首页 > 最新文献

JHN Journal最新文献

英文 中文
Case Report: Signal Drop on MRA Imaging of the Internal Carotid Artery after Neuroform Stent Placement 病例报告:神经形态支架置入后颈动脉MRA信号下降
Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.004.1.004
A. Pandey, Meryl A. Severson Iii, R. Rosenwasser
{"title":"Case Report: Signal Drop on MRA Imaging of the Internal Carotid Artery after Neuroform Stent Placement","authors":"A. Pandey, Meryl A. Severson Iii, R. Rosenwasser","doi":"10.29046/JHNJ.004.1.004","DOIUrl":"https://doi.org/10.29046/JHNJ.004.1.004","url":null,"abstract":"","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130470587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Re-implantation of Intrathecal Delivery System after Removal Secondary to Infection or Wound Dehiscence 感染或创面裂开切除鞘内输送系统后成功再植入术
Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.005.1.005
Y. Ooi, J. Malone, Rn Cnrn Teresita DeVera Bsn, Rn Carol Blyzniuk Bsn, A. Sharan
1Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 2Department of Neurological Surgery, Jefferson University Physicians, Philadelphia, PA 3Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA An intrathecal delivery system allows direct infusion of analgesics and antispasmodic drugs into the cerebral spinal fluid in patients with chronic intractable pain or spasticity. Intrathecal therapy effective but any surgical intervention carries the risk of complications. Complications encountered with this therapy include wound dehiscence (spontaneous reopening) and infection, which often lead to explanation of the intrathecal pump. Later re-implanation is feasible, but there is limited information regarding successful retention of the device after re-implantation. A recurring problem with generating reliable guidelines in neurosurgery is that some situations occur too rarely for evidence to be much more than anecdotal.
一种鞘内给药系统可以将镇痛药和抗痉挛药物直接输注到慢性难治性疼痛或痉挛患者的脑脊液中。鞘内治疗有效,但任何手术干预都有并发症的风险。这种治疗的并发症包括伤口裂开(自发重开)和感染,这通常导致鞘内泵。以后再植入术是可行的,但是关于再植入术后成功保留装置的信息有限。在制定可靠的神经外科指导方针时,一个反复出现的问题是,有些情况发生得太少,证据只能是轶事。
{"title":"Successful Re-implantation of Intrathecal Delivery System after Removal Secondary to Infection or Wound Dehiscence","authors":"Y. Ooi, J. Malone, Rn Cnrn Teresita DeVera Bsn, Rn Carol Blyzniuk Bsn, A. Sharan","doi":"10.29046/JHNJ.005.1.005","DOIUrl":"https://doi.org/10.29046/JHNJ.005.1.005","url":null,"abstract":"1Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 2Department of Neurological Surgery, Jefferson University Physicians, Philadelphia, PA 3Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA An intrathecal delivery system allows direct infusion of analgesics and antispasmodic drugs into the cerebral spinal fluid in patients with chronic intractable pain or spasticity. Intrathecal therapy effective but any surgical intervention carries the risk of complications. Complications encountered with this therapy include wound dehiscence (spontaneous reopening) and infection, which often lead to explanation of the intrathecal pump. Later re-implanation is feasible, but there is limited information regarding successful retention of the device after re-implantation. A recurring problem with generating reliable guidelines in neurosurgery is that some situations occur too rarely for evidence to be much more than anecdotal.","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125511211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Surgeon Opinions on Use of Epidural Steroids in Treatment of Lumbar Disk Disease: Results of an Online Survey 外科医生对硬膜外类固醇治疗腰椎间盘疾病的意见:一项在线调查的结果
Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.004.2.001
J. Ratliff, M. Maltenfort, Bryan Lebude
{"title":"Surgeon Opinions on Use of Epidural Steroids in Treatment of Lumbar Disk Disease: Results of an Online Survey","authors":"J. Ratliff, M. Maltenfort, Bryan Lebude","doi":"10.29046/JHNJ.004.2.001","DOIUrl":"https://doi.org/10.29046/JHNJ.004.2.001","url":null,"abstract":"","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"192 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121105211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Applications of the Pipeline Embolization Device 管道栓塞装置的临床应用
