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Carcinoma neuroendocrino de vulva, una entidad poco frecuente. Reporte del primer caso en Venezuela 神经内分泌外阴癌,罕见的实体。委内瑞拉第一例病例报告
Q4 Medicine Pub Date : 2023-04-30 DOI: 10.51288/00830213
María Nastasi, Ernesto Lara, Rosa Mata, Carmen Silva, Elianny Betancourt
Vulvar cancer represents 1% of cancers in women; vulvar neuroendocrine carcinoma is extremely rare, with less than 20 published cases. Its behavior is very aggressive, producing early local recurrences, lymph node and distant metastases. The case of a 60-year-old patient who consulted for a vulvar lesion of 6 months of evolution, with extension to the lower third of the urethra and vagina and left inguinal nodal plastron is described. The vulvar biopsy reported malignant round cell neoplasm and the immunohistochemistry result was compatible with neuroendocrine carcinoma. She received concurrent chemotherapy and radiotherapy, evidencing a complete response in the vulva and a partial response in the inguinal region.Later, bilateral inguinofemoral lymphadenectomy was performed. Neuroendocrine carcinoma of the vulva should be considered when managing malignant vulvar pathology, timely diagnosis requires histology and immunohistochemistry to establish an adequate prognosis and treatment.
外阴癌占女性癌症的1%;外阴神经内分泌癌极为罕见,已发表病例不足20例。其行为具有很强的侵袭性,可产生早期局部复发、淋巴结和远处转移。本文描述了一位60岁的患者因外阴病变演变6个月而就诊的病例,外阴病变延伸至尿道和阴道的下三分之一以及左侧腹股沟淋巴结板。外阴活检报告恶性圆细胞瘤,免疫组化结果与神经内分泌癌一致。她同时接受化疗和放疗,外阴完全缓解,腹股沟部分缓解。术后行双侧腹股沟淋巴结切除术。在处理外阴恶性病理时应考虑外阴神经内分泌癌,及时诊断需要组织学和免疫组化来确定适当的预后和治疗。
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引用次数: 0
Anillo vaginal anticonceptivo (MyRing®): estudio multicéntrico en mujeres venezolanas 阴道避孕环®): 委内瑞拉妇女的多中心研究
Q4 Medicine Pub Date : 2023-04-30 DOI: 10.51288/00830205
Rita Pizzi, Manuel Peroza, Mireya González-Blanco, Indira Centeno, Paula Cortiñas, María Mercedes Pérez
Objective: To evaluate the factors associated with the use of the vaginal ring in Venezuelan women of reproductive age, with a desire for contraception and with an active sexual life. Methods: Observational - descriptive, multicenter study. The sample was non-probabilistic, deliberate and voluntary. The vaginal ring was provided for three cycles and follow-up visits were made at the end of the first and third menstrual cycles. Acceptability, tolerability, compliance, menstrual cycle control, and the presence of adverse effects were evaluated. Results: A total of 140 women were included, whose mean age was 31.01 ± 8.14 years. The reasons for selecting the vaginal ring were: effectively prevents pregnancy (69.29 %), easy to use (68.57 %), method of monthly use (65.71 %). The bleeding pattern was reported as regular in 95% of the women in the second consultation and in 92.8% in the third; 88.57% reported absence of intermenstrual bleeding. There was adequate compliance in 97.86%; 96.43% expressed that it was easy to use and 92.86% comfortable at a sexual level. There were no statistically significant differences in the average weight at the second and third consultation (p > 0.05), nor in systolic and diastolic blood pressure (p > 0.05). There were no adverse events in 77%, when there were, the most frequent were headache, nausea and mastodynia; there were no serious adverse events or pregnancy. Conclusion: The contraceptive vaginal ring is a well-tolerated option with excellent acceptance, sexual and general satisfaction, safe, with few adverse events.
