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A Retrospective Comparative Study to Evaluate the Clinical Efficacy Using a Bioactive Glass Ceramic Spacer in Posterior Lumbar Interbody Fusion 应用生物活性玻璃陶瓷垫片进行后路腰椎椎体间融合临床疗效的回顾性比较研究
Pub Date : 2021-10-30 DOI: 10.32587/jnic.2021.00367
Chan Hee Shin, S. Hwang, J. Kim, S. Yoon, B. Cho
Considering the advancement of bone graft substitution, the authors aimed to achieve clinical safety by simultaneously using one bioactive ceramic spacer (NovoMax) and a conventional polyetheretherketone (PEEK) cage at first use. We compared the results between different cages, even in the same disc space and to the control group using only conventional PEEK cages. Methods This retrospective analysis included data from patients who underwent posterior lumbar interbody fusion surgery between 2015 and 2017. The hybrid group (H group) included 19 patients with 21 lumbar disc levels, and the control group was defined as the PEEK group (P group), which included 16 patients with 18 disc levels. The degree of fusion was confirmed on computed tomography based on the fusion grade system and dynamic X-rays. We analyzed the fusion rate between the two groups using Cox proportional hazard model. Results There were 14 cases (72.2%) in Group P and 15 cases (71.4%) in Group H with confirmed complete union during the observation period (p=0.62). The relative hazard of incomplete fusion with osteolysis in both the P and H groups was increased by 5.41 times (p=0.004, confidence interval 1.704–17.204). In the H group, significant instrument-related complications, such as fragmentation, slippage, subsidence, and osteolysis were observed in the Novomax cage. Conclusions Using NovoMax could result in osteolysis, cage migration, fragmentation, or subsidence. The use of NovoMax is expected to be compatible for bone fusion surgery, but close attention should be paid to some problems that may accompany it.
考虑到骨移植替代技术的进步,作者的目标是通过首次使用一个生物活性陶瓷间隔器(NovoMax)和一个传统的聚醚醚酮(PEEK)笼同时使用来达到临床安全性。我们比较了不同笼之间的结果,即使在相同的椎间盘空间和对照组只使用传统的PEEK笼。方法回顾性分析2015年至2017年接受后路腰椎椎体间融合术患者的数据。混合组(H组)包括19例患者,共21个腰椎间盘节段;对照组定义为PEEK组(P组),共16例患者,共18个腰椎间盘节段。基于融合等级系统和动态x射线在计算机断层扫描上确认融合程度。采用Cox比例风险模型分析两组融合率。结果观察期内,P组有14例(72.2%),H组有15例(71.4%)完全愈合(P =0.62)。P组和H组不完全融合合并骨溶解的相对危险度增加了5.41倍(P =0.004,可信区间为1.704 ~ 17.204)。在H组中,在Novomax笼中观察到明显的器械相关并发症,如碎裂、滑移、下沉和骨溶解。结论:使用NovoMax可能导致骨溶解、骨笼移动、碎裂或下沉。使用NovoMax有望兼容骨融合手术,但应密切关注可能伴随的一些问题。
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引用次数: 1
Pituitary Adenoma Confined Within the Pituitary Stalk: A Case Report and Literature Review 垂体腺瘤局限于垂体柄内:1例报告及文献复习
Pub Date : 2021-10-30 DOI: 10.32587/jnic.2021.00416
Jae Hyun Park, T. Roh, J. Kim, Se-Hyuk Kim
Pituitary adenomas are among the most common intracranial tumors, accounting for 10–15% of all intracranial tumors. Nonfunctioning pituitary adenomas require surgical management when they are expected to show symptoms attributed to mass effect. The majority of pituitary adenomas originate from the anterior pituitary gland; that is, majority of pituitary adenomas grow within the sella turcica. Furthermore, pituitary adenomas may dilate the diaphragm and extend beyond the suprasellar area. On rare occasions, they may be present in extra-sellar sites not continuous with the pituitary gland, with or without an adenoma in the pituitary gland. First described by Erdheim in 1909 and predominantly described in case reports, such cases may be referred to as ectopic pituitary adenomas (EPAs). Though most pituitary adenomas are found in continuity with the gland, such ectopic forms of pituitary adenomas are usually Pituitary adenomas within the pituitary stalk, without pituitary gland involvement, are extremely rare. To date, only six cases of pituitary adenomas confined to the pituitary stalk have been reported in English publications; all of which were functional tumors suspected to originate from the pars tuberalis. Herein, we report a case of a non-functioning pituitary adenoma thought to originate from and confined within the pituitary stalk. The patients had normal hormone levels during the initial evaluation and underwent surgery using the endonasal trans-sphenoidal approach. Histopathological examination was performed to confirm the diagnosis. A careful review of the literature was also performed.
