首页 > 最新文献

Journal of Equine Science最新文献

英文 中文
ADAMTS Proteases: Potential Biomarkers and Novel Therapeutic Targets for Cartilage Health ADAMTS蛋白酶:软骨健康的潜在生物标志物和新的治疗靶点
Q3 Veterinary Pub Date : 2020-06-30 DOI: 10.5772/intechopen.93046
S. Kandir
The equine locomotor system’s health plays a key role on athletic performance. Bone and joint diseases are the major causes of lameness. Poor performance and diseases lead to great economic loss to equestrian sports and horse breeders. Therefore, prevention, early diagnosis, and therapy of joint diseases are important. A disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) proteinase family plays an important role in many physiological processes such as tissue reorganization, coagulation, and angiogenesis. Aggrecan proteinases ADAMTS-4 and ADAMTS-5 are physiologically responsible for the restructuring with enzymatic cleavage of the cartilage, specific biomarkers in the synovium or body fluids for early diagnosis, and potential specific therapeutic targets in order to their role on degenerative joint diseases physiopathology in humans and various animals.
马运动系统的健康对运动表现起着关键作用。骨骼和关节疾病是跛行的主要原因。表现不佳和疾病给马术运动和马匹饲养者带来了巨大的经济损失。因此,预防、早期诊断和治疗关节疾病是非常重要的。具有凝血反应蛋白基序的崩解素样和金属蛋白酶(ADAMTS)蛋白酶家族在许多生理过程中发挥重要作用,如组织重组、凝血和血管生成。聚集蛋白蛋白酶ADAMTS-4和ADAMTS-5在生理上负责软骨的酶促裂解重组,是滑膜或体液中的特异性生物标志物,用于早期诊断,以及潜在的特异性治疗靶点,以便它们在人类和各种动物的退行性关节疾病的生理病理中发挥作用。
{"title":"ADAMTS Proteases: Potential Biomarkers and Novel Therapeutic Targets for Cartilage Health","authors":"S. Kandir","doi":"10.5772/intechopen.93046","DOIUrl":"https://doi.org/10.5772/intechopen.93046","url":null,"abstract":"The equine locomotor system’s health plays a key role on athletic performance. Bone and joint diseases are the major causes of lameness. Poor performance and diseases lead to great economic loss to equestrian sports and horse breeders. Therefore, prevention, early diagnosis, and therapy of joint diseases are important. A disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) proteinase family plays an important role in many physiological processes such as tissue reorganization, coagulation, and angiogenesis. Aggrecan proteinases ADAMTS-4 and ADAMTS-5 are physiologically responsible for the restructuring with enzymatic cleavage of the cartilage, specific biomarkers in the synovium or body fluids for early diagnosis, and potential specific therapeutic targets in order to their role on degenerative joint diseases physiopathology in humans and various animals.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"185 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74080195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses 基因疗法作为治疗马自然发生的腱鞘炎和腱鞘炎的现代方法
Q3 Veterinary Pub Date : 2020-06-19 DOI: 10.5772/intechopen.92352
E. Zakirova, Kovac Milomir, M. Zhuravleva, Catrin Rutland, A. Rizvanov
Tendon and ligament injuries have always been complex to treat, with recovery often taking many months, if successful at all. This chapter looks at recent work undertaken using regenerative medicine, specifically gene therapy and the advances that have been made in equine therapy. It looks at the process from plasmid construction, in vitro testing through to trialing the equine-specific plasmid construct in horses with superficial digital flexor tendon (tendinitis) and suspensory ligament branch injuries. It also looks at the rationale for utilizing vascular endothelial growth factor (VEGF164) and a basic fibroblast growth factor (FGF2) for these trials and the cellular effects and potential mechanisms of actions.