Pub Date : 1900-01-01 DOI: 10.29046/jhnj.013.2.004
B. Daou, E. Atallah, Bs Evan Fitchett, N. Chalouhi, R. Starke, B. J. Oliver, Bs Maria Montano, P. Jabbour, Md Mba Facs Faha Robert H. Rosenwasswer, Md Faans Stavropoula Tjoumakaris
{"title":"Clinical Applications of the Pipeline Embolization Device","authors":"B. Daou, E. Atallah, Bs Evan Fitchett, N. Chalouhi, R. Starke, B. J. Oliver, Bs Maria Montano, P. Jabbour, Md Mba Facs Faha Robert H. Rosenwasswer, Md Faans Stavropoula Tjoumakaris","doi":"10.29046/jhnj.013.2.004","DOIUrl":"https://doi.org/10.29046/jhnj.013.2.004","url":null,"abstract":"","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121801001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a Clinical Guideline for CT Scans in Closed Head Injury 制定闭合性颅脑损伤CT扫描临床指南
Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.006.1.002
Chengyuan Wu, J. Jallo
Trauma Several years ago, every patient that was brought to Thomas Jefferson University Hospital with a closed head injury would receive a CT scan — regardless of whether or not that patient already had a scan performed at an outside institution. If the scan demonstrated any intracranial pathology, then a repeat CT scan was performed 12 hours after the initial scan as long as the patient remained neurologically stable. Ultimately, every patient received two CT scans at our institution separated by 12 hours. Now, each patient is followed by a total of three CT scans. If a patient had undergone a CT scan at an outside institution, this scan was loaded onto the Jefferson system and was considered their first CT scan. A follow-up CT scan was to be performed 6 hours after the initial scan if any intracranial pathology was noted. As long as the patient remained neurologically stable, a third and final CT scan was to be performed sometime between 12 to 24 hours after the initial scan. Therefore, patients with non-operative intracranial hemorrhage received two or three CT scans at our institution and were observed for at least 24 hours. In both situations, routine follow-up imaging was performed on all patients with an initial intracranial lesion resulting from head trauma. This practice is founded on the recommendation that " early imaging, rather than awaiting neurological deterioration, reduces the delay in detection and treatment of acute intracranial injury. " This is based largely on the existing literature regarding epidural hematomas (EDH) and severe head injury. More than 50% of patients with severe head injuries have progression of findings on CT scan that otherwise would go undetected due to their poor initial clinical status. 1 Case reports have illustrated the need for repeat imaging in the setting of " ultra-early " CT scans, which may not capture a developing hematoma. 2 In addition, EDHs have been reported to be more likely to enlarge if captured within 6 hours of injury 3 — again enforcing the importance of repeat imaging for these patients. At the same time, while such case reports and small case series have demonstrated the importance of imaging at least 6 hours after the initial injury, patients who have already had a negative CT scan generally do not get a repeated scan, — even if the negative scan was performed within 6 hours of their injury. Overall, …
几年前,每个被送到托马斯·杰斐逊大学医院的闭锁性头部损伤的病人都会接受CT扫描——不管这个病人是否已经在外部机构做过扫描。如果扫描显示颅内病变,则在初次扫描后12小时进行重复CT扫描,只要患者神经系统保持稳定。最终,每个病人都在我们的机构接受了两次CT扫描,间隔12小时。现在,每个病人都要接受三次CT扫描。如果患者在外部机构接受过CT扫描,则该扫描被加载到Jefferson系统中,并被视为他们的第一次CT扫描。如果发现颅内病变,应在初次扫描后6小时进行后续CT扫描。只要患者神经系统保持稳定,第三次也是最后一次CT扫描将在初次扫描后的12至24小时内进行。因此,非手术性颅内出血患者在我院接受2 ~ 3次CT扫描,观察时间至少24小时。在这两种情况下,对所有因头部创伤引起的初始颅内病变的患者进行常规随访影像学检查。这种做法是建立在“早期成像,而不是等待神经系统恶化,减少延迟检测和治疗急性颅内损伤”的建议之上的。这主要是基于现有的关于硬膜外血肿(EDH)和严重头部损伤的文献。超过50%的严重头部损伤患者在CT扫描中发现进展,否则由于其初始临床状况不佳而无法发现。病例报告表明,在“超早期”CT扫描中需要重复成像,这可能无法捕获正在发展的血肿。2此外,据报道,如果在受伤后6小时内捕获edh, edh更有可能扩大3 -再次强调了对这些患者进行重复成像的重要性。同时,虽然这些病例报告和小病例系列已经证明了在初次损伤后至少6小时进行影像学检查的重要性,但已经进行过CT阴性扫描的患者通常不会进行重复扫描,即使阴性扫描是在受伤后6小时内进行的。总的来说,……
