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[Severe acute hepatitis by delta virus superinfection: diagnostic significance of molecular biology.] 重型急性肝炎丁型病毒重复感染的分子生物学诊断意义
Q4 Medicine Pub Date : 2016-03-01
Cristina Fernández, Juan Ramón Larrubia, Ana Avellón, Nora Mariela Martínez, Antonio Gómez, Alejandro González Praetorius

HDV infection may occur within a primary HBV infection (co-infection) or by sub sequent acquisition ofthe virus in patients with chronic hepatitis B (superinfection). Acute HDV infection is rarely diagnosed. Since cero conversion usually takes place about six weeks after viral infection, early diagnosis requires the use of direct diagnostic techniques, such as antigen HD V (HDAg) detection, or genomic amplification by means of molecular biology methods (RT-PCR). Here were port the case of a patient with chronic HBV infection that develops a severe acute hepatitis due to VHD superinfec- tion only detected by molecular biology.

HDV感染可能发生在原发性HBV感染(合并感染)中,也可能发生在慢性乙型肝炎患者随后获得病毒(重复感染)中。急性HDV感染很少被诊断出来。由于cero转化通常在病毒感染后约6周发生,因此早期诊断需要使用直接诊断技术,例如抗原HD V (HDAg)检测,或通过分子生物学方法(RT-PCR)进行基因组扩增。这里有一例慢性HBV感染患者由于VHD重叠感染而发展为严重急性肝炎的病例-仅通过分子生物学检测。
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引用次数: 0
[A histological unexpected finding.] [组织学上意想不到的发现]
Q4 Medicine Pub Date : 2016-03-01
Raquel Ratto, Adriana Bosolino, Nicolás Pagliere
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引用次数: 0
[Epigastric pain and extraluminal retroperitoneal gas.] [胃脘痛及腔外腹膜后气体。]
Q4 Medicine Pub Date : 2016-03-01
Daniel López Rey, Amelia Bargiela Lemos, Daniel Romeu Vilar, Tania Perez Ramos
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引用次数: 0
[Syncrhonous carcinosarcoma of the extrahepatic bile duct and gallbladder.] 肝外胆管及胆囊的同时性癌肉瘤。
Q4 Medicine Pub Date : 2016-03-01
Ana Alberca Páramo, David Padilla Valverde, Pedro Villarejo Campos, Esther Pilar Garcia Santos, Jose Luis Bertelli Puche, Paloma Núńez Guerrero, Margarita Delgado, Jesus Martin Fernindez

Carcinosarcoma is a malignant neoplasm characterized for intermingled epithelial and mesenchymal components.

Case report: A preoperative suspected diagnosis will allow a radical therapy avoiding a very bad prognosis. We report on a male patient who was operated in our Service with diagnosis of synchronous carcinosarcoma of gallbladder and extrahepatic bile duct and a review of the Medical Literature.

Discussion: A gallblader carcinosarcoma showing extension into common bile duct is very rare, a carcinosarcoma of the bile duct is exceptional, and a synchronous carcinosarcoma ofthe bile duct and gallbladder has not been reported previously.

癌肉瘤是一种以上皮和间质成分混合为特征的恶性肿瘤。病例报告:术前疑似诊断将允许根治性治疗,避免非常糟糕的预后。我们报告一位在本院手术诊断为胆囊及肝外胆管同步癌肉瘤的男性病人,并复习医学文献。讨论:胆管癌肉瘤向胆总管延伸是非常罕见的,胆管癌肉瘤是例外,胆管和胆囊同步癌肉瘤以前未见报道。
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引用次数: 0
Extensive mesenteric lipodystrophy of the left colon: case report and brief review of the literature. 左结肠广泛肠系膜脂肪营养不良:病例报告及文献回顾。
Q4 Medicine Pub Date : 2016-03-01
Alejandro Rey, Virginia Margarita Cano Busnelli, Juan Pablo Santino, Fernando Van Domselaar, Guillermo Ojea Quintana, Alberto Cristian Seehaus, Juan Andrés De Paula