肌腱和韧带损伤的治疗一直很复杂,即使治愈,也需要数月才能恢复。本章着眼于最近使用再生医学进行的工作,特别是基因治疗和在马治疗中取得的进展。它观察了从质粒构建、体外测试到在患有浅指屈肌腱(肌腱炎)和悬韧带分支损伤的马身上试验马特异性质粒构建的过程。它还着眼于在这些试验中使用血管内皮生长因子(VEGF164)和基本成纤维细胞生长因子(FGF2)的基本原理以及细胞效应和潜在的作用机制。
{"title":"Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses","authors":"E. Zakirova, Kovac Milomir, M. Zhuravleva, Catrin Rutland, A. Rizvanov","doi":"10.5772/intechopen.92352","DOIUrl":"https://doi.org/10.5772/intechopen.92352","url":null,"abstract":"Tendon and ligament injuries have always been complex to treat, with recovery often taking many months, if successful at all. This chapter looks at recent work undertaken using regenerative medicine, specifically gene therapy and the advances that have been made in equine therapy. It looks at the process from plasmid construction, in vitro testing through to trialing the equine-specific plasmid construct in horses with superficial digital flexor tendon (tendinitis) and suspensory ligament branch injuries. It also looks at the rationale for utilizing vascular endothelial growth factor (VEGF164) and a basic fibroblast growth factor (FGF2) for these trials and the cellular effects and potential mechanisms of actions.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77103271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene Therapy for the Treatment of Equine Osteoarthritis 马骨关节炎的基因治疗
Q3 Veterinary Pub Date : 2020-06-19 DOI: 10.5772/intechopen.93000
R. W. Levings, Andrew D. Smith, P. Levings, G. Palmer, Anthony Dacanay, P. Colahan, S. Ghivizzani
Osteoarthritis (OA) is the predominant cause of lameness in horses. As in humans, the clinical symptoms of equine OA are persistent pain and dysfunction of the affected joint. Its pathology is similarly marked by progressive deterioration of the articular cartilage, subchondral bone sclerosis, marginal osteophytes, soft tissue inflammation and joint effusion. Disease pathogenesis is mediated by elevated levels of inflammatory cytokines and proteolytic enzymes in the articular tissues and synovial fluid. Existing pharmacologic agents can alleviate OA joint pain; none are able to inhibit erosive disease progression. As several gene-based treatments for human disease have received approval by the Food and Drug Administration (FDA), the transition to veterinary medicine will almost certainly follow. Several viral vector systems have demonstrated highly efficient gene transfer to the equine joint, enabling expression of therapeutic transgenes at efficacious levels for well over a year. Because of its large size, the equine joint is well suited to studies of gene-based therapies for arthritic disease. The forelimb joints are vulnerable to OA onset, and treatment and diagnostic modalities are the same in humans and horses. Here, we discuss the various gene-transfer approaches under investigation and the current progress toward the development an effective gene therapy for equine OA.
骨关节炎(OA)是马跛行的主要原因。与人类一样,马关节炎的临床症状是受影响关节的持续疼痛和功能障碍。其病理特征同样为关节软骨进行性恶化、软骨下骨硬化、边缘骨赘、软组织炎症和关节积液。疾病的发病机制是由关节组织和滑液中炎症细胞因子和蛋白水解酶水平升高介导的。现有药物可减轻OA关节疼痛;没有一种药物能够抑制糜烂性疾病的进展。由于几种基于基因的人类疾病治疗方法已经获得了美国食品和药物管理局(FDA)的批准,向兽药的过渡几乎肯定会随之而来。一些病毒载体系统已经证明了高效的基因转移到马关节,使治疗性转基因在一年多的时间内有效表达。因为它的大尺寸,马的关节非常适合研究基于基因的治疗关节炎疾病。前肢关节易患OA,人和马的治疗和诊断方式相同。在这里,我们讨论了各种正在研究的基因转移方法以及目前开发有效的马OA基因治疗的进展。
{"title":"Gene Therapy for the Treatment of Equine Osteoarthritis","authors":"R. W. Levings, Andrew D. Smith, P. Levings, G. Palmer, Anthony Dacanay, P. Colahan, S. Ghivizzani","doi":"10.5772/intechopen.93000","DOIUrl":"https://doi.org/10.5772/intechopen.93000","url":null,"abstract":"Osteoarthritis (OA) is the predominant cause of lameness in horses. As in humans, the clinical symptoms of equine OA are persistent pain and dysfunction of the affected joint. Its pathology is similarly marked by progressive deterioration of the articular cartilage, subchondral bone sclerosis, marginal osteophytes, soft tissue inflammation and joint effusion. Disease pathogenesis is mediated by elevated levels of inflammatory cytokines and proteolytic enzymes in the articular tissues and synovial fluid. Existing pharmacologic agents can alleviate OA joint pain; none are able to inhibit erosive disease progression. As several gene-based treatments for human disease have received approval by the Food and Drug Administration (FDA), the transition to veterinary medicine will almost certainly follow. Several viral vector systems have demonstrated highly efficient gene transfer to the equine joint, enabling expression of therapeutic transgenes at efficacious levels for well over a year. Because of its large size, the equine joint is well suited to studies of gene-based therapies for arthritic disease. The forelimb joints are vulnerable to OA onset, and treatment and diagnostic modalities are the same in humans and horses. Here, we discuss the various gene-transfer approaches under investigation and the current progress toward the development an effective gene therapy for equine OA.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89820153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Colostral and foal serum immunoglobulin G levels and associations with perinatal abnormalities in heavy draft horses in Japan. 初马和马驹血清免疫球蛋白G水平与日本重牵拉马围产期异常的关系。
