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Application of Artificial Intelligence in Diagnosis of Pancreaticobiliary Diseases 人工智能在胰胆道疾病诊断中的应用
Pub Date : 2021-04-30 DOI: 10.15279/KPBA.2021.26.3.209
K. Lee
1) 췌장낭종 Springer (Johns Hopkins University) 연구팀에서 췌장 낭종으로 수술은 받은 환자 436명의 데이터를 수집하여 지도학습(supervised learning) 방식으로 AI ‘컴프시스트 (CompCyst)’를 훈련시켰다. 이 방법은 multivariate organization of combined alterations (MOCA) 알고리즘을 이용하여 임상 양상, 영상 검사, 낭종의 단백질 분석, DNA 돌연변이, 염색체 변이들의 정보 분석방법을 학습시켰다. 이후 AI 진단법 컴프시스트로 다른 췌장 낭종 환자 426명을 대상으로 퇴원해야 하는 환자(양성), 경과 관찰이 필요한 환자, 수술해야 하는 환자 3단계로 분류하였다. Received dec. 22, 2020 Revised Jan. 8, 2021 Accepted Jan. 11, 2021
1)胰腺囊肿Springer (Johns Hopkins University)研究小组收集436名接受胰腺囊肿手术的患者的数据,以supervised learning的方式训练AI“CompCyst”。该方法利用multivariate organization of combined alterations (MOCA)算法学习了临床情况、影像检查、囊肿蛋白质分析、DNA突变和染色体变异的信息分析方法。之后AI诊断法以426名其他胰腺囊肿患者为对象,分为需要出院的患者(阳性)、需要经过观察的患者、需要手术的患者3个阶段。Received dec. 22 2020 Revised Jan. 8 2021 Accepted Jan. 11 2021
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引用次数: 0
ERCP Room Setting: What Doctors Starting ERCP Need to Know ERCP的房间设置:开始ERCP的医生需要知道什么
Pub Date : 2021-04-30 DOI: 10.15279/KPBA.2021.26.2.67
E. Lee, H. Chon, Ju Sang Park, S. Yi, Dong Wook Lee, C. Park, Kwang Bum Cho
To date, there is no standardization of the endoscopi c retrograde cholangiopancreatography (ERCP) room setting regarding with the size, equipment or space arrangement. Therefore, the authors visited 11 tertiary hospitals that recently remodeled or newly designed the ERCP room to analyze and identify their advantages and disadvantages. The ERCP room should have enough space for equipments including fluoroscopy, endoscopy, electrosurgical unit, preparation table and for patient movement. The EUS room does not require an independent space unless it is a very large scale hospital, and the ERCP room can be shared. Considering the pros and cons of each equipment, adequate fluoroscopic device should be selected depending on the hospital circumstance. Expensive equipment for X-ray fluoroscopy system is not necessarily good, and it is necessary to install equipment suitable for each hospital situation by understanding the advantages and disadvantages of fluoroscopy. For prevention of ERCP-related radiation hazard, both endoscopist and assistants should wear radiation-blocking apron, thyroid protectors, and lead glasses. Furthermore, a shield that can block radiation between the endoscopist and the patient should be installed to protect high-energy scattered waves. One-way direction should be designed to prevent cross infection when moving the endoscopic equipment from the ERCP to the cleaning room. If possible, it is recommended to keep a cardiopulmonary resuscitation cart in the ERCP room.
