Pub Date : 2023-05-30DOI: 10.59657/2993-1118.brs.23.008
Diatta Boubacar Ahy, Arahou Teba, Patrice Mendy, Ndiague Fall, Pie Nibirantije, Ndiaye Coumba, N. Ndour, N. Mame, D. Saer, Diop Assane, Ndiaye Maodo, D. Moussa, Ly Fatimata, Niang Suzanne Oumou
Introduction: Atopic dermatitis (AD) is a chronic inflammatory disease that is on the rise in industrialized countries. It is underestimated in Africa. This study aimed to describe the epidemiological, clinical, therapeutic, and evolutionary profile of atopic dermatitis, and to identify its impact on patients' quality of life. Methodology: We conducted a retrospective multicenter descriptive-analytical cross-sectional study in three dermatology referral departments in Dakar for over 3 years. We included all patients who consulted us for atopic dermatitis. Results: We identified 301 cases of atopic dermatitis, representing a hospital frequency of 0.6%. The mean age was 17 years. Pruritus was the main functional symptom. According to SCORAD, atopic dermatitis was mild in 50 cases (16.6%), moderate in 226 cases (75.10%), and severe in 25 cases (8.3%). AD was associated with seborrheic dermatitis in 1.9% and allergic contact dermatitis in 1.6%. Skin infections included staphylococcal in 8.97%, herpetic in 3.03% and scabies in 1.6%. Topical steroids and skin infections were the first-line treatment, in combining with therapeutic education. Methotrexate and azathioprine were used in 3 cases. Complete response was observed in 76.6% of patients. Conclusion: Atopic dermatitis is a common chronic inflammatory disease in Senegal. Early management and therapeutic education can prevent complications and reduce the psychological and social impact.
{"title":"Atopic Dermatitis in Senegal: Epidemiological, Clinical, and Therapeutic Features","authors":"Diatta Boubacar Ahy, Arahou Teba, Patrice Mendy, Ndiague Fall, Pie Nibirantije, Ndiaye Coumba, N. Ndour, N. Mame, D. Saer, Diop Assane, Ndiaye Maodo, D. Moussa, Ly Fatimata, Niang Suzanne Oumou","doi":"10.59657/2993-1118.brs.23.008","DOIUrl":"https://doi.org/10.59657/2993-1118.brs.23.008","url":null,"abstract":"Introduction: Atopic dermatitis (AD) is a chronic inflammatory disease that is on the rise in industrialized countries. It is underestimated in Africa. This study aimed to describe the epidemiological, clinical, therapeutic, and evolutionary profile of atopic dermatitis, and to identify its impact on patients' quality of life. Methodology: We conducted a retrospective multicenter descriptive-analytical cross-sectional study in three dermatology referral departments in Dakar for over 3 years. We included all patients who consulted us for atopic dermatitis. Results: We identified 301 cases of atopic dermatitis, representing a hospital frequency of 0.6%. The mean age was 17 years. Pruritus was the main functional symptom. According to SCORAD, atopic dermatitis was mild in 50 cases (16.6%), moderate in 226 cases (75.10%), and severe in 25 cases (8.3%). AD was associated with seborrheic dermatitis in 1.9% and allergic contact dermatitis in 1.6%. Skin infections included staphylococcal in 8.97%, herpetic in 3.03% and scabies in 1.6%. Topical steroids and skin infections were the first-line treatment, in combining with therapeutic education. Methotrexate and azathioprine were used in 3 cases. Complete response was observed in 76.6% of patients. Conclusion: Atopic dermatitis is a common chronic inflammatory disease in Senegal. Early management and therapeutic education can prevent complications and reduce the psychological and social impact.","PeriodicalId":355237,"journal":{"name":"Dermatology Research and Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115939046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-30DOI: 10.59657/2993-1118.brs.23.009
Diatta Boubacar Ahy, Malky Maysae, Mendy Patrice, Pie Nibirantije, Ndiaye Tening Mame, Fall Ndiague, S. Mamadou, N. Ndour, Diop Khadim, D. Saer, Diop Assane, Ndiaye Maodo, D. Moussa, Ly Fatimata, Niang Suzanne Oumou
Introduction: Systemic diseases (SD) include all non-organ-specific autoimmune and/or inflammatory disorders. In children, their severity is related to severe visceral damage and iatrogenic complications of treatment. This study aimed to determine the epidemiological, clinical evolutionary aspects of systemic diseases in children. Methodology: A cross-sectional, analytic study was carried out in the Dermato-pediatrics Department of the Albert Royer Hospital in Dakar from January 2020 to June 2022 (30 months). We included all children aged 0 to 16 years followed up for systemic autoimmune disease. Results: We collected 18 cases of systemic diseases in children, representing a hospital frequency of 0.36%. The SD were of the lupus type in 7 cases, dermatomyositis in 4 cases, scleroderma in 3 cases, mixed connectivity’s in 3 cases and APLS in 1 case. The sex ratio was 0.12. The mean age of the children was 10 years [4-14 years]. In lupus, lesions were acute in 5 cases, subacute in 1 case and chronic in 1 case. In dermatomyositis, the cutaneous manifestations were: periorbital erythredema, ulcer-necrotic lesions, atrophic lesions of photo-exposed areas, non-erosive cheilitis, a non-scarring alopecia, Gottron papules, poikiloderma and calcinosis. Dermatomyositis was associated with extracutaneous muscular, articular, cardiovascular and pulmonary involvement. In scleroderma, cutaneous manifestations included sclerodactyly, Raynaud's phenomenon and cutaneous sclerosis. Visceral involvement included rhythm disturbances and pulmonary fibrosis. Necrotic ulcers and cyanosis of the extremities were the circumstances in which APLS was discovered. The association lupus-dermatomyositis represented (66.7%) and lupus-APLS (33.3%). Corticosteroid therapy was administered in 38.8% of cases. The outcome was favorable in 27.77% (n=5), with death noted in 3 cases. Conclusion: Systemic autoimmune diseases of children are rare disorders. They are characterized by their clinical polymorphism and the severity of visceral damage. Early treatment and therapeutic education of parents can improve prognosis.
