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Synchronous Abdominal Wall and Small Bowel Transplantation: Critical Insights at Four Year Follow Up 腹壁和小肠同步移植:四年随访的重要启示
Pub Date : 2024-05-06 DOI: 10.1055/a-2320-5368
Nicholas C. Oleck, Ralph Erdmann, K. Ravindra, Debra Sudan, Brett T. Phillips, S. Mithani, Detlev Erdmann, Andrew Atia
This four-year follow-up of synchronous abdominal wall allotransplantation (AW-VCA) and small bowel transplantation reveals novel insights and innovations in abdominal wall VCA. The case, involving a 37-year-old male Army veteran, showcases the benefits of AW-VCA in addressing loss of abdominal domain in intestinal transplantation (ITx). The events leading to ultimate rejection of both the AW-VCA and small bowel graft at four years highlights the complex interplay between graft survival, patient compliance, and immunosuppressive management. Notably, a significant discordance between AW-VCA and ITx rejection patterns was identified, questioning the reliability of skin components in AW-VCA as early indicators of ITx rejection. Furthermore, the behavior of the vascularized abdominal fascia, observed post-excision of the small bowel graft, offers new understanding of the immunologic response to fascia-only grafts. This follow-up emphasizes the complexities of graft survival, patient compliance, and immunosuppressive management, underscoring the need for ongoing research and innovation in the field.
这篇对同步腹壁异位移植(AW-VCA)和小肠移植的四年随访揭示了腹壁VCA的新见解和创新。该病例涉及一名 37 岁的男性退伍军人,展示了腹壁同种异体移植(AW-VCA)在解决肠移植(ITx)中腹腔域缺失问题方面的优势。四年后,导致AW-VCA和小肠移植物最终发生排斥反应的事件凸显了移植物存活率、患者依从性和免疫抑制管理之间复杂的相互作用。值得注意的是,AW-VCA 和 ITx 排斥模式之间存在明显的不一致,这对将 AW-VCA 中的皮肤成分作为 ITx 排斥的早期指标的可靠性提出了质疑。此外,在切除小肠移植物后观察到的腹部血管化筋膜的行为,让人们对仅筋膜移植物的免疫反应有了新的认识。此次随访强调了移植物存活、患者依从性和免疫抑制管理的复杂性,突出了该领域持续研究和创新的必要性。
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引用次数: 0
Stable Arterial Perforators Mapping in Lower Leg Using Color-coded Doppler Sonography, Acoustic Doppler and Thermal Imaging Camera in Patients Undergoing Digital Subtraction Arteriography 使用彩色多普勒超声、声学多普勒和热成像摄像机为接受数字减影动脉造影术的患者绘制稳定的小腿动脉穿孔图
Pub Date : 2024-01-09 DOI: 10.1055/a-2241-2323
Vanesa Lovětínská, Andrej Sukop, Jakub Sulženko, Adam Hora, Matěj Patzelt, B. Kožnar, Karol Kovačič, Michal Kamenistý, Jozef Kučerák
Background: Chronic defects in the lower leg present significant challenges in plastic surgery due to their diverse etiologies and association with impaired peripheral circulation. This study describes the localization of stable perforators and assesses their changing velocities after digital subtraction angiography (DSA).Methods: 10 patients with lower extremity defects requiring DSA, had undergone examinations applying standard methods. The localization of 40 stable perforators originating from three main arteries in crura was performed before and after angiography. Where stenoses or occlusions were observed, percutaneous transluminal angioplasty (PTA) was conducted, and changes in the perforator velocities following reperfusion were measured.Results: Angiographic abnormalities were observed in all cases. Prior to PTA, acoustic Dopplers detected 37 out of 40 perforators (90%), while color-coded sonography detected 35 out of 40 perforators (87.5%). After PTA, these numbers increased to 38 out of 40 (95%) and 37 out of 40 (92.5%) respectively. The mean flow characteristics included the peak systolic velocities (PSV) of 21.9 and 27.2, end-diastolic velocities (EDV) of 9.4 and 11.4 respectively. Post-intervention 16 micro vessels exhibited enlarged lumen diameters ranging from 1 to 3 mm, resulting in increased perfusion values for PSV in 85.2% (21.9/27.2) and EDV in 88.2% (9.4/11.4) of the patients. However, 2 perforators showed decreases in flow velocity after PTA.Conclusion: In most patients with chronic lower leg wounds and other comorbidities, adequate perforators for reconstruction can be identified by using conventional methods. PTA interventions positively impact blood flow in perforators, although they are not necessarily required prior to reconstruction.