Mesenteric lipodystrophy is a rare inflammatory process that predominantly affects mesenteric adipose tissue of the small bowell. Several mechanisms have been suggested as responsible for this entity although the precise etiolog remains unknown. The diagnosis is based on CT or MRI imaging and generally confirmed by surgical biopsies. Treatment is individualized and empiric and depends on disease stage and symptoms. We report a case of a 35-year-old male who was admitted to our hospital with a history of abdominal pain, constipation and a palpable mass in the left lower quadrant. Abdominal CT scan showed diffuse thickening of the descending and rectosigmoid colon, associated with increased density of the mesenteric fat. After failure ofan initial treat- ment with glucocorticoids, he underwent a laparoscopic sigmoidectomy. Histopatholog analysis revealed extensive stea- tonecrosis ofpericolonicfat and lipid-ladenfoamy cells which was consistent with the diagnosis of mesenteric lipodystrophy. Clinical presentation and treatment as well as a brief review of the literature are discussed.

肠系膜脂肪营养不良是一种罕见的炎症过程,主要影响小肠的肠系膜脂肪组织。虽然确切的病因尚不清楚,但已有几种机制被认为是造成这种实体的原因。诊断基于CT或MRI成像,通常由手术活检证实。治疗是个体化和经验性的,取决于疾病的阶段和症状。我们报告一例35岁男性,因腹痛、便秘和左下腹可触及肿块而入院。腹部CT扫描显示下行结肠和直肠乙状结肠弥漫性增厚,并伴有肠系膜脂肪密度增高。在最初的糖皮质激素治疗失败后,他接受了腹腔镜乙状结肠切除术。组织病理学分析显示结肠周围脂肪和脂质泡沫细胞广泛的蒸汽-张力坏死,与肠系膜脂肪营养不良的诊断一致。临床表现和治疗以及简要回顾文献进行了讨论。
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引用次数: 0
[Inflammatory fibroid polyp as the cause of upper gastrointestinal bleeding.] 【炎性肌瘤息肉为上消化道出血的原因】
Q4 Medicine Pub Date : 2016-03-01
Anibal D Genna

The inflammatory fibroid polyp or Vanek's tumor is a benign polypoid lesion that can be found in any section of the digestive tract. It is most frequently located in the stomach and when found in this organ, the symptoms include upper gastrointestinal bleeding (often silent), anemia and melena. The case described below, on the contrary, presents a gastric inflammatory fibroid polyp which developed acute upper gastrointestinal bleeding and required surgical treatment.

炎性肌瘤息肉或Vanek肿瘤是一种良性息肉样病变,可在消化道的任何部位发现。它最常见于胃,当在胃中发现时,症状包括上消化道出血(通常无症状)、贫血和黑黑症。下面的病例,相反,呈现胃炎性肌瘤息肉,并发急性上消化道出血,需要手术治疗。
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引用次数: 0
[Pediatric acute liver failure. Working group of the Latinamerican Society of Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN).] 小儿急性肝衰竭。拉丁美洲儿科胃肠病学、肝病学和营养学学会(LASPGHAN)工作组。
Q4 Medicine Pub Date : 2016-03-01
Mirta Ciocca, Alejandro Costagdta, Miriam Cuarterolo, Laura Delgado, Lidia Garcete, Marcela Godoy, Carmen Esther López, Carola López, Margarita Ramonet