目的:评估与委内瑞拉育龄妇女使用阴道环相关的因素,有避孕的愿望和积极的性生活。方法:观察-描述,多中心研究。样本是非概率的、故意的和自愿的。提供了三个周期的阴道环,并在第一和第三个月经周期结束时进行了后续访问。评估可接受性、耐受性、依从性、月经周期控制和不良反应的存在。结果:共纳入140例女性,平均年龄31.01±8.14岁。选择阴道环的原因为:有效预防妊娠(69.29%)、使用方便(68.57%)、每月使用方法(65.71%)。在第二次咨询中95%的妇女报告出血模式为常规,在第三次咨询中为92.8%;88.57%报告无经间出血。97.86%符合要求;96.43%的人表示使用方便,92.86%的人表示在性层面上感到舒适。第二次和第三次问诊时的平均体重(p < 0.05)、收缩压和舒张压(p < 0.05)均无统计学差异。77%的患者未发生不良事件,当出现不良事件时,最常见的是头痛、恶心和乳突痛;没有严重的不良事件或妊娠。结论:阴道避孕环是一种耐受性良好的选择,可接受性好,性满意,一般满意,安全,不良事件少。
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引用次数: 0
VIH/SIDA en embarazadas: evaluación hematológica e inmunológica y peso de sus neonatos 孕妇的艾滋病毒/艾滋病:新生儿的血液学和免疫学评估和体重
Q4 Medicine Pub Date : 2023-04-30 DOI: 10.51288/00830208
Aixa Müller, A. Soyano, Aleidah Salazar, Rafael Cortés Charry, Bahilda Martínez, M. Colina, Neibys Anallarit García de Franquiz
Objective: To determine the incidence of infection by human immunodeficiency virus and the effects on the weight of the newborn, in pregnant women who attend the University Hospital of Caracas. Methods: Seropositive pregnant women for human immunodeficiency virus infection were included. Elisa was performed for human immunodeficiency virus infection, Websternblot, hematology and chemistry, CD3, CD4 and CD8 lymphocytes by cytometry, viral load, the weight of 204 neonates and the treatment scheme received were recorded. Results: The frequency of infection by human immunodeficiency virus in pregnant women has increased since the year 2000; most occur during the third trimester. 68.55% of pregnant women in the second and third trimester had hemoglobin greater than 11 g and 31.45% had hemoglobin between 7 and 10 g. The CD4/CD8 ratio was decreased. Second trimester CD4 counts were lowest in patients with hemoglobin between 7 and 10 grams. This relationship was not seen in the third trimester, perhaps because of the degree of viral suppression by treatment; mothers of 95.7% of low birth weight infants received combination antiretroviral therapy, there were no low birth weight infants born to mothers who received monotherapy. Conclusion: The prevalence of human immunodeficiency virus infection was 1.6%. The prevalence of anemia was 31.45%. The CD4/CD8 ratio was decreased. There were 11.3% of neonates with low birth weight, in 95.7% the mothers received combination antiretroviral therapy.
目的:了解在加拉加斯大学医院就诊的孕妇感染人类免疫缺陷病毒的发生率及其对新生儿体重的影响。方法:纳入人类免疫缺陷病毒感染血清阳性孕妇。对204例新生儿进行人免疫缺陷病毒感染Elisa检测、韦氏免疫印迹检测、血液学及化学检测、细胞计数检测CD3、CD4、CD8淋巴细胞、病毒载量、体重及接受治疗方案的记录。结果:自2000年以来,孕妇感染人类免疫缺陷病毒的频率有所上升;大多数发生在妊娠晚期。68.55%的孕妇在妊娠中晚期血红蛋白大于11g, 31.45%的孕妇血红蛋白在7 ~ 10g之间。CD4/CD8比值降低。在妊娠中期,血红蛋白在7到10克之间的患者CD4计数最低。这种关系在妊娠晚期未见,可能是因为治疗对病毒的抑制程度;95.7%的低出生体重儿的母亲接受了抗逆转录病毒联合治疗,没有接受单一治疗的母亲所生的低出生体重儿。结论:免疫缺陷病毒感染率为1.6%。贫血患病率为31.45%。CD4/CD8比值降低。11.3%的新生儿低出生体重,95.7%的母亲接受了抗逆转录病毒联合治疗。
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引用次数: 0
Factores asociados al rechazo del método anticonceptivo vasectomía en población masculina de Chile 智利男性人群拒绝输精管切除避孕方法的相关因素
Q4 Medicine Pub Date : 2023-04-30 DOI: 10.51288/00830209
Naira Compiano Marguart, Víctor Lagos Castillo, Claudia Larenas Gacitúa, María Valdivia Vásquez, Ramon Gelabert Santané, Bárbara Cerda Aedo
Objective: Identify relevant factors associated with vasectomy rejection in the male population of Chile, between 30 and 60 years. Methodology: The sample was surveyed through Google Forms, with a questionnaire that measured beliefs towards vasectomy, through a Likert-type scale. The statistical tests used were chi-square and Fisher’s exact test. Results: The most relevant factors were membership of a religious group and region of residence. Participants who did not identify with any religious group had a lower negative perception of vasectom (p = 0,0435). Conclusion: Vasectomy is prejudiced by lack of knowledge and accessibility to it. Therefore, there is an urgent need for greater dissemination of its benefits in the public and private health system, also, implement accessibility programs for men who do not intend to have children in the future.