背景:小腿慢性缺损是整形外科面临的重大挑战,因为其病因多种多样,并与外周循环受损有关。本研究描述了稳定穿孔器的定位,并评估了其在数字减影血管造影(DSA)后的速度变化。在血管造影前后,对起源于腓肠肌三条主要动脉的 40 条稳定穿孔器进行了定位。在观察到狭窄或闭塞的地方,进行了经皮腔内血管成形术(PTA),并测量了再灌注后穿孔器速度的变化:结果:所有病例均观察到血管造影异常。在 PTA 之前,声学多普勒可检测到 40 个穿孔器中的 37 个(90%),而彩色超声波可检测到 40 个穿孔器中的 35 个(87.5%)。PTA 术后,这两个数字分别增至 40 例中的 38 例(95%)和 40 例中的 37 例(92.5%)。平均血流特征包括收缩峰值速度(PSV)分别为 21.9 和 27.2,舒张末速度(EDV)分别为 9.4 和 11.4。干预后,16 条微血管的管腔直径扩大了 1 至 3 毫米不等,85.2%(21.9/27.2)的患者的 PSV 和 88.2%(9.4/11.4)的 EDV 灌注值增加。然而,有 2 条穿孔器在 PTA 后流速下降:结论:对于大多数有慢性小腿伤口和其他合并症的患者,使用传统方法可以找到足够的穿孔器进行重建。PTA干预对穿孔器的血流有积极影响,但重建前不一定需要进行PTA干预。
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引用次数: 0
Conventional and Robot-Assisted Microvascular Anastomosis - Systematic Review 传统与机器人辅助微血管吻合术 - 系统性综述
Pub Date : 2024-01-05 DOI: 10.1055/a-2239-5212
Benedictus Ansell Susanto, Nadine Aurelie, William Nathaniel, P. Atmodiwirjo, M. R. Ramadan, R. Djohan
Background: The complexity of plastic microsurgery yields many risks. Robot assistance has been sought to maximize outcome and minimize complications. Reportedly, it offers increased dexterity and flexibility with attenuated human flaws, such as tremors and fatigue. This systematic review will further investigate that claim.Methods: A systematic search was conducted for operative outcomes and operator experience of reconstructive plastic microsurgery compared between conventional and robot-assisted procedures. Data were summarized then meta-analyzed or qualitatively assessed and critically appraised to determine the difference robot assistance offers.Results: This review comprises 4 studies, mainly investigating robot-assisted microvascular anastomosis. Meta-analysis of anastomosis time reveals that robot-assisted takes more time than conventional without offering substantial health-related improvements. However, it offers greater comfort, consistency, and flexibility for operators.Conclusions: Robot assistance lengthens operative times because of its relative lack of implementation and subsequent lack of experienced operators. Times were quick to be improved as repeated procedures were performed and technical complications can be resolved by more experience with robotic equipment. Furthermore, it generally offers better operator experience. Despite this, robot assistance does not offer a better health outcome compared to conventional anastomosis although its benefits may lie in aesthetic outcomes instead. Exploration of that aspect as well as non-summarizable health outcomes are the two primary limitations of this review that warrants further investigation into the subject.
背景:整形显微外科手术的复杂性带来了许多风险。为了最大限度地提高手术效果并减少并发症,人们一直在寻求机器人辅助。据报道,机器人可提高灵巧性和灵活性,减少震颤和疲劳等人为缺陷。本系统综述将进一步研究这一说法:方法:对传统手术和机器人辅助手术的手术效果和操作者的整形显微外科经验进行了系统检索。对数据进行总结,然后进行荟萃分析或定性评估和批判性评价,以确定机器人辅助带来的差异:本综述包括4项研究,主要调查机器人辅助下的微血管吻合术。对吻合时间的元分析表明,机器人辅助比传统方法花费更多时间,但在健康相关方面却没有实质性改善。然而,它为操作者提供了更大的舒适度、一致性和灵活性:结论:机器人辅助延长了手术时间,这是因为机器人辅助相对缺乏实施,而且随后缺乏有经验的操作人员。随着手术的重复进行,时间很快就能得到改善,而且技术并发症也能通过机器人设备的更多使用经验得到解决。此外,它通常还能为操作者提供更好的经验。尽管如此,与传统的吻合术相比,机器人辅助并不能提供更好的健康结果,尽管其优势可能在于美学效果。对这一方面的探讨以及无法总结的健康结果是本综述的两个主要局限性,值得对这一主题进行进一步研究。
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引用次数: 0
Neo-Forearm Functional Reconstruction after Temporary Ectopic Hand Implantation for Salvage of Hand after Extensive Crush Injury to Forearm 前臂大面积挤压伤后为挽救手部而进行临时异位手部植入后的新前臂功能重建术
Pub Date : 2024-01-01 DOI: 10.1055/s-0043-1778080
Raja Tiwari, Suvashis Dash, S. Chauhan, Shivangi Saha, Misha Ahir, M. Singhal
