Shreya Datta, Abhishek De, Sushil Singh, Aarti Sarda, Sandipan Dhar
Chronic spontaneous urticaria (CSU) is a distressing skin condition that is characterized by the daily or nearly daily appearance of pruritus and wheals of more than 6-week duration. CSU is now believed to have two endotypes, namely, the more common auto-allergic type and the more recalcitrant autoimmune type. It is often difficult to treat the disorder and various treatment modalities are recommended for symptom control, including second-generation non-sedative antihistamines, cyclosporin, and omalizumab. To track the progression of the disease and the efficacy of treatment, certain biomarkers play a key role. Biomarkers identified for CSU include some major ones such as Interleukin (IL)-6, IL-17, and IL-31 and minor ones such as periostin and oncostatin-M. Not only do they may serve as important prognostic tools for proper diagnosis of the disease, but they have also been utilized in several clinical studies to track the progression of the disease, which underlines their importance in the clinical setting.
{"title":"Biomarkers of chronic spontaneous urticaria","authors":"Shreya Datta, Abhishek De, Sushil Singh, Aarti Sarda, Sandipan Dhar","doi":"10.25259/ijsa_14_2023","DOIUrl":"https://doi.org/10.25259/ijsa_14_2023","url":null,"abstract":"Chronic spontaneous urticaria (CSU) is a distressing skin condition that is characterized by the daily or nearly daily appearance of pruritus and wheals of more than 6-week duration. CSU is now believed to have two endotypes, namely, the more common auto-allergic type and the more recalcitrant autoimmune type. It is often difficult to treat the disorder and various treatment modalities are recommended for symptom control, including second-generation non-sedative antihistamines, cyclosporin, and omalizumab. To track the progression of the disease and the efficacy of treatment, certain biomarkers play a key role. Biomarkers identified for CSU include some major ones such as Interleukin (IL)-6, IL-17, and IL-31 and minor ones such as periostin and oncostatin-M. Not only do they may serve as important prognostic tools for proper diagnosis of the disease, but they have also been utilized in several clinical studies to track the progression of the disease, which underlines their importance in the clinical setting.","PeriodicalId":340475,"journal":{"name":"Indian Journal of Skin Allergy","volume":"176 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121828826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of COVID-19 vaccination and Urticarial vasculitis","authors":"V. M. Santos, T. Sugai","doi":"10.25259/ijsa_13_2023","DOIUrl":"https://doi.org/10.25259/ijsa_13_2023","url":null,"abstract":"","PeriodicalId":340475,"journal":{"name":"Indian Journal of Skin Allergy","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116512605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anantpreet Singh, N. Kansal, Ashok Singh, Omna Chawla
Urticarial vasculitis is a cutaneous disease characterized by recurring wheals along with histopathological evidence of leukocytoclastic vasculitis, along with potential systemic complications. Urticarial vasculitis clinically presents with erythematous wheals. The measurement of complement levels is useful in classifying urticarial vasculitis. Here, we describe a rare case of normocomplementemic urticarial vasculitis clinically mimicking subacute cutaneous lupus erythematosus in a young female.
{"title":"Normocomplementemic urticarial vasculitis simulating subacute cutaneous lupus erythematosus","authors":"Anantpreet Singh, N. Kansal, Ashok Singh, Omna Chawla","doi":"10.25259/ijsa_5_2023","DOIUrl":"https://doi.org/10.25259/ijsa_5_2023","url":null,"abstract":"Urticarial vasculitis is a cutaneous disease characterized by recurring wheals along with histopathological evidence of leukocytoclastic vasculitis, along with potential systemic complications. Urticarial vasculitis clinically presents with erythematous wheals. The measurement of complement levels is useful in classifying urticarial vasculitis. Here, we describe a rare case of normocomplementemic urticarial vasculitis clinically mimicking subacute cutaneous lupus erythematosus in a young female.","PeriodicalId":340475,"journal":{"name":"Indian Journal of Skin Allergy","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114475758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Digital object identifiers (DOIs) have become essential tools in academic publishing for linking and identifying digital objects. This review examines the structure and assignment process of DOIs, shedding light on their critical importance in scholarly communication. DOIs consist of a unique alphanumeric string, including a prefix and a suffix, which serves as a persistent link to digital objects. By providing a standardized identifier, DOIs enhance the discoverability, accessibility, and referencing of various digital objects, including journal articles. The DOI also plays a crucial role in article promotion. With a DOI, authors, publishers, and researchers can effectively share and promote their articles, facilitating their discoverability in academic and research communities. However, challenges may arise with DOIs, such as non-functional links. This review provides troubleshooting tips for resolving such issues, including checking for typographical errors, validating the source, and seeking assistance from the DOI registration agency or the publisher.
