European Journal of Hybrid Imaging最新文献_第2页

Association between PET–CT accumulation in the hypothalamic/pituitary regions and neuron-specific enolase/primary tumor in limited-stage small cell lung cancer: a case-controlled retrospective study PET-CT 在下丘脑/垂体区域的积累与局限期小细胞肺癌的神经元特异性绒毛膜/原发肿瘤之间的关联：一项病例对照回顾性研究

IF 1.7 Q2 Computer Science

European Journal of Hybrid Imaging

Pub Date : 2024-02-05 DOI: 10.1186/s41824-024-00190-z

Yukinori Okada, Tatsuhiko Zama, Tomohiro Itonaga, Ryuji Mikami, Mitsuru Okubo, Shinji Sugahara, Motoki Nakai, Koichiro Abe, Mana Yoshimura, Kazuhiro Saito

Research on the relationship between neuron-specific enolase (NSE) levels and normal organs, particularly the central nervous system, in small cell lung cancer is limited. Therefore, this study aimed to investigate the relationship between positron emission tomography–computed tomography (PET–CT) accumulation at hypothalamic/pituitary regions, tumor activity, and NSE level in limited-stage small cell lung cancer. We retrospectively analyzed patients who were diagnosed with limited-stage small cell lung cancer at Tokyo Medical University Hospital between July 1, 2019, and May 31, 2023, and were treated with chemoradiotherapy or radiotherapy. Leukocytes, erythrocytes, hemoglobin, platelets, total protein, albumin, NSE, and carcinoembryonic antigen were measured in blood samples obtained before treatment initiation. The maximum standardized uptake value (SUVmax), volume, and total lesion glycolysis (TLG) of each hypothalamic /pituitary region, primary tumor, and lymph node metastases were extracted from PET–CT images. The total tumor volume (primary tumor volume plus lymph node metastases volume) and total TLG (primary tumor TLG plus lymph node metastases TLG) were calculated. This study included 19 patients (mean age, 70.1 ± 8.8 years; 13 men and 6 women); the pathology in all patients was small cell lung cancer. Patients were classified into two groups according to the NSE reference value (16.3 ng/mL): six patients having NSE level below the reference value and 13 having NSE level above the reference value. The SUVmax in the hypothalamic/pituitary region was 2.95 in the NSE < 16.3 ng/mL group and 4.10 in the NSE > 16.3 ng/mL group, with a statistically significant difference (p = 0.03). The total tumor volume was 17.8 mL in the NSE < 16.3 ng/mL group and 98.9 mL in the NSE > 16.3 ng/mL group, with a statistically significant difference (p < 0.01). A correlation coefficient of r = 0.458 (p = 0.0486) was observed between SUVmax in the hypothalamus/pituitary and NSE level. A correlation coefficient of r = 0.647 (p < 0.01) was also observed between total tumor volume and NSE level. Finally, a correlation coefficient of r = 0.53 (p = 0.01) was observed between hypothalamic/pituitary TLG and primary tumor TLG. The findings demonstrated a correlation between hypothalamic/pituitary activity and tumor activity, suggesting the prognostic significance of NSE.