Background Extensive crush injuries to forearm pose a unique problem where replantation of uninjured hands to the forearm is not immediately possible due to difficulties in delineating tissue necrosis. Ectopic hand implantation preserves the hand and allows replanting the hand back to the forearm stump, but the tissues preserved in the stump could be inadequate to provide good hand function. In these subsets of cases, forearm reconstruction with composite flaps may offer a better chance of getting good hand function. Methods We present a case of a 29-year-old male, a left-handed factory worker, with severe crushing of the left forearm by a hydraulic pressing machine with a relatively undamaged hand. A three-staged reconstruction was done with the recovery of the left hand after below elbow amputation and replanted to the left lower third of leg. Then a neo-forearm was reconstructed using a functioning free fibula, vastus lateralis muscle, and anterolateral thigh skin flap. Finally, the ectopically banked hand was returned to the reconstructed neo forearm. Results After 2 years follow-up, protective sensation and grip strength of 2 pounds had developed in the hand. The disabilities of arm, shoulder, and hand score was 21, and he was able to perform multiple tasks using the left hand independently and as an assistive hand. Conclusion The consensus on indications of ectopic banking is still open for debate. The addition of our ectopic replantation technique followed by neo-forearm reconstruction and replantation of the hand into the reconstructed neo-forearm, which is a novel concept, will broaden the horizon of reconstructive paradigm.
背景前臂大面积挤压伤带来了一个独特的问题,由于难以确定组织坏死的范围,无法立即将未受伤的手重新植入前臂。异位手部植入术可以保留手部,并将手移植回前臂残端,但残端保留的组织可能不足以提供良好的手部功能。在这些病例中,使用复合皮瓣重建前臂可能更有机会获得良好的手部功能。方法 我们介绍了一例 29 岁的男性病例,他是一名左撇子工厂工人,左前臂被液压机严重挤压,但手部受损相对较轻。手术分三个阶段进行,首先在肘部以下截肢后恢复左手,并将其移植到左腿下三分之一处。然后使用功能正常的游离腓骨、大腿外侧肌和大腿前外侧皮瓣重建新前臂。最后,异位移植的手被放回重建的新前臂。结果 随访两年后,患者手部的保护性感觉和握力已达到 2 磅。手臂、肩部和手部残疾评分为 21 分,他能够独立使用左手或作为辅助手完成多项任务。结论 关于异位再植适应症的共识仍有待商榷。我们的异位再植技术加上新前臂重建和将手再植到重建的新前臂中这一新颖概念,将拓宽重建范例的视野。
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引用次数: 0
Combined Application of a Novel Robotic System and Exoscope for Microsurgical Anastomoses: Preclinical Performance 新型机器人系统与外窥镜在显微外科吻合中的联合应用:临床前性能
Pub Date : 2023-10-26 DOI: 10.1055/a-2199-2584
Kai J Wessel, Isa Wendenburg, Shaghayegh Gorji, Alexander Dermietzel, Matthias M Aitzetmueller, Charalampos Varnava, Philipp Wiebringhaus, Marie-Luise Klietz, Tobias Hirsch, Maximilian Kueckelhaus
Background: The concept of robotic microsurgery is becoming increasingly known as several robotic systems tailored to the specific needs of microsurgery are being introduced. Training with these devices is essential to draw conclusions about their potential clinical utility. This study describes the training and learning curve of experienced microsurgeons and complete novices using such a robotic surgical system in combination with an exoscope. Methods: Four experienced microsurgeons and three complete novices performed a total of 62 manual and robot-assisted anastomoses. The time for anastomosis completion, surgeon's satisfaction with the anastomosis and with the robotic system were recorded. The anastomoses’ quality was assessed using the Structured Assessment of Microsurgery Skills (SAMS) and the Anastomosis Lapse Index (ALI). The Rapid Entire Body Assessment (REBA) was used for ergonomics evaluation. Results: All expert microsurgeons and novices improved their performance during training. The average anastomosis time decreased significantly while satisfaction with the anastomosis and robotic system increased significantly over time. Multiple SAMS score parameters increased significantly throughout robotic but not manual training and the ALI score demonstrated more errors in the manual group. The REBA score displayed a significantly lower risk for musculoskeletal disorders in the robotic group. Conclusion: Currently, the first clinical applications of robotic surgical systems specifically designed for microsurgery are being reported. The introduction of such systems into clinical practice can be expected to have a steep learning curve, as demonstrated in our study. Meanwhile, robotic systems for microsurgical procedures may hold great potential for improvement of surgical quality and ergonomics.