Q3 Veterinary Pub Date : 2020-06-01 Epub Date: 2020-06-24 DOI: 10.1294/jes.31.29
Takahiro Aoki, Akiko Chiba, Megumi Itoh, Yasuo Nambo, Norio Yamagishi, Ken-Ichi Shibano, Soon Hon Cheong

The purpose of this study was to elucidate the colostral and foal serum immunoglobulin G (IgG) concentration values in heavy draft horses in Japan and to examine the effects of peripartum mare condition on colostral immunity. Colostrum was obtained 1 hr after foaling (pre-suckling; n=178). Blood was collected from the jugular vein of the foals (n=147) at 24 to 48 hr after birth. The foaling statuses of 73 mares were recorded. The average colostral IgG concentration was 10,540 ± 3,190 mg/dl (median=10,928; range 1,434-17,514 mg/dl). The average serum IgG concentration obtained from neonatal foals 24 to 48 hr after birth was 1,750 ± 919 mg/dl (median=1,890; range 0-3,510 mg/dl). Although colostral IgG did not differ between the normal foaling mare (n=59) and dystocial mare (n=14), foal serum IgG was lower in foals born in dystocia than in foals in normal foaling (P<0.05). This study demonstrates reference values for colostral and foal serum IgG specific to heavy draft horses in Japan and suggests that dystocia may interfere with the acquisition of colostral immunity in neonatal foals.

本研究旨在研究日本重驮马初马和马驹血清免疫球蛋白G (IgG)的浓度,并探讨围产期母马状况对初马免疫的影响。初乳在产驹1小时后获得(预哺乳;n = 178)。马驹(n=147)在出生后24至48小时从颈静脉采血。记录了73匹母马的产驹情况。初乳IgG平均浓度为10,540±3,190 mg/dl(中位数=10,928;范围1434 - 17514毫克/分升)。新生儿马驹出生后24 ~ 48小时血清IgG平均浓度为1750±919 mg/dl(中位数= 1890;范围0- 3510 mg/dl)。虽然初乳IgG在正常产驹(n=59)和难产驹(n=14)之间没有差异,但难产驹的血清IgG低于正常产驹(P
{"title":"Colostral and foal serum immunoglobulin G levels and associations with perinatal abnormalities in heavy draft horses in Japan.","authors":"Takahiro Aoki,&nbsp;Akiko Chiba,&nbsp;Megumi Itoh,&nbsp;Yasuo Nambo,&nbsp;Norio Yamagishi,&nbsp;Ken-Ichi Shibano,&nbsp;Soon Hon Cheong","doi":"10.1294/jes.31.29","DOIUrl":"https://doi.org/10.1294/jes.31.29","url":null,"abstract":"<p><p>The purpose of this study was to elucidate the colostral and foal serum immunoglobulin G (IgG) concentration values in heavy draft horses in Japan and to examine the effects of peripartum mare condition on colostral immunity. Colostrum was obtained 1 hr after foaling (pre-suckling; n=178). Blood was collected from the jugular vein of the foals (n=147) at 24 to 48 hr after birth. The foaling statuses of 73 mares were recorded. The average colostral IgG concentration was 10,540 ± 3,190 mg/dl (median=10,928; range 1,434-17,514 mg/dl). The average serum IgG concentration obtained from neonatal foals 24 to 48 hr after birth was 1,750 ± 919 mg/dl (median=1,890; range 0-3,510 mg/dl). Although colostral IgG did not differ between the normal foaling mare (n=59) and dystocial mare (n=14), foal serum IgG was lower in foals born in dystocia than in foals in normal foaling (P<0.05). This study demonstrates reference values for colostral and foal serum IgG specific to heavy draft horses in Japan and suggests that dystocia may interfere with the acquisition of colostral immunity in neonatal foals.</p>","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"31 2","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/e4/jes-31-029.PMC7316699.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38118159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Relationships between morphometric measurements and musculoskeletal disorders in jumping Thoroughbred horses. 形态测量与跳跃纯种马肌肉骨骼疾病的关系。
Q3 Veterinary Pub Date : 2020-06-01 Epub Date: 2020-06-24 DOI: 10.1294/jes.31.23
Mohamed B Mostafa, Yahya M Elemmawy

There is limited knowledge about causes of musculoskeletal injury in jumping Thoroughbred horses. The objective of this study was to describe the relationships between musculoskeletal disorders and linear and angular limb measurements acquired from photographs of horses with markers at specific reference points. The diagnosed musculoskeletal disorders in either fore or hind limbs were flexor tendonitis, suspensory ligaments desmitis, and osteoarthritis of the distal intertarsal and tarso-metatarsal and carpometacarpal joints. Lengths and angles in 17 clinically normal jumping Thoroughbred horses and 34 horses with musculoskeletal problems were measured. Horses with musculoskeletal disorders had significantly shorter neck, shoulder, and pelvis lengths (P<0.05), significantly longer arm and forearm front lengths (P<0.05), and significantly lower front shoulder, elbow, and hind fetlock joint angles (P<0.05). In conclusion, this study describes significant relationships between linear and angular morphometric measurements and musculoskeletal disorders in jumping Thoroughbred horses. These data could possibly provide indicators for better selection of jumpers with less risk of developing orthopedic disorders.