有关小细胞肺癌中神经元特异性烯醇化酶（NSE）水平与正常器官（尤其是中枢神经系统）之间关系的研究十分有限。因此，本研究旨在探讨正电子发射计算机断层扫描（PET-CT）在局限期小细胞肺癌下丘脑/垂体区域的积累、肿瘤活性和 NSE 水平之间的关系。我们对2019年7月1日至2023年5月31日期间在东京医科大学附属医院确诊为局限期小细胞肺癌并接受化疗或放疗的患者进行了回顾性分析。在开始治疗前采集的血液样本中测量了白细胞、红细胞、血红蛋白、血小板、总蛋白、白蛋白、NSE和癌胚抗原。从 PET-CT 图像中提取每个下丘脑/垂体区域、原发肿瘤和淋巴结转移灶的最大标准化摄取值（SUVmax）、体积和总病变糖酵解（TLG）。计算出肿瘤总体积（原发肿瘤体积加淋巴结转移体积）和总酵解糖度（原发肿瘤酵解糖度加淋巴结转移酵解糖度）。本研究共纳入 19 例患者（平均年龄为 70.1 ± 8.8 岁，男性 13 例，女性 6 例），所有患者的病理类型均为小细胞肺癌。根据 NSE 参考值（16.3 纳克/毫升）将患者分为两组：6 名患者的 NSE 水平低于参考值，13 名患者的 NSE 水平高于参考值。NSE 16.3 纳克/毫升组下丘脑/垂体区域的 SUVmax 为 2.95，差异有统计学意义（P = 0.03）。NSE 16.3 ng/mL 组的肿瘤总体积为 17.8 mL，差异有统计学意义（p < 0.01）。下丘脑/垂体 SUVmax 与 NSE 水平之间的相关系数为 r = 0.458（p = 0.0486）。肿瘤总体积与 NSE 水平之间的相关系数为 r = 0.647（p < 0.01）。最后，下丘脑/垂体 TLG 与原发肿瘤 TLG 之间的相关系数为 r = 0.53（p = 0.01）。研究结果表明，下丘脑/垂体活性与肿瘤活性之间存在相关性，这表明 NSE 对预后具有重要意义。

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引用次数: 0

18F-FACBC and 18F-FDG PET/MRI in the evaluation of 3 patients with primary central nervous system lymphoma: a pilot study 18F-FACBC 和 18F-FDG PET/MRI 在评估 3 名原发性中枢神经系统淋巴瘤患者中的应用：一项试点研究

IF 1.7 Q2 Computer Science

European Journal of Hybrid Imaging

Pub Date : 2024-01-31 DOI: 10.1186/s41824-024-00189-6

Trine Husby, Knut Johannessen, Erik Magnus Berntsen, Håkon Johansen, Guro Fanneløb Giskeødegård, Anna Karlberg, Unn-Merete Fagerli, Live Eikenes

This PET/MRI study compared contrast-enhanced MRI, 18F-FACBC-, and 18F-FDG-PET in the detection of primary central nervous system lymphomas (PCNSL) in patients before and after high-dose methotrexate chemotherapy. Three immunocompetent PCNSL patients with diffuse large B-cell lymphoma received dynamic 18F-FACBC- and 18F-FDG-PET/MRI at baseline and response assessment. Lesion detection was defined by clinical evaluation of contrast enhanced T1 MRI (ce-MRI) and visual PET tracer uptake. SUVs and tumor-to-background ratios (TBRs) (for 18F-FACBC and 18F-FDG) and time-activity curves (for 18F-FACBC) were assessed. At baseline, seven ce-MRI detected lesions were also detected with 18F-FACBC with high SUVs and TBRs (SUVmax:mean, 4.73, TBRmax: mean, 9.32, SUVpeak: mean, 3.21, TBRpeak:mean: 6.30). High TBR values of 18F-FACBC detected lesions were attributed to low SUVbackground. Baseline 18F-FDG detected six lesions with high SUVs (SUVmax: mean, 13.88). In response scans, two lesions were detected with ce-MRI, while only one was detected with 18F-FACBC. The lesion not detected with 18F-FACBC was a small atypical MRI detected lesion, which may indicate no residual disease, as this patient was still in complete remission 12 months after initial diagnosis. No lesions were detected with 18F-FDG in the response scans. 18F-FACBC provided high tumor contrast, outperforming 18F-FDG in lesion detection at both baseline and in response assessment. 18F-FACBC may be a useful supplement to ce-MRI in PCNSL detection and response assessment, but further studies are required to validate these findings. Trial registration ClinicalTrials.gov. Registered 15th of June 2017 (Identifier: NCT03188354, https://clinicaltrials.gov/study/NCT03188354 ).

