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Organophosphorus poisoning causing haemorrhagic pancreatitis - a case series. 有机磷中毒导致出血性胰腺炎--一个病例系列。
Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-09-10 DOI: 10.1177/00258172241257326
Aditya Anand, Munesh Kumar, S K Tandon

Organophosphorus, an insecticide used in agricultural and industrial settings, is the most common cause of poisoning in India. Organophosphorus is a nerve poison that causes irreversible inhibition of acetylcholinesterase, which leads to the accumulation of acetylcholine, resulting in excessive cholinergic stimulation of several organ systems. Several complications have been reported, but pancreatitis is quite rare and mainly due to ductal hypertension and injury to parenchyma, consequent to cholinergic hyperactivity in the pancreas. We present a case series of four cases where organophosphorus poisoning was suspected. Autopsy revealed that, in all four cases, the stomach walls were congested, pancreas showed gross haemorrhage over the surface and on cut sections, with other visceral organs showing generalised congestion. Later, after visceral and histopathological examination, all cases were confirmed as organophosphorus (dichlorvos) poisoning with haemorrhagic pancreatitis. Acute pancreatitis in organophosphorus poisoning usually has a subclinical course and gets masked by the systemic effects. Haemorrhagic pancreatitis sequela of acute pancreatitis is a rare and fatal complication of organophosphorus poisoning.

有机磷是一种用于农业和工业环境的杀虫剂,是印度最常见的中毒原因。有机磷是一种神经毒物,会对乙酰胆碱酯酶产生不可逆的抑制作用,导致乙酰胆碱蓄积,从而对多个器官系统产生过度的胆碱能刺激。已有多种并发症的报道,但胰腺炎相当罕见,主要是由于胰腺胆碱能亢进导致的导管高压和实质损伤。我们介绍了四例疑似有机磷中毒的系列病例。尸检显示,在所有四例病例中,胃壁都充血,胰腺表面和切片上都有大出血,其他内脏器官也普遍充血。后来,经过内脏和组织病理学检查,确认所有病例均为有机磷(敌敌畏)中毒并伴有出血性胰腺炎。有机磷中毒的急性胰腺炎通常呈亚临床过程,并被全身影响所掩盖。急性胰腺炎的出血性胰腺炎后遗症是有机磷中毒的一种罕见的致命并发症。
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引用次数: 0
Digital-first primary care: An ambivalent legacy of Covid-19? 数字优先的初级保健:Covid-19 的矛盾遗产?
Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-07-29 DOI: 10.1177/00258172241252223
Kartina A Choong

The vast majority of GP appointments had to move from in-person to remote consultation during the pandemic. Rather than phasing this out now that the threat of the coronavirus has begun to ebb, the UK government has announced that digital-first primary care will continue for the foreseeable future. While remote consultation can be beneficial on several fronts, it can compromise professional identity, therapeutic alliance, patient safety and access to healthcare. A hasty push towards normalising digitally-enabled care may therefore increase the risk of misdiagnoses, medical negligence, unnecessary referrals and health inequity. To enhance the gains and iron out the challenges associated with IT-led triage and consultations, it is important to reflect on the lessons learned from the pandemic.

在大流行期间,绝大多数全科医生的预约不得不从面对面转为远程会诊。现在,冠状病毒的威胁已经开始减弱,英国政府并没有逐步停止这种做法,而是宣布在可预见的未来继续推行数字优先的初级医疗服务。虽然远程会诊在多个方面都能带来益处,但它也会损害专业身份、治疗联盟、患者安全和医疗服务的可及性。因此,仓促推动数字化医疗的正常化可能会增加误诊、医疗疏忽、不必要的转诊和医疗不公平的风险。为了提高收益并克服与信息技术主导的分诊和会诊相关的挑战,重要的是要反思从大流行病中吸取的经验教训。
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引用次数: 0
500 bee stings in a single fatal encounter. 500 次蜜蜂蜇伤,一次致命。
Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-06-13 DOI: 10.1177/00258172241241463
Tanya Singh, Jagadish R Padubidri, Akshath Ks, Sowmya J Rao, Matthew A Manoj

Incidences of multiple bee stings have been increasing globally; the substantial amount of bee venom injected in such incidents can result in anaphylactic shock, rhabdomyolysis and renal failure, proving fatal in some cases. While anaphylactic reactions are more common and have established treatment protocols, inflammatory response induced by the venom demands a tailored approach. Here we report a case of a 70-year-old male in India who succumbed from approximately 500 bee stings. Based on our literature review, this case stands out as one of the first reported fatalities caused by 500 bee stings in our country. The unidentified species of bees in this case makes management of such bee venom-related toxic reactions more difficult. This report emphasises the importance of prompt and appropriate interventions.