背景:机器人显微外科手术的概念正变得越来越为人所知,因为一些专门针对显微外科手术需求的机器人系统正在被引入。使用这些设备进行培训对于得出关于其潜在临床应用的结论至关重要。本研究描述了有经验的显微外科医生和完全的新手使用这种结合外窥镜的机器人手术系统的培训和学习曲线。方法:4名经验丰富的显微外科医生和3名完全新手共进行了62例人工和机器人辅助吻合术。记录吻合完成时间、外科医生对吻合的满意度和对机器人系统的满意度。采用显微手术技能结构化评估(SAMS)和吻合失误指数(ALI)对吻合质量进行评价。采用快速全身评估法(REBA)进行人体工程学评价。结果:所有显微外科专家和新手在训练过程中均有提高。随着时间的推移,平均吻合时间明显缩短,而对吻合和机器人系统的满意度明显提高。多个SAMS评分参数在机器人训练过程中显著增加,但在人工训练过程中没有增加,而人工组的ALI评分显示出更多的错误。REBA评分显示机器人组患肌肉骨骼疾病的风险明显较低。结论:目前,专门为显微外科设计的机器人手术系统的首次临床应用正在报道中。正如我们的研究所表明的那样,将这种系统引入临床实践可能会有一个陡峭的学习曲线。同时,显微外科手术的机器人系统在提高手术质量和人体工程学方面具有很大的潜力。
{"title":"Combined Application of a Novel Robotic System and Exoscope for Microsurgical Anastomoses: Preclinical Performance","authors":"Kai J Wessel, Isa Wendenburg, Shaghayegh Gorji, Alexander Dermietzel, Matthias M Aitzetmueller, Charalampos Varnava, Philipp Wiebringhaus, Marie-Luise Klietz, Tobias Hirsch, Maximilian Kueckelhaus","doi":"10.1055/a-2199-2584","DOIUrl":"https://doi.org/10.1055/a-2199-2584","url":null,"abstract":"Background: The concept of robotic microsurgery is becoming increasingly known as several robotic systems tailored to the specific needs of microsurgery are being introduced. Training with these devices is essential to draw conclusions about their potential clinical utility. This study describes the training and learning curve of experienced microsurgeons and complete novices using such a robotic surgical system in combination with an exoscope. Methods: Four experienced microsurgeons and three complete novices performed a total of 62 manual and robot-assisted anastomoses. The time for anastomosis completion, surgeon's satisfaction with the anastomosis and with the robotic system were recorded. The anastomoses’ quality was assessed using the Structured Assessment of Microsurgery Skills (SAMS) and the Anastomosis Lapse Index (ALI). The Rapid Entire Body Assessment (REBA) was used for ergonomics evaluation. Results: All expert microsurgeons and novices improved their performance during training. The average anastomosis time decreased significantly while satisfaction with the anastomosis and robotic system increased significantly over time. Multiple SAMS score parameters increased significantly throughout robotic but not manual training and the ALI score demonstrated more errors in the manual group. The REBA score displayed a significantly lower risk for musculoskeletal disorders in the robotic group. Conclusion: Currently, the first clinical applications of robotic surgical systems specifically designed for microsurgery are being reported. The introduction of such systems into clinical practice can be expected to have a steep learning curve, as demonstrated in our study. Meanwhile, robotic systems for microsurgical procedures may hold great potential for improvement of surgical quality and ergonomics.","PeriodicalId":34024,"journal":{"name":"Journal of Reconstructive Microsurgery Open","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136376353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PLA-based In house 3D-printed intraoperative surgical model is a time- and cost-efficient approach for mandibular reconstruction. 基于pla的内部3d打印术中手术模型是一种既省时又经济的下颌重建方法。
Pub Date : 2023-08-29 DOI: 10.1055/a-2162-0460
K. Bangun, V. Tania, Windy Cendrick, J. Halim, P. Atmodiwirjo, Mohamad Rachadian Ramadan, P. Kreshanti
Introduction. Patients with malignant mandibular reconstructive cases, commonly people often have contralateral normal side to act as a template during preoperative computer-assisted planning. Moreover, the development of Computer-Assisted Design/ Manufacturing Technology aids in the process to produce a template for cutting and/or custom fixation (pre-bending). Therefore, CAD/CAM technology has been greatly used in enhancing accuracy and reducing operation time, and minimizing possible complications due to thorough accurate planning. Method. This study displayed 5 case series incorporating In-House 3D Printed Models cases. 3D imaging was retrieved from CT scan DICOM Files, the file will then be processed to recreate a symmetrical post operative look. Furthermore, the rendered 3D File will be printed with the in-house printer using polylactic acid (PLA) Material. A sterilized 3D printed model will then be used intraoperatively to allow pre-bending of any implants for the case. Then the process, time, and cost of each case were documented.Results 100% success rate in processing all 5 cases into 3D Printed Model. The printing time consumes on average 7 hours,39 minutes (ranging from 5 hours, 59 minutes up to 9 hours, 43 minutes) and costs on average $ 1.83 on each print (ranging from $ 1.69 up to $ 2.10). Conclusion. 3D Printed reconstructed models as guidance to aid the surgeon from visualization of the post-operative look, up to intraoperative pre-bending of the implants used. Thus allowing better efficiency in reducing operation time, better post-operative look, and fewer complications. However, a bigger sample RCT will allow more detailed information.
