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2015 International Symposium on Bioelectronics and Bioinformatics (ISBB)最新文献

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Channel models of body area networks for human motion 人体运动的身体区域网络通道模型
Pub Date : 2015-12-03 DOI: 10.1109/ISBB.2015.7344931
Di-hui Li, Jinzhao Lin, Yu Pang, Guoquan Li, Zhangyong Li, Wei Wang, Peng Sun
The channel characteristics of the body area network are important to transmission rate and transmission robustness. Current explorations mainly concern the channel characteristics in static state of the human body. In this paper, we establish human motion models of sitting to standing, walking and running postures, and calculate the path loss values in 2.4GHz for the models. The experimental results show that the path loss values vary sharply in the process of human movement, which is very helpful to determine the transmission power and design BAN sensor nodes.
体域网络的信道特性对传输速率和传输鲁棒性有重要影响。目前的研究主要集中在人体静态状态下的经络特性。本文建立了人体坐姿到站立姿势、行走姿势和跑步姿势的运动模型,并计算了模型在2.4GHz下的路径损耗值。实验结果表明,在人体运动过程中,路径损耗值变化很大,这对确定传输功率和设计BAN传感器节点有很大的帮助。
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引用次数: 2
PD of two kinds of blood pulse wave as an alternative of PAT PD的两种血脉波作为PAT的替代
Pub Date : 2015-12-03 DOI: 10.1109/ISBB.2015.7344912
Yibin Li, Xiaomeng Chen, N. Deng
Peak Delay (PD) of two different blood pulse waves measured at the same site is intensively studied in this paper. The derived expression, based on Womersley theory and simplified Navier-Stokes equations, implies that PD is closely related to the change of the Young's modulus of the blood vessel, which is promising in noninvasively BP monitoring. Traditionally, BP is estimated with Pulse Transit Time (PTT) or Pulse Arrival Time (PAT). Experiment results show that PAT and PD are inversely related with correlation coefficient from 0.78 to 0.95 when BP is relatively stable. If BP changes remarkably, calibration should be conducted to better trace PAT with PD. Therefore PTT or PAT can be replaced by PD for continuous and noninvasive BP monitoring, with the convenience that the measuring site is concentrated on fingertip.
本文对同一位置测得的两种不同血脉搏波的峰值延迟(PD)进行了深入的研究。基于Womersley理论和简化的Navier-Stokes方程推导出的表达式表明,PD与血管杨氏模量的变化密切相关,在无创血压监测中具有广阔的应用前景。传统上,用脉冲传递时间(PTT)或脉冲到达时间(PAT)来估计血压。实验结果表明,当BP相对稳定时,PAT和PD呈负相关,相关系数在0.78 ~ 0.95之间。如果BP变化明显,则应进行校准,以便用PD更好地跟踪PAT。因此,PD可以代替PTT或PAT进行连续、无创的血压监测,且方便测量部位集中在指尖。
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引用次数: 1
Low-power design towards implantable neural signal processor- energy efficiency analysis for near-threshold voltage circuits design 面向植入式神经信号处理器的低功耗设计——近阈值电压电路设计的能效分析
Pub Date : 2015-12-03 DOI: 10.1109/ISBB.2015.7344957
I-Chyn Wey, Jia-Feng Huang, C. Gong, Shiang-Wei Li, Chang-Chieh Lin, C. Chien, Yu-Fan Luo, Y. Kuo, Meng-Jung Chang, Chin-Chih Hsu
In this paper, we review state-of-the-art low-voltage fault-tolerable logic techniques that are promising for medical implants. The paper also proposes a method to get the efficiency comparison of computational time delay, power consumption, energy efficiency and progress variation of logic gates such as static, transmission gate, DCVSL, dynamic and pesudo in different temperature, time and variations so that the researchers can have a design reference for ultra low-power digital blocks of the implantable systems.
