{"title":"Using Market Indices to Optimize Company Supply Chain","authors":"Charley L. Wan","doi":"10.36838/v4i6.3","DOIUrl":"https://doi.org/10.36838/v4i6.3","url":null,"abstract":"","PeriodicalId":346661,"journal":{"name":"International Journal of High School Research","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130566330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Glycans, carbohydrates on cell membranes, are often overexpressed in cancer cells. Sialic acid, a sugar found at the terminal branch of glycans, plays a vital role in carbohydrate-protein interactions, intercellular communication, and bacterial or viral infections. However, hypersialylation of glycans has been linked to hallmarks of cancer such as tumor growth, angiogenesis, metastasis, and resistance to immune cells. Upregulation of sialylation promotes evasion of immune surveillance and survival of malignant cells. Given this role of sialic acid, inhibiting the sialylation of glycans could provide quantum leaps in treating cancer. Over-sialylation is significant to cancer mechanisms (growth, metastasis, and immune evasion); therefore, a high therapeutic value could be found in preventing sialic acid’s role in cancer. This paper reviews how sialic acid plays a key role in assisting the growth and survival of cancer cells, despite human immune cells' attacks; it also summarizes findings that encourage removing hypersialiated glycans as a strategy against multiple cancerous cell types.
{"title":"Tumor Proliferation Through Sialic Acid Dynamics and Anti-Siglec-Sialoglycans Preventive Strategies","authors":"Phuc (James) Nguyen","doi":"10.36838/v4i6.14","DOIUrl":"https://doi.org/10.36838/v4i6.14","url":null,"abstract":": Glycans, carbohydrates on cell membranes, are often overexpressed in cancer cells. Sialic acid, a sugar found at the terminal branch of glycans, plays a vital role in carbohydrate-protein interactions, intercellular communication, and bacterial or viral infections. However, hypersialylation of glycans has been linked to hallmarks of cancer such as tumor growth, angiogenesis, metastasis, and resistance to immune cells. Upregulation of sialylation promotes evasion of immune surveillance and survival of malignant cells. Given this role of sialic acid, inhibiting the sialylation of glycans could provide quantum leaps in treating cancer. Over-sialylation is significant to cancer mechanisms (growth, metastasis, and immune evasion); therefore, a high therapeutic value could be found in preventing sialic acid’s role in cancer. This paper reviews how sialic acid plays a key role in assisting the growth and survival of cancer cells, despite human immune cells' attacks; it also summarizes findings that encourage removing hypersialiated glycans as a strategy against multiple cancerous cell types.","PeriodicalId":346661,"journal":{"name":"International Journal of High School Research","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116961360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Skin Cancer Patients’ Psychological Well-Being: Identifying the Statistically Significant Predictors","authors":"Madeleine M. Lepley","doi":"10.36838/v4i5.11","DOIUrl":"https://doi.org/10.36838/v4i5.11","url":null,"abstract":"","PeriodicalId":346661,"journal":{"name":"International Journal of High School Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127375959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Poacher Activity Detection Device for Wildlife Conservation","authors":"Shreya Kakhandiki","doi":"10.36838/v4i5.17","DOIUrl":"https://doi.org/10.36838/v4i5.17","url":null,"abstract":"","PeriodicalId":346661,"journal":{"name":"International Journal of High School Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134341127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Dietary Fiber on Asthma Through Cytokine Production","authors":"Samyuktha Natesan","doi":"10.36838/v4i5.12","DOIUrl":"https://doi.org/10.36838/v4i5.12","url":null,"abstract":"","PeriodicalId":346661,"journal":{"name":"International Journal of High School Research","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122981945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yasmine P. Ackall, Katherine M. Lopez, Pristine C. Onuoha, Micah E. van Praag
{"title":"Effects of Urbanization on a North Carolina Piedmont Stream","authors":"Yasmine P. Ackall, Katherine M. Lopez, Pristine C. Onuoha, Micah E. van Praag","doi":"10.36838/v4i5.22","DOIUrl":"https://doi.org/10.36838/v4i5.22","url":null,"abstract":"","PeriodicalId":346661,"journal":{"name":"International Journal of High School Research","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122683939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Smoking Associated Cancer Mortality Trends in Select Countries","authors":"Siddharth Srivatsan","doi":"10.36838/v4i5.19","DOIUrl":"https://doi.org/10.36838/v4i5.19","url":null,"abstract":"","PeriodicalId":346661,"journal":{"name":"International Journal of High School Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128133556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of Highly Efficient Cellular Uptake Cell-Penetrating Peptide for Novel Cancer Treatment","authors":"Hong Sik Kim","doi":"10.36838/v4i5.2","DOIUrl":"https://doi.org/10.36838/v4i5.2","url":null,"abstract":"","PeriodicalId":346661,"journal":{"name":"International Journal of High School Research","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117056789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of Mining Waste in Civil Construction","authors":"Pedro Valim Hespanha Gonçalves","doi":"10.36838/v4i5.6","DOIUrl":"https://doi.org/10.36838/v4i5.6","url":null,"abstract":"","PeriodicalId":346661,"journal":{"name":"International Journal of High School Research","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115397291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chinese Media Representations of Chinese Women during COVID-19: Implications, Impacts, and Future","authors":"Cai Wu","doi":"10.36838/v4i5.21","DOIUrl":"https://doi.org/10.36838/v4i5.21","url":null,"abstract":"","PeriodicalId":346661,"journal":{"name":"International Journal of High School Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126085790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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