迄今为止,内窥镜逆行胆管造影(ERCP)的房间设置在大小、设备或空间安排方面没有标准化。因此,笔者走访了11家新近改建或新设计ERCP室的三级医院,分析并找出其优缺点。ERCP室应有足够的空间放置透视、内窥镜、电外科、准备台等设备,并为患者提供活动空间。EUS室不需要独立空间,除非是非常大型的医院,而ERCP室可以共用。考虑到每种设备的优缺点,应根据医院的具体情况选择合适的透视设备。x线透视系统的设备昂贵并不一定是好的,了解透视的优缺点,安装适合各医院情况的设备是必要的。为预防与ercp相关的辐射危害,内镜医师和助手都应佩戴防辐射围裙、甲状腺护具和含铅眼镜。此外,内窥镜医师和病人之间应该安装一个可以阻挡辐射的防护罩,以保护高能散射波。当内窥镜设备从ERCP移动到洁净室时,应设计单向,以防止交叉感染。如果可能,建议在ERCP室保留一辆心肺复苏车。
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引用次数: 0
Evaluation of Patients Suspected of Common Bile Duct Stone 怀疑胆总管结石患者的评价
Pub Date : 2019-10-31 DOI: 10.15279/kpba.2019.24.4.163
J. Yoon
Common bile duct stones (CBDS) are estimated to be present in 10–20% of individuals with symptomatic gallstones. Most patients with gallstones remain asymptomatic throughout their lifetime, but 10–25% of them may develop biliary pain or complications including pain, jaundice, infection and acute pancreatitis, with an annual risk of about 2–3% for symptomatic disease and 1–2% for major complications. The primary treatment, endoscopic retrograde cholangio-pacreatography (ERCP), is minimally invasive but associated with adverse events in 6% to 15% of patients. Therefore, exact evaluation of CBDS is important in patients with gallstones. Clinicians are therefore confronted with a number of potentially valid options such as endoscopic ultrasonography versus magnetic retrograde cholangiopancreatography in order to diagnose suspected CBDS. The aim of this review for evaluation of patients suspected of common bile duct stone is to provide practical advice on how to manage patients with CBDS. It considers diagnostic strategies in patients with suspected CBDS, as well as the different therapeutic options available for CBDS.
一般胆管结石(CBDS)估计存在于10-20%的个体有症状的胆结石。大多数胆结石患者终生无症状,但其中10-25%的患者可能出现胆道疼痛或并发症,包括疼痛、黄疸、感染和急性胰腺炎,每年出现症状性疾病的风险约为2-3%,出现主要并发症的风险约为1-2%。主要的治疗方法是内镜逆行胆管造影(ERCP),是微创的,但在6%至15%的患者中存在不良事件。因此,准确评估胆结石患者的CBDS非常重要。因此,临床医生面临着许多潜在的有效选择,如内窥镜超声检查与磁逆行胰胆管造影,以诊断疑似CBDS。本综述的目的是评估疑似胆总管结石的患者,为如何管理CBDS患者提供实用建议。它考虑了疑似CBDS患者的诊断策略,以及可用于CBDS的不同治疗方案。
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引用次数: 0
Surgical Indications and Postsurgical Follow-up Strategy for Pancreatic Cystic Neoplasm 胰腺囊性肿瘤的手术指征及术后随访策略
Pub Date : 2019-10-31 DOI: 10.15279/kpba.2019.24.4.159
J. H. Lee
The increasing discovery of pancreatic cystic neoplasm is a recent trend because of the widespread use and development of imaging techniques. Physicians have to recognize the different characteristics of the cystic neoplasms so that a determination may be selected regarding the potential for malignancy. Appropriate evaluation of pancreatic cystic lesion includes a multidisciplinary approach involving gastroenterologists with experience in endoscopic ultrasound, radiologist, and pancreatic surgeons. The selective approach is important in management of this neoplasm with minimizing incorrect diagnosis and unnecessary surgery. Considering the characteristic features of pancreatic cystic neoplasm, the clinical decision should be tailored according to needs and conditions of the individual patients
由于影像技术的广泛应用和发展,越来越多的胰腺囊性肿瘤的发现是最近的趋势。医生必须认识到囊性肿瘤的不同特征,以便对恶性肿瘤的可能性做出判断。胰腺囊性病变的适当评估包括多学科方法,包括具有内镜超声经验的胃肠病学家、放射科医生和胰腺外科医生。选择性的方法是重要的,以减少错误的诊断和不必要的手术治疗这种肿瘤。考虑到胰腺囊性肿瘤的特点,临床决策应根据个体患者的需要和情况量身定制
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引用次数: 0
Recent Update in Pathologic Diagnosis for Pancreatic Cystic Neoplasm 胰腺囊性肿瘤病理诊断的最新进展
Pub Date : 2019-10-31 DOI: 10.15279/kpba.2019.24.4.137
K. Jang