{"title":"Developing a Clinical Guideline for CT Scans in Closed Head Injury","authors":"Chengyuan Wu, J. Jallo","doi":"10.29046/JHNJ.006.1.002","DOIUrl":"https://doi.org/10.29046/JHNJ.006.1.002","url":null,"abstract":"Trauma Several years ago, every patient that was brought to Thomas Jefferson University Hospital with a closed head injury would receive a CT scan — regardless of whether or not that patient already had a scan performed at an outside institution. If the scan demonstrated any intracranial pathology, then a repeat CT scan was performed 12 hours after the initial scan as long as the patient remained neurologically stable. Ultimately, every patient received two CT scans at our institution separated by 12 hours. Now, each patient is followed by a total of three CT scans. If a patient had undergone a CT scan at an outside institution, this scan was loaded onto the Jefferson system and was considered their first CT scan. A follow-up CT scan was to be performed 6 hours after the initial scan if any intracranial pathology was noted. As long as the patient remained neurologically stable, a third and final CT scan was to be performed sometime between 12 to 24 hours after the initial scan. Therefore, patients with non-operative intracranial hemorrhage received two or three CT scans at our institution and were observed for at least 24 hours. In both situations, routine follow-up imaging was performed on all patients with an initial intracranial lesion resulting from head trauma. This practice is founded on the recommendation that \" early imaging, rather than awaiting neurological deterioration, reduces the delay in detection and treatment of acute intracranial injury. \" This is based largely on the existing literature regarding epidural hematomas (EDH) and severe head injury. More than 50% of patients with severe head injuries have progression of findings on CT scan that otherwise would go undetected due to their poor initial clinical status. 1 Case reports have illustrated the need for repeat imaging in the setting of \" ultra-early \" CT scans, which may not capture a developing hematoma. 2 In addition, EDHs have been reported to be more likely to enlarge if captured within 6 hours of injury 3 — again enforcing the importance of repeat imaging for these patients. At the same time, while such case reports and small case series have demonstrated the importance of imaging at least 6 hours after the initial injury, patients who have already had a negative CT scan generally do not get a repeated scan, — even if the negative scan was performed within 6 hours of their injury. Overall, …","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133665715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
An Outcome Comparison of Electrode Configurations and Intraoperative Testing Techniques for Thoracic Spinal Cord Stimulators for Chronic Neuropathic Pain 胸椎脊髓刺激器治疗慢性神经性疼痛的电极配置和术中测试技术的结果比较
Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.007.2.001
Angud Mehdi, D. Penn, Chengyuan Wu, A. Sharan
INTRODUCTION Thoracic spinal cord stimulation (tSCS) is a therapeutic option for the treatment of neuropathic pain, such as that generated from post-laminectomy syndrome, reflex sympathetic dystrophy, or neuritis. Two variables that have scarcely been examined in relation to effective stimulation are the electrode type used and the method of intraoperative confirmation of paresthesia employed. We compared the effective paresthesia distribution of 3 distinct configurations of thoracic spinal cord stimulator electrodes and the 2 different neurophysiological techniques of intraoperative paresthesia confirmation.