介绍。在恶性下颌骨再造术的病例中,一般人在术前常以对侧正常侧作为模板进行计算机辅助规划。此外,计算机辅助设计/制造技术的发展有助于生产用于切割和/或定制固定(预弯曲)的模板。因此,CAD/CAM技术在提高精度和缩短操作时间方面得到了广泛的应用,并且由于全面准确的规划,可以最大限度地减少可能出现的并发症。方法。本研究展示了5个案例系列,包括内部3D打印模型案例。从CT扫描的DICOM文件中检索3D图像,然后对该文件进行处理,以重建对称的术后外观。此外,渲染的3D文件将使用内部打印机使用聚乳酸(PLA)材料打印。灭菌的3D打印模型将在术中使用,以便预先弯曲任何植入物。然后记录每个病例的过程、时间和成本。结果5例病例3D打印模型的成功率均为100%。打印时间平均为7小时39分钟(从5小时59分钟到9小时43分钟不等),每张打印的平均成本为1.83美元(从1.69美元到2.10美元不等)。结论:3D打印重建模型作为指导,可以帮助外科医生从术后外观的可视化到术中所使用的植入物的预弯曲。从而提高手术效率,缩短手术时间,改善术后美观,减少并发症。然而,更大的样本RCT将提供更详细的信息。
{"title":"PLA-based In house 3D-printed intraoperative surgical model is a time- and cost-efficient approach for mandibular reconstruction.","authors":"K. Bangun, V. Tania, Windy Cendrick, J. Halim, P. Atmodiwirjo, Mohamad Rachadian Ramadan, P. Kreshanti","doi":"10.1055/a-2162-0460","DOIUrl":"https://doi.org/10.1055/a-2162-0460","url":null,"abstract":"Introduction. Patients with malignant mandibular reconstructive cases, commonly people often have contralateral normal side to act as a template during preoperative computer-assisted planning. Moreover, the development of Computer-Assisted Design/ Manufacturing Technology aids in the process to produce a template for cutting and/or custom fixation (pre-bending). Therefore, CAD/CAM technology has been greatly used in enhancing accuracy and reducing operation time, and minimizing possible complications due to thorough accurate planning. \u0000\u0000Method. This study displayed 5 case series incorporating In-House 3D Printed Models cases. 3D imaging was retrieved from CT scan DICOM Files, the file will then be processed to recreate a symmetrical post operative look. Furthermore, the rendered 3D File will be printed with the in-house printer using polylactic acid (PLA) Material. A sterilized 3D printed model will then be used intraoperatively to allow pre-bending of any implants for the case. Then the process, time, and cost of each case were documented.\u0000\u0000Results 100% success rate in processing all 5 cases into 3D Printed Model. The printing time consumes on average 7 hours,39 minutes (ranging from 5 hours, 59 minutes up to 9 hours, 43 minutes) and costs on average $ 1.83 on each print (ranging from $ 1.69 up to $ 2.10). \u0000\u0000Conclusion. 3D Printed reconstructed models as guidance to aid the surgeon from visualization of the post-operative look, up to intraoperative pre-bending of the implants used. Thus allowing better efficiency in reducing operation time, better post-operative look, and fewer complications. However, a bigger sample RCT will allow more detailed information.","PeriodicalId":34024,"journal":{"name":"Journal of Reconstructive Microsurgery Open","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42597808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry Payments and Academic Influence in Reconstructive Microsurgery 重建显微外科的产业支付与学术影响
Pub Date : 2023-08-29 DOI: 10.1055/a-2162-0604
I. Sethi, J. Mellia, Alexander I. Murphy, Fortunay H. Diatta, Paul A. Asadourian, J. Fischer, S. Azoury, D. Bui
Background: Financial relationships between industry and microsurgeons help facilitate innovation but have the potential to bias a surgeon’s academic work. To better understand industry-academic relationships, this study investigated the association between industry payments made to microsurgeons and their academic influence. Methods: A cross-sectional analysis of microsurgeons at ACGME-accredited plastic surgery residency programs during the 2020-2021 academic year was performed. The Center for Medicare and Medicaid Services’ Open Payments Database was used to collect industry payments (research and non-research related) to each surgeon. Academic influence was measured by h-index and number of publications. Mann-Whitney U and Kruskal Wallis tests were used for statistical analysis.Results: Of the 199 microsurgeons identified, 156 (78.39%) received an industry non-research payment, but 0 (0.0%) received an industry research payment. Surgeons who received any amount of industry payments did not have a higher mean h-index or higher mean number of publications than surgeons with no industry payments. However, surgeons with total industry payments over $10,000 (n=15) had a higher number of publications than surgeons with no industry payments (135.47 vs. 36.02, p=0.0074), $0-$1000 in payments (135.47 vs. 34.37, p=0.0006), and $1,000-$10,000 in payments (135.47 vs. 45.43, p=0.0268). Surgeons with total industry payments over $10,000 also had higher h-indices than surgeons with $0-$1000 in payments (24.4 vs. 10.34, p=0.0039) and $1,000-$10,000 in payments (24.4 vs. 11.34, p=0.0413). Conclusion: Industry funding is associated with higher h-index and higher number of publications for high earners (>$10,000). Private companies may favor these surgeons for their academic expertise.