{"title":"Digital object identifier: What it is and why it matters?","authors":"Himel Mondal, Shaikat Mondal","doi":"10.25259/ijsa_20_2023","DOIUrl":"https://doi.org/10.25259/ijsa_20_2023","url":null,"abstract":"Digital object identifiers (DOIs) have become essential tools in academic publishing for linking and identifying digital objects. This review examines the structure and assignment process of DOIs, shedding light on their critical importance in scholarly communication. DOIs consist of a unique alphanumeric string, including a prefix and a suffix, which serves as a persistent link to digital objects. By providing a standardized identifier, DOIs enhance the discoverability, accessibility, and referencing of various digital objects, including journal articles. The DOI also plays a crucial role in article promotion. With a DOI, authors, publishers, and researchers can effectively share and promote their articles, facilitating their discoverability in academic and research communities. However, challenges may arise with DOIs, such as non-functional links. This review provides troubleshooting tips for resolving such issues, including checking for typographical errors, validating the source, and seeking assistance from the DOI registration agency or the publisher.","PeriodicalId":340475,"journal":{"name":"Indian Journal of Skin Allergy","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127157136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vitamin D levels in patients with chronic spontaneous urticaria","authors":"V. M. Santos, T. Sugai","doi":"10.25259/ijsa_3_2023","DOIUrl":"https://doi.org/10.25259/ijsa_3_2023","url":null,"abstract":"","PeriodicalId":340475,"journal":{"name":"Indian Journal of Skin Allergy","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115075681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Indian Journal of Skin Allergy: Journey of past 1 year","authors":"K. Godse","doi":"10.25259/ijsa_11_2023","DOIUrl":"https://doi.org/10.25259/ijsa_11_2023","url":null,"abstract":"","PeriodicalId":340475,"journal":{"name":"Indian Journal of Skin Allergy","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115830850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Penis size has always been a considerable concern to a lot of men. Many men look for ways to increase their penile size, ranging from oral medication, stretch apparatus, injections, and surgery, to traditional methods. Smilax rotundifolia, also known as daun bungkus or common greenbrier in the western hemisphere, is a local herb most found in the West Papua region of Indonesia. This plant has been used for a variety of medicinal purposes but has recently gained fame as a novel penis enlargement. However, these claims have not been scientifically proven. A 25-year-old male presented with an ill-defined erythematous patch with multiple geographic erosion and diffuse edema after using a local herb called S. rotundifolia, also known as daun bungkus or common greenbrier. The patient was treated with an oral antihistamine, topical corticosteroids, and antibiotics. The condition improved within 2 weeks. S. rotundifulia, also known as daun bungkus, is a local herb from Papua, Indonesia, believed to have penis-enlargement properties. Research is still scarce on the active ingredients in this plant, and one study suggests that it contains triterpenoid saponin and saponin steroid. The active ingredients in this plant may be responsible for the development of contact dermatitis. Due to the popularity of this plant as an alternative penis augmentation product, it is important for practitioners to be aware of this product and its adverse effects. Further studies are also needed to examine the active ingredients in this plant.
{"title":"A rare case of diffuse penile phytocontact dermatitis caused by common greenbrier","authors":"A. Wirya, S. Wirya, Ivan Kurniadi","doi":"10.25259/ijsa_22_2022","DOIUrl":"https://doi.org/10.25259/ijsa_22_2022","url":null,"abstract":"Penis size has always been a considerable concern to a lot of men. Many men look for ways to increase their penile size, ranging from oral medication, stretch apparatus, injections, and surgery, to traditional methods. Smilax rotundifolia, also known as daun bungkus or common greenbrier in the western hemisphere, is a local herb most found in the West Papua region of Indonesia. This plant has been used for a variety of medicinal purposes but has recently gained fame as a novel penis enlargement. However, these claims have not been scientifically proven. A 25-year-old male presented with an ill-defined erythematous patch with multiple geographic erosion and diffuse edema after using a local herb called S. rotundifolia, also known as daun bungkus or common greenbrier. The patient was treated with an oral antihistamine, topical corticosteroids, and antibiotics. The condition improved within 2 weeks. S. rotundifulia, also known as daun bungkus, is a local herb from Papua, Indonesia, believed to have penis-enlargement properties. Research is still scarce on the active ingredients in this plant, and one study suggests that it contains triterpenoid saponin and saponin steroid. The active ingredients in this plant may be responsible for the development of contact dermatitis. Due to the popularity of this plant as an alternative penis augmentation product, it is important for practitioners to be aware of this product and its adverse effects. Further studies are also needed to examine the active ingredients in this plant.","PeriodicalId":340475,"journal":{"name":"Indian Journal of Skin Allergy","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121420937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exosome therapy in atopic dermatitis – A way to look forward","authors":"N. Sharma, Farhat Khan, P. Sahu","doi":"10.25259/ijsa_26_2022","DOIUrl":"https://doi.org/10.25259/ijsa_26_2022","url":null,"abstract":"","PeriodicalId":340475,"journal":{"name":"Indian Journal of Skin Allergy","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128275456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The next-generation high affinity monoclonal immunoglobulin E (IgE) inhibitor Ligelizumab is being tested in clinical studies to treat chronic spontaneous urticaria (CSU). In 2020, the US Food and Drug Administration (FDA) designated Ligelizumab (QGE031) as a breakthrough therapy for patients with chronic idiopathic urticaria; however, FDA clearance has not yet been granted, despite the phase 3 trial’s completion. Recent clinical investigations have shown that it has a considerable affinity for the high-affinity IgE receptor (FcRI) on the surface of immune cells, which is quite beneficial in the management of the distressing symptoms of CSU. Studies have been done comparing Ligelizumab to Omalizumab, the current standard of care for treating CSU that is refractory. While omalizumab is more effective than Ligelizumab at inhibiting IgE: CD23 interactions, Ligelizumab exhibits stronger inhibition of IgE binding to FcRI, basophil activation, IgE synthesis by B cells, and passive systemic anaphylaxis. To learn about this molecule’s extended characteristics, long-term efficacy and safety, and potential uses in other dermatological disorders, more clinical data is needed.