在本文中,我们回顾了最先进的低压容错逻辑技术,有望用于医疗植入物。本文还提出了一种方法,对静态、传输门、DCVSL、动态、伪等逻辑门在不同温度、时间和变化情况下的计算时延、功耗、能效和进度变化进行效率比较,为可植入系统的超低功耗数字模块的设计提供参考。
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引用次数: 0
An effective method for ultrasound thyroid nodules segmentation 一种有效的超声甲状腺结节分割方法
Pub Date : 2015-12-03 DOI: 10.1109/ISBB.2015.7344960
Wenpeng Du, N. Sang
Ultrasound thyroid nodules segmentation is a much tough task due to the speckle noise, intensity heterogeneity, and low contrast. In this paper, we introduce an effective segmentation method to make the problem better. Our works are composed of pre-processing, extracting boundaries, postprocessing. First, we suppress the speckle noise by speckle reducing anisotropic diffusion method. Second, we introduce a reasonable and effective speed stopping term based local phase symmetry feature which is theoretically intensity invariant, and the new speed stop term is incorporated into distance regularized level set evolution. Then, to remedy the emerging problems, we do some effective post-processing. Qualitative and quantitative comparative results demonstrate the superiority of our proposed method.
超声甲状腺结节分割是一项艰巨的任务,由于斑点噪声,强度不均,对比度低。在本文中,我们引入了一种有效的分割方法来解决这个问题。我们的作品由预处理、提取边界、后处理组成。首先,采用散斑减小各向异性扩散方法抑制散斑噪声。其次,引入合理有效的基于局部相位对称特征的速度停止项,该特征理论上是强度不变的,并将新的速度停止项引入到距离正则化水平集演化中;然后,为了弥补出现的问题,我们做了一些有效的后处理。定性和定量对比结果证明了本文方法的优越性。
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引用次数: 16
A robust method for interactive segmentation of Circle of Willis 威利斯圆交互式分割的鲁棒方法
Pub Date : 2015-12-03 DOI: 10.1109/ISBB.2015.7344926
Zhiyang Song, Xing Chen, Mingquan Zhou, Zhongke Wu, Wuyang Shui, Xingce Wang
The Circle of Willis (CoW) is a circulatory anastomosis that supplies blood to the brain and surrounding structure. Detecting and quantifying the CoW is essential for the prevention and treatment of aneurysm rupture and cerebral Infarction. In this paper, we present a robust interactive method to segment CoW mesh model from the whole cerebrovascular mesh base on graph-cut. First we construct the weighted graph G based on the input sketch. Then we find the minimum cost along the partitioned edges with Min-Cut/Max-Flow method. Moreover, we combine the shape-diameter function (SDF) and the angles between the normal vector of the neighbor face to construct the penalty energy which makes the method stable. Computational results show that the proposed interactive algorithm is robust, real time performance and friendly to user.
威利斯环(CoW)是一种循环吻合,为大脑和周围结构提供血液。对脑梗死和动脉瘤破裂的预防和治疗有重要意义。本文提出了一种基于图切(graph-cut)的鲁棒交互式脑血管网格模型分割方法。首先,我们基于输入草图构造加权图G。然后用Min-Cut/Max-Flow方法求出沿分割边的最小代价。此外,我们结合形状-直径函数(SDF)和相邻面法向量之间的夹角来构造惩罚能量,使方法稳定。计算结果表明,所提出的交互算法具有鲁棒性、实时性和用户友好性。
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引用次数: 0
A wideband current source for System-on-Chip Bio-Impedance Spectroscopy using a CCII drive and Pseudo-Resistor feedback 使用CCII驱动和伪电阻反馈的片上系统生物阻抗谱的宽带电流源
Pub Date : 2015-12-03 DOI: 10.1109/ISBB.2015.7344935
Wen-Yaw Chung, Angelito A. Silverio, Shu-Yu Chang, Ming-Ying Zhou, Vincent F. S. Tsai
In this paper, a wideband Current Source (CS) for System on Chip (SoC) Bio-Impedance Spectroscopy (BIS) application is presented. The circuit consists of a load-in loop inverting amplifier current source back-end with a PMOS Pseudo-Resistor (PR) feedback, and a Norton current source front-end drive in the form of a Second Generation Current Conveyor (CCII). The load-in-loop structure allows a differential interface to the Sample Under Study (SUT) permitting the four-point probe interface. The use of a PR array results in the creation of a high impedance feedback while consuming small chip area. The CCII drive increases the output impedance of the CS towards the MHz range. Comparison of 6 load-in-loop CS (LL-CS) structures confirm the performance of our design in terms of output impedance, and excitation current precision over a wide frequency range covering the beta-dispersion range of BIS (~10MHz). The LL-CS structures are realized using TSMC 0.35um CMOS 2P4M Mixed Mode Technology.