胸椎脊髓刺激(tSCS)是治疗神经性疼痛的一种治疗选择,如椎板切除术后综合征、反射性交感神经营养不良或神经炎引起的神经性疼痛。关于有效刺激的两个变量是使用的电极类型和术中确认感觉异常的方法,这两个变量几乎没有被检查过。我们比较了3种不同配置的胸脊髓刺激器电极的有效感觉异常分布,以及2种不同的术中感觉异常确认的神经生理技术。
{"title":"An Outcome Comparison of Electrode Configurations and Intraoperative Testing Techniques for Thoracic Spinal Cord Stimulators for Chronic Neuropathic Pain","authors":"Angud Mehdi, D. Penn, Chengyuan Wu, A. Sharan","doi":"10.29046/JHNJ.007.2.001","DOIUrl":"https://doi.org/10.29046/JHNJ.007.2.001","url":null,"abstract":"INTRODUCTION Thoracic spinal cord stimulation (tSCS) is a therapeutic option for the treatment of neuropathic pain, such as that generated from post-laminectomy syndrome, reflex sympathetic dystrophy, or neuritis. Two variables that have scarcely been examined in relation to effective stimulation are the electrode type used and the method of intraoperative confirmation of paresthesia employed. We compared the effective paresthesia distribution of 3 distinct configurations of thoracic spinal cord stimulator electrodes and the 2 different neurophysiological techniques of intraoperative paresthesia confirmation.","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"194 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131926036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimally Invasive Surgery for Skull Base Tumors 颅底肿瘤的微创手术
Pub Date : 1900-01-01 DOI: 10.29046/jhnj.004.2.004
James J. Evans, M. Rosen
{"title":"Minimally Invasive Surgery for Skull Base Tumors","authors":"James J. Evans, M. Rosen","doi":"10.29046/jhnj.004.2.004","DOIUrl":"https://doi.org/10.29046/jhnj.004.2.004","url":null,"abstract":"","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123103477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anemia and Blood Transfusion in Subarachnoid Hemorrhage 蛛网膜下腔出血的贫血和输血
Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.004.4.006
Monisha A. Kumar
Anemia in Subarachnoid Hemorrhage Anemia is a common problem among critically ill patients. Nearly two thirds of patients are anemic on admission to the intensive care unit (ICU)1 and between 70-95% of patients develop anemia by day 3.2,3 Lower hemoglobin levels decrease the oxygen carrying capacity of blood and may reduce tissue oxygenation. This is particularly detrimental for patients with subarachnoid hemorrhage (SAH) as they are subject to increased metabolic demand for oxygen from cerebral ischemia.
蛛网膜下腔出血贫血是危重症患者的常见问题。近三分之二的患者在进入重症监护病房(ICU)时就贫血1,70-95%的患者在第一天出现贫血3.2,3较低的血红蛋白水平降低了血液的携氧能力,并可能减少组织氧合。这对蛛网膜下腔出血(SAH)患者尤其有害,因为他们受到脑缺血对氧气代谢需求增加的影响。
{"title":"Anemia and Blood Transfusion in Subarachnoid Hemorrhage","authors":"Monisha A. Kumar","doi":"10.29046/JHNJ.004.4.006","DOIUrl":"https://doi.org/10.29046/JHNJ.004.4.006","url":null,"abstract":"Anemia in Subarachnoid Hemorrhage Anemia is a common problem among critically ill patients. Nearly two thirds of patients are anemic on admission to the intensive care unit (ICU)1 and between 70-95% of patients develop anemia by day 3.2,3 Lower hemoglobin levels decrease the oxygen carrying capacity of blood and may reduce tissue oxygenation. This is particularly detrimental for patients with subarachnoid hemorrhage (SAH) as they are subject to increased metabolic demand for oxygen from cerebral ischemia.","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125087345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Utility of Biomarkers in the Evaluation of Fever in the Intensive Care Unit After Brain Injury 生物标志物在脑损伤后重症监护病房发热评估中的应用
Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.012.1.006
Umer Mukhtar, Umer Shoukat, M. Athar, F. Rincon
Fever is frequent in patients with neurologic injury. Differentiating infectious fever from central fever can be challenging. It is important to diagnose the cause of fever in the neurological intensive care unit because of the detrimental effects of fever on brain injured patients. This is a comprehensive review of the role of the two commonly available biomarkers, C-reactive protein and procalcitonin in differentiating the central fever from infectious fever.
