Pub Date : 2023-06-16DOI: 10.21428/3d48c34a.180cc7cb
Mosamat Umma Kulsum, Ishtiaq Hossain Ornab
{"title":"Engaging the community and building public trust in health research.","authors":"Mosamat Umma Kulsum, Ishtiaq Hossain Ornab","doi":"10.21428/3d48c34a.180cc7cb","DOIUrl":"https://doi.org/10.21428/3d48c34a.180cc7cb","url":null,"abstract":"","PeriodicalId":353726,"journal":{"name":"The Global Health Network Conference Proceedings 2022","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130543692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.21428/3d48c34a.c7202307
T. T. Eliya, Chukwuebuka Ugwu, Bimba John, Bassey Emmana, Kushim Jonathan, Ajide Bukola Adeoola, Ishaku Precious, Ekwu James
Tuberculosis (TB) culture is the gold standard for the diagnosis of Mycobacterium tuberculosis (Mtb) and enables full drug susceptibility testing. However, culture contamination remains a challenge in TB culture resulting to significant loss of time and resources and potentially, poor treatment outcomes on account of incorrect clinical decision-making. The purpose of this study is to assess the effect of sputum transit time on contamination rate and the yield of Mtb. We conducted a retrospective analysis of all samples received for TB culture at a Reference Laboratory, from January to December 2021. Samples were decontaminated by using the standard N-Acetyl L-cysteine (NALC)/Sodium Hydroxide (NaOH) method to process the sputum samples and inoculated on solid media. The number of days from sample collection to processing was documented for all 988 valid samples received within the study period. We conducted univariable logistic regression to explore the relationship between transit time and contamination rate. We report percentages, and Odds ratios with associated 95% confidence intervals. Of 988 diagnosis and follow-up samples received, 508(58.7%) were from males while 14(1.4%) were from children (≤ 14y). Overall, 56 samples were contaminated of which 17 were positive on AFB. A contamination rate of 4.1%, 7.1% and 8.3% were recorded for Optimal (0-7 days), Delayed (8-14 days), and Extended delay (>15 days) samples respectively. Compared to samples analyzed within optimal transit time, those with Delayed and Extended delay transit times had greater odds of being contaminated with OR of 1.811 (0.997-3.290) and 2.148 (0.983-4.688) respectively. The study revealed that TB culture contamination rate tends to increase with number of days taken for sample movement from collection to processing. However, the association detected fell slightly short of achieving statistical significance. It is also instructive that about one in three samples that were contaminated (17/56) was positive on AFB which could have far-reaching implications for the clinical decision-making and management of persons being
{"title":"Impact of Sputum Transit Time on TB Isolation and Culture Contamination Rate","authors":"T. T. Eliya, Chukwuebuka Ugwu, Bimba John, Bassey Emmana, Kushim Jonathan, Ajide Bukola Adeoola, Ishaku Precious, Ekwu James","doi":"10.21428/3d48c34a.c7202307","DOIUrl":"https://doi.org/10.21428/3d48c34a.c7202307","url":null,"abstract":"Tuberculosis (TB) culture is the gold standard for the diagnosis of Mycobacterium tuberculosis (Mtb) and enables full drug susceptibility testing. However, culture contamination remains a challenge in TB culture resulting to significant loss of time and resources and potentially, poor treatment outcomes on account of incorrect clinical decision-making. The purpose of this study is to assess the effect of sputum transit time on contamination rate and the yield of Mtb. We conducted a retrospective analysis of all samples received for TB culture at a Reference Laboratory, from January to December 2021. Samples were decontaminated by using the standard N-Acetyl L-cysteine (NALC)/Sodium Hydroxide (NaOH) method to process the sputum samples and inoculated on solid media. The number of days from sample collection to processing was documented for all 988 valid samples received within the study period. We conducted univariable logistic regression to explore the relationship between transit time and contamination rate. We report percentages, and Odds ratios with associated 95% confidence intervals. Of 988 diagnosis and follow-up samples received, 508(58.7%) were from males while 14(1.4%) were from children (≤ 14y). Overall, 56 samples were contaminated of which 17 were positive on AFB. A contamination rate of 4.1%, 7.1% and 8.3% were recorded for Optimal (0-7 days), Delayed (8-14 days), and Extended delay (>15 days) samples respectively. Compared to samples analyzed within optimal transit time, those with Delayed and Extended delay transit times had greater odds of being contaminated with OR of 1.811 (0.997-3.290) and 2.148 (0.983-4.688) respectively. The study revealed that TB culture contamination rate tends to increase with number of days taken for sample movement from collection to processing. However, the association detected fell slightly short of achieving statistical significance. It is also instructive that about one in three samples that were contaminated (17/56) was positive on AFB which could have far-reaching implications for the clinical decision-making and management of persons being","PeriodicalId":353726,"journal":{"name":"The Global Health Network Conference Proceedings 2022","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131505985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.21428/3d48c34a.de00f2c6
V. Jorge, C. Machado