Pancreas cystic neoplasm is a relatively common disease. However, its’ pathologic diagnosis is not easy. The most frequent problem is low cellularity when compared to another organ cytology or biopsy material. Considering the procedure and anatomic difficulty, it is not uncommon to observe a low cellular smear or scanty volume of cells in the biopsy specimen. In this case, the molecular pathology test, including nextgeneration sequencing, may be helpful. If pathologist can identify some mutation in cells or cystic fluid, differential diagnosis of cystic neoplasm may be possible. These are KRAS and GNAS, VHL, and CTNNB1 mutation in mucinous cystic neoplasm, intraductal papillary-mucinous neoplasm, serous cystic neoplasm, and solid pseudopapillary neoplasm, respectively. The next-generation sequencing is an emerging molecular test that can detect multiple biomarkers for diagnosis, including pancreas cystic neoplasm. It has been reported that next-generation sequencing test can be applied for differential diagnosis of pancreas cystic neoplasm. However, these molecular pathology tests were not all-around; it needs to be properly managed with pathologist’s quality control. It should be remembered that even if it goes through quality control, it may show a failure rate of around 30%. Despite the advances in molecular methods of high techniques, it should be remembered that the most important thing in pathologic diagnosis of pancreas cystic neoplasm is an endoscopist’s skill and pathologist’s expertise those provide adequate specimen and accurate diagnosis.
胰腺囊性肿瘤是一种较为常见的疾病。然而,其病理诊断并不容易。与其他器官细胞学或活检材料相比,最常见的问题是低细胞性。考虑到手术过程和解剖学上的困难,在活检标本中观察到低细胞涂片或细胞稀少的情况并不罕见。在这种情况下,分子病理学测试,包括下一代测序,可能会有所帮助。如果病理学家能在细胞或囊性液体中发现一些突变,囊性肿瘤的鉴别诊断可能是可能的。这些分别是KRAS和GNAS, VHL和CTNNB1在粘液囊性肿瘤,导管内乳头状-粘液性肿瘤,浆液性囊性肿瘤和实性假乳头状肿瘤中的突变。下一代测序是一种新兴的分子检测,可以检测多种生物标志物用于诊断,包括胰腺囊性肿瘤。有报道称,下一代测序技术可用于胰腺囊性肿瘤的鉴别诊断。然而,这些分子病理学检查并不是全面的;需要在病理学家的质量控制下妥善管理。需要注意的是,即使经过质量控制,也可能出现30%左右的不合格率。尽管高技术分子方法取得了进展,但在胰腺囊性肿瘤的病理诊断中,最重要的是内窥镜医师的技术和病理学家的专业知识,以提供足够的标本和准确的诊断。
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引用次数: 0
Endoscopic Ultrasound-based Approach in the Diagnosis and Treatment for Pancreatic Cystic Lesions 超声内镜在胰腺囊性病变诊治中的应用
Pub Date : 2019-10-31 DOI: 10.15279/kpba.2019.24.4.147
J. Choi, S. Lee
The accurate diagnosis of pancreatic cystic lesions (PCLs) is important because they determine the strategy of treatment or follow-up. Endoscopic ultrasound (EUS) has been widely used in diagnosis and treatment of PCLs. EUS can be used to obtain additional information in the case of an indeterminate cyst on computed tomography or magnetic resonance imaging, or in case of showing a worrisome feature. Contrastenhanced EUS showed highly accurate for differential diagnosing of non-neoplastic cysts from neoplastic cyst, and it also useful for distinguishing mural nodules from mucin. EUS-guided fine needle aspiration can be used to analyze cytology, chemistry, and molecular markers in cystic fluid if there is insufficient evidence for the diagnosis by non-invasive modalities. Needle-based confocal laser endomicroscopy allows real time diagnosis of PCLs with good accuracy during EUS-guided fine needle aspiration by subcellular level imaging. Through-the-needle cystoscopy or through-the-needle forceps biopsy are also attempted in these days but the evidence for its effectiveness is insufficient. EUS-guided ablation procedures are emerging as a minimally invasive therapeutic methods for unmet needs in dichotomous treatment policy for PCLs. Large long-term follow-up observational studies have been reported on the feasibility and efficacy of EUS-guided ablation for PCLs with ethanol or in combination with chemoagent. Further study for the actual treatment effects or real clinical benefit would be needed. The use of EUS in the diagnosis and treatment of PCLs is expected to make much progress in the future.