关于跳跃纯种马肌肉骨骼损伤的原因的知识有限。本研究的目的是描述肌肉骨骼疾病与从特定参考点标记的马照片中获得的线性和角状肢体测量之间的关系。前肢或后肢诊断出的肌肉骨骼疾病为屈肌腱炎、悬吊韧带炎、远端跗骨间关节、跗跖关节和腕掌关节骨关节炎。对17匹临床正常跳跃的纯种马和34匹有肌肉骨骼问题的马进行了长度和角度的测量。患有肌肉骨骼疾病的马的颈部、肩部和骨盆长度明显较短
{"title":"Relationships between morphometric measurements and musculoskeletal disorders in jumping Thoroughbred horses.","authors":"Mohamed B Mostafa,&nbsp;Yahya M Elemmawy","doi":"10.1294/jes.31.23","DOIUrl":"https://doi.org/10.1294/jes.31.23","url":null,"abstract":"<p><p>There is limited knowledge about causes of musculoskeletal injury in jumping Thoroughbred horses. The objective of this study was to describe the relationships between musculoskeletal disorders and linear and angular limb measurements acquired from photographs of horses with markers at specific reference points. The diagnosed musculoskeletal disorders in either fore or hind limbs were flexor tendonitis, suspensory ligaments desmitis, and osteoarthritis of the distal intertarsal and tarso-metatarsal and carpometacarpal joints. Lengths and angles in 17 clinically normal jumping Thoroughbred horses and 34 horses with musculoskeletal problems were measured. Horses with musculoskeletal disorders had significantly shorter neck, shoulder, and pelvis lengths (P<0.05), significantly longer arm and forearm front lengths (P<0.05), and significantly lower front shoulder, elbow, and hind fetlock joint angles (P<0.05). In conclusion, this study describes significant relationships between linear and angular morphometric measurements and musculoskeletal disorders in jumping Thoroughbred horses. These data could possibly provide indicators for better selection of jumpers with less risk of developing orthopedic disorders.</p>","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"31 2","pages":"23-27"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/b4/jes-31-023.PMC7316700.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38118158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Morphometric measurements of the feet of working donkeys Equus asinus in Egypt. 埃及驴脚的形态计量学测量。
Q3 Veterinary Pub Date : 2020-06-01 Epub Date: 2020-06-24 DOI: 10.1294/jes.31.17
Mohamed B Mostafa, Ahmed I Abdelgalil, Shaaban F Farhat, Zoe Raw, Laura M Kubasiewicz

Working equids rely on sound, balanced hooves, but data describing the typical morphology of the legs and feet of working donkeys are currently lacking. To address this gap in knowledge, the front and hind feet of twenty healthy working donkeys were measured and compared. Hoof width, weight-bearing lengths, heel width, dorsal hoof wall length and lateral and medial heel length of the hoof wall were determined, as well as toe angle, heel angle, hoof pastern axis, coronary band angle and a measure of 'ground surface size'. Viewed from the ground surface of the foot, front feet were more rounded and significantly larger than hind feet. Measures of medial-lateral balance and toe-heel angle ratio were within the recommended healthy guidelines for horses. Hoof pastern axis was broken forward for the studied animals, which supports previous research suggesting that a broken forward hoof pastern axis is normal for donkeys, although further study would be required to confirm whether this conformation is natural. Significant correlations were found between estimated body mass and hoof width in both the front and hind feet. These measurements provide valuable insight into the relationship between hoof and body characteristics, which may aid the development of guidelines for the trimming and management of working donkey hooves. Further study is, however, advised to confirm natural hoof conformation.