{"title":"Autoimmune Systemic Diseases in Children: Epidemiology and Clinical Phenotypes in Senegal","authors":"Diatta Boubacar Ahy, Malky Maysae, Mendy Patrice, Pie Nibirantije, Ndiaye Tening Mame, Fall Ndiague, S. Mamadou, N. Ndour, Diop Khadim, D. Saer, Diop Assane, Ndiaye Maodo, D. Moussa, Ly Fatimata, Niang Suzanne Oumou","doi":"10.59657/2993-1118.brs.23.009","DOIUrl":"https://doi.org/10.59657/2993-1118.brs.23.009","url":null,"abstract":"Introduction: Systemic diseases (SD) include all non-organ-specific autoimmune and/or inflammatory disorders. In children, their severity is related to severe visceral damage and iatrogenic complications of treatment. This study aimed to determine the epidemiological, clinical evolutionary aspects of systemic diseases in children. Methodology: A cross-sectional, analytic study was carried out in the Dermato-pediatrics Department of the Albert Royer Hospital in Dakar from January 2020 to June 2022 (30 months). We included all children aged 0 to 16 years followed up for systemic autoimmune disease. Results: We collected 18 cases of systemic diseases in children, representing a hospital frequency of 0.36%. The SD were of the lupus type in 7 cases, dermatomyositis in 4 cases, scleroderma in 3 cases, mixed connectivity’s in 3 cases and APLS in 1 case. The sex ratio was 0.12. The mean age of the children was 10 years [4-14 years]. In lupus, lesions were acute in 5 cases, subacute in 1 case and chronic in 1 case. In dermatomyositis, the cutaneous manifestations were: periorbital erythredema, ulcer-necrotic lesions, atrophic lesions of photo-exposed areas, non-erosive cheilitis, a non-scarring alopecia, Gottron papules, poikiloderma and calcinosis. Dermatomyositis was associated with extracutaneous muscular, articular, cardiovascular and pulmonary involvement. In scleroderma, cutaneous manifestations included sclerodactyly, Raynaud's phenomenon and cutaneous sclerosis. Visceral involvement included rhythm disturbances and pulmonary fibrosis. Necrotic ulcers and cyanosis of the extremities were the circumstances in which APLS was discovered. The association lupus-dermatomyositis represented (66.7%) and lupus-APLS (33.3%). Corticosteroid therapy was administered in 38.8% of cases. The outcome was favorable in 27.77% (n=5), with death noted in 3 cases. Conclusion: Systemic autoimmune diseases of children are rare disorders. They are characterized by their clinical polymorphism and the severity of visceral damage. Early treatment and therapeutic education of parents can improve prognosis.","PeriodicalId":355237,"journal":{"name":"Dermatology Research and Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116420756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-30DOI: 10.59657/2993-1118.brs.23.003
N. Dimchova, Broshtilova V, A. Batashki, S. Bezhanova, J. Velevska, I. Yungareva, S. Marina
Schnitzler syndrome is a rare auto-inflammatory disease with a chronic relapsing course, characterized by recurrent urticarial lesions and monoclonal gammopathy. The manifestations of systemic inflammation are complemented by fever, bone and muscle pain, arthralgia/arthritis, lymphadenopathy, hepato- or splenomegaly, increased levels of acute inflammatory markers. A biological marker of the disease is the monoclonal gammopathy. Patients show high risk to develop AA-amyloidosis and lymphoproliferative diseases. A patient with a 5-year delay in diagnosis, who has responded well to systemic corticosteroids is presented. A comprehensive review of the new insights of disease pathogenesis and therapy is also highlighted.