垂体腺瘤是最常见的颅内肿瘤之一,占所有颅内肿瘤的10-15%。无功能垂体腺瘤需要手术治疗时,他们预计表现出症状归因于质量效应。大多数垂体腺瘤起源于垂体前叶;也就是说,大多数垂体腺瘤生长在蝶鞍内。此外,垂体腺瘤可使横膈膜扩张并延伸至鞍上区以外。在极少数情况下,它们可能出现在鞍外部位,与垂体不连续,伴或不伴垂体腺瘤。Erdheim于1909年首次描述并主要在病例报告中描述,此类病例可称为异位垂体腺瘤(EPAs)。虽然大多数垂体腺瘤与腺呈连续性,但这种异位形式的垂体腺瘤通常是垂体柄内的垂体腺瘤,不累及垂体,极为罕见。迄今为止,只有6例垂体腺瘤局限于垂体柄已报道在英文出版物;均为怀疑起源于结节部的功能性肿瘤。在此,我们报告一个无功能的垂体腺瘤认为起源于和局限于垂体柄。患者在初始评估时激素水平正常,并采用鼻内经蝶窦入路进行手术。组织病理学检查证实了诊断。还对文献进行了仔细的审查。
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引用次数: 0
Risk Factors for Hospital-Acquired Pneumonia in Hemorrhagic Stroke Patients Treated in the Intensive Care Unit 重症监护病房出血性卒中患者医院获得性肺炎的危险因素
Pub Date : 2021-10-30 DOI: 10.32587/jnic.2021.00395
Sol-ji Jung, Ja Myoung Lee, T. An, In Sung Park
Pneumonia is a very serious medical complication in patients with hemorrhagic stroke such as spontaneous intracerebral hemorrhage and subarachnoid hemorrhage. In the case of hemorrhagic stroke patients, hospital-acquired pneumonia increases morbidity, mortality and medical costs in addition to the already poor prognosis of hemorrhagic stroke. The purpose of this study was to identify risk factors for hospital-acquired pneumonia in hemorrhagic stroke patients treated in the intensive care unit. Methods Our study was a retrospective review of 112 hemorrhagic stroke patients treated in an intensive care unit who were hospitalized in the neurosurgery department of Gyeonsang National University Hospital from August 2019 to July 2020. The data included basic demographic data, the underlying disease, lifestyle factors, neurological evaluation results, severity of the condition and other characteristics. The radiological data and medical records of the patients were retrospectively analyzed. Results A total of 97 patients were included in the study, and 10 of them met the diagnostic criteria for hospital-acquired pneumonia. Diabetes mellitus, a high simplified acute physiology score 3 (SAPS3), a low glasgow coma scale (GCS) score, mechanical ventilation, tracheostomy, dysphagia and nasogastric tube feeding were identified as risk factors for the development of hospital-acquired pneumonia (p<0.05). Six of 10 bacterial pathogens isolated from sputum were identified as multidrug-resistant pathogens. Hospital-acquired pneumonia led to further antibiotic treatment and general deterioration, which in turn increased the intensive care unit length of stay (p<0.001). Conclusion We found that mechanical ventilation, tracheostomy, dysphagia, tube feeding, a high SAPS3, and a low GCS score were risk factors for hospital-acquired pneumonia (HAP) in hemorrhagic stroke patients. Efforts will be needed to prevent pneumonia by understanding the risk factors for HAP identified in our study.