胰腺囊性病变(PCLs)的准确诊断非常重要,因为它决定了治疗和随访的策略。内镜超声(EUS)在pcl的诊断和治疗中得到了广泛的应用。如果囊肿在计算机断层扫描或磁共振成像上表现不明确,或表现出令人担忧的特征,EUS可用于获得额外的信息。对比增强EUS对非肿瘤性囊肿和肿瘤性囊肿的鉴别诊断具有较高的准确性,对壁结节和粘蛋白的鉴别也有一定的帮助。在无创诊断证据不足的情况下,eus引导下的细针穿刺可用于分析囊性液中的细胞学、化学和分子标志物。针头为基础的共聚焦激光内镜可以实时诊断pcl,在eus引导下的细针穿刺亚细胞水平成像具有良好的准确性。穿刺针膀胱镜检查或穿刺针钳活检在这些天也尝试过,但其有效性的证据不足。eus引导下的消融术正在成为一种微创治疗方法,以满足pcl二分法治疗政策中未满足的需求。大量长期随访观察性研究报道了eus引导下乙醇或化疗药物联合消融pcl的可行性和疗效。实际的治疗效果或真正的临床获益需要进一步的研究。EUS在pcl诊断和治疗中的应用有望在未来取得很大进展。
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引用次数: 1
Endoscopic Papillary Balloon Dilation/Endoscopic Papillary Large Balloon Dilation 内镜下乳头状球囊扩张/内镜下乳头状大球囊扩张
Pub Date : 2019-10-31 DOI: 10.15279/kpba.2019.24.4.175
Seok Jeong
Endoscopic papillary balloon dilation (EPBD) and endoscopic papillary large balloon dilation (EPLBD) have been performed all around the world over several decades for the treatment of common bile duct stone. EPBD using small dilation balloon catheter can preserve sphincter of Oddi function and reduce the recurrence rate of bile duct stone compared to endoscopic sphincterotomy (EST). EPBD is a procedure with low risk of bleeding, which is appropriate for patients with coagulopathy, hepatic cirrhosis, end-stage of renal disease, and surgically altered anatomy such as Billroth II gastrectomy and periampullary diverticulum. However, it has a higher risk of postprocedure pancreatitis than EST. EPLBD using large balloon catheter (12 mm or more of diameter) is proper for more than 10 mm of common bile duct stone. The advantages of EPLBD are reduced need for mechanical lithotripsy with decreased procedure time and radiation exposure time irrespective of the precedence of EST. EPLBD also requires fewer endoscopic retrograde cholangiopancreatography sessions and is more costeffective. The incidence of post-procedure pancreatitis is lower in EPLBD than EST. If EPBD and EPLBD are done under the guidelines, these would be safe and effective and may be alternatives to EST for common bile duct stone.