背景:行业和微型外科医生之间的财务关系有助于促进创新,但也有可能对外科医生的学术工作产生偏见。为了更好地理解行业与学术的关系,本研究调查了行业向微型外科医生支付的款项与其学术影响力之间的关系。方法:对2020-2021学年ACGME认可的整形外科住院医师项目的外科医生进行横断面分析。医疗保险和医疗补助服务中心的开放支付数据库用于收集每位外科医生的行业付款(研究和非研究相关)。学术影响力是通过h指数和出版物数量来衡量的。Mann-Whitney U和Kruskal-Wallis检验用于统计分析。结果:在确定的199名微型外科医生中,156人(78.39%)获得了行业非研究付款,但0人(0.0%)获得了产业研究付款。与没有行业付款的外科医生相比,接受任何行业付款的医生的平均h指数或出版物的平均数量都不高。然而,行业总付款超过10000美元的外科医生(n=15)的出版物数量高于没有行业付款的外科医生(135.47对36.02,p=0.0074),0-1000美元的付款(135.47%对34.37,p=0.0006),以及1000至10000美元的付款(135.47对45.43,p=0.0268)。行业总付款超过10000美元的外科医生的h指数也高于支付0至1000美元(24.4对10.34,p=0.0039)和1000至10000加元(24.4比11.34,p=0.0413)的外科医生。结论:行业资金与高收入者的h指数和出版物数量较高(>10000美元)有关。私营公司可能会因为这些外科医生的学术专长而青睐他们。
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引用次数: 0
How a robotic visualization system can facilitate targeted muscle reinnervation 机器人可视化系统如何促进定向肌肉神经再生
Pub Date : 2023-07-21 DOI: 10.1055/a-2134-8633
Vesta Brauckmann, J. Mayor, Luisa Ernst, Jennifer Ernst
Background:To enable and further improve microsurgical outcomes, different loupes and optic based microscopes have been proposed in recent years. In amputation surgery continuous progress and prosthetic developments have provided amputees with improved degree of function and quality of life.We present a 17-year-old patient who suffered traumatic loss of the left upper limb and underwent TMR-surgery facilitated by a 3D-robotic-exoscope-system. Methods:The rerouting of the distal ends of the arm-nerves (Targeted Muscle Reinnervation) was performed in the upper limb of a traumatic transhumeral amputee patient using 3D-robotic-exoscope-system (RS, RoboticScope). Perioperative data was collected and compared to standard. Users’ evaluation of the system during the surgical procedure was done using a 5-point-Likert-Scale.Results:Operation time was 311 minutes, the robotic system was used for 101 minutes. Overall users´ evaluation revealed 4,5 for selected items on the Likert-Scale. The evaluation showed similar results in evaluation of the system by main and assistant surgeons. No special training was required beforehand. The bimanual control allowed for improved personal freedom in the surgical field at a comfortable position. The imaging of colors will need future improvements until authentic representation of in situ structures is achieved. Conclusions:Major advantages of a robotic Scope-3D-exoscope-system are improved image quality, ergonomic position, and increased accessibility in a wider operating field due to system implied features. Another benefit is digital documentation, simultaneous education through possibility of capturing images and videos and easy transportation between operating rooms without risk to harm the vulnerable optic. Digital microscopes are still not yet implemented as standard of care.
