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Tissue Engineering Using Ceramics and Polymers最新文献

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Interface tissue engineering 界面组织工程
Pub Date : 2012-12-11 DOI: 10.1201/B13978-36
Helen H. Lu, Nora T. Khanarian, K. L. Moffat, S. D. Subramony
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引用次数: 0
Advanced imaging/MRI for tissue engineering 组织工程的高级成像/MRI
Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-820508-2.00016-7
A. Hahn, F. Kurz
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引用次数: 0
Transplantation of engineered cells and tissues 工程细胞和组织的移植
Pub Date : 1900-01-01 DOI: 10.1533/9780857097163.2.252
J. Mansbridge
Publisher Summary Despite experience with organ transplantation, implantation of tissue-engineered products containing live cells has thus far shown no clinical evidence for immune rejection. Limited testing for specific mechanisms of rejection has shown no evidence of humoral or cell-mediated reaction to the implants. The major reason for the lack of immunogenicity lies in the lack of antigen-presenting cells in the implants and inclusion of such cells has been found experimentally to confer reject ability. In a transplanted organ, endothelial cells are a major source of antigen-presenting cells and acute rejection may be seen as an attack on the vascular system that rapidly extends to other cells. It has also been found that fibroblasts in scaffold-based 3D culture show a selective response to γ-interferon, which, although it induces molecules associated with antigen presentation in many cell types under suitable culture conditions, does not do so in this case. The use of allogeneic cells has many advantages for manufacturing, even if it can be applied only to part of the final construct; therefore, it would be valuable to ascertain the scope of cells types immune to rejection. At present, it applies to fibroblasts and smooth muscle cells, but not to endothelial cells or hemopoietic cells, although claims have been made for bone marrow stem cells including their ability to suppress responses to allogeneic cells. In the case of stem cells, it may be true that undifferentiated cells are non-immunogenic but that they may become immunogenic if they differentiate into antigen-presenting cells, such as macrophages, dendritic cells, and endothelial cells. Determination of the range of cells showing minimal immunogenicity would be a valuable contribution to tissue engineering.
尽管有器官移植的经验,但迄今为止,含有活细胞的组织工程产品的植入尚未显示出免疫排斥的临床证据。对特定排斥机制的有限测试表明,没有证据表明对植入物有体液或细胞介导的反应。缺乏免疫原性的主要原因在于植入物中缺乏抗原呈递细胞,实验发现这种细胞的包含赋予了排斥能力。在移植器官中,内皮细胞是抗原呈递细胞的主要来源,急性排斥反应可能被视为对血管系统的攻击,并迅速扩展到其他细胞。研究还发现,基于支架的3D培养中的成纤维细胞对γ-干扰素表现出选择性反应,尽管在合适的培养条件下,γ-干扰素在许多细胞类型中诱导与抗原呈递相关的分子,但在这种情况下却没有这样做。使用同种异体细胞在制造中有很多优势,即使它只能应用于最终结构的一部分;因此,确定对排斥免疫的细胞类型的范围是有价值的。目前,它适用于成纤维细胞和平滑肌细胞,但不适用于内皮细胞或造血细胞,尽管骨髓干细胞有抑制同种异体细胞反应的能力。就干细胞而言,未分化的细胞可能是非免疫原性的,但如果它们分化为抗原呈递细胞,如巨噬细胞、树突状细胞和内皮细胞,它们可能会成为免疫原性的。确定显示最小免疫原性的细胞范围将对组织工程做出有价值的贡献。
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引用次数: 0
Ceramic biomaterials for tissue engineering 组织工程用陶瓷生物材料
Pub Date : 1900-01-01 DOI: 10.1533/9780857097163.1.3
J. Huang, S. Best
Abstract: This chapter reviews the range of ceramics currently used in skeletal repair and tissue regeneration and covers the bioinert, bioactive and resorbable ceramics, glasses and glass ceramics. The scope of the chapter includes the relationships between microstructure (crystalline and non-crystalline) and properties (mechanical properties, surface properties, biocompatibility and bioactivity). The processing (porous tissue engineering scaffolds and surface modification) of bioceramics is also considered. Based on the stringent requirements for clinical application, prospects for the development of advanced ceramic materials for tissue engineering are highlighted for the future.
摘要:本章综述了目前用于骨骼修复和组织再生的陶瓷的范围,包括生物惰性、生物活性和可吸收陶瓷、玻璃和玻璃陶瓷。本章的范围包括微观结构(晶体和非晶体)和性能(机械性能、表面性能、生物相容性和生物活性)之间的关系。生物陶瓷的加工(多孔组织工程支架和表面改性)也被考虑。基于临床应用的严格要求,展望了未来用于组织工程的先进陶瓷材料的发展前景。
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引用次数: 7
Nanofibrous scaffolds for skin tissue engineering and wound healing applications 纳米纤维支架在皮肤组织工程和伤口愈合中的应用
Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-820508-2.00020-9
G. Rivero, M. D. Popov Pereira da Cunha, P. C. Caracciolo, G. Abraham
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引用次数: 2
Index 指数
Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-820508-2.09993-1
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引用次数: 0
Natural hydrogels for bone tissue engineering 骨组织工程用天然水凝胶
Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-820508-2.00009-x
L. Parmentier, S. van Vlierberghe
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引用次数: 2
Overview of scaffolds processing technologies 支架加工技术综述
Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-820508-2.00002-7
U. D'Amora, A. Ronca, M. Raucci, L. Ambrosio
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引用次数: 0
Bioceramic nanoparticles in tissue engineering and drug delivery 生物陶瓷纳米颗粒在组织工程和药物输送中的应用
Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-820508-2.00022-2
V. Sokolova, M. Epple
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引用次数: 0
Dense collagen-based scaffolds for soft tissue engineering applications 致密胶原基支架在软组织工程中的应用
Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-820508-2.00010-6
Hyeree Park, D. Rosenzweig, S. Nazhat
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引用次数: 5
期刊
Tissue Engineering Using Ceramics and Polymers
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