本文介绍了一种用于片上系统(SoC)生物阻抗谱(BIS)应用的宽带电流源(CS)。该电路由带PMOS伪电阻(PR)反馈的负载环反相放大器电流源后端和第二代电流传送带(CCII)形式的诺顿电流源前端驱动组成。负载在环结构允许一个差分接口到被研究样品(SUT),允许四点探针接口。使用PR阵列会产生高阻抗反馈,同时消耗小芯片面积。CCII驱动器增加了CS在MHz范围内的输出阻抗。通过对6种负载在环CS (LL-CS)结构的比较,证实了我们的设计在输出阻抗和激励电流精度方面的性能,在覆盖BIS的β色散范围(~10MHz)的宽频率范围内。LL-CS结构采用台积电0.35um CMOS 2P4M混合模式技术实现。
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引用次数: 8
A brain controlled wheelchair based on common spatial pattern 基于共同空间模式的脑控轮椅
Pub Date : 2015-12-03 DOI: 10.1109/ISBB.2015.7344913
Yanyan Xie, Xiaoou Li
This paper was proposed for the feature extraction problem in Brain Computer Interface (BCI) which was based on the motor imagery. Common Spatial Pattern (CSP) was used to extract useful features from the Electroencephalograph (EEG) signals. Firstly, a preprocessing step was applied to remove noises. Secondly, CSP was used to analyze with EEG signals. Support Vector Machine (SVM) was investigated to classify motor imagery state. The EEG signals of motor imagery provided by dataset I of 2004 BCI Competition III were used for the validation. The results showed that the algorithm can extract the obvious characteristics efficiently. Finally, the proposed method was used in a wheelchair application. Experimental results showed that the proposed approach was promising for implementing human-computer interaction, especially for EEG-based brain controlled wheelchair.
针对基于运动图像的脑机接口(BCI)特征提取问题,提出了一种基于运动图像的脑机接口特征提取方法。利用共同空间模式(CSP)从脑电图信号中提取有用的特征。首先,采用预处理步骤去除噪声。其次,利用CSP对脑电信号进行分析。采用支持向量机(SVM)对运动意象状态进行分类。使用2004年脑机接口大赛数据集1提供的运动图像脑电信号进行验证。结果表明,该算法能有效地提取出明显的特征。最后,将该方法应用于轮椅的实际应用。实验结果表明,该方法对于实现人机交互,特别是基于脑电图的脑控轮椅具有良好的应用前景。
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引用次数: 12
Automatic assessment of putonghua articulation and pronunciation disorder 普通话发音及发音障碍的自动评估
Pub Date : 2015-12-03 DOI: 10.1109/ISBB.2015.7344910
Boyu Si, Zhaomin Huang
In this paper, an automatic assessment system has been developed for Putonghua articulation and pronunciation assessment. The framework of developing the system consists of designing the vocabularies respectively for the two assessment parts with standard scoring regulations, constructing the speech recognition module which makes use of a HMM based acoustic model with 39 parameters including logarithmic energy, the previous 12 MFCCs and their first and second difference extracted from the records of speech and the Speech SDK which is a developing kit from Microsoft to improve the accuracy, and building disorder diagnosis module according to the clinical requirement. In order to measure accuracy of this objective method, a comparative experiment is carried out with the subjective one, the results show that the two methods are almost the same and have a extremely correlation in both the articulation and pronunciation assessments.