肺炎是自发性脑出血、蛛网膜下腔出血等出血性卒中患者非常严重的医学并发症。对于出血性中风患者,医院获得性肺炎增加了发病率、死亡率和医疗费用,此外,出血性中风的预后已经很差。本研究的目的是确定重症监护病房出血性卒中患者发生医院获得性肺炎的危险因素。方法回顾性分析2019年8月至2020年7月在庆尚大学附属医院神经外科重症监护病房接受治疗的112例出血性脑卒中患者。数据包括基本人口统计数据、潜在疾病、生活方式因素、神经学评估结果、病情严重程度和其他特征。回顾性分析患者的放射学资料和医疗记录。结果共纳入97例患者,其中10例符合医院获得性肺炎诊断标准。糖尿病、高急性生理评分3分(SAPS3)、低格拉斯哥昏迷评分(GCS)、机械通气、气管造口术、吞咽困难和鼻胃管喂养被认为是医院获得性肺炎发生的危险因素(p<0.05)。从痰中分离的10种细菌病原体中有6种被鉴定为多重耐药病原体。医院获得性肺炎导致进一步的抗生素治疗和总体恶化,这反过来又增加了重症监护病房的住院时间(p<0.001)。结论机械通气、气管造口术、吞咽困难、管饲、高SAPS3和低GCS评分是出血性脑卒中患者发生医院获得性肺炎(HAP)的危险因素。通过了解我们研究中确定的HAP的危险因素,需要努力预防肺炎。
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引用次数: 0
Allergic Reaction Induced Brainstem Stroke in a Patient With Moyamoya Disease: A Case Report 烟雾病患者的过敏反应诱发脑干中风1例报告
Pub Date : 2021-10-30 DOI: 10.32587/jnic.2021.00409
S. Rho, Hyo Joon Kim
Moyamoya disease is characterized by progressive peripheral stenosis of the internal carotid artery (ICA) and its proximal branches and can cause both ischemic and hemorrhagic strokes. However, its underlying pathophysiology has not yet been fully elucidated, and this poor knowledge reflects the uncertainty and heterogeneity of patient management. To date, no pharmacological treatment has been found to reverse the gradual loss in the ICA. Antiplatelet agents are commonly prescribed for ischemic moyamoya disease, although the coexistence of bleeding risk should be considered. Allergy-induced anaphylactic reactions can result in vasodilation, hypotension, bronchospasm, and angioedema, and are characterized by a rapid onset of respiratory and circulatory disturbances. This can lead to cerebrovascular collapse; however, such cases are rarely reported. In this case report, an allergic reaction was found A patient who ate peaches and developed urticaria complained of left sided weakness within minutes. Upon admission, the vital signs and breathing pattern became stable without evidence of anaphylaxis. After magnetic resonance imaging evaluation, the patient was diagnosed with acute ischemic stroke in the right pons, and cerebral angiography revealed moyamoya disease. Reports regarding an allergic reaction without anaphylaxis causing a stroke were extremely limited; however, no study has reported that allergy can cause a stroke in patients with moyamoya to date. Therefore, an ischemic stroke may occur in a patient with moyamoya only with an allergic reaction considered and reported as something that should be considered significant in the daily routine and medication for a patient with moyamoya.
烟雾病以颈内动脉(ICA)及其近端分支进行性外周狭窄为特征,可引起缺血性和出血性中风。然而,其潜在的病理生理学尚未完全阐明,这种贫乏的知识反映了患者管理的不确定性和异质性。到目前为止,还没有发现药物治疗可以逆转ICA的逐渐丧失。抗血小板药物通常用于缺血性烟雾病,但应考虑出血风险共存。过敏引起的过敏反应可导致血管舒张、低血压、支气管痉挛和血管性水肿,并以快速发作的呼吸和循环障碍为特征。这会导致脑血管衰竭;然而,这种情况很少被报道。在这个病例报告中,发现了一个过敏反应,一个病人吃了桃子后出现荨麻疹,在几分钟内抱怨左侧虚弱。入院后,生命体征和呼吸方式稳定,无过敏反应迹象。经磁共振成像评估,诊断为右脑桥急性缺血性脑卒中,脑血管造影显示烟雾病。关于没有过敏反应引起中风的过敏反应的报告非常有限;然而,到目前为止,还没有研究报告过敏会导致烟雾病患者中风。因此,在烟雾病患者的日常生活和用药中,只有考虑并报告过敏反应时,才可能发生缺血性中风。
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引用次数: 0
Clinical Outcomes of Cranioplasty Using a Customized Artificial Bone Flap Made by a 3D Printing Technique 使用3D打印技术定制人工骨瓣颅骨成形术的临床效果
Pub Date : 2021-10-30 DOI: 10.32587/jnic.2021.00388
J. Lee, Y. Shim, Sung-Tae Kim, W. Lee, K. Lee, S. Paeng, S. Pyo
Cranioplasty is required to restore the appearance of the skull, Objective To analyze the outcomes of using a customized artificial skull bone flap made with a three-dimensional (3D) printing technique for cranioplasty and compare them with those of the autobone technique. Method Between December 2018 and February 2020, 24 cranioplasties were performed for 24 hemispheres using a customized artificial bone flap made by 3D printing. Simultaneously, 19 cranioplasties for 19 hemispheres were performed using an autobone. Three patients underwent cranioplasty using both a customized artificial bone flap and autobone for each hemisphere. Patient’s demographics, reason for craniectomy, interval