目的:确定智利30至60岁男性人群输精管切除术排斥反应的相关因素。方法:通过谷歌表格对样本进行调查,并通过Likert型量表对输精管切除术的信念进行问卷调查。使用的统计检验是卡方检验和Fisher精确检验。结果:最相关的因素是宗教团体的成员和居住地区。不认同任何宗教团体的参与者对输精管切除术的负面认知较低(p=0.0435)。结论:输精管切除术由于缺乏知识和可及性而受到损害。因此,迫切需要在公共和私人卫生系统中更多地宣传其益处,并为未来不打算生育的男性实施无障碍计划。
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引用次数: 0
Sutura de B-Lynch profiláctica: eficacia en la prevención de la hemorragia posparto en pacientes de alto riesgo 预防b -林奇缝合线:预防高危患者产后出血的有效性
Q4 Medicine Pub Date : 2023-04-30 DOI: 10.51288/00830204
Génesis Cañizalez, Edgardo José Pérez, Aida Lara Croes, Hecna Carrillo García
Objective: To evaluate the effectiveness of prophylactic B-Lynch suture in the prevention of postpartum bleeding in patients at high risk for uterine atony, from the Concepción Palaces Maternity Delivery Room Service. Methods: Prospective, comparative and longitudinal study, which included 30 patients with risk factors for uterine atonia, randomly distributed in two groups: with and without B-Lynch compression suture. Echosonographic, clinical and paraclinical follow-up was performed at 12 and 24 hours after the postoperative period. A statistically significant contrast was considered if p < 0.05. Results: Haemoglobin reduction in patients with compressive suture was 0.5 ± 0.4 g/dl and hematocrit was 1.4 ± 1.1%; in the control group it was 1.6 ± 1.6 g/dl and 4 ± 4.7%, respectively (p-0.014/p-0.058). Bleeding at 12 and 24 hours was scarce in 73.3% and 93.3% of patients with compressive and moderate sutures or abundant in 100% and 93.4% of the control group (p-0.000). The reduction in the size of the uterus was greater in the experimental group than in the control group (p-0.000); 33.4% of patients with B-Lynch sutures and 93.4% without sutures had severe or unbearable pain at 12 hours (p-0.007) and at 24 hours there were no cases with severe or unbearable pain in the first group but in the second the frequency was 60%. Conclusions: Prophylactic B-Lynch suture is effective for preventing postpartum uterine atonia hemorrhage
目的:评价预防性B-Lynch缝合预防子宫张力增高高危患者产后出血的效果。方法:前瞻性、对比性和纵向研究,选取30例存在子宫张力紧张危险因素的患者,随机分为B-Lynch加压缝合组和未加压缝合组。术后12、24小时分别行超声、临床及临床旁随访。p < 0.05为差异有统计学意义。结果:加压缝合患者血红蛋白降低0.5±0.4 g/dl,红细胞压积降低1.4±1.1%;对照组分别为1.6±1.6 g/dl和4±4.7% (p-0.014/p-0.058)。压缩缝合和中等缝合的患者在12和24小时出血较少,分别为73.3%和93.3%,对照组出血较多,分别为100%和93.4% (p-0.000)。实验组子宫缩小幅度大于对照组(p-0.000);采用B-Lynch缝合的患者和未采用B-Lynch缝合的患者中,33.4%和93.4%的患者在12小时出现严重或难以忍受的疼痛(p-0.007),在24小时,第一组无严重或难以忍受的疼痛,而第二组的发生率为60%。结论:预防性B-Lynch缝合是预防产后子宫张力紧张出血的有效方法
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引用次数: 0
Cáncer endometrial: hallazgos en la citología cervical. Un caso clínico 子宫内膜癌:宫颈细胞学发现。临床病例
Q4 Medicine Pub Date : 2023-04-30 DOI: 10.51288/00830212
María Carolina Moreno Barrios, Adriana Rodríguez
Endometrial cancer represents the most common gynecological neoplasm in developed countries and the second in developing countries after cervical cancer. The sensitivity and usefulness of cervical cytology for the detection of cervical cancer and precursor lesions, especially those of squamous origin, has been clearly established, but the usefulness of this sampling to detect lesions at the level of the uterine cavity is limited due to the difficulty of sampling and other interpretability factors. That is why the following clinical case is presented in which a clear and accurate orientation of endometrial adenocarcinoma was established in a sample taken from the cervix in a post-menopausal patient after presenting an abnormal vaginal bleeding