{"title":"Schnitzler Syndrome: Clinical Case and Review of The Literature","authors":"N. Dimchova, Broshtilova V, A. Batashki, S. Bezhanova, J. Velevska, I. Yungareva, S. Marina","doi":"10.59657/2993-1118.brs.23.003","DOIUrl":"https://doi.org/10.59657/2993-1118.brs.23.003","url":null,"abstract":"Schnitzler syndrome is a rare auto-inflammatory disease with a chronic relapsing course, characterized by recurrent urticarial lesions and monoclonal gammopathy. The manifestations of systemic inflammation are complemented by fever, bone and muscle pain, arthralgia/arthritis, lymphadenopathy, hepato- or splenomegaly, increased levels of acute inflammatory markers. A biological marker of the disease is the monoclonal gammopathy. Patients show high risk to develop AA-amyloidosis and lymphoproliferative diseases. A patient with a 5-year delay in diagnosis, who has responded well to systemic corticosteroids is presented. A comprehensive review of the new insights of disease pathogenesis and therapy is also highlighted.","PeriodicalId":355237,"journal":{"name":"Dermatology Research and Reports","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126282967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-30DOI: 10.59657/2993-1118.brs.23.005
Latika Giri, Suyash Acharya, N. Bhandari, G. Sharma, Prabesh Gautam
Leprosy affects multiple systems and causes morbidity. However, with attainment of global elimination, and prevalence being 0.89/10000 at national level in Nepal; it is seldom considered a diagnosis when it doesn't manifest telltale signs. Leprosy can masquerade various dermatological, orthopedic or neurological problems thus delaying the diagnosis.
{"title":"Case Report of Delayed Treatment of Lepromatous Leprosy Masquerading as Acne Vulgaris in Post Elimination Era in Nepal","authors":"Latika Giri, Suyash Acharya, N. Bhandari, G. Sharma, Prabesh Gautam","doi":"10.59657/2993-1118.brs.23.005","DOIUrl":"https://doi.org/10.59657/2993-1118.brs.23.005","url":null,"abstract":"Leprosy affects multiple systems and causes morbidity. However, with attainment of global elimination, and prevalence being 0.89/10000 at national level in Nepal; it is seldom considered a diagnosis when it doesn't manifest telltale signs. Leprosy can masquerade various dermatological, orthopedic or neurological problems thus delaying the diagnosis.","PeriodicalId":355237,"journal":{"name":"Dermatology Research and Reports","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129902235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-07DOI: 10.59657/2993-1118.brs.22.001
Rosales Sotomayor A, Castro- Molina SA, Mendez Flores Silvia, Barrera Godinez A, Carrillo Cordova Dulce Maria, López-Loya Dominguez Cherit Judith
Sjogren’s syndrome is a systemic autoimmune disorder that mainly affects exocrine glands, although the clinical manifestations include both exocrine gland involvement and extraglandular disease features. In addition to dryness, musculoskeletal pain and fatigue are the hallmarks of this disease and constitute the classic symptom triad presented by the vast majority of patients. The authors present the case of a 59-year-old woman with achalasia, sicca syndrome, subcutaneous nodules affecting the knees, purpuric plaques on the palms and vitiligo. Serological tests were consistent with Sjögren′s syndrome, therefore the diagnosis of primary Sjögren’s syndrome with extensive cutaneous manifestations as extraglandular organ involvement was made.
{"title":"Multiple Cutaneous Features Associated with Primary Sjogren’s Syndrome","authors":"Rosales Sotomayor A, Castro- Molina SA, Mendez Flores Silvia, Barrera Godinez A, Carrillo Cordova Dulce Maria, López-Loya Dominguez Cherit Judith","doi":"10.59657/2993-1118.brs.22.001","DOIUrl":"https://doi.org/10.59657/2993-1118.brs.22.001","url":null,"abstract":"Sjogren’s syndrome is a systemic autoimmune disorder that mainly affects exocrine glands, although the clinical manifestations include both exocrine gland involvement and extraglandular disease features. In addition to dryness, musculoskeletal pain and fatigue are the hallmarks of this disease and constitute the classic symptom triad presented by the vast majority of patients. The authors present the case of a 59-year-old woman with achalasia, sicca syndrome, subcutaneous nodules affecting the knees, purpuric plaques on the palms and vitiligo. Serological tests were consistent with Sjögren′s syndrome, therefore the diagnosis of primary Sjögren’s syndrome with extensive cutaneous manifestations as extraglandular organ involvement was made.","PeriodicalId":355237,"journal":{"name":"Dermatology Research and Reports","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115940424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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