between craniectomy and cranioplasty, surface area of the skull defect and bone flap, bone flap coverage of the defect, cranioplasty-related factors, and clinical outcome were assessed. Results Forty patients who underwent cranioplasty (bone flap, 21; autobone flap, 16; and artificial bone/ autobone flaps, 3) were enrolled. The artificial bone flap covered more skull defects than the autobone flap (98.6% vs. 90.9%, p=0.000). There were two and six operation-related complications in the artificial bone flap and autobone flap groups, respectively (P=0.061). The subtemporal area was completely covered in the artificial bone flap group. Two patients had an infection of the autobone flap and had it replaced by a 3D printing flap. No patient showed a reduction in the modified Rankin Scale score after surgery, and the clinical course was confirmed to have improved. Conclusions Cranioplasty using customized artificial bone flap made by 3D printing technique was effective for covering the skull defect and tends to have a low complication rate compared to the autobone.
目的分析三维打印技术定制人工颅骨瓣颅骨成形术的效果,并与自体骨成形术进行比较。方法于2018年12月至2020年2月,采用3D打印定制的人工骨瓣对24个半球进行了24例颅骨成形术。同时,使用自体骨对19个半球进行了19个颅骨成形术。三名患者接受了颅骨成形术,每个半球使用定制的人工骨瓣和自体骨。评估患者的人口统计学特征、开颅原因、开颅与颅骨成形术之间的间隔、颅骨缺损和骨瓣的表面积、缺损的骨瓣覆盖、颅骨成形术相关因素和临床结果。结果行颅骨成形术40例(骨瓣21例;Autobone皮瓣,16;人工骨/汽车骨瓣,3个)。人工骨瓣修复颅骨缺损的比例高于自体骨瓣(98.6%比90.9%,p=0.000)。人工骨瓣组术后并发症2例,自体骨瓣组术后并发症6例(P=0.061)。人工骨瓣组颞下区完全覆盖。两名患者的自体骨瓣感染,并将其替换为3D打印瓣。术后无患者改良Rankin量表评分下降,临床病程得到改善。结论3D打印定制人工骨瓣颅骨成形术可有效覆盖颅骨缺损,与自体骨相比,并发症发生率低。
{"title":"Clinical Outcomes of Cranioplasty Using a Customized Artificial Bone Flap Made by a 3D Printing Technique","authors":"J. Lee, Y. Shim, Sung-Tae Kim, W. Lee, K. Lee, S. Paeng, S. Pyo","doi":"10.32587/jnic.2021.00388","DOIUrl":"https://doi.org/10.32587/jnic.2021.00388","url":null,"abstract":"Cranioplasty is required to restore the appearance of the skull, Objective To analyze the outcomes of using a customized artificial skull bone flap made with a three-dimensional (3D) printing technique for cranioplasty and compare them with those of the autobone technique. Method Between December 2018 and February 2020, 24 cranioplasties were performed for 24 hemispheres using a customized artificial bone flap made by 3D printing. Simultaneously, 19 cranioplasties for 19 hemispheres were performed using an autobone. Three patients underwent cranioplasty using both a customized artificial bone flap and autobone for each hemisphere. Patient’s demographics, reason for craniectomy, interval between craniectomy and cranioplasty, surface area of the skull defect and bone flap, bone flap coverage of the defect, cranioplasty-related factors, and clinical outcome were assessed. Results Forty patients who underwent cranioplasty (bone flap, 21; autobone flap, 16; and artificial bone/ autobone flaps, 3) were enrolled. The artificial bone flap covered more skull defects than the autobone flap (98.6% vs. 90.9%, p=0.000). There were two and six operation-related complications in the artificial bone flap and autobone flap groups, respectively (P=0.061). The subtemporal area was completely covered in the artificial bone flap group. Two patients had an infection of the autobone flap and had it replaced by a 3D printing flap. No patient showed a reduction in the modified Rankin Scale score after surgery, and the clinical course was confirmed to have improved. Conclusions Cranioplasty using customized artificial bone flap made by 3D printing technique was effective for covering the skull defect and tends to have a low complication rate compared to the autobone.","PeriodicalId":356321,"journal":{"name":"Journal of Neurointensive Care","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125426768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypothermia for the Management of Intracranial Hypertension in Severe Brain Trauma: The Paradigm is Broken? 低温治疗重型颅脑外伤患者颅内高压:模式被打破了吗?
