Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275810
Suleyman Ozsari
Aim:Early diagnosis is very important in some cancers such as breast, cervical and colorectal. However, the COVID-19 pandemic has severely disrupted cancer screening programmers in many countries. In this study, it is aimed to contribute to the literature on this subject by reviewing the status of local cancer screenings during the pandemic period.Methods: This retrospective study includes the 114.727 people in the risky group for cancer screening determined in Bolu, Turkey as two groups. During 2017-2019 years was determined as pre-pandemic group while the year of 2020 was the pandemic group. Data about patients’ results of smear / HPV (Human Papilloma Virus), fecal occult blood test (FOBT) and mammography had analyzed and compared with chi-square test.Results:For all of the screening strategies, smear / HPV, FOBT and mammography, mean of screening cases, positive cases and biopsies had significantly decreased (p<0.05),but there was no statistically difference for mean of definitive diagnoses about all of these cancers even if it has been decreased between two groups.Conclusion: The results of our study show that cancer screening processes are significantly disrupted during the pandemic period. Therefore, it is important to develop new screening strategies for the uninterrupted execution of cancer screening programs, especially during pandemic periods. However, we believe in the necessity of supporting studies with larger patient groups.
{"title":"Cancer screening in the COVID-19 pandemic; Development of early diagnostic strategies","authors":"Suleyman Ozsari","doi":"10.30714/j-ebr.2022275810","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275810","url":null,"abstract":"Aim:Early diagnosis is very important in some cancers such as breast, cervical and colorectal. However, the COVID-19 pandemic has severely disrupted cancer screening programmers in many countries. In this study, it is aimed to contribute to the literature on this subject by reviewing the status of local cancer screenings during the pandemic period.Methods: This retrospective study includes the 114.727 people in the risky group for cancer screening determined in Bolu, Turkey as two groups. During 2017-2019 years was determined as pre-pandemic group while the year of 2020 was the pandemic group. Data about patients’ results of smear / HPV (Human Papilloma Virus), fecal occult blood test (FOBT) and mammography had analyzed and compared with chi-square test.Results:For all of the screening strategies, smear / HPV, FOBT and mammography, mean of screening cases, positive cases and biopsies had significantly decreased (p<0.05),but there was no statistically difference for mean of definitive diagnoses about all of these cancers even if it has been decreased between two groups.Conclusion: The results of our study show that cancer screening processes are significantly disrupted during the pandemic period. Therefore, it is important to develop new screening strategies for the uninterrupted execution of cancer screening programs, especially during pandemic periods. However, we believe in the necessity of supporting studies with larger patient groups.","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"07 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131134258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275818
Mehmet Ali Kosekli
{"title":"Is Helicobacter pylori prevalence associated with the family population","authors":"Mehmet Ali Kosekli","doi":"10.30714/j-ebr.2022275818","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275818","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134270245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275813
Meliha Ekinci, H. Akbaba, R. Santos-Oliveira, Derya Ilem-Ozdemir
{"title":"Development and validation of UV/VIS spectroscopy method for determination of atezolizumab in pharmaceutical products","authors":"Meliha Ekinci, H. Akbaba, R. Santos-Oliveira, Derya Ilem-Ozdemir","doi":"10.30714/j-ebr.2022275813","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275813","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123621842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275816
Emrah Acar, N. Ozgul, Ibrahim Donmez, O. Yalcin, Oguz Kayabas, S. Alan, İ. A. İzgi
{"title":"The combined S velocity achieved from tricuspid annulus and pulmonary annulus with tissue Doppler imaging could predict the proximal right coronary artery occlusion in patients with inferior myocardial infarction","authors":"Emrah Acar, N. Ozgul, Ibrahim Donmez, O. Yalcin, Oguz Kayabas, S. Alan, İ. A. İzgi","doi":"10.30714/j-ebr.2022275816","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275816","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134053458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275812
E. Afsin, M. Polatlı, G. Bozkurt
{"title":"DNA investigation in the exhaled breath condensate (EBC) in non-small cell lung cancer","authors":"E. Afsin, M. Polatlı, G. Bozkurt","doi":"10.30714/j-ebr.2022275812","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275812","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"318 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115958171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275814
S. Karahan, O. İnce, F. Katkat, I. Sahin, E. Okuyan, M. Degertekin
{"title":"Clopidogrel versus ticagrelor in chronic kidney disease patients presenting with acute coronary syndrome: A retrospective evaluation","authors":"S. Karahan, O. İnce, F. Katkat, I. Sahin, E. Okuyan, M. Degertekin","doi":"10.30714/j-ebr.2022275814","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275814","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"209 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133424325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-15DOI: 10.30714/j-ebr.2022275811