发烧是神经损伤患者的常见病。区分感染性发热和中枢性发热可能具有挑战性。由于发热对脑损伤患者的不利影响,在神经内科重症监护病房诊断发热的原因非常重要。本文全面回顾了两种常用的生物标志物c反应蛋白和降钙素原在区分中心性发热和感染性发热中的作用。
{"title":"Utility of Biomarkers in the Evaluation of Fever in the Intensive Care Unit After Brain Injury","authors":"Umer Mukhtar, Umer Shoukat, M. Athar, F. Rincon","doi":"10.29046/JHNJ.012.1.006","DOIUrl":"https://doi.org/10.29046/JHNJ.012.1.006","url":null,"abstract":"Fever is frequent in patients with neurologic injury. Differentiating infectious fever from central fever can be challenging. It is important to diagnose the cause of fever in the neurological intensive care unit because of the detrimental effects of fever on brain injured patients. This is a comprehensive review of the role of the two commonly available biomarkers, C-reactive protein and procalcitonin in differentiating the central fever from infectious fever.","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132007468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Use of Expandable Cages in Metastasis to the Spine 可膨胀笼在脊柱转移中的应用
Pub Date : 1900-01-01 DOI: 10.29046/jhnj.004.4.002
Shiveindra B. Jeyamohan, A. Vaccaro, J. Harrop
Introduction: Expandable cages have been utilized as an option for immediate spinal stabilization after vertebrectomy. However, long-term follow-up in the oncology population has not been studied, and results remain unclear. This single-institution series of patients represents our success in utilizing expandable cages. Methods: A retrospective chart review for patients with spinal metastasis treated with expandable cages between 2001 and 2006 was performed with IRB approval. Data regarding date of anterior and posterior surgery, immediate postoperative neurological status versus preoperative status, revision, equipment status, pseudoarthrosis, time to ambulation, and mortality were gathered and analyzed. Results: Twenty-four patients with metastatic cancer to the spine were studied. Cages were placed from T5-L5, 21 of which were single level. Of the 24 patients, 5 (21%) were neurologically intact pre-operatively and postoperatively. 13 of the 24 (54%) improved postoperatively. The remaining six (25%) illustrated no change in neurologic status. No patients deteriorated. At two years’ follow-up, overall patient survival was 79%. Average time to ambulation for patients followed was 11.5 days. No revisions were done for hardware failure, while one revision was performed for tumor progression. Conclusions: Expandable cages appear to be a valid treatment option for the immediate stabilization of the spine following corpectomy from spinal metastasis. Results indicate that fast recovery, reasonable long-term mortality, and immediate stabilization are achievable with this modality. Consequently, expandable cages should be considered as a valid option in the treatment for stabilization following corpectomy in metastasis to the spine. Introduction The spinal column is a frequent site of metastatic disease, particularly from lung, prostate, breast, kidney as the primary sources, whereas primary spinal column tumors comprise a minority of spinal pathology (<2%) 4. Although patients may present in a variety of conditions, pathologic fractures or increased axial spinal pain are frequent issues. Surgical treatment for this disease includes decompression of the neural elements, alleviation of painful symptoms, resolution of mechanical instabilization, and resection of the oncologic burden 2. Surgical treatment options for patients with progressive neurologic deterioration include anterior, posterior or combined decompression with subsequent spinal reconstructions. Expandable cages have recently been utilized as a treatment option for spinal reconstruction after vertebrectomy, particularly in the trauma population1. With increased familiarity of these devices, cages are now being utilized after corpectomy from tumor metastasis, but data regarding this treatment option is lacking 2-3. Vertebral body replacement with expandable cages may provide several potential theoretical advantages such as permitting optimal anatomic placement in addition to concurrent correcti