Pub Date : 2021-10-30 DOI: 10.32587/jnic.2021.00381
A. A. Chacón-Aponte, É. A. Durán-Vargas, I. Lozada‐Martínez, M. Bolaño-Romero, L. Moscote-Salazar, Tariq Janjua, O. J. Díaz-Castillo
imately 350 per 100,000 person-years and is a leading cause of death and disability in trauma patients. The presentation of TBI varies from mild alterations of consciousness to a comatose state and death. However, despite the existence of many classification systems, the simplest includes mild, moderate, and severe TBI, in which the nature of the injury and the impact on the patient's clinical condition is considered. In the last decade, a clear trend has been demonstrated towards deterioration in patients with severe TBI, in which the whole brain is affected precisely because of the characteristics and degree of injury. This deterioration may be associated with a loss of autoregulation due to the lack of reactivity of cerebral vascular pressure, resulting in hyperemia, interstitial edema and subsequent intracranial hypertension (ICH). Normal intracranial pressure in adults is less than 15 mm Hg, values that remain above 20 mm Hg are considered pathological and are an indication for intensified treatment in patients with TBI. It is important to consider that ICH can result from primary injury (hematoma expansion) or secondary damage (water accumulation, impaired autoregulation, ischemia, and contusion expansion). This is associated with high mortality rates, so multiple early, stepwise, and rescue management strategies have been proposed for its control, which is aimed at preventing secondary injury by avoiding hypotension, hypoxia and maintaining adequate cerebral perfusion pressure (CPP). Targeted treatment is essential and may include cerebrospinal fluid (CSF) drainage, use of hyperosmolar therapies, induction of hypothermia, hyperventilation, administration of barbiturates, or performance of decompressive surgery. Therapeutic hypothermia (TH) is one of the few neuroprotectants that has moved from preclinical work to clinical use. For example, it was previously used to prevent brain damage during cardiac surgical procedures, but more recently it has also been used to improve both neurological and physical outHypothermia for the Management of Intracranial Hypertension in Severe Brain Trauma: The Paradigm is Broken?
大约每10万人中有350人,是创伤患者死亡和残疾的主要原因。创伤性脑损伤的表现从轻微的意识改变到昏迷状态和死亡不等。然而,尽管存在许多分类系统,最简单的分类系统包括轻度、中度和重度TBI,其中考虑了损伤的性质和对患者临床状况的影响。在过去的十年中,严重脑外伤患者的功能有明显的恶化趋势,由于损伤的特点和程度,整个大脑都受到了影响。这种恶化可能与由于缺乏对脑血管压力的反应性而导致的自身调节丧失有关,从而导致充血、间质水肿和随后的颅内高压(ICH)。成人正常颅内压小于15mm Hg,高于20mm Hg被认为是病理性的,是TBI患者加强治疗的指征。重要的是要考虑到脑出血可能是由原发性损伤(血肿扩张)或继发性损伤(水分积聚、自我调节受损、缺血和挫伤扩张)引起的。这与高死亡率相关,因此提出了多种早期、逐步和抢救管理策略来控制其,旨在通过避免低血压、缺氧和维持适当的脑灌注压(CPP)来预防继发性损伤。有针对性的治疗是必要的,可能包括脑脊液(CSF)引流、使用高渗疗法、诱导低体温、过度通气、施用巴比妥类药物或进行减压手术。治疗性低温(TH)是为数不多的已从临床前工作转移到临床使用的神经保护剂之一。例如,它以前被用于在心脏手术过程中预防脑损伤,但最近它也被用于改善神经和物理体温,以治疗严重脑外伤中的颅内高压:范式被打破了吗?