工作的马依靠健全、平衡的蹄子,但描述工作驴腿和脚的典型形态的数据目前缺乏。为了解决这一知识差距,测量和比较了20头健康工作驴的前脚和后脚。测定了蹄宽、负重长度、足跟宽度、蹄背壁长度、蹄壁外侧和内侧的足跟长度,以及趾角、足跟角、蹄粘轴、冠状带角和“地面尺寸”。从脚的地面表面看,前脚比后脚更圆,明显更大。测量内侧-外侧平衡和脚趾-脚跟角比在推荐的马健康指南范围内。被研究动物的蹄骨轴向前断裂,这支持了之前的研究,即驴的蹄骨轴向前断裂是正常的,尽管需要进一步的研究来证实这种构象是否是自然的。在前脚和后脚的估计体重和蹄宽之间发现了显著的相关性。这些测量结果对蹄和身体特征之间的关系提供了有价值的见解,这可能有助于制定修剪和管理工作驴蹄的指导方针。然而,建议进一步研究以确认天然的蹄形。
{"title":"Morphometric measurements of the feet of working donkeys <i>Equus asinus</i> in Egypt.","authors":"Mohamed B Mostafa,&nbsp;Ahmed I Abdelgalil,&nbsp;Shaaban F Farhat,&nbsp;Zoe Raw,&nbsp;Laura M Kubasiewicz","doi":"10.1294/jes.31.17","DOIUrl":"https://doi.org/10.1294/jes.31.17","url":null,"abstract":"<p><p>Working equids rely on sound, balanced hooves, but data describing the typical morphology of the legs and feet of working donkeys are currently lacking. To address this gap in knowledge, the front and hind feet of twenty healthy working donkeys were measured and compared. Hoof width, weight-bearing lengths, heel width, dorsal hoof wall length and lateral and medial heel length of the hoof wall were determined, as well as toe angle, heel angle, hoof pastern axis, coronary band angle and a measure of 'ground surface size'. Viewed from the ground surface of the foot, front feet were more rounded and significantly larger than hind feet. Measures of medial-lateral balance and toe-heel angle ratio were within the recommended healthy guidelines for horses. Hoof pastern axis was broken forward for the studied animals, which supports previous research suggesting that a broken forward hoof pastern axis is normal for donkeys, although further study would be required to confirm whether this conformation is natural. Significant correlations were found between estimated body mass and hoof width in both the front and hind feet. These measurements provide valuable insight into the relationship between hoof and body characteristics, which may aid the development of guidelines for the trimming and management of working donkey hooves. Further study is, however, advised to confirm natural hoof conformation.</p>","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"31 2","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/43/jes-31-017.PMC7316701.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38118157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Investigation into Whether Proximal Suspensory Desmitis of the Hindlimb Could Predispose Horses to Sacroiliac Disease 马后肢近端悬吊炎是否易患骶髂疾病的研究
Q3 Veterinary Pub Date : 2020-05-07 DOI: 10.5772/intechopen.92353
Anne Skivington, M. Kovač, E. Zakirova, A. Rizvanov, Catrin Rutland
Proximal suspensory desmopathy/desmitis (PSD) of the hindlimb is a well understood condition with widely accepted treatment protocols; however, there is little research demonstrating understanding or potential correlation between hindlimb PSD and sacroiliac disease (SID). Several studies have examined the co-existence of hindlimb PSD and SID each investigating unique predisposing factors. This has led to little direct correlation of cause and effect with no definitive conclusions drawn. The need to be objective is highlighted by the limited number of studies and that two studies used anecdotal evidence to support their hypothesis and thus creating the question does hindlimb proximal suspensory desmopathy predispose horses to sacroiliac disease? This review looks at the two conditions and compares the literature for each, including the incidence, biomechanics, anatomy, and treatment. The review further discusses whether one disorder predisposes horses/equids to the other.