这项 PET/MRI 研究比较了对比增强 MRI、18F-FACBC 和 18F-FDG-PET 在检测大剂量甲氨蝶呤化疗前后患者原发性中枢神经系统淋巴瘤（PCNSL）方面的作用。三名免疫功能正常的弥漫大B细胞淋巴瘤PCNSL患者在基线和反应评估时接受了动态18F-FACBC-和18F-FDG-PET/MRI检查。病灶检测是通过对比增强 T1 MRI（ce-MRI）的临床评估和可视 PET 示踪剂摄取来定义的。对 SUV 和肿瘤-背景比 (TBR) （18F-FACBC 和 18F-FDG）以及时间-活性曲线（18F-FACBC）进行了评估。基线时，7 个 ce-MRI 检测到的病灶也用 18F-FACBC 检测到了高 SUV 和高 TBR（SUVmax:平均值为 4.73，TBRmax:平均值为 9.32，SUVpeak:平均值为 3.21，TBRpeak:平均值为 6.30）：6.30).18F-FACBC 检测到的病灶的 TBR 值高是因为 SUV 背景低。基线 18F-FDG 检测到六个病灶的 SUV 值较高（SUVmax：平均值为 13.88）。在响应扫描中，ce-MRI 检测到两个病灶，而 18F-FACBC 仅检测到一个病灶。18F-FACBC未检测到的病灶是MRI检测到的一个小的非典型病灶，这可能表明没有残留疾病，因为该患者在初次诊断12个月后仍处于完全缓解状态。在反应扫描中，18F-FDG 没有检测到病灶。18F-FACBC 的肿瘤对比度高，在基线和反应评估的病灶检测中均优于 18F-FDG。在PCNSL检测和反应评估中，18F-FACBC可能是ce-MRI的有益补充，但还需要进一步的研究来验证这些发现。试验注册 ClinicalTrials.gov.2017年6月15日注册（标识符：NCT03188354，https://clinicaltrials.gov/study/NCT03188354 ）。

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引用次数: 0

Diagnostic value of FDG PET-CT in differentiating lung adenocarcinoma from squamous cell carcinoma FDG PET-CT 在区分肺腺癌和鳞癌方面的诊断价值

IF 1.7 Q2 Computer Science

European Journal of Hybrid Imaging

Pub Date : 2024-01-30 DOI: 10.1186/s41824-024-00187-8

Adem Maman, Sadık Çiğdem, İdris Kaya, Rabia Demirtaş, Onur Ceylan, Sevilay Özmen

Lung cancer is the leading cause of cancer-related deaths worldwide. The combination of fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) and computed tomography (CT) has a major impact on the diagnosis, staging, treatment planning and follow-up of lung cancer patients. The maximum standardized uptake value (SUVmax) is an easily performed and most widely used semi-quantitative index for the analysis of FDG PET images and estimation of metabolic activity. This study aimed to investigate the role of PET/CT in differentiating adenocarcinoma (ADC), the most common lung cancer, from squamous cell carcinoma (SCC) by comparing FDG uptake measured as SUVmax. Between 2019 and 2022, 76 patients diagnosed with non-small cell lung cancer (NSCLC) at the Department of Pathology, Atatürk University Faculty of Medicine, with histopathologic evidence of adenocarcinoma or squamous cell carcinoma, underwent retrospective analysis using PET/CT scanning to measure PET parameters of the lesions and compare them with histopathology. Among 76 NSCLC patients included in the study, 43 (57%) were histopathologically diagnosed as ADC and 33 (43%) as SCC. SUVmax, SUVmean, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values of lesions in patients with SCC were statistically significantly higher than those in patients with ADC (p values 0.007, 0.009, 0.003 and 0.04, respectively). Lung SCC has higher metabolic uptake values than ADC, and PET/CT can be used to differentiate them.