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引用次数: 0
Critical Care in Patient with Neuromuscular Cervicothoracic Kyphosis 神经肌肉型颈胸后凸症的重症监护
Pub Date : 2019-09-23 DOI: 10.32587/jnic.2019.00185
Kwang-Ui Hong, Jong-myung Jung, S. Hyun, Ki-Jeong Kim, T. Jahng
A 10-year-old boy had a neuromuscular cervicothoracic kyphosis and kyphotic deformity got worse as he grew. He underwent posterior spinal fusion from T6 to pelvis two years ago. However, kyphosis progressed gradually, and difficulty occurred in breathing with a ventilator. We perform deformity correction with vertebral column resection at T5 and posterior fixation from T2 to T9 and posterior onlay fusion. Surgical correction is offered to stop the kyphosis progression, and finally to maintain the airway. After surgery, the patient transferred to an intensive care unit for respiratory care. The patient’s breathing was much better than before surgery, and the patient was transferred to the general ward. We report the importance of postoperative care in spinal deformity patient with respiratory distress.
一个10岁的男孩患有神经肌肉性颈胸后凸,随着他的成长,后凸畸形变得越来越严重。他两年前接受了从T6到骨盆的后路脊柱融合术。然而,后凸逐渐恶化,使用呼吸机呼吸困难。我们通过T5椎体切除和从T2到T9的后路固定和后路嵌体融合进行畸形矫正。手术矫正是为了停止后凸的进展,并最终维持气道。手术后,病人转到重症监护室进行呼吸护理。病人的呼吸比术前好多了,被转到普通病房。我们报告呼吸窘迫脊柱畸形患者术后护理的重要性。
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引用次数: 0
Preliminary Experience of Lvis Blue in the Internal Carotid Artery for The Treatment Of Wide-Necked Intracranial Aneurysms 颈内动脉内灌注Lvis Blue治疗颅内宽颈动脉瘤的初步经验
Pub Date : 2019-09-23 DOI: 10.32587/jnic.2019.00178
Jeong Hwa Kim, C. Jang, Jae Whan Lee, K. Park, Joonho Chung
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引用次数: 1
Crescent Sign Following Enterprise-Stent assisted Coil Embolization of Distal Internal Carotid Artery Aneurysms 企业支架辅助线圈栓塞颈内动脉远端动脉瘤后的新月征
Pub Date : 2019-09-19 DOI: 10.32587/jnic.2019.00206
Young-Jin Kim, J. Yeon, Jong-Soo Kim, Seung-Chyul Hong
We aimed to determine the “significant crescent signs” associated with delayed thromboembolic events (DTE) after changes in antiplatelet medication and to evaluate their incidence and natural course. Methods Between April 2009 and April 2011, 105 consecutive patients underwent stent-assisted coil embolization for unruptured intracranial aneurysms (n=107) in a single tertiary hospital. Sixty-three cases fulfilled the inclusion criteria and were included in this study. Crescent sign was evaluated through follow-up magnetic resonance angiography (MRA) immediately (<48 hours), 6 to 12 months, 1 to 2 years, and 2 to 4 years and correlated with the occurrence of DTE. Results Crescent signs were identified in 26 (41.3%) of 63 cases on immediate follow-up MRA. During the mean radiological follow-up of 53 months, the crescent signs (larger than 5 mm in length) persisted for more than 1 year in 11 (42.3%) of 26 cases. The crescent signs on follow-up MRA showed decreased size in 10 of 26 cases and disappeared in 5 cases. DTE occurred in 6 (9.5%) of 63 cases. In these 6 cases, all DTE occurred when the antiplatelet regimen was changed or stopped. Five of these six cases exhibited a crescent sign measuring over 5 mm in length, at the time of stroke. Conclusions Crescent signs may be associated with DTE. When crescent signs are larger than 5 mm in length and continuously identified on follow-up MRA, continued dual antiplatelet treatment is required.