Pediatric acute liver failure is a syndrome ofsevere and sudden dysfunction of the hepatocytes which produces a failure in synthetic and detoxifyingfunction. It is an infrequent and severe disease butpotentiallyfatal, occurring in children with no prior history of liver disease. Etiology is related to the age and geographic region of the patient, recognizing the origin: metabolic, infectious, drug exposure, autoinmune, vascular and oncologic. Indeterminate cause where all the etiological search is negative, can range between 18 and 47%, depending on the center and access to the realization of etiological studies. The process which determines the liver injury is still not well known and is considered multifactorial. Essentially, it depends on host susceptibility, the cause and severity of the damage and the ability of liver regeneration. The clinical presentation depends on the etiology, which usually begins with an episode ofacute hepatitis, that in the following days or weeks presents unfavorable outcome, deepening jaundice, affecting the general state and presenting severe coagulopathy that characterizes the syndrome. The treatment consists of general measures which take into account the metabolic disorders, nutritional aspect, and the prevention and treatment of all complications that occur in the evolutionary course (infectious, neurological, etc). Besides it is also vital to implement the specific treatment of those diseases which can benefit from it (alloimmune hepatitis, galactosemia, tyrosinemia, herpes simplex infection, Wilson's disease, etc.). However, despite therapeutic advances, acute liver failure results in death or liver transplantation in over 45% ofcases.

小儿急性肝衰竭是一种肝细胞严重、突发性功能障碍导致合成和解毒功能衰竭的综合征。这是一种罕见和严重的疾病,但可能致命,发生在没有肝脏疾病史的儿童中。病因学与患者的年龄和地理区域有关,认识到病因:代谢、感染、药物暴露、自身免疫、血管和肿瘤。所有病原学研究结果均为阴性的不确定原因,其范围可在18%至47%之间,这取决于中心和实现病原学研究的途径。决定肝损伤的过程尚不清楚,被认为是多因素的。从本质上讲,它取决于宿主的易感性、损伤的原因和严重程度以及肝脏再生的能力。临床表现取决于病因,通常从急性肝炎发作开始,在接下来的几天或几周内出现不良结果,加重黄疸,影响一般状态,并表现出严重的凝血功能障碍,这是该综合征的特征。治疗包括考虑到代谢紊乱、营养方面以及预防和治疗进化过程中发生的所有并发症(传染病、神经系统等)的一般措施。此外,还必须对那些可以从中受益的疾病(同种免疫肝炎、半乳糖血症、酪氨酸血症、单纯疱疹感染、威尔逊病等)实施具体治疗。然而,尽管治疗进步,急性肝功能衰竭导致死亡或肝移植的病例超过45%。
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引用次数: 0
[Pediatric gastrointestinal disorders at hight altitude. Report of two cases and review of literature.] [高空儿童胃肠道疾病。]两例报告及文献复习。
Q4 Medicine Pub Date : 2016-03-01
Wilson Daza Carreño, Clara Plata García, Ana María Rojas Velásquez, Silvana Dadán

Upon ascending above 2500 meters sea level, the human body undergoes a series of physiological changes that have been studied during years. These changes undertake various systems including gastrointestinal tract, with diverse clinical manifestations, most mild and therefore little reported and are underdiagnosed. Two pediatric patients who atended to the Pediatric Unit of Gastroenterolog, Hepatolog and Nutrition (Gastronutriped) in Bogota, in whose we documented symptoms affecting gastrointestinal tract associated with high altitude.Regarding to these cases, a review of the available literature focusing on physiolog, clinical manifestations and feasible treatment was made. The final aim of this article is to sensitize to health care professionals working in cities located at high altitudes, to consider this entity as a differential diagnosis in children from places with lower altitude.

在海拔2500米以上的地方,人体会经历一系列生理变化,这是多年来研究的结果。这些变化发生在包括胃肠道在内的各个系统,具有不同的临床表现,大多数轻微,因此很少报告和诊断不足。在波哥大胃肠病学、肝病学和营养儿科(gastronnutriped)就诊的两名儿科患者,我们记录了与高海拔相关的胃肠道症状。针对这些病例,我们从生理学、临床表现和可行的治疗方法等方面回顾了现有的文献。本文的最终目的是提高在高海拔城市工作的卫生保健专业人员的敏感性,将这种实体视为来自低海拔地区的儿童的鉴别诊断。
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引用次数: 0
[Patient-Related Factors Affecting Bowel Preparation Prior to Colonoscopy.] [影响结肠镜检查前肠道准备的患者相关因素]
Q4 Medicine Pub Date : 2016-03-01
Ignacio Fanjul, Juan Lasa, Rafael Moore, Melisa Senderovsky, Daniel Peralta, Guillermo Dima, Inacio Zubiaurre, Abel Novillo, Luis Soifer