{"title":"Implementation of Data Platforms in the context of Open Science: the experience of Fiocruz","authors":"V. Jorge, C. Machado","doi":"10.21428/3d48c34a.de00f2c6","DOIUrl":"https://doi.org/10.21428/3d48c34a.de00f2c6","url":null,"abstract":"","PeriodicalId":353726,"journal":{"name":"The Global Health Network Conference Proceedings 2022","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130213061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.21428/3d48c34a.66ca725e
G. Odey, Madonna Badom, H. Obaje
{"title":"Towards Achieving improved access to youth-friendly Sexual Reproductive Health and Rights (SRHR) services in Cross River State (CRS) Nigeria; Sustaining Evidence-Driven Advocacy through the CRS SRHR policy.","authors":"G. Odey, Madonna Badom, H. Obaje","doi":"10.21428/3d48c34a.66ca725e","DOIUrl":"https://doi.org/10.21428/3d48c34a.66ca725e","url":null,"abstract":"","PeriodicalId":353726,"journal":{"name":"The Global Health Network Conference Proceedings 2022","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127669279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.21428/3d48c34a.8a98998e
Charity Hungu, Relebogile Mapuroma, J. Ncayiyana, M. Atela
They
他们
{"title":"Community Health Volunteers and their role in facilitating adoption of health interventions in the community.","authors":"Charity Hungu, Relebogile Mapuroma, J. Ncayiyana, M. Atela","doi":"10.21428/3d48c34a.8a98998e","DOIUrl":"https://doi.org/10.21428/3d48c34a.8a98998e","url":null,"abstract":"They","PeriodicalId":353726,"journal":{"name":"The Global Health Network Conference Proceedings 2022","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121600543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.21428/3d48c34a.119d9c4e
Yaocihuatl Castañeda Borrayo, S. L. Cortés, Leslie Guadalupe Rivera Rodríguez
Yaocihuatl Castañeda Borrayo1 Silvia Graciela León Cortés2 Leslie Guadalupe Rivera Rodríguez2 1Instituto Mexicano del Seguro Social, Unidad de Investigación Epidemiológica y en Servicios de Salud, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Órganos de Operación Administrativa Desconcentrada., Mexico, 2University of Guadalajara, University Center for Health Sciences, Department of Public Health, Doctorate in Occupational Health Sciences., Mexico
{"title":"Diabetes mellitus as a cause of disability in Mexico from 1998 to 2020.","authors":"Yaocihuatl Castañeda Borrayo, S. L. Cortés, Leslie Guadalupe Rivera Rodríguez","doi":"10.21428/3d48c34a.119d9c4e","DOIUrl":"https://doi.org/10.21428/3d48c34a.119d9c4e","url":null,"abstract":"Yaocihuatl Castañeda Borrayo1 Silvia Graciela León Cortés2 Leslie Guadalupe Rivera Rodríguez2 1Instituto Mexicano del Seguro Social, Unidad de Investigación Epidemiológica y en Servicios de Salud, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Órganos de Operación Administrativa Desconcentrada., Mexico, 2University of Guadalajara, University Center for Health Sciences, Department of Public Health, Doctorate in Occupational Health Sciences., Mexico","PeriodicalId":353726,"journal":{"name":"The Global Health Network Conference Proceedings 2022","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121605605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.21428/3d48c34a.ab93d1a0
Miriam Nakanwagi, Dennis Adoa, Esther Nyamugisa, E. Magongo
{"title":"Trends of children and adolescents in HIV care during and after the COVID19 lock-down in Uganda, 2020 – 2021: a descriptive analysis of surveillance data","authors":"Miriam Nakanwagi, Dennis Adoa, Esther Nyamugisa, E. Magongo","doi":"10.21428/3d48c34a.ab93d1a0","DOIUrl":"https://doi.org/10.21428/3d48c34a.ab93d1a0","url":null,"abstract":"","PeriodicalId":353726,"journal":{"name":"The Global Health Network Conference Proceedings 2022","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116164467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.21428/3d48c34a.52e86d6d
Abolanle Adebisi, M. Adeleke, K. Fasasi, O. Surakat
Background: Schistosomiasis is the most prevalent waterborne parasitic diseases in rural communities and urban populations which depend on streams and rivers for domestic and agricultural purposes. Provision of water, sanitation and hygiene (WASH) resources has been advocated a strategy for sustainable control of soil-transmitted helminthiasis (STH). Studies on Schistosoma haematobium amongst school children in osogbo metropolis in Osun state, Nigeria was carried out to determine the prevalence of schistosomiasis in school age children and the status of WASH resources. Method: A total of 216 (104 males and 112 females) urine was collected in a collection tube. Schistosoma haematobium infection was detected by microscopic examination of schistosome egg in the urine. A structured survey form (Questionnaire) was administered to each participants to inquiry about their demographic characteristics, sanitation and hygiene practices (WASH activity) both at home and in the school and also their knowledge about schistosomiasis using WHO standard questionnaire. The samples was centrifuged and kept in the fridge at 40C until further analysis. 50 samples were further analyzed for DNA extraction using the Genomic DNA Extraction kits by NIMR BIOTECH (Research for national Health), extracted/ eluted DNA was stored at -20oC in the freezer. The supposed DNAs obtained were subjected to Polymerase Chain Reaction (PCR) using the conventional method to detect the scistosome DNA. Result: But none of the 50 samples pool tested was positive to any of the target DNA gel electrophorensis. This study observed no detectable DNA in the urine samples. Conclusion: It is hence suggested that there was little risk of prevalence of schistosomiasis infection in Osogbo during this study period. However, further investigations, as well as, continual prevalence investigation are recommended.