子宫内膜癌症是发达国家最常见的妇科肿瘤,也是发展中国家仅次于癌症的第二大妇科肿瘤。子宫颈细胞学检测子宫颈癌症和前体病变,特别是鳞状病变的敏感性和实用性已经明确,但由于取样困难和其他可解释性因素,这种取样检测子宫腔水平病变的实用性受到限制。这就是为什么以下临床病例中,在一名绝经后患者出现异常阴道出血后,从宫颈取样,确定了子宫内膜腺癌的清晰准确方向
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引用次数: 0
Impacto y consecuencias de la violencia ginecológica en la vida de las mujeres 妇科暴力对妇女生活的影响和后果
Q4 Medicine Pub Date : 2023-02-23 DOI: 10.51288/00830109
Manuel Cárdenas Castro, Stella Salinero Rates
Objective: The objective was to analyze a set of results on gynecological violence and relate them to their impact on the perception of the body, sexuality, self-image and self-esteem. Methods: A descriptive cross-sectional study was carried out. 812 stories of women from different regions of Chile were analyzed. Results: Three kinds of consequences of violence were detected: adoption of protection and shelter measures, impact on the experience of themselves and their bodies, and physical and emotional consequences of violence in their lives. Additionally, some experiences of autonomy recovery in gynecological health care are presented. Conclusion: Gynecological violence is part of the common experience of women and can constitute a serious public health problem and become a barrier to women’s access to health services.
目的:分析一组关于妇科暴力的结果,并将其与它们对身体感知、性取向、自我形象和自尊的影响联系起来。方法:采用描述性横断面研究。对来自智利不同地区的812名妇女的故事进行了分析。结果:发现了三种暴力后果:采取保护和庇护措施,对自己和身体体验的影响,以及暴力在他们生活中的身心后果。此外,还介绍了在妇科保健中自主恢复的一些经验。结论:妇科暴力是妇女常见经历的一部分,可能构成严重的公共卫生问题,并成为妇女获得医疗服务的障碍。
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引用次数: 1
Comparación de hallazgos histeroscópicos vs. histerosalpingográficos en pacientes sometidas a tratamiento de fertilidad 生育治疗患者宫腔镜和子宫输卵管造影结果的比较
Q4 Medicine Pub Date : 2023-02-23 DOI: 10.51288/00830107
Luis D. Segura Bannatyne, J. Pérez-Wulff.
Objective: To compare hysteroscopic vs. hysterosalpingographic findings in female patients subject fertility treatment. Methods: Observational, descriptive, retrospective study to determine the causes of infertility, and analytical to evaluate the correspondence of the findings between hysterosalpingography and hysteroscopy of women who attended the fertility clinic of the Leopoldo Aguerrevere Clinic between January 2018 and May of 2022. Results: The most frequent causes of infertility were age (52.6%), tubal factor (12.4%) and early ovarian failure (11.7%); 47.4% had two causes of infertility, 44.5% only one and 8.1% three causes. In vitro fertilization (50.4%) was the most commonly used treatment to achieve pregnancy. In hysterosalpingography, 67.9 % normal patients were reported, of the total polyps reported, 5.1 % had one polyp and 4.4 % two polyps. In hysteroscopy, 46 % normal patients were reported, of the total polyps, 30.7 % presented one polyp, 4.4 % two and 0.7 % three polyps. Among the most common findings there was discordance between hysterosalpingography and hysteroscopy, with coincidences being less than 50%. The Kappa index indicated that the correspondence between the two studies was low. Conclusions: hysteroscopy is a necessary technique for the study of endouterine disorders in infertile women, providing information on uterine endocavitary lesions, which may not be appreciated with hysterosalpingography, the latter can be used for presumptive diagnosis of endometrial pathology and evaluation of permeability of the fallopian tubes