导读:椎体切除术后,可膨胀的固定架被用作立即稳定脊柱的一种选择。然而,肿瘤人群的长期随访尚未研究,结果仍不清楚。这个单一机构系列的患者代表了我们在使用可扩展笼方面的成功。方法:回顾性回顾2001年至2006年经IRB批准的脊柱转移患者使用膨胀笼治疗的病例。收集和分析有关前后路手术日期、术后立即神经系统状态与术前状态、翻修、设备状态、假关节、活动时间和死亡率的数据。结果:对24例脊柱转移性肿瘤进行了研究。从T5-L5放置笼子,其中21个为单层。在24例患者中,5例(21%)术前和术后神经功能完整。24例患者中13例(54%)术后改善。其余6例(25%)未见神经状态改变。没有患者病情恶化。在两年的随访中,患者的总生存率为79%。随访患者的平均行走时间为11.5天。没有因硬件故障而进行修订,而因肿瘤进展而进行了一次修订。结论:对于脊柱转移性椎体切除术后的脊柱即刻稳定,可膨胀笼似乎是一种有效的治疗选择。结果表明,该方法可实现快速恢复,合理的长期死亡率和立即稳定。因此,在椎体切除术后转移至脊柱的稳定治疗中,应考虑使用可膨胀的固定架。脊柱是转移性疾病的常见部位,尤其是肺、前列腺、乳腺、肾脏为主要来源,而原发性脊柱肿瘤仅占脊柱病理的少数(<2%)4。尽管患者可能出现多种情况,但病理性骨折或增加的轴向脊柱疼痛是常见的问题。这种疾病的手术治疗包括神经元件的减压、疼痛症状的缓解、机械不稳定的解决和肿瘤负担的切除2。进行性神经功能恶化患者的手术治疗选择包括前路、后路或联合减压并随后进行脊柱重建。近年来,可膨胀笼已被用作椎体切除术后脊柱重建的一种治疗选择,特别是在创伤人群中。随着对这些装置的熟悉程度的提高,笼子现在被用于肿瘤转移的椎体切除术后,但关于这种治疗选择的数据缺乏2-3。椎体置换术中使用可伸缩支架可能提供几个潜在的理论优势,如允许最佳解剖放置,同时矫正脊柱畸形。这篇文章包括对脊柱转移性疾病椎体切除术后可扩展笼的临床资料的回顾性回顾。我们的假设是这些装置耐受性良好,因此是这一困难患者群体的治疗选择。临床资料和方法:2001年6月至2006年11月,通过回顾性的图表回顾,对24例连续患者进行了可扩展笼重建,以治疗转移性疾病并病理性骨折。患者研究方案通过机构内部审查委员会批准。纳入标准为:年龄大于18岁,T4 ~ L5间行椎体切除术,病理证实有转移性疾病。纳入分析的数据点包括:年龄、转移水平、原发肿瘤组织学、功能结果、活动时间、再次手术需要和其他围手术期并发症。神经系统检查采用ASIA评分系统,运动评分为6分制(0-5),针刺和触觉评分为3分制(0、1、2)。所有病例均进行术后成像以评估结构稳定性和Shiveindra Jeyamohan, BS1, Alexander Vaccaro, MD, PhD 2, James S Harrop, MD 3费城托马斯杰斐逊大学杰斐逊医学院,PA 2费城罗夫曼研究所,PA 3费城托马斯杰斐逊大学神经外科
{"title":"Use of Expandable Cages in Metastasis to the Spine","authors":"Shiveindra B. Jeyamohan, A. Vaccaro, J. Harrop","doi":"10.29046/jhnj.004.4.002","DOIUrl":"https://doi.org/10.29046/jhnj.004.4.002","url":null,"abstract":"Introduction: Expandable cages have been utilized as an option for immediate spinal stabilization after vertebrectomy. However, long-term follow-up in the oncology population has not been studied, and results remain unclear. This single-institution series of patients represents our success in utilizing expandable cages. Methods: A retrospective chart review for patients with spinal metastasis treated with expandable cages between 2001 and 2006 was performed with IRB approval. Data regarding date of anterior and posterior surgery, immediate postoperative neurological status versus preoperative status, revision, equipment status, pseudoarthrosis, time to ambulation, and mortality were gathered and analyzed. Results: Twenty-four patients with metastatic cancer to the spine were studied. Cages were placed from T5-L5, 21 of which were single level. Of the 24 patients, 5 (21%) were neurologically intact pre-operatively and postoperatively. 13 of the 24 (54%) improved postoperatively. The remaining six (25%) illustrated no change in neurologic status. No patients deteriorated. At two years’ follow-up, overall patient survival was 79%. Average time to ambulation for patients followed was 11.5 days. No revisions were done for hardware failure, while one revision was performed for tumor progression. Conclusions: Expandable cages appear to be a valid treatment option for the immediate stabilization of the spine following corpectomy from spinal metastasis. Results indicate that fast recovery, reasonable long-term mortality, and immediate stabilization are achievable with this modality. Consequently, expandable cages should be considered as a valid option in the treatment for stabilization following corpectomy in metastasis to the spine. Introduction The spinal column is a frequent site of metastatic disease, particularly from lung, prostate, breast, kidney as the primary sources, whereas primary spinal column tumors comprise a minority of spinal pathology (<2%) 4. Although patients may present in a variety of conditions, pathologic fractures or increased axial spinal pain are frequent issues. Surgical treatment for this disease includes decompression of the neural elements, alleviation of painful symptoms, resolution of mechanical instabilization, and resection of the oncologic burden 2. Surgical treatment options for patients with progressive neurologic deterioration include anterior, posterior or combined decompression with subsequent spinal reconstructions. Expandable cages have recently been utilized as a treatment option for spinal reconstruction after vertebrectomy, particularly in the trauma population1. With increased familiarity of these devices, cages are now being utilized after corpectomy from tumor metastasis, but data regarding this treatment option is lacking 2-3. Vertebral body replacement with expandable cages may provide several potential theoretical advantages such as permitting optimal anatomic placement in addition to concurrent correcti","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132064929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
期刊
JHN Journal
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1