背景:血吸虫病是农村社区和城市人口中最普遍的水传播寄生虫病,这些社区和城市人口的生活和农业目的依赖于溪流和河流。提供水、环境卫生和个人卫生(WASH)资源是一项可持续控制土壤传播蠕虫病(STH)的战略。对尼日利亚奥松州奥索博市学龄儿童中的血血吸虫病进行了研究,以确定学龄儿童中血吸虫病的流行情况和讲卫生资源的状况。方法:采用尿管收集216例(男104例,女112例)尿液。尿中血吸虫卵镜检发现血血吸虫感染。向每位参与者发放了一份结构化调查表(问卷),以使用世卫组织标准问卷询问他们的人口特征、家庭和学校的环境卫生和个人卫生习惯(WASH活动)以及他们对血吸虫病的了解情况。样品被离心并保存在40摄氏度的冰箱里,等待进一步的分析。使用NIMR BIOTECH (Research for national Health)的基因组DNA提取试剂盒对50份样本进行进一步分析提取DNA,提取/洗脱的DNA在-20℃冷冻保存。将得到的假定DNA进行聚合酶链反应(PCR),采用常规方法检测裂体DNA。结果:50份样本均无靶DNA凝胶电泳阳性。本研究未在尿液样本中发现可检测到的DNA。结论:本研究期间,奥索博省血吸虫病流行风险较小。但是,建议进行进一步的调查以及持续的流行率调查。
{"title":"Evaluation of Schistosoma haematobium and Access to Wash Facilities by School Age Children in Osogbo Metropolis, Osun State, Nigeria.","authors":"Abolanle Adebisi, M. Adeleke, K. Fasasi, O. Surakat","doi":"10.21428/3d48c34a.52e86d6d","DOIUrl":"https://doi.org/10.21428/3d48c34a.52e86d6d","url":null,"abstract":"Background: Schistosomiasis is the most prevalent waterborne parasitic diseases in rural communities and urban populations which depend on streams and rivers for domestic and agricultural purposes. Provision of water, sanitation and hygiene (WASH) resources has been advocated a strategy for sustainable control of soil-transmitted helminthiasis (STH). Studies on Schistosoma haematobium amongst school children in osogbo metropolis in Osun state, Nigeria was carried out to determine the prevalence of schistosomiasis in school age children and the status of WASH resources. Method: A total of 216 (104 males and 112 females) urine was collected in a collection tube. Schistosoma haematobium infection was detected by microscopic examination of schistosome egg in the urine. A structured survey form (Questionnaire) was administered to each participants to inquiry about their demographic characteristics, sanitation and hygiene practices (WASH activity) both at home and in the school and also their knowledge about schistosomiasis using WHO standard questionnaire. The samples was centrifuged and kept in the fridge at 40C until further analysis. 50 samples were further analyzed for DNA extraction using the Genomic DNA Extraction kits by NIMR BIOTECH (Research for national Health), extracted/ eluted DNA was stored at -20oC in the freezer. The supposed DNAs obtained were subjected to Polymerase Chain Reaction (PCR) using the conventional method to detect the scistosome DNA. Result: But none of the 50 samples pool tested was positive to any of the target DNA gel electrophorensis. This study observed no detectable DNA in the urine samples. Conclusion: It is hence suggested that there was little risk of prevalence of schistosomiasis infection in Osogbo during this study period. However, further investigations, as well as, continual prevalence investigation are recommended.","PeriodicalId":353726,"journal":{"name":"The Global Health Network Conference Proceedings 2022","volume":"91 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120866642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.21428/3d48c34a.d27f28ed
Ruth M. Ogboye, J. Soyinka, O. Bolaji, A. Adegbola
As per current treatment guidelines, artemether-lumefantrine, and efavirenz (EFV)-based antiretroviral therapy are recommended drugs for falciparum malaria and HIV infections, respectively. A liquid chromatography-ultraviolet detection (LC-UV) method for simultaneous quantification of lumefantrine and EFV was developed and validated for efficacy and pharmacokinetic clinical studies. Lumefantrine and EFV were separated using a 100 x 4.6 mm x 3 µm Fortis C 18 chromatographic column, and a multistep gradient mobile phase. Calibration was obtained with a series of standard solutions containing known concentrations of the chemical reference of both analytes prepared concomitantly in drug-free plasma. The assay was validated within the calibration ranges of 78.125 to 20000 ng/mL for lumefantrine and 187.15 to 24000 ng/mL for EFV. Stability assessment