Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275810
Suleyman Ozsari
Aim:Early diagnosis is very important in some cancers such as breast, cervical and colorectal. However, the COVID-19 pandemic has severely disrupted cancer screening programmers in many countries. In this study, it is aimed to contribute to the literature on this subject by reviewing the status of local cancer screenings during the pandemic period.Methods: This retrospective study includes the 114.727 people in the risky group for cancer screening determined in Bolu, Turkey as two groups. During 2017-2019 years was determined as pre-pandemic group while the year of 2020 was the pandemic group. Data about patients’ results of smear / HPV (Human Papilloma Virus), fecal occult blood test (FOBT) and mammography had analyzed and compared with chi-square test.Results:For all of the screening strategies, smear / HPV, FOBT and mammography, mean of screening cases, positive cases and biopsies had significantly decreased (p<0.05),but there was no statistically difference for mean of definitive diagnoses about all of these cancers even if it has been decreased between two groups.Conclusion: The results of our study show that cancer screening processes are significantly disrupted during the pandemic period. Therefore, it is important to develop new screening strategies for the uninterrupted execution of cancer screening programs, especially during pandemic periods. However, we believe in the necessity of supporting studies with larger patient groups.
{"title":"Cancer screening in the COVID-19 pandemic; Development of early diagnostic strategies","authors":"Suleyman Ozsari","doi":"10.30714/j-ebr.2022275810","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275810","url":null,"abstract":"Aim:Early diagnosis is very important in some cancers such as breast, cervical and colorectal. However, the COVID-19 pandemic has severely disrupted cancer screening programmers in many countries. In this study, it is aimed to contribute to the literature on this subject by reviewing the status of local cancer screenings during the pandemic period.Methods: This retrospective study includes the 114.727 people in the risky group for cancer screening determined in Bolu, Turkey as two groups. During 2017-2019 years was determined as pre-pandemic group while the year of 2020 was the pandemic group. Data about patients’ results of smear / HPV (Human Papilloma Virus), fecal occult blood test (FOBT) and mammography had analyzed and compared with chi-square test.Results:For all of the screening strategies, smear / HPV, FOBT and mammography, mean of screening cases, positive cases and biopsies had significantly decreased (p<0.05),but there was no statistically difference for mean of definitive diagnoses about all of these cancers even if it has been decreased between two groups.Conclusion: The results of our study show that cancer screening processes are significantly disrupted during the pandemic period. Therefore, it is important to develop new screening strategies for the uninterrupted execution of cancer screening programs, especially during pandemic periods. However, we believe in the necessity of supporting studies with larger patient groups.","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"07 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131134258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275818
Mehmet Ali Kosekli
{"title":"Is Helicobacter pylori prevalence associated with the family population","authors":"Mehmet Ali Kosekli","doi":"10.30714/j-ebr.2022275818","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275818","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134270245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275813
Meliha Ekinci, H. Akbaba, R. Santos-Oliveira, Derya Ilem-Ozdemir
{"title":"Development and validation of UV/VIS spectroscopy method for determination of atezolizumab in pharmaceutical products","authors":"Meliha Ekinci, H. Akbaba, R. Santos-Oliveira, Derya Ilem-Ozdemir","doi":"10.30714/j-ebr.2022275813","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275813","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123621842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275812
E. Afsin, M. Polatlı, G. Bozkurt
{"title":"DNA investigation in the exhaled breath condensate (EBC) in non-small cell lung cancer","authors":"E. Afsin, M. Polatlı, G. Bozkurt","doi":"10.30714/j-ebr.2022275812","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275812","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"318 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115958171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275816
Emrah Acar, N. Ozgul, Ibrahim Donmez, O. Yalcin, Oguz Kayabas, S. Alan, İ. A. İzgi
{"title":"The combined S velocity achieved from tricuspid annulus and pulmonary annulus with tissue Doppler imaging could predict the proximal right coronary artery occlusion in patients with inferior myocardial infarction","authors":"Emrah Acar, N. Ozgul, Ibrahim Donmez, O. Yalcin, Oguz Kayabas, S. Alan, İ. A. İzgi","doi":"10.30714/j-ebr.2022275816","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275816","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134053458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275814
S. Karahan, O. İnce, F. Katkat, I. Sahin, E. Okuyan, M. Degertekin
{"title":"Clopidogrel versus ticagrelor in chronic kidney disease patients presenting with acute coronary syndrome: A retrospective evaluation","authors":"S. Karahan, O. İnce, F. Katkat, I. Sahin, E. Okuyan, M. Degertekin","doi":"10.30714/j-ebr.2022275814","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275814","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"209 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133424325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275811
S. Ozek
{"title":"The effect of having COVID-19 on insomnia, fatigue, and quality of life: A comparative study with vaccinated and unvaccinated COVID-19-negative patients","authors":"S. Ozek","doi":"10.30714/j-ebr.2022275811","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275811","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121206037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.30714/j-ebr.2022173848
T. Ozcan, Y. Sara, Kutluk Bilge Arıkan, Bengi Unal, C. T. Unal