在全球范围内,多次被蜜蜂蜇伤的事件日益增多;在此类事件中注入的大量蜂毒可导致过敏性休克、横纹肌溶解症和肾功能衰竭,在某些情况下甚至是致命的。过敏性反应较为常见,并有既定的治疗方案,而毒液诱发的炎症反应则需要量身定制的治疗方法。在此,我们报告了一例印度 70 岁男性因约 500 次蜜蜂蜇伤而死亡的病例。根据我们的文献综述,该病例是我国首次报道的因被 500 只蜜蜂蜇伤而死亡的病例之一。由于本病例中蜜蜂的种类不明,因此处理此类与蜂毒有关的中毒反应更加困难。本报告强调了及时采取适当干预措施的重要性。
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引用次数: 0
The brick kiln child workers of Pakistan. 巴基斯坦砖窑童工
Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1177/00258172241275250
John F Mayberry, Affifa Farrukh

Pakistani law recognises that no young person under the age of 18 years can enter into a valid and binding contract. In hazardous industries, such as brick kilns, none of the children working in them have any formal contract, so limiting any rights they may have. Any contract that does exist is with the child's father and will be linked to everlasting debts and constitutes a form of bondage. This paper reviews the adverse medical effects on children of such employment.

巴基斯坦法律承认,未满 18 岁的青少年不能签订有效和有约束力的合同。在砖窑等危险行业工作的儿童都没有任何正式合同,因此他们可能拥有的任何权利都受到限制。任何确实存在的合同都是与孩子的父亲签订的,并将与永久债务挂钩,构成一种束缚。本文回顾了这种工作对儿童造成的不良医疗影响。
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引用次数: 0
Whistleblowing in the NHS - how to best protect oneself from the costs and consequences. 国家医疗服务系统中的举报--如何最好地保护自己免受代价和后果的影响。
Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI: 10.1177/00258172241273546
Samantha Prosser
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引用次数: 0
When things go wrong - consent, manslaughter and clinical negligence. 当事情出错时--同意、过失杀人和临床过失。
Q2 Medicine Pub Date : 2024-09-01 Epub Date: 2024-03-28 DOI: 10.1177/00258172241231181
David Sellu
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引用次数: 0
Simulation-based training in cardiology/The role of simulation and AI in education. 基于模拟的心脏病学培训/模拟和人工智能在教育中的作用。
Q2 Medicine Pub Date : 2024-09-01 Epub Date: 2024-05-17 DOI: 10.1177/00258172241236588
Vassilios Hurmusiadis, Kevin Sherman
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引用次数: 0
Reverse case in child sexual abuse. 儿童性虐待的反面案例。
Q2 Medicine Pub Date : 2024-09-01 Epub Date: 2024-02-09 DOI: 10.1177/00258172231214767
Dubravko Habek, Jurica Habek

Child sexual abuse is a public health and medico-legal problem in developed and developing countries. Prompted by rare presentations of cases from this issue that change the course and outcome of events, we present the completed criminal-medico-legislative procedure as a contribution to the dynamics of the investigative process from my own many years of forensic practice. Two preschool teachers of late reproductive age from a home for neglected children reported to the State Attorney's Office a former ward of the home, now an older minor, and an auxiliary employee of the same home, for having sexual relations with a two-year-old girl. But the state attorney also ordered an examination of the reported young man, so the reported case that the teachers "saw" penetrative intercourse was rejected by the expert and the state attorney as an action impossible without injuring the girl at that age. Further investigation proved the continuous sexual abuse by two teachers of the young man since he was 13 years old, i.e. for three years, which he did not report for fear that he would be kicked out of the home. He had sexual relations with each of them several times during those incriminated years. After his statement, other employees of the home were questioned as witnesses who confirmed the suspect boy's claims. He was then released from custody, and the teachers were dismissed from their jobs and accused of years of sexual abuse of minors and abuse of their position and authority as competent persons.