背景:为了实现和进一步提高显微外科手术的效果,近年来提出了不同的放大镜和光学显微镜。截肢手术的不断进步和假肢的发展为截肢者提供了更好的功能程度和生活质量。我们报告了一位17岁的患者,他遭受了左上肢的创伤性损失,并在3d机器人-外窥镜系统的帮助下接受了tmr手术。方法:采用3d -robot -exoscope系统(RS, RoboticScope)对上肢创伤性肱骨截肢患者进行上肢神经远端改道(靶向肌肉神经移植)。收集围手术期资料并与标准进行比较。手术过程中用户对系统的评价采用5点李克特量表。结果:手术时间为311 min,机器人系统使用时间为101 min。总体用户的评价显示,在李克特量表上,所选项目的得分为4.5分。评价结果显示,主副医师对该系统的评价结果相似。事先不需要特别训练。双手控制允许在一个舒适的位置提高手术领域的个人自由。在真实再现原位结构之前,颜色成像还需要进一步改进。结论:机器人scope- 3d -exoscope系统的主要优点是提高了图像质量,符合人体工程学的位置,并且由于系统隐含的特性而增加了更广泛操作领域的可及性。另一个好处是数字文档,通过捕获图像和视频的可能性进行同步教育,以及在手术室之间方便的运输,而不会有伤害脆弱的视神经的风险。数码显微镜仍未成为医疗标准。
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引用次数: 0
48 hour ex-vivo perfusion and two hour simulated reperfusion after a traumatic major amputation of the upper extremity 外伤性上肢大截肢术后48小时离体灌注和2小时模拟再灌注
Pub Date : 2022-12-28 DOI: 10.1055/a-2004-0041
Viola-Antonia Stögner, L. Neubert, Alexander Kaltenborn, B. Wiegmann, C. Krettek, P. M. Vogt, N. Krezdorn
Background: Extremity replantation as well as allotransplantation aim to restore form and function of the amputated limb. Both approaches, however, are clearly limited by the ischemic time. Ex-vivo perfusion (EVP), already well established in the field of solid organ transplantation, represents a promising tool to overcome this restriction.Methods: We have currently established the technical requirements to provide ex-vivo perfusion (EVP) to severed limbs in a clinical hospital setting and hereby report of a 48-hour hypothermic EVP (EVP48) of an upper extremity amputated at the level of the proximal humerus, followed by a 2-hour simulated reperfusion (2SR) with donor blood.Results: Muscle biopsies revealed histopathologically well preserved, vital muscle tissue after EVP24, and partially grouped muscle fiber necrosis with predominantly vital muscle tissue after EVP48 and 2SR. Analyses of perfusate samples showed a marked decline of biochemical muscle damage markers during EVP48. Cytokine analysis disclosed an isolated increase of the pro-inflammatory cytokines interleukine-6, monocyte chemotactic protein-1 and interferon-γ during EVP and 2SR. Magnetic resonance imaging, performed after EVP48, indicated partial muscle necrosis of the intrinsic hand muscles only, whilst no signs for infection or inflammation were present.Conclusion: Our single case experience shows the general feasibility of an amputated limb ex-vivo salvage perfusion setting to allow for delayed replantation up to 24 hours. Nevertheless, an accurate prior planning, is crucial to ensure successful implementation of EVP in the acute clinical setting.
背景:四肢再植和异体移植旨在恢复截肢后的形态和功能。然而,这两种方法显然都受到缺血时间的限制。体外灌注(EVP)已经在实体器官移植领域得到了很好的应用,它是克服这一限制的一种很有前途的工具。方法:我们目前已经制定了在临床医院环境中为断肢提供离体灌注(EVP)的技术要求,并在此报告了对肱骨近端截肢的上肢进行48小时低温EVP(EVP48),然后用供体血进行2小时模拟再灌注(2SR)。结果:肌肉活检显示EVP24后组织病理学上保存良好的重要肌肉组织,EVP48和2SR后部分分组的肌肉纤维坏死,主要是重要肌肉组织。对灌注液样本的分析显示,在EVP48期间,生化肌肉损伤标志物显著下降。细胞因子分析显示,在EVP和2SR期间,促炎细胞因子白细胞介素-6、单核细胞趋化蛋白-1和干扰素-γ单独增加。EVP48后进行的磁共振成像显示,手部固有肌肉仅部分坏死,而没有感染或炎症迹象。结论:我们的单一病例经验表明,截肢离体挽救灌注设置允许延迟24小时再植的总体可行性。然而,准确的事先计划对于确保在急性临床环境中成功实施EVP至关重要。
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引用次数: 0
DIEP Flap Transplantation in Monozygotic Twins for Breast Reconstruction: A Case Report and Literature Review DIEP皮瓣移植用于单卵双生子乳房重建:1例报告及文献复习
Pub Date : 2022-12-07 DOI: 10.1055/a-2086-5667
C. Ozturk, Arvind D. Manisundaram, Mariangela Rivera, C. Ozturk, W. Moon