后肢近端悬吊韧带病/韧带炎(PSD)是一种被广泛接受的治疗方案;然而,很少有研究表明后肢PSD与骶髂疾病(SID)之间的理解或潜在的相关性。一些研究已经检查了后肢PSD和SID的共存,每个研究都研究了独特的易感因素。这导致因果关系几乎没有直接联系,也没有得出明确的结论。数量有限的研究强调了客观的必要性,其中两项研究使用了轶事证据来支持他们的假设,从而产生了后肢近端悬吊韧带病是否使马易患骶髂疾病的问题?这篇综述着眼于这两种情况,并比较了每一种情况的文献,包括发病率、生物力学、解剖学和治疗。这篇综述进一步讨论了一种疾病是否使马/马易患另一种疾病。
{"title":"Investigation into Whether Proximal Suspensory Desmitis of the Hindlimb Could Predispose Horses to Sacroiliac Disease","authors":"Anne Skivington, M. Kovač, E. Zakirova, A. Rizvanov, Catrin Rutland","doi":"10.5772/intechopen.92353","DOIUrl":"https://doi.org/10.5772/intechopen.92353","url":null,"abstract":"Proximal suspensory desmopathy/desmitis (PSD) of the hindlimb is a well understood condition with widely accepted treatment protocols; however, there is little research demonstrating understanding or potential correlation between hindlimb PSD and sacroiliac disease (SID). Several studies have examined the co-existence of hindlimb PSD and SID each investigating unique predisposing factors. This has led to little direct correlation of cause and effect with no definitive conclusions drawn. The need to be objective is highlighted by the limited number of studies and that two studies used anecdotal evidence to support their hypothesis and thus creating the question does hindlimb proximal suspensory desmopathy predispose horses to sacroiliac disease? This review looks at the two conditions and compares the literature for each, including the incidence, biomechanics, anatomy, and treatment. The review further discusses whether one disorder predisposes horses/equids to the other.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73682431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medieval Equine Medicine from Armenia 来自亚美尼亚的中世纪马医学
Q3 Veterinary Pub Date : 2020-03-12 DOI: 10.5772/INTECHOPEN.91379
Jasmine Dum-Tragut
The Armenian medieval and early modern equine medicine has rarely been noticed or researched by veterinarians, historians of science, philologists, or medieval researchers. As Armenia represents both a geographical border and cultural corridor between Muslim East and Christian West, a consideration of its hippiatric texts and their integration into the general history of veterinary medicine can only lead to a deeper understanding of equine medicine from the medieval to the early modern period. They could also contribute toward tracing the paths of knowledge diffusion and transmission across political, linguistic, and religious-cultural boundaries in the time of the Crusades. The role of Armenian manuscripts bridging the traditions of equine medicine from the Muslim East and the Christian West is examined by revealing the complicated history of Armenian horse treatises that traveled the long way from Baghdad via Sis to Tbilisi.
亚美尼亚中世纪和近代早期的马药很少被兽医、科学历史学家、语言学家或中世纪研究人员注意到或研究。由于亚美尼亚代表了东方穆斯林和西方基督教之间的地理边界和文化走廊,考虑到它的嬉皮士文本和它们融入兽医学的一般历史,只能导致从中世纪到近代早期对马医学的更深层次的理解。它们也有助于追踪十字军东征时期跨越政治、语言和宗教文化界限的知识扩散和传播的路径。通过揭示从巴格达经Sis到第比利斯的漫长旅程的亚美尼亚马论文的复杂历史,亚美尼亚手稿的作用是连接东方穆斯林和西方基督教的马医学传统。
{"title":"Medieval Equine Medicine from Armenia","authors":"Jasmine Dum-Tragut","doi":"10.5772/INTECHOPEN.91379","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.91379","url":null,"abstract":"The Armenian medieval and early modern equine medicine has rarely been noticed or researched by veterinarians, historians of science, philologists, or medieval researchers. As Armenia represents both a geographical border and cultural corridor between Muslim East and Christian West, a consideration of its hippiatric texts and their integration into the general history of veterinary medicine can only lead to a deeper understanding of equine medicine from the medieval to the early modern period. They could also contribute toward tracing the paths of knowledge diffusion and transmission across political, linguistic, and religious-cultural boundaries in the time of the Crusades. The role of Armenian manuscripts bridging the traditions of equine medicine from the Muslim East and the Christian West is examined by revealing the complicated history of Armenian horse treatises that traveled the long way from Baghdad via Sis to Tbilisi.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78373710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Strategies for Prevention and Treatment of Equine Postoperative Ileus: A Multimodal Approach 目前预防和治疗马术后肠梗阻的策略:一种多模式的方法
Q3 Veterinary Pub Date : 2020-03-02 DOI: 10.5772/intechopen.91290
M. Kovač, R. Aliev, S. Pozyabin, Nevena Drakuĺ, A. Rizvanov
Equine paralytic (postoperative) ileus generally refers to an acute condition of impaired gastrointestinal motility. Paralytic ileus is most frequently seen following abdominal surgery on the small intestine in horses. Three main mechanisms are involved separately or simultaneously in its causation, namely neurogenicendocrinic, inflammatory-endotoxic and pharmacological mechanisms. Regardless of the cause, equine paralytic ileus can be fatal, if not properly diagnosed and treated. Over the past 22 years (1997–2019), we have diagnosed and treated more than 180 horses with postoperative ileus using differing methods. Based on our results and experience, and that of others, we have developed a multimodal strategy to reduce the incidence of postoperative ileus. This has resulted in effective treatment of ileus-diagnosed patients in 94% of cases, a significant improvement in survival rates over the last 20 years. In this review, we described pre-, intra-, and postoperative multiple supplementary preventative and treatment procedures that cure this condition. These methods are dependent on individual cases but include the control of endotoxemia and inflammation, as well as using the least traumatic surgical techniques, carrying out the pelvic flexure colotomy, improved anesthesia techniques, treating with continuous postoperative peritoneal lavage, the use of fluid, antibiotic and NSAIDs therapy, according to a scheme the use of different prokinetic agents (including metoclopramide, neostigmine methylsulfate and domperidone), nasogastric decompression, management to minimize the surgical and postoperative stress reaction and judicious timing of postoperative feeding of horses.