目的:比较接受生育治疗的女性患者的宫腔镜和子宫输卵管造影结果。方法:通过观察、描述性、回顾性研究来确定不孕原因,并通过分析来评估2018年1月至2022年5月期间在Leopoldo Aguerrevie诊所生育诊所就诊的女性的子宫输卵管造影和宫腔镜检查结果的一致性。结果:不孕最常见的原因是年龄(52.6%)、输卵管因素(12.4%)和早期卵巢功能衰竭(11.7%);47.4%有两种原因导致不孕,44.5%只有一种原因,8.1%有三种原因。体外受精(50.4%)是实现妊娠最常用的治疗方法。子宫输卵管造影中,67.9%的正常患者报告,在报告的息肉总数中,5.1%有一个息肉,4.4%有两个息肉。宫腔镜检查中,46%的正常患者出现息肉,其中30.7%的患者出现一个息肉,4.4%的患者出现两个息肉,0.7%的患者出现三个息肉。在最常见的发现中,子宫输卵管造影和宫腔镜检查之间存在不一致,一致性低于50%。Kappa指数表明,这两项研究之间的对应度较低。结论:宫腔镜检查是研究不孕妇女子宫内膜疾病的必要技术,可以提供子宫内膜病变的信息,而子宫输卵管造影可能无法识别这些信息,后者可用于子宫内膜病理的推定诊断和输卵管通透性的评估
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引用次数: 0
Manejo quirúrgico conservador de la hemorragia posparto mediante sutura compresiva uterina (Técnica de Hayman). Reporte de caso 宫缩缝合法保守治疗产后出血(Hayman技术)。病例报告
Q4 Medicine Pub Date : 2023-02-23 DOI: 10.51288/00830113
Marcos Edisson Bustillos Solórzano, Diana Navarrete Tinajero
Postpartum hemorrhage is one of the most frequent complications in obstetrics, being the second cause of maternal mortality worldwide. Uterine atony is its main cause. Once the hemorrhage is established, the time and management of it will depend on the expertise of the obstetrician. Initially, treatment focuses on the use of uterotonic drugs, but in the absence of an adequate response, conservative surgical management may be chosen. Compressive uterine sutures are considered a good treatment option. An effective and simple surgical technique is described by Hayman, a valuable tool for the control of postpartum hemorrhage. We present the case of a 17-year-old patient, 37 weeks pregnant and diagnosed with severe preeclampsia, who presents placental abruption and posterior uterine atony, who underwent uterine compressive suture by Hayman technique, with satisfactory evolution.
产后出血是产科最常见的并发症之一,是全球孕产妇死亡的第二大原因。子宫无力是其主要原因。一旦确定出血,出血的时间和处理将取决于产科医生的专业知识。最初,治疗的重点是使用子宫内药物,但在没有足够反应的情况下,可以选择保守的手术治疗。子宫压缩缝合被认为是一个很好的治疗选择。Hayman描述了一种有效而简单的手术技术,这是控制产后出血的一种有价值的工具。我们报告了一例17岁的患者,怀孕37周,被诊断为严重先兆子痫,表现为胎盘早剥和子宫后部无力,通过Hayman技术进行子宫压缩缝合,进展令人满意。
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引用次数: 0
Embarazo ectópico cornual. A propósito de un caso 异位角妊娠。关于一个案例
Q4 Medicine Pub Date : 2023-02-23 DOI: 10.51288/00830114
M. Seco, Nazira Monsalve, J. Contreras
Ectopic pregnancy is defined as a pregnancy that occurs outside the uterine cavity, the most common location being in the ampullary region of the uterine tube. In the literature, the terms interstitial pregnancy and cornual pregnancy are often used synonymously, they represent between 1.1% and 6.3% of ectopic pregnancies in general and correspond to only 2.2% of tubal ectopic pregnancies; its etiology is multifactorial. In gestations greater than 12 weeks, uterine rupture occurs in 20-35% of cases, generating massive hemoperitoneum that could quickly lead to hypovolemic shock, maternal death or permanent sequelae of infertility. For this reason, treatment options will depend on the time of diagnosis and the hemodynamic stability of the patient.
宫外孕被定义为发生在子宫腔外的妊娠,最常见的位置是在输卵管的壶腹区。在文献中,间质妊娠和宫角妊娠通常是同义使用的,它们在一般异位妊娠中占1.1% - 6.3%,在输卵管性异位妊娠中仅占2.2%;其病因是多因素的。在妊娠超过12周的情况下,20-35%的病例发生子宫破裂,产生大量腹膜出血,可迅速导致低血容量性休克、产妇死亡或永久性不孕后遗症。因此,治疗方案将取决于诊断时间和患者的血流动力学稳定性。
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引用次数: 0
期刊
Revista de Obstetricia y Ginecologia de Venezuela
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