S. Ozek
{"title":"The effect of having COVID-19 on insomnia, fatigue, and quality of life: A comparative study with vaccinated and unvaccinated COVID-19-negative patients","authors":"S. Ozek","doi":"10.30714/j-ebr.2022275811","DOIUrl":"https://doi.org/10.30714/j-ebr.2022275811","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121206037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.30714/j-ebr.2022173848
T. Ozcan, Y. Sara, Kutluk Bilge Arıkan, Bengi Unal, C. T. Unal
Tuba Ozcan, Yildirim Sara, Kutluk Bilge Arikan, Bengi Unal , Cagri Temucin Unal Department of Medical Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, Turkey Department of Mechanical Engineering, TED University, Faculty of Engineering, Ankara, Turkey Department of Psychology, Çanakkale Onsekiz Mart University, Faculty of Arts and Sciences, Çanakkale, Turkey Neuroscience and Neurotechnology Center of Excellence (NÖROM), Ankara, Turkey
{"title":"The link between learning performance, immobility in the forced swim test, and hippocampal glia","authors":"T. Ozcan, Y. Sara, Kutluk Bilge Arıkan, Bengi Unal, C. T. Unal","doi":"10.30714/j-ebr.2022173848","DOIUrl":"https://doi.org/10.30714/j-ebr.2022173848","url":null,"abstract":"Tuba Ozcan, Yildirim Sara, Kutluk Bilge Arikan, Bengi Unal , Cagri Temucin Unal Department of Medical Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, Turkey Department of Mechanical Engineering, TED University, Faculty of Engineering, Ankara, Turkey Department of Psychology, Çanakkale Onsekiz Mart University, Faculty of Arts and Sciences, Çanakkale, Turkey Neuroscience and Neurotechnology Center of Excellence (NÖROM), Ankara, Turkey","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134584053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.30714/j-ebr.2022173850
B. Sahin, R. Akkaya, S. Karabulut
Aim: To investigate the possible anticonvulsive effect of the selective COX-2 inhibitor meloxicam in pentylenetetrazole (PTZ)-induced epileptic seizures in mice and to examine its possible role on inhibition and excitation balance in the brain. Method: 30 BALB-c albino mice (16-18 weeks old) weighing 30-33 gr were used. Animals were randomly divided into five groups (n = 6 for each group). Group 1: control, group 2: received saline (10 ml/kg, i.p.) 30 minutes before PTZ (60 mg/kg i.p.) administration, group 3: received saline (10 ml/kg, i.p.) 30 minutes after PTZ (60 mg/kg i.p.) injection, group 4: received 60 mg/kg meloxicam i.p., 30 minutes before PTZ (60 mg/kg i.p.) administration. Group 5: received meloxicam (60 mg/kg i.p.) 30 minutes after PTZ injection (60 mg/kg, i.p.). The animals were observed for 30 minutes and the seizure stages and first myoclonic jerk times (FMJ) were recorded. After 24 hours, brain tissues were removed and the cortex and hippocampus were separated for biochemical assessments. ELISA method was used to measure GABA and glutamate levels. Results: Administration of meloxicam before PTZ induced seizure, reduced seizure stages and prolonged FMJ duration (p<0.05). Pre-treatment with meloxicam increased GABA levels in the cortex and decreased glutamate levels in the hippocampus (p<0.05). Post-treatment of meloxicam after PTZ-induced seizure increased GABA levels in the hippocampus (p<0.05). Conclusion: The results of our experimental study suggest that meloxicam has anti-convulsive effects and these effects may be mediated by GABA and glutamate, which are the main indicators of inhibition and excitation balance in the brain.
{"title":"Meloxicam, a selective COX-2 inhibitor, displays anticonvulsive effects in pentylenetetrazole-induced acute seizures in mice through GABA and glutamate mediated mechanism","authors":"B. Sahin, R. Akkaya, S. Karabulut","doi":"10.30714/j-ebr.2022173850","DOIUrl":"https://doi.org/10.30714/j-ebr.2022173850","url":null,"abstract":"Aim: To investigate the possible anticonvulsive effect of the selective COX-2 inhibitor meloxicam in pentylenetetrazole (PTZ)-induced epileptic seizures in mice and to examine its possible role on inhibition and excitation balance in the brain. Method: 30 BALB-c albino mice (16-18 weeks old) weighing 30-33 gr were used. Animals were randomly divided into five groups (n = 6 for each group). Group 1: control, group 2: received saline (10 ml/kg, i.p.) 30 minutes before PTZ (60 mg/kg i.p.) administration, group 3: received saline (10 ml/kg, i.p.) 30 minutes after PTZ (60 mg/kg i.p.) injection, group 4: received 60 mg/kg meloxicam i.p., 30 minutes before PTZ (60 mg/kg i.p.) administration. Group 5: received meloxicam (60 mg/kg i.p.) 30 minutes after PTZ injection (60 mg/kg, i.p.). The animals were observed for 30 minutes and the seizure stages and first myoclonic jerk times (FMJ) were recorded. After 24 hours, brain tissues were removed and the cortex and hippocampus were separated for biochemical assessments. ELISA method was used to measure GABA and glutamate levels. Results: Administration of meloxicam before PTZ induced seizure, reduced seizure stages and prolonged FMJ duration (p<0.05). Pre-treatment with meloxicam increased GABA levels in the cortex and decreased glutamate levels in the hippocampus (p<0.05). Post-treatment of meloxicam after PTZ-induced seizure increased GABA levels in the hippocampus (p<0.05). Conclusion: The results of our experimental study suggest that meloxicam has anti-convulsive effects and these effects may be mediated by GABA and glutamate, which are the main indicators of inhibition and excitation balance in the brain.","PeriodicalId":348987,"journal":{"name":"Experimental Biomedical Research","volume":"51 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132359473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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