几十年来,内镜下乳头状球囊扩张术(EPBD)和内镜下乳头状大球囊扩张术(EPLBD)在世界各地都被用于治疗胆总管结石。与内镜下括约肌切开术(EST)相比,EPBD采用小扩张球囊导管可保留Oddi括约肌功能,降低胆管结石复发率。EPBD是一种低出血风险的手术,适用于凝血功能障碍、肝硬化、终末期肾病和手术改变解剖结构(如Billroth II型胃切除术和壶腹周围憩室)的患者。然而,它比EST有更高的术后胰腺炎风险。对于大于10mm的胆总管结石,EPLBD使用大球囊导管(直径12mm或更大)是合适的。EPLBD的优点是减少了机械碎石的需要,减少了手术时间和辐射暴露时间,与EST的优先级无关。EPLBD还需要更少的内窥镜逆行胆管胰管造影次数,更具成本效益。EPLBD的术后胰腺炎发生率低于EST。如果在指南下进行EPBD和EPLBD,它们将是安全有效的,可能是胆总管结石的替代方法。
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引用次数: 0
Pancreatic Cystic Neoplasm: Radiologic Evaluation and Differential Diagnosis 胰腺囊性肿瘤:影像学评价与鉴别诊断
Pub Date : 2019-10-31 DOI: 10.15279/kpba.2019.24.4.141
Mi-Suk Park
Pancreatic cystic neoplasm is a clinically challenging entity. Its incidence estimated up to 45% of the general population. The biological behavior ranges from benign to malignant disease. The strategy for pancreatic cystic neoplasm could be to prevent progression to pancreatic cancer while minimizing the costs. The first step for the correct management is correct diagnosis. In this paper, the radiological differential diagnosis of them will be described.
胰腺囊性肿瘤是一种具有临床挑战性的肿瘤。其发病率估计高达总人口的45%。生物行为从良性到恶性不等。胰腺囊性肿瘤的治疗策略可能是在降低成本的同时防止胰腺癌的发展。正确管理的第一步是正确诊断。本文就其影像学鉴别诊断作一综述。
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引用次数: 0
Selective Biliary Cannulation for a Papilla in the 9 o’clock Position Using Pull and Rotatable Sphincterotome 采用牵引和可旋转括约肌切开术治疗9点钟位置乳头的选择性胆道插管
Pub Date : 2019-10-31 DOI: 10.15279/kpba.2019.24.4.182
J. H. Jun, Y. Doh, J. Jang, I. Baek, S. Jung
A 50-year-old woman visited the emergency room of Daejeon Eulji University Hospital with the primary complaint of right upper-quadrant pain. Her past medical history included a Billroth II operation with Braun anastomosis for stomach cancer. Upon physical examination, the patient had blood pressure of 100/50 mmHg, pulse rate of 116/min, respiratory rate of 18 breaths/min, and body temperature of 37.1°C. Laboratory tests indicated that the patient had a white blood cell count of 4,940/μL, hemoglobin concentration of 12.8 g/dL, platelet count of 52,000/μL, total bilirubin concentration of 1.75 mg/dL, aspartate aminotransferase level of 126 IU/L, alanine aminotransferase level of 450 IU/L, alkaline phosphatase level of 153 IU/L, amylase level of 248 U/L, lipase level of 668 U/L, and C-reactive protein level of 0.75 mg/dL. An abdominal computed tomography scan showed that the patient had biliary tree dilatation and gallbladder distension due to distal common bile duct (CBD) stones. Gallbladder stones and pericholecystic infiltration were also observed (Fig. 1). The next day, we performed endoscopic retrograde cholangiopancreatography (ERCP) for CBD stone removal. Using a cap-fitted forward-viewing endoscope (Olympus GIF Q260, Olympus Optical Co., Tokyo, Japan), the papilla was located at the 9 o’clock