本文开发了一个用于普通话发音和发音的自动测试系统。系统的开发框架包括:分别为两个评估部分设计具有标准评分规则的词汇表;构建语音识别模块,该模块利用基于HMM的声学模型(包括对数能量在内的39个参数)、从语音记录中提取的前12个mfc及其一、二次差以及微软开发工具包speech SDK来提高准确率;并根据临床需要构建障碍诊断模块。为了衡量该客观方法的准确性,与主观方法进行了对比实验,结果表明,两种方法几乎相同,并且在发音和发音方面都有极高的相关性。
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引用次数: 1
In-vitro hyperthermia studied by cellular impedance sensors 细胞阻抗传感器研究体外热疗
Pub Date : 2015-12-03 DOI: 10.1109/ISBB.2015.7344965
Xinwu Xie, Ran Liu, Weixing Chen, Youchun Xu, Jing Cheng
In this paper, we used an experimental platform based on cellular impedance sensors to study cellular changes after hyperthermia treatments. Impedance profiling showed high correlation with traditional MTT results, thus the impedance data represent cell viabilities very well. Then, status of cells under six typical hyperthermia treatments with different temperatures between 41-46 °C and different treating durations (0-30 min, 45 °C) were examined by the platform separately. The results showed increasing cell damage occurred when temperature or duration increased, and indicated the thresholds of temperature (~43 °C). Moreover, it is possible that a thermal isoeffect dose (TID) threshold exists in the two cell lines (equivalent time at 43 °C EM43=30~40 min). These results fit previous theories of hyperthermia, demonstrating that the cellular impedance sensor is a useful analytical tool for the in vitro research of thermal therapy.
在本文中,我们使用基于细胞阻抗传感器的实验平台来研究热疗后细胞的变化。阻抗分析结果与传统的MTT结果具有较高的相关性,因此阻抗数据可以很好地反映细胞活力。然后,通过平台分别检测在41-46℃不同温度和不同处理时间(0-30 min, 45℃)下6种典型热疗处理下的细胞状态。结果表明,随着温度或持续时间的增加,细胞损伤程度增加,并提示温度阈值(~43℃)。此外,两种细胞系可能存在热等效应剂量(TID)阈值(43℃下等效时间EM43=30~40 min)。这些结果与先前的热疗理论相吻合,表明细胞阻抗传感器是热疗体外研究的有用分析工具。
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引用次数: 1
Actuator design for robotic powered an ankle-foot prosthesis 机器人踝足假体驱动器设计
Pub Date : 2015-12-03 DOI: 10.1109/ISBB.2015.7344942
M. Ahmed, Fawaz Wahid, Ahsan Ali, M. Tiwana, J. Iqbal, N. Lovell
Below-knee amputation is one of the most critical types of amputations related to gait disability. A very effective therapy is to replace the amputated part by a robotic prosthetic lower limb. This limb consists of different design parameters with most important and crucial being its actuator. Since the power transmission to the foot and movement control is directed through the actuator, it is very important to use an actuator which fulfills all the vital parameters required for the prosthesis to work effectively i.e. weight, torque and speed. Conventional actuators available on the market do not control all these parameters. The purpose of this paper is the development of an effective actuator design, for assisting robotic prostheses that can be used by amputated people in the everyday environment to obtain natural gait. The presented design has been validated using finite element analysis (FEA).
膝下截肢是与步态障碍相关的最关键的截肢类型之一。一种非常有效的治疗方法是用机器人假肢代替被截肢的部分。该分支由不同的设计参数组成,其中最重要和最关键的是其执行机构。由于动力传递到足部和运动控制是通过致动器进行的,因此使用一个能满足假肢有效工作所需的所有重要参数(即重量、扭矩和速度)的致动器是非常重要的。市场上现有的传统执行器不能控制所有这些参数。本文的目的是开发一种有效的执行器设计,以辅助截肢者在日常环境中使用的机器人假肢获得自然步态。采用有限元分析(FEA)对设计进行了验证。
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引用次数: 5
期刊
2015 International Symposium on Bioelectronics and Bioinformatics (ISBB)
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