马麻痹性(术后)肠梗阻通常是指胃肠道运动受损的急性状态。麻痹性肠梗阻是最常见的腹部手术后小肠在马。其发病机制分别或同时涉及三种主要机制,即神经源性内分泌机制、炎症内毒素机制和药理学机制。不管病因如何,马麻痹性肠梗阻如果没有得到正确的诊断和治疗,可能是致命的。在过去的22年里(1997-2019),我们使用不同的方法诊断和治疗了180多匹马的术后肠梗阻。根据我们的结果和经验,以及其他人的经验,我们开发了一种多模式策略来减少术后肠梗阻的发生率。这使得94%的肠梗阻确诊患者得到有效治疗,在过去20年生存率显著提高。在这篇综述中,我们描述了治疗这种疾病的术前、术中和术后多种补充预防和治疗方法。这些方法取决于个别病例,但包括控制内毒素血症和炎症,以及使用创伤最小的手术技术,进行盆腔屈曲结肠切除术,改进麻醉技术,术后持续腹腔灌洗,使用液体,抗生素和非甾体抗炎药治疗,根据方案使用不同的促动力学药物(包括甲氧氯普胺,甲基硫酸新斯的明和多潘立酮),鼻胃减压,尽量减少手术和术后应激反应的处理以及术后喂养马的明智时机。
{"title":"Current Strategies for Prevention and Treatment of Equine Postoperative Ileus: A Multimodal Approach","authors":"M. Kovač, R. Aliev, S. Pozyabin, Nevena Drakuĺ, A. Rizvanov","doi":"10.5772/intechopen.91290","DOIUrl":"https://doi.org/10.5772/intechopen.91290","url":null,"abstract":"Equine paralytic (postoperative) ileus generally refers to an acute condition of impaired gastrointestinal motility. Paralytic ileus is most frequently seen following abdominal surgery on the small intestine in horses. Three main mechanisms are involved separately or simultaneously in its causation, namely neurogenicendocrinic, inflammatory-endotoxic and pharmacological mechanisms. Regardless of the cause, equine paralytic ileus can be fatal, if not properly diagnosed and treated. Over the past 22 years (1997–2019), we have diagnosed and treated more than 180 horses with postoperative ileus using differing methods. Based on our results and experience, and that of others, we have developed a multimodal strategy to reduce the incidence of postoperative ileus. This has resulted in effective treatment of ileus-diagnosed patients in 94% of cases, a significant improvement in survival rates over the last 20 years. In this review, we described pre-, intra-, and postoperative multiple supplementary preventative and treatment procedures that cure this condition. These methods are dependent on individual cases but include the control of endotoxemia and inflammation, as well as using the least traumatic surgical techniques, carrying out the pelvic flexure colotomy, improved anesthesia techniques, treating with continuous postoperative peritoneal lavage, the use of fluid, antibiotic and NSAIDs therapy, according to a scheme the use of different prokinetic agents (including metoclopramide, neostigmine methylsulfate and domperidone), nasogastric decompression, management to minimize the surgical and postoperative stress reaction and judicious timing of postoperative feeding of horses.","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80006584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Seroprevalence of Brucella antibodies in Donkeys (Equus asinus) in Yobe south senatorial zone, Northeastern Nigeria. 尼日利亚东北部约贝南参议院区驴(马)布鲁氏菌抗体的血清阳性率
Q3 Veterinary Pub Date : 2020-03-01 Epub Date: 2020-03-19 DOI: 10.1294/jes.31.5
Shuaibu G Adamu, Musa Hassan, Mohammed B Ardo

A cross-sectional survey was conducted to determine the seroprevalence and risk factors influencing the presence of Brucella spp. antibodies in donkeys in Yobe south senatorial zone, Nigeria. The study was aimed at determining the importance of Brucella spp. infection in donkeys (Equus asinus). A total of 200 sera samples from of 105 males and 95 female donkeys were collected and screened for brucellosis using the rose bengal plate test (RBPT) and the indirect enzyme-linked immunosorbent assay (iELISA). Data obtained were analyzed to determine associations and risk