Introduction: Colorectal cancer is a major health problem worldwide because it is the third most common cancer and the third leading cause of cancer mortality in western countries. Screening for colorectal cancer in asymptomatic patients is crucialfor reducing the incidence and colonoscopy is one of the methods of choice. The ability of colonoscopy in detecting small lesions is clearly influenced by the quality of the colonic preparation.

Objectives: To know which are the variablesrelating to the patient and the type ofpreparation that affect the quality of colonic cleansing.

Materials and methods: It was designed a cross-sectional study. It was administered a questionnaire for the enrolled subjects to assess the presence offactors that could affect the quality of colonic cleansing. Then they underwent a colonoscopy. The different variables between subjects with adequate or inadequate colonic cleansing were compared.

Results: We evaluated 277 subjects. In multivariate analysis the only variables that showed significant differences are split dose [OR 0.45 (0.21 to 0.99)] and age [OR 1.02 (1-1.05)]. Obesity showed no significant differences in multivariate analysis [OR 1.84 (0.9-3.78)].

Conclusions: Age and split-dose were the only variables significantly associated with the quality of bowel preparation prior to colonoscopy. Not so constipation or the presence ofdiverticula, so these patients do not require special preparation regimes.

导读:结直肠癌是世界范围内的一个主要健康问题,因为它是西方国家第三大常见癌症和第三大癌症死亡原因。对无症状患者进行结直肠癌筛查是降低发病率的关键,结肠镜检查是首选方法之一。结肠镜检查小病变的能力明显受到结肠准备质量的影响。目的:了解哪些与患者和制剂类型相关的变量会影响结肠清洁的质量。材料与方法:采用横断面研究设计。对入组受试者进行问卷调查,以评估可能影响结肠清洁质量的存在因素。然后他们接受了结肠镜检查。比较结肠清洁充分或不充分受试者之间的不同变量。结果:我们评估了277名受试者。在多变量分析中,显示有显著差异的变量只有分离剂量[OR 0.45(0.21 ~ 0.99)]和年龄[OR 1.02(1 ~ 1.05)]。肥胖在多因素分析中无显著差异[OR 1.84(0.9-3.78)]。结论:年龄和分离剂量是唯一与结肠镜检查前肠道准备质量显著相关的变量。不存在便秘或憩室,所以这些病人不需要特殊的准备方案。
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引用次数: 0
Esophageal metalic stent migration. Case report of adislodged stent retrieval. 食管金属支架移位。脱位支架置入术1例报告。
Q4 Medicine Pub Date : 2015-12-01
María Soledad Rubio Mainardi, Álvaro Alcaraz, Saleg Patricia, María Eugenia Romero, Federico Moser, Lucio Ricardo Obeide

Background: Metallic stent placing is the first choice in thetreatment of malign or benign strictures of the esophagus. Stentmigration is a well-known complication of this procedure. Wereport a case of stent migration in which surgical laparoscopicintervention was used to retrieve it.

Methods: An 85 yearsold man with unsuccessfully endoscopic retrieval of a migratedstent underwent laparoscopic gastrotomy for solution. The patientrecovered without incident.

Conclusion: This case illustratesthat laparoscopic technique can be an optional way toretrieve migrated stents in selected patients.

背景:金属支架是治疗食管恶性或良性狭窄的首选方法。支架移位是该手术的一个众所周知的并发症。我们报告了一例支架移位,其中腹腔镜手术干预用于取出支架。方法:一名85岁男性,内镜下取出移位支架失败,行腹腔镜胃切开术。病人安然康复。结论:本病例说明腹腔镜技术可以作为一种可选的方法,在选定的患者中取出移位的支架。
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引用次数: 0
期刊
Acta Gastroenterologica Latinoamericana
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