Abstract Background  Composite tissue allotransplants are performed for various defects when local, or distant reconstructive options are limited. Though this type of transplant replaces similar tissue, it is complicated by immunosuppression. This limitation may be avoided in monozygotic twins since they share identical genetic code. Free soft tissue transplantation across identical twins has been reported for breast, scalp, and thoracic reconstruction when autologous tissues were insufficient. We present a case of a successful deep inferior epigastric artery perforator (DIEP) flap transplantation in monozygotic twins. Methods  The recipient twin was a patient with history of breast cancer and failed prosthetic reconstruction. She desired autologous reconstruction with a DIEP flap but had insufficient donor tissue. She refused alternative sites; however, she had an identical twin willing to donate her excess abdominal tissue. The twins underwent deoxyribonucleic acid testing, human leukocyte antigen/blood type testing, and screening for communicable diseases. Results  The twins were found to have greater than 99.99% probability of being monozygotic twins. A bipedicled conjoined DIEP was harvested from donor twin and transplanted to recipient twin. Immunosuppressive regimen was not utilized. Patients healed uneventfully and are currently 5 years postop without long-term complications. Conclusion  Isogeneic flap transplant is a viable option to consider when autologous tissues are restricted, and monozygotic twins are present. Appropriate counseling of twins is critical for a successful and satisfactory outcome.
摘要背景 当局部或远处重建选择有限时,对各种缺陷进行复合组织同种异体移植。尽管这种类型的移植替代了类似的组织,但它因免疫抑制而变得复杂。单卵双胞胎可以避免这种限制,因为他们共享相同的遗传密码。据报道,当自体组织不足时,同卵双胞胎之间的自由软组织移植可用于乳房、头皮和胸部重建。我们报告了一例成功的单卵双胞胎上腹部深下动脉穿支(DIEP)皮瓣移植。方法 接受移植的双胞胎患者有癌症病史,假体重建失败。她希望用DIEP皮瓣进行自体重建,但供体组织不足。她拒绝其他网站;然而,她有一对同卵双胞胎愿意捐献她多余的腹部组织。这对双胞胎接受了脱氧核糖核酸检测、人类白细胞抗原/血型检测和传染病筛查。后果 这对双胞胎被发现有超过99.99%的概率是同卵双胞胎。从供体双胞胎身上采集双足连体DIEP,并将其移植到受体双胞胎身上。未使用免疫抑制方案。患者顺利痊愈,目前术后5年无长期并发症。结论 当自体组织受到限制,并且存在单卵双胞胎时,同种异体皮瓣移植是一个可行的选择。对双胞胎进行适当的咨询对取得成功和令人满意的结果至关重要。
{"title":"DIEP Flap Transplantation in Monozygotic Twins for Breast Reconstruction: A Case Report and Literature Review","authors":"C. Ozturk, Arvind D. Manisundaram, Mariangela Rivera, C. Ozturk, W. Moon","doi":"10.1055/a-2086-5667","DOIUrl":"https://doi.org/10.1055/a-2086-5667","url":null,"abstract":"Abstract Background  Composite tissue allotransplants are performed for various defects when local, or distant reconstructive options are limited. Though this type of transplant replaces similar tissue, it is complicated by immunosuppression. This limitation may be avoided in monozygotic twins since they share identical genetic code. Free soft tissue transplantation across identical twins has been reported for breast, scalp, and thoracic reconstruction when autologous tissues were insufficient. We present a case of a successful deep inferior epigastric artery perforator (DIEP) flap transplantation in monozygotic twins. Methods  The recipient twin was a patient with history of breast cancer and failed prosthetic reconstruction. She desired autologous reconstruction with a DIEP flap but had insufficient donor tissue. She refused alternative sites; however, she had an identical twin willing to donate her excess abdominal tissue. The twins underwent deoxyribonucleic acid testing, human leukocyte antigen/blood type testing, and screening for communicable diseases. Results  The twins were found to have greater than 99.99% probability of being monozygotic twins. A bipedicled conjoined DIEP was harvested from donor twin and transplanted to recipient twin. Immunosuppressive regimen was not utilized. Patients healed uneventfully and are currently 5 years postop without long-term complications. Conclusion  Isogeneic flap transplant is a viable option to consider when autologous tissues are restricted, and monozygotic twins are present. Appropriate counseling of twins is critical for a successful and satisfactory outcome.","PeriodicalId":34024,"journal":{"name":"Journal of Reconstructive Microsurgery Open","volume":"08 1","pages":"e66 - e72"},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48579759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Reconstructive Microsurgery Open
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