二组(比较)41例患者只接受药物治疗:在CIS二级预防框架下的标准基础治疗和旨在纠正和预防神经认知、循环障碍的治疗。我们的研究结果表明,与仅使用药物治疗相比,使用由物理和医学方法组成的综合康复治疗方案对缺血性卒中运动障碍患者明显更有效。
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引用次数: 1
Review of the pathogenesis, clinical manifestations and peculiarities of neuropsychic disorders caused by COVID-19 新冠肺炎致神经精神障碍的发病机制、临床表现及特点综述
Pub Date : 2021-01-01 DOI: 10.26565/2312-5675-2021-17-05
The article presents literature data numerous studies of patients with COVID-19. The available information helps to explain the nature and structure of the virus, the ways of penetration and its distribution in the human body, its interaction with the immune, nervous, endocrine, vascular, muscular systems, as well as the pathogenesis, clinic, diagnosis and treatment of this contingent of patients. Due to tropisms SARS-CoV-2 to the human cells specifi c S glycoprotein this virus can bind receptor human angiotensin-converting enzyme 2 (ACE-2), fuse with host cells and disseminate in the organism. Renin-angiotensin-aldosteron system (RAAS) plays an important role in regulation of blood vessels, heart, kidneys functions. ACE-2 has an infl uence on the infl ammatory, fi brotic and immunomodulatory mechanisms. Inhibition of these protection functions due to spread SARS-CoV-2 in human body leads to the progression of cardiovascular, renal and pulmonary diseases. Some authors describe indirectly the viral entry into the brain parenchyma by infecting the T-lymphocytes, that usually is accompanied by infl ammatory reactions with an increase in the specifi c cytokines such as interleukins (IL) — 6, IL-8, tumor necrosis factor, monocyte chemoattractant protein-1 (MCP-1). The peculiarities of the binding of the virus to the human cells are the presence of neurotropic properties and the ability to change the permeability of blood brain barier (BBB). Other authors note that the virus crosses the BBB directly through the olfactory neurons and also the brain’s circumventricular organs structures, surrounding the third and fourth ventricles, and promote the infection of nervous system. It can also cause intravascular coagulation and blood clotting, which may lead to various diseases of the nervous system. In this regard, an important task for neurologists is to further study the eff ect of the COVID-19 virus on the nervous system and prevent the occurrence of its complications.
本文介绍了有关COVID-19患者的文献资料和大量研究。现有的信息有助于解释病毒的性质和结构,渗透方式及其在人体内的分布,与免疫、神经、内分泌、血管、肌肉系统的相互作用,以及这类患者的发病机制、临床、诊断和治疗。由于SARS-CoV-2对人类细胞特异性S糖蛋白的趋向性,该病毒可以结合受体人血管紧张素转换酶2 (ACE-2),与宿主细胞融合并在生物体中传播。肾素-血管紧张素-醛固酮系统(RAAS)在血管、心脏、肾脏功能的调节中起着重要作用。ACE-2对炎症、纤维化和免疫调节机制均有影响。由于SARS-CoV-2在人体内的传播,这些保护功能受到抑制,导致心血管、肾脏和肺部疾病的进展。一些作者间接地描述了病毒通过感染t淋巴细胞进入脑实质,这通常伴随着炎症反应,特定细胞因子如白细胞介素(IL) - 6、IL-8、肿瘤坏死因子、单核细胞趋化蛋白-1 (MCP-1)增加。病毒与人类细胞结合的特点是具有嗜神经性和改变血脑屏障(BBB)渗透性的能力。其他作者指出,病毒直接通过嗅觉神经元和大脑第三和第四脑室周围的脑室周围器官结构穿过血脑屏障,并促进神经系统的感染。它还可以引起血管内凝血和血液凝固,这可能导致各种神经系统疾病。因此,进一步研究covid -19病毒对神经系统的影响,预防其并发症的发生是神经科医生的一项重要任务。
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引用次数: 0
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Psikhiatriia nevrologiia ta medichna psikhologiia
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