我们的目的是确定抗血小板药物改变后与延迟血栓栓塞事件(DTE)相关的“显著新月征象”,并评估其发生率和自然过程。方法2009年4月至2011年4月,在某三级医院连续行支架辅助线圈栓塞治疗未破裂颅内动脉瘤105例(n=107)。63例符合纳入标准,纳入本研究。通过随访磁共振血管造影(MRA)即刻(<48小时)、6 ~ 12个月、1 ~ 2年、2 ~ 4年评估新月征与DTE发生的相关性。结果63例患者中有26例(41.3%)出现新月征。在平均53个月的放射学随访中,26例患者中有11例(42.3%)的月牙征(长度大于5mm)持续1年以上。随访MRA示10例月牙征缩小,5例月牙征消失。63例中有6例(9.5%)发生DTE。在这6例中,所有的DTE都发生在改变或停止抗血小板治疗方案时。这6个病例中有5个在中风时表现出长度超过5毫米的新月形征象。结论新月征可能与DTE有关。当月牙征长度大于5mm且在后续MRA中持续发现时,需要继续双重抗血小板治疗。
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引用次数: 0
Radiologic Factors for Predicting Dynamic Spinal Cord Compression in Conventional Cervical MRI 传统颈椎MRI预测动态脊髓压迫的放射学因素
Pub Date : 2019-09-19 DOI: 10.32587/jnic.2019.00192
Kwang-Ui Hong, Jong-myung Jung, S. Hyun, Ki-Jeong Kim, T. Jahng
Objective Conventional cervical MRI is the gold standard exam for diagnosis of cervical myelopathy, but cannot detect dynamic cord compression. This study aims to evaluate radiologic factors suggesting dynamic spinal cord compression. Methods We retrospectively reviewed the patients who examined dynamic MRI in addition to conventional MRI. A total of 50 patients were included in this study, comprised of 36 in the group P (aggravation of spinal cord compression on dynamic MRI) and 14 in the group N (non-aggravation of spinal cord compression on dynamic MRI). Radiologic factors were compared. Results The following factors were analyzed: age, cervical canal diameter (CCD), spinal cord diameter (SCD), subarachnoid space (SAS), cervical lordosis (CL), cervical ROM, anterior length of cervical cord (ALCC), posterior length of cervical cord (PLCC), length of anterior column (LAC), and length of posterior column (LPC), Significant differences were found in age, CCD, SAS, CL, LPC (p<0.05). In ROC curves, age (AUC 0.813, cut-off value 54), CCD (AUC 0.858, cut-off value 10.32), and SAS (AUC 0.884, cut-off value 3.25) were a significant factor in predicting deterioration of spinal cord compression during the dynamic posture. Conclusion Dynamic MRI is more useful for the diagnosis of dynamic spinal cord compression in the following conditions: age is 54 years or older, CCD average is less than 10.32 mm, SAS average is less than 3.25 mm, CL is -1.98 ̊ or LPC is less than 105.45 mm.
目的常规颈椎MRI是诊断颈椎病的金标准检查,但不能检测脊髓动态受压。本研究旨在评估提示动态脊髓压迫的放射学因素。方法回顾性分析在常规MRI基础上进行动态MRI检查的患者。本研究共纳入50例患者,其中P组36例(动态MRI显示脊髓压迫加重),N组14例(动态MRI显示脊髓压迫未加重)。比较放射学因素。结果分析年龄、颈椎管直径(CCD)、脊髓直径(SCD)、蛛网膜下腔间隙(SAS)、颈椎前凸(CL)、颈椎ROM、颈髓前长度(ALCC)、颈髓后长度(PLCC)、前柱长度(LAC)、后柱长度(LPC)等因素,年龄、CCD、SAS、CL、LPC差异有统计学意义(p<0.05)。在ROC曲线中,年龄(AUC 0.813,截断值54)、CCD (AUC 0.858,截断值10.32)和SAS (AUC 0.884,截断值3.25)是预测动态体位时脊髓压迫恶化的重要因素。结论:年龄54岁及以上、CCD平均值小于10.32 mm、SAS平均值小于3.25 mm、CL > -1.98 mm或LPC小于105.45 mm,动态MRI对脊髓受压诊断更有价值。
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Journal of Neurointensive Care
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