儿童性虐待是发达国家和发展中国家的一个公共卫生和医学法律问题。在这一问题上,罕见地出现了一些改变事件进程和结果的案例,在此,我们介绍已完成的刑事-医疗-立法程序,作为我多年法医实践中对调查过程动态的贡献。一家被忽视儿童之家的两名晚育学龄前教师向州检察官办公室举报,该儿童之家的一名前被监护人(现为年长的未成年人)和同一家儿童之家的一名辅助雇员与一名两岁女童发生了性关系。但是,州检察官也下令对被举报的年轻人进行检查,因此,专家和州检察官拒绝接受教师 "看到 "插入式性交的举报,认为这种行为不可能不伤害这个年龄段的女孩。进一步的调查证明,自该青年 13 岁起,即三年来,他一直受到两名教师的性虐待,但他因 为害怕被赶出家门而没有报案。在这些被指控的岁月里,他与这两位老师都发生过数次性关系。在他陈述之后,该养老院的其他员工作为证人接受了询问,证实了嫌疑男孩的说法。他随后被释放,而教师们则被解雇,并被指控多年来对未成年人实施性虐待以及滥用其作为主管人员的地位和权力。
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引用次数: 0
Death of a child due to venom toxicity following multiple honey bee stings: A case report. 一名儿童在多次被蜜蜂蜇伤后因毒液中毒死亡:病例报告。
Q2 Medicine Pub Date : 2024-09-01 Epub Date: 2024-02-10 DOI: 10.1177/00258172231218862
Bajrang K Singh, Mahendra Sharma, Surya Prakash Lra, M Chauhan

Most bee stings are not life-threatening. Bee venom often causes local, mild allergic reactions in people, but even a single bee sting may induce a fatal anaphylactic reaction. Usually, anaphylactic reaction is the cause of death, but, when a child suffers multiple stings (more than 30), direct toxicity of venom can also be fatal. A three-year-old male child was brought to the hospital with pain, swelling and redness at the sting sites. He had more than 35 stings at various sites over his face, on his tongue and over his body. He died 10 hours after the incidence of the honey bee stings and was maintaining oxygen saturation until the terminal stage of his life. At autopsy, the honey bee sting sites showed redness, swelling and a small effusion of blood surrounding the stinger tracks. On the tongue two stingers were found in situ. Facial puffiness and eyelid swelling, along with congested organs, were also found, but features suggestive of anaphylactic death like airway oedema, mucous plug or cyanosis were absent. Hospital treatment records show that blood pressure remained low with tachycardia despite treatment. Having regard for all the evidence it was concluded that death was due to multiple honey bee stings that caused direct venom toxicity.

大多数蜜蜂蜇伤不会危及生命。蜂毒通常会引起人的局部轻度过敏反应,但即使是一次蜂蜇也可能诱发致命的过敏反应。通常,过敏性反应是死亡的原因,但是,当儿童遭受多次蜇伤(超过 30 次)时,毒液的直接毒性也可能致命。一名三岁男童因蛰伤部位疼痛、红肿而被送往医院。他的脸部、舌头和全身多处被蜇伤超过 35 处。他在被蜜蜂蜇伤 10 小时后死亡,氧气饱和度一直维持到生命的最后阶段。尸检结果显示,蜜蜂蜇伤部位发红、肿胀,蜇痕周围有少量渗血。在舌头上发现了两根蜂刺。还发现面部浮肿、眼睑肿胀以及器官充血,但没有气道水肿、粘液栓塞或紫绀等过敏性死亡的特征。医院治疗记录显示,尽管进行了治疗,但血压仍然很低,并伴有心动过速。考虑到所有证据,得出的结论是,死亡是由于多次蜜蜂蜇伤导致直接毒液中毒所致。
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引用次数: 0
Diagnostic errors in rheumatology and medico-legal consequences. 风湿病学诊断错误及医疗法律后果。
Q2 Medicine Pub Date : 2024-09-01 Epub Date: 2024-05-17 DOI: 10.1177/00258172241235016
Marc A Golstein

Medical errors and adverse effects of treatment are inherent to medical practice. Like any other medical specialty, rheumatology is not exempt. Although the problem is imprecisely quantified, according to some authors it affects up to 10% of hospitalised patients. Describing and qualifying misdiagnoses in rheumatology will help us to understand and reduce these. Further, misdiagnosis generates unjustified costs and medico-legal consequences with errors in initial diagnosis the basis for medico-legal disputes involving assessment of work incapacity.

医疗失误和治疗不良反应是医疗实践中固有的现象。与其他医学专科一样,风湿病学也不能幸免。尽管这一问题的量化并不精确,但据一些学者称,它影响到多达 10% 的住院患者。对风湿病学中的误诊进行描述和定性将有助于我们了解和减少误诊。此外,误诊还会产生不合理的费用和医疗法律后果,因为初步诊断错误是涉及丧失工作能力评估的医疗法律纠纷的基础。
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Medico-Legal Journal
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