factors. The analysis revealed that 21.5% and 18.5% were seropositive by RBPT and iELISA respectively, with 22.0% and 20.0% of the male and female donkeys being seropositive by RBPT, and 19.0% and 17.9% of the male and female donkeys being seropositive by iELISA, respectively. There was a statistically significant association between donkey age and positive rate of iELISA for detecting Brucella infection. Though the positive rate was higher for males than females, there was no statistically significant association between sex and location of donkeys and the sensitivities of RBPT and iELISA for detecting Brucella infection. In conclusion, this study indicates that brucellosis exists with high seroprevalence particularly among male and adult donkeys and is of public health significance and economic importance because it can lead to infertility and abortion in the stock.

在尼日利亚约贝南参议院区进行了一项横断面调查,以确定驴的血清流行率和影响布鲁氏菌抗体存在的危险因素。本研究旨在确定驴(Equus asinus)布鲁氏菌感染的重要性。收集了105头公驴和95头母驴共200份血清样本,采用玫瑰孟加拉平板试验(RBPT)和间接酶联免疫吸附试验(iELISA)筛查布鲁氏菌病。对获得的数据进行分析,以确定相关性和危险因素。结果表明,RBPT和iELISA血清阳性率分别为21.5%和18.5%,其中RBPT血清阳性率分别为22.0%和20.0%,iELISA血清阳性率分别为19.0%和17.9%。驴龄与布鲁氏菌elisa检测阳性率有统计学意义。虽然公驴的阳性率高于母驴,但驴的性别和位置与RBPT和iELISA检测布鲁氏菌感染的敏感性无统计学意义。总之,本研究表明,布鲁氏菌病存在较高的血清患病率,特别是在公驴和成年驴中,具有重要的公共卫生意义和经济意义,因为它可导致畜群不孕和流产。
{"title":"Seroprevalence of Brucella antibodies in Donkeys (<i>Equus asinus</i>) in Yobe south senatorial zone, Northeastern Nigeria.","authors":"Shuaibu G Adamu,&nbsp;Musa Hassan,&nbsp;Mohammed B Ardo","doi":"10.1294/jes.31.5","DOIUrl":"https://doi.org/10.1294/jes.31.5","url":null,"abstract":"<p><p>A cross-sectional survey was conducted to determine the seroprevalence and risk factors influencing the presence of Brucella spp. antibodies in donkeys in Yobe south senatorial zone, Nigeria. The study was aimed at determining the importance of Brucella spp. infection in donkeys (Equus asinus). A total of 200 sera samples from of 105 males and 95 female donkeys were collected and screened for brucellosis using the rose bengal plate test (RBPT) and the indirect enzyme-linked immunosorbent assay (iELISA). Data obtained were analyzed to determine associations and risk factors. The analysis revealed that 21.5% and 18.5% were seropositive by RBPT and iELISA respectively, with 22.0% and 20.0% of the male and female donkeys being seropositive by RBPT, and 19.0% and 17.9% of the male and female donkeys being seropositive by iELISA, respectively. There was a statistically significant association between donkey age and positive rate of iELISA for detecting Brucella infection. Though the positive rate was higher for males than females, there was no statistically significant association between sex and location of donkeys and the sensitivities of RBPT and iELISA for detecting Brucella infection. In conclusion, this study indicates that brucellosis exists with high seroprevalence particularly among male and adult donkeys and is of public health significance and economic importance because it can lead to infertility and abortion in the stock.</p>","PeriodicalId":35701,"journal":{"name":"Journal of Equine Science","volume":"31 1","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/22/jes-31-005.PMC7078490.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37765629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
期刊
Journal of Equine Science
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1