was carried out with or without heating the quality sample to 58°C for 45 min. The method was employed to measure the plasma concentrations of lumefantrine and EFV in a study conducted among malaria-HIV co-infected patients. Lumefantrine and EFV were well separated from each other and from the biological matrix. The method demonstrated a good recovery of 72.64% for lumefantrine and 117.17% for EFV. The intra-and inter-day accuracy presented as 95.36-105.14% for lumefantrine and 104.11-115% for EFV and precision ranged from 1.15 to 6.45% for lumefantrine and 0.43 to 13.12 for EFV, were within ±15% at the three quality control levels. The analytes from both quality control lots and samples collected from HIV-malaria co-infected individuals were found to be stable post-deactivation of infectious virus by heating to 58 °C for 45 min. The assay is accurate, precise and shown to simultaneously measure the lumefantrine and EFV in human
{"title":"A simple high-performance liquid chromatographic assay for lumefantrine in plasma in the presence of efavirenz-based antiretroviral therapy","authors":"Ruth M. Ogboye, J. Soyinka, O. Bolaji, A. Adegbola","doi":"10.21428/3d48c34a.d27f28ed","DOIUrl":"https://doi.org/10.21428/3d48c34a.d27f28ed","url":null,"abstract":"As per current treatment guidelines, artemether-lumefantrine, and efavirenz (EFV)-based antiretroviral therapy are recommended drugs for falciparum malaria and HIV infections, respectively. A liquid chromatography-ultraviolet detection (LC-UV) method for simultaneous quantification of lumefantrine and EFV was developed and validated for efficacy and pharmacokinetic clinical studies. Lumefantrine and EFV were separated using a 100 x 4.6 mm x 3 µm Fortis C 18 chromatographic column, and a multistep gradient mobile phase. Calibration was obtained with a series of standard solutions containing known concentrations of the chemical reference of both analytes prepared concomitantly in drug-free plasma. The assay was validated within the calibration ranges of 78.125 to 20000 ng/mL for lumefantrine and 187.15 to 24000 ng/mL for EFV. Stability assessment was carried out with or without heating the quality sample to 58°C for 45 min. The method was employed to measure the plasma concentrations of lumefantrine and EFV in a study conducted among malaria-HIV co-infected patients. Lumefantrine and EFV were well separated from each other and from the biological matrix. The method demonstrated a good recovery of 72.64% for lumefantrine and 117.17% for EFV. The intra-and inter-day accuracy presented as 95.36-105.14% for lumefantrine and 104.11-115% for EFV and precision ranged from 1.15 to 6.45% for lumefantrine and 0.43 to 13.12 for EFV, were within ±15% at the three quality control levels. The analytes from both quality control lots and samples collected from HIV-malaria co-infected individuals were found to be stable post-deactivation of infectious virus by heating to 58 °C for 45 min. The assay is accurate, precise and shown to simultaneously measure the lumefantrine and EFV in human","PeriodicalId":353726,"journal":{"name":"The Global Health Network Conference Proceedings 2022","volume":"616 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120932829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.21428/3d48c34a.6e26a90e
E. L. Acen, I. A. Biraro, M. Bbuye, D. Kateete, M. Joloba, W. Worodria
{"title":"Knowledge of Tuberculosis Disease Among Newly Diagnosed Patients: A cross Sectional study","authors":"E. L. Acen, I. A. Biraro, M. Bbuye, D. Kateete, M. Joloba, W. Worodria","doi":"10.21428/3d48c34a.6e26a90e","DOIUrl":"https://doi.org/10.21428/3d48c34a.6e26a90e","url":null,"abstract":"","PeriodicalId":353726,"journal":{"name":"The Global Health Network Conference Proceedings 2022","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126371501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}