position (Fig. 2A). On fluoroscopy, the endoscope showed a figure 8 shape different from that in a normal Billroth II operation (Fig. 2B). We then attempted to unsuccessfully manipulate the endoscope and fix the papilla at the 12 o’clock position. To facilitate the use of a rotatable sphincterotome, the endoscope was replaced with a doublechannel endoscope (GIF-2T240, Olympus Optical Co., Tokyo, Japan) but the papilla remained at the 9 o’clock position. A sphincterotome (TRUEtome; Boston ScienReceived May 31, 2019 Revised Jun. 18, 2019 Accepted Jul. 23, 2019
以右上腹疼痛为主诉来到大田乙支大学医院急诊室的50岁女性。既往病史包括胃癌Billroth II手术及Braun吻合。体检时,患者血压100/50 mmHg,脉搏116次/min,呼吸18次/min,体温37.1℃。实验室检查:患者白细胞计数4940 /μL,血红蛋白浓度12.8 g/dL,血小板计数52000 /μL,总胆红素浓度1.75 mg/dL,天冬氨酸转氨酶126 IU/L,丙氨酸转氨酶450 IU/L,碱性磷酸酶153 IU/L,淀粉酶248 U/L,脂肪酶668 U/L, c反应蛋白0.75 mg/dL。腹部计算机断层扫描显示,由于远端胆总管(CBD)结石,患者有胆道扩张和胆囊膨胀。还观察到胆囊结石和胆囊周围浸润(图1)。第二天,我们进行了内镜逆行胆管造影(ERCP)去除CBD结石。使用帽式前视内窥镜(Olympus GIF Q260, Olympus Optical Co., Tokyo, Japan),乳头位于9点钟位置(图2A)。在透视下,内窥镜显示与正常Billroth II手术不同的图8形状(图2B)。然后我们试图操纵内窥镜并将乳头固定在12点钟位置,但没有成功。为了方便使用可旋转括约肌切开术,将内窥镜更换为双通道内窥镜(GIF-2T240, Olympus Optical Co., Tokyo, Japan),但乳头仍保持在9点钟位置。括约肌切开术(TRUEtome;Boston scien2019年5月31日收稿,2019年6月18日修订,2019年7月23日收稿
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引用次数: 0
Endoscopic Sphincterotomy, Balloon Stone Extraction, and Basket Stone Extraction 内窥镜括约肌切开术,球囊结石取出术,篮状结石取出术
Pub Date : 2019-10-31 DOI: 10.15279/kpba.2019.24.4.168
S. Jang, D. Lee
Endoscopic sphincterotomy is performed after selective cannulation to remove the gallstone. Endoscopic sphincterotomy can cause complications such as bleeding, perforation and pancreatitis. Various types of endoscopic sphincter incision method and current generators used for incisions have been developed to reduce the incidence of such complications and increase the success rate of the procedure. In addition, guidelines for the direction and extent of endoscopic sphincterotomy and incision technique are established. The method used for the removal of gallstones after the endoscopic sphincterotomy is a method using a balloon and/or a basket. This review introduces the technical methods of endoscopic sphincterotomy and discusses the clinical indications and technical methods for representative methods of effective gallstone removal. Korean J Pancreas Biliary Tract 2019;24(4):168-174
选择性插管后行内镜下括约肌切开术取出胆结石。内窥镜括约肌切开术可引起出血、穿孔和胰腺炎等并发症。为了减少此类并发症的发生,提高手术成功率,开发了多种内镜下括约肌切口方法和用于切口的电流发生器。此外,还建立了内镜下括约肌切开术的方向和范围及切口技术指南。内窥镜括约肌切开术后胆结石切除的方法是使用球囊和/或篮子的方法。本文综述了内镜下括约肌切开术的技术方法,并讨论了有代表性的有效胆结石切除方法的临床适应症和技术方法。中华胰胆道杂志;2019;24(4):168-174
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引用次数: 0
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The Korean Journal of Pancreas and Biliary Tract
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