Tuba Ozcan, Yildirim Sara, Kutluk Bilge Arikan, Bengi Unal , Cagri Temucin Unal Department of Medical Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, Turkey Department of Mechanical Engineering, TED University, Faculty of Engineering, Ankara, Turkey Department of Psychology, Çanakkale Onsekiz Mart University, Faculty of Arts and Sciences, Çanakkale, Turkey Neuroscience and Neurotechnology Center of Excellence (NÖROM), Ankara, Turkey
{"title":"The link between learning performance, immobility in the forced swim test, and hippocampal glia","authors":"T. Ozcan, Y. Sara, Kutluk Bilge Arıkan, Bengi Unal, C. T. Unal","doi":"10.30714/j-ebr.2022173848","DOIUrl":"https://doi.org/10.30714/j-ebr.2022173848","url":null,"abstract":"Tuba Ozcan, Yildirim Sara, Kutluk Bilge Arikan, Bengi Unal , Cagri Temucin Unal Department of Medical Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, Turkey Department of Mechanical Engineering, TED University, Faculty of Engineering, Ankara, Turkey Department of Psychology, Çanakkale Onsekiz Mart University, Faculty of Arts and Sciences, Çanakkale, Turkey Neuroscience and Neurotechnology Center of Excellence (NÖROM), Ankara, Turkey","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134584053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.30714/j-ebr.2022173852
Ilyas Ozcicek, N. Ayturk, N. Ayşit
Aim: Gold nanoparticles (AuNPs) have many biomedical applications due to their unique properties (e.g., chemical stability, optical properties, biocompatibility, easy synthesizability, and multiple functionalizations). This study aimed to synthesize two highly monodispersed and stable AuNPs of different sizes (AuNP20 and AuNP50), modified with polyethyleneimine (PEI) and polyethylene glycol (PEG), and systematically investigate their toxicological effects on histological changes in the organs of BALB/c mice. Methods: AuNPs (AuNP20 and AuNP50) were synthesized, and their surfaces were coated with PEI and PEG. All necessary characterizations were performed. After the application of two different doses of intravenous injections (IV) of the AuNPs (0.5 and 5 mg Au/kg), their toxicological effects and histological changes in the various mice organs (e.g., liver, spleen, kidney, brain) were evaluated with multiple parameters 48 h post injection. Fourteen days after a single high dose (5 mg Au/kg) IV injection of AuNPs, transmission electron microscopy (TEM) analysis was performed to reveal their ultrastructural effects in the liver of the mice. Results: Stable and highly monodispersed AuNPs were synthesized successfully. Since the liver is the most critical organ in nanotoxicological evaluations, changes in the parameters of AuNPs were shown to have remarkable effects. Although there were no differences in the impact caused between the two AuNPs sizes, the microstructure of the liver tissue treated with AuNP nanoparticles with PEI or PEG coatings was similar to that observed in the control group. Microstructural histological changes in the other organs (e.g., brain, kidney, and spleen) were relatively less than those found in the liver. The PEI and PEG surface coatings generally increased the biocompatibility of the AuNPs. According to the TEM analysis data, apparent cellular changes were observed after a long exposure period in the AuNP groups without an additional surface coating. Although slight cellular alterations were observed in the AuNP groups coated with PEG and PEI, the morphology of the hepatocyte cells was generally healthy. Conclusion: The surface coating of the AuNPs was a more decisive parameter than the size of the nanoparticles in terms of in vivo histological toxicity. The stability, biocompatibility, and surface coating of the AuNPs were critical parameters for potential nanoteranostic applications.
{"title":"Histological changes in mice tissues induced by gold nanoparticles with different surface coatings and sizes","authors":"Ilyas Ozcicek, N. Ayturk, N. Ayşit","doi":"10.30714/j-ebr.2022173852","DOIUrl":"https://doi.org/10.30714/j-ebr.2022173852","url":null,"abstract":"Aim: Gold nanoparticles (AuNPs) have many biomedical applications due to their unique properties (e.g., chemical stability, optical properties, biocompatibility, easy synthesizability, and multiple functionalizations). This study aimed to synthesize two highly monodispersed and stable AuNPs of different sizes (AuNP20 and AuNP50), modified with polyethyleneimine (PEI) and polyethylene glycol (PEG), and systematically investigate their toxicological effects on histological changes in the organs of BALB/c mice. Methods: AuNPs (AuNP20 and AuNP50) were synthesized, and their surfaces were coated with PEI and PEG. All necessary characterizations were performed. After the application of two different doses of intravenous injections (IV) of the AuNPs (0.5 and 5 mg Au/kg), their toxicological effects and histological changes in the various mice organs (e.g., liver, spleen, kidney, brain) were evaluated with multiple parameters 48 h post injection. Fourteen days after a single high dose (5 mg Au/kg) IV injection of AuNPs, transmission electron microscopy (TEM) analysis was performed to reveal their ultrastructural effects in the liver of the mice. Results: Stable and highly monodispersed AuNPs were synthesized successfully. Since the liver is the most critical organ in nanotoxicological evaluations, changes in the parameters of AuNPs were shown to have remarkable effects. Although there were no differences in the impact caused between the two AuNPs sizes, the microstructure of the liver tissue treated with AuNP nanoparticles with PEI or PEG coatings was similar to that observed in the control group. Microstructural histological changes in the other organs (e.g., brain, kidney, and spleen) were relatively less than those found in the liver. The PEI and PEG surface coatings generally increased the biocompatibility of the AuNPs. According to the TEM analysis data, apparent cellular changes were observed after a long exposure period in the AuNP groups without an additional surface coating. Although slight cellular alterations were observed in the AuNP groups coated with PEG and PEI, the morphology of the hepatocyte cells was generally healthy. Conclusion: The surface coating of the AuNPs was a more decisive parameter than the size of the nanoparticles in terms of in vivo histological toxicity. The stability, biocompatibility, and surface coating of the AuNPs were critical parameters for potential nanoteranostic applications.","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"27 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114032275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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