{"title":"Ligelizumab: A novel molecule in the management of chronic spontaneous urticaria","authors":"S. Datta, Dishani Chakraborty, Abhishek De","doi":"10.25259/ijsa_8_2023","DOIUrl":"https://doi.org/10.25259/ijsa_8_2023","url":null,"abstract":"The next-generation high affinity monoclonal immunoglobulin E (IgE) inhibitor Ligelizumab is being tested in clinical studies to treat chronic spontaneous urticaria (CSU). In 2020, the US Food and Drug Administration (FDA) designated Ligelizumab (QGE031) as a breakthrough therapy for patients with chronic idiopathic urticaria; however, FDA clearance has not yet been granted, despite the phase 3 trial’s completion. Recent clinical investigations have shown that it has a considerable affinity for the high-affinity IgE receptor (FcRI) on the surface of immune cells, which is quite beneficial in the management of the distressing symptoms of CSU. Studies have been done comparing Ligelizumab to Omalizumab, the current standard of care for treating CSU that is refractory. While omalizumab is more effective than Ligelizumab at inhibiting IgE: CD23 interactions, Ligelizumab exhibits stronger inhibition of IgE binding to FcRI, basophil activation, IgE synthesis by B cells, and passive systemic anaphylaxis. To learn about this molecule’s extended characteristics, long-term efficacy and safety, and potential uses in other dermatological disorders, more clinical data is needed.","PeriodicalId":340475,"journal":{"name":"Indian Journal of Skin Allergy","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116437219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. S. Ahmed, Abhishek De, Aarti Sarda, K. Godse, S. Dhar
The four Janus Kinase (JAK) proteins and seven signal transducer and activator of transcription (STAT) factors mediate the intracellular signaling pathway of cytokine receptors, which are described in the pathogenesis of many autoimmune, allergic, and inflammatory dermatoses. The development of targeted small-molecule therapies like JAK inhibitors has enabled a paradigm shift in the treatment of various cutaneous disorders. JAK inhibitors are effective in the treatment of atopic dermatitis, vitiligo, alopecia areata, psoriasis, lupus erythematosus, dermatomyositis, mastocytosis, etc. Various blood parameters include complete blood count, liver, and renal function, the viral marker to be checked and tuberculosis to be ruled out before starting the therapy. There is a risk of acquiring serious infections such as upper respiratory tract infections, urinary tract infections, reactivation of latent tuberculosis, opportunistic infections, hepatitis B virus reactivation, and alteration of various blood parameters; so regular monitoring is required. The use of JAK inhibitors will open a new horizon by reducing the burden of systemic steroids and other non-specific immunosuppressants in the treatment of immune-mediated inflammatory dermatoses.
{"title":"JAK inhibitors in dermatology","authors":"S. S. Ahmed, Abhishek De, Aarti Sarda, K. Godse, S. Dhar","doi":"10.25259/ijsa_7_2021","DOIUrl":"https://doi.org/10.25259/ijsa_7_2021","url":null,"abstract":"The four Janus Kinase (JAK) proteins and seven signal transducer and activator of transcription (STAT) factors mediate the intracellular signaling pathway of cytokine receptors, which are described in the pathogenesis of many autoimmune, allergic, and inflammatory dermatoses. The development of targeted small-molecule therapies like JAK inhibitors has enabled a paradigm shift in the treatment of various cutaneous disorders. JAK inhibitors are effective in the treatment of atopic dermatitis, vitiligo, alopecia areata, psoriasis, lupus erythematosus, dermatomyositis, mastocytosis, etc. Various blood parameters include complete blood count, liver, and renal function, the viral marker to be checked and tuberculosis to be ruled out before starting the therapy. There is a risk of acquiring serious infections such as upper respiratory tract infections, urinary tract infections, reactivation of latent tuberculosis, opportunistic infections, hepatitis B virus reactivation, and alteration of various blood parameters; so regular monitoring is required. The use of JAK inhibitors will open a new horizon by reducing the burden of systemic steroids and other non-specific immunosuppressants in the treatment of immune-mediated inflammatory dermatoses.","PeriodicalId":340475,"journal":{"name":"Indian Journal of Skin Allergy","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121311024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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