Background: Head and neck squamous cell carcinoma (HNSCC) represents a significant global oncological challenge with a rising incidence, particularly due to HPV-associated oropharyngeal squamous cell carcinomas (OPSCC). These tumours differ from HPV-negative entities biologically, clinically, and prognostically. Conventional diagnostic approaches, based on tissue biopsy and imaging techniques, face several limitations - from invasiveness and the inability to monitor disease dynamics to low sensitivity in the early detection of recurrence.
Aim: This paper provides a comprehensive overview of circulating tumour DNA (ctDNA), specifically HPV-associated ctDNA, as a novel non-invasive biomarker enabling more accurate diagnosis, monitoring of treatment response, and early detection of recurrence in patients with HNSCC.
Conclusion: ctDNA exhibits specific biological and physical characteristics that allow its reliable detection and differentiation from normal circulating cell-free DNA. Owing to its short half-life, ctDNA provides real-time insights into disease dynamics, while its concentration and fragmentation patterns reflect tumour burden and biological activity. Monitoring ctDNA holds significant potential as a pivotal clinical tool in the era of precision oncology, facilitating earlier recurrence detection, improved patient stratification, and optimization of therapeutic strategies in HPV-associated HNSCC.
{"title":"Circulating tumor DNA in HPV-associated head and neck cancers - a novel clinical tool in the era of precision oncology.","authors":"M Lacek, R Lohynská","doi":"10.48095/ccko2025422","DOIUrl":"https://doi.org/10.48095/ccko2025422","url":null,"abstract":"<p><strong>Background: </strong>Head and neck squamous cell carcinoma (HNSCC) represents a significant global oncological challenge with a rising incidence, particularly due to HPV-associated oropharyngeal squamous cell carcinomas (OPSCC). These tumours differ from HPV-negative entities biologically, clinically, and prognostically. Conventional diagnostic approaches, based on tissue biopsy and imaging techniques, face several limitations - from invasiveness and the inability to monitor disease dynamics to low sensitivity in the early detection of recurrence.</p><p><strong>Aim: </strong>This paper provides a comprehensive overview of circulating tumour DNA (ctDNA), specifically HPV-associated ctDNA, as a novel non-invasive biomarker enabling more accurate diagnosis, monitoring of treatment response, and early detection of recurrence in patients with HNSCC.</p><p><strong>Conclusion: </strong>ctDNA exhibits specific biological and physical characteristics that allow its reliable detection and differentiation from normal circulating cell-free DNA. Owing to its short half-life, ctDNA provides real-time insights into disease dynamics, while its concentration and fragmentation patterns reflect tumour burden and biological activity. Monitoring ctDNA holds significant potential as a pivotal clinical tool in the era of precision oncology, facilitating earlier recurrence detection, improved patient stratification, and optimization of therapeutic strategies in HPV-associated HNSCC.</p>","PeriodicalId":35565,"journal":{"name":"Klinicka Onkologie","volume":"38 6","pages":"422-426"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivona Šimková, R. Aiglová, Filip Koubek, J. Precek, Jan Látal, Eva Buriánková, Libuše Quinn, Lenka Henzlová, Miloš Táborský, Hana Švébišová, Lucie Tučková, Bohuslav Melichar
{"title":"Carcinoid syndrome with right-sided valve involvement – a case report and review of the literature","authors":"Ivona Šimková, R. Aiglová, Filip Koubek, J. Precek, Jan Látal, Eva Buriánková, Libuše Quinn, Lenka Henzlová, Miloš Táborský, Hana Švébišová, Lucie Tučková, Bohuslav Melichar","doi":"10.48095/ccko2024139","DOIUrl":"https://doi.org/10.48095/ccko2024139","url":null,"abstract":"","PeriodicalId":35565,"journal":{"name":"Klinicka Onkologie","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Significance of aberrant DNA methylation for cancer diagnostics and therapy","authors":"Teodor Urban, Petra Pokorna, Ondřej Slabý","doi":"10.48095/ccko202488","DOIUrl":"https://doi.org/10.48095/ccko202488","url":null,"abstract":"","PeriodicalId":35565,"journal":{"name":"Klinicka Onkologie","volume":"45 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monika Švecová, Katarína Fiedlerová, Mária Mareková, Katarína Dunayová
{"title":"Potential application of body fluids autofluorescence in the non-invasive diagnosis of endometrial cancer","authors":"Monika Švecová, Katarína Fiedlerová, Mária Mareková, Katarína Dunayová","doi":"10.48095/ccko2024102","DOIUrl":"https://doi.org/10.48095/ccko2024102","url":null,"abstract":"","PeriodicalId":35565,"journal":{"name":"Klinicka Onkologie","volume":"2 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Homolová, Eva Bojtárová, Monika Kováčová, Kristína Klučková, Magda Suchánková, Mária Kušíková, Martin Mistrík, Ivana Shawkatová
{"title":"Factors influencing overall survival and GvHD development after allogeneic hematopoietic stem cell transplantation – single centre experience","authors":"M. Homolová, Eva Bojtárová, Monika Kováčová, Kristína Klučková, Magda Suchánková, Mária Kušíková, Martin Mistrík, Ivana Shawkatová","doi":"10.48095/ccko2024118","DOIUrl":"https://doi.org/10.48095/ccko2024118","url":null,"abstract":"","PeriodicalId":35565,"journal":{"name":"Klinicka Onkologie","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tebentafusp in the treatment of metastatic uveal melanoma – the first patient treated in the Czech Republic","authors":"M. Klabusay, Barbora Bábková","doi":"10.48095/ccko2024134","DOIUrl":"https://doi.org/10.48095/ccko2024134","url":null,"abstract":"","PeriodicalId":35565,"journal":{"name":"Klinicka Onkologie","volume":"56 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jindřich Fínek, Michal Vočka, Jan Bauer, Eugen Kubala, Kateřina Zycháčková, Marcela Šedivá, Mahmud Gharibyar, Ilona Kocáková, Eva Čmuchařová, Marie Vaňková
{"title":"Feasibility of implementation of the early tumor shrinkage as a potential predictive marker to daily clinical practice in patients with RAS wild type metastatic colorectal cancer, treated with cetuximab – a non-interventional observational study","authors":"Jindřich Fínek, Michal Vočka, Jan Bauer, Eugen Kubala, Kateřina Zycháčková, Marcela Šedivá, Mahmud Gharibyar, Ilona Kocáková, Eva Čmuchařová, Marie Vaňková","doi":"10.48095/ccko2024110","DOIUrl":"https://doi.org/10.48095/ccko2024110","url":null,"abstract":"","PeriodicalId":35565,"journal":{"name":"Klinicka Onkologie","volume":"46 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michal Eid, Arnošt Martínek, Jiří Dolina, M. Uvírová, Petr Dítě
{"title":"Gut microbiome and pancreatic cancer","authors":"Michal Eid, Arnošt Martínek, Jiří Dolina, M. Uvírová, Petr Dítě","doi":"10.48095/ccko202420","DOIUrl":"https://doi.org/10.48095/ccko202420","url":null,"abstract":"","PeriodicalId":35565,"journal":{"name":"Klinicka Onkologie","volume":"174 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号