肺癌是全球癌症相关死亡的主要原因。氟-18-脱氧葡萄糖正电子发射断层扫描（18F-FDG PET）与计算机断层扫描（CT）的结合对肺癌患者的诊断、分期、治疗计划和随访具有重要影响。最大标准化摄取值（SUVmax）是分析 FDG PET 图像和估算代谢活性的半定量指标，易于操作且应用最为广泛。本研究旨在通过比较以 SUVmax 测量的 FDG 摄取值，研究 PET/CT 在区分腺癌（ADC）（最常见的肺癌）和鳞癌（SCC）方面的作用。2019年至2022年期间，阿塔图尔克大学医学院病理学系对76名确诊为非小细胞肺癌（NSCLC）、组织病理学证据为腺癌或鳞癌的患者进行了回顾性分析，使用PET/CT扫描测量病变的PET参数，并与组织病理学进行比较。在纳入研究的 76 例 NSCLC 患者中，43 例（57%）经组织病理学诊断为 ADC，33 例（43%）为 SCC。SCC患者病灶的SUVmax、SUVmean、代谢肿瘤体积（MTV）和总病灶糖酵解（TLG）值在统计学上明显高于ADC患者（P值分别为0.007、0.009、0.003和0.04）。肺SCC的代谢摄取值高于ADC，PET/CT可用于区分它们。

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引用次数: 0

Exploring the applicability of a lesion segmentation method on [¹⁸F]fluorothymidine PET/CT images in diffuse large B-cell lymphoma. 探索病灶分割方法在弥漫大 B 细胞淋巴瘤 [18F]fluorothymidine PET/CT 图像中的适用性。

IF 1.7 Q2 Computer Science

European Journal of Hybrid Imaging

Pub Date : 2023-12-25 DOI: 10.1186/s41824-023-00184-3

Germán Pitarch, Yamila Rotstein Habarnau, Roxana Chirico, Brenda Konowalik, Amalia Pérez, Alejandro Valda, María Bastianello

Background and purpose: The determination of the total metabolic tumour volume based on [¹⁸F]fluorothymidine ([¹⁸F]FLT) PET/CT images in diffuse large B-cell lymphoma has a potential clinical value for detecting early relapse in this type of heterogeneous lymphoproliferative tumours. Tumour segmentation is a key step in this process. For this purpose, our objective was to determine a segmentation threshold of [¹⁸F]FLT PET/CT images, based on a reference tissue uptake, on a cohort of patients with diffuse large B-cell lymphoma (DLBCL) that have been scanned at different stages of the treatment.

Methods: We enrolled 23 adult patients with DLBCL confirmed in II-IV stages without nervous system compromise. All patients were scanned using [¹⁸F]FLT PET/CT at the time of diagnosis (baseline PET), interim PET (iPET), and at the end of treatment (fPET). The administered activity was 1.8-2.6 MBq/kg body weight, performed 60-70 min after injection and without use of contrast-enhanced CT. First, we assessed the [¹⁸F]FLT uptake stability in liver and bone marrow along the patient follow-up. For the lesion segmentation, three threshold values were assessed.

Results: Both, liver, and bone marrow can be indistinctly taken as reference tissue. The SUV threshold for a voxel to be considered as belonging to a lesion is expressed in terms of a percentage relative to the patient's uptake in the reference tissue. Found thresholds were: for liver, 62%, 33%, 27%; and for bone marrow, 35%, 21% and 22%, for baseline, iPET and fPET stages, respectively. The relative threshold throughout the treatment has a decreasing tendency along the stages.

Conclusion: Based on the results obtained with [¹⁸F]FLT PET/CT during staging and follow-up in patients with DLBCL, reference values were obtained for each stage referring to liver and bone marrow uptake that could be used in clinical practice oncology.

背景和目的：根据弥漫大B细胞淋巴瘤的[18F]氟胸苷（[18F]FLT）PET/CT图像确定肿瘤的总代谢体积对检测这类异质性淋巴增生性肿瘤的早期复发具有潜在的临床价值。肿瘤分割是这一过程中的关键步骤。为此，我们的目标是根据参考组织摄取量，确定弥漫大 B 细胞淋巴瘤（DLBCL）患者在不同治疗阶段扫描的 [18F]FLT PET/CT 图像的分割阈值：我们招募了 23 名成年 DLBCL 患者，这些患者均已确诊为 II-IV 期，且没有神经系统受损。所有患者均在诊断时（基线 PET）、中期 PET（iPET）和治疗结束时（fPET）接受了[18F]FLT PET/CT 扫描。给药活性为 1.8-2.6 MBq/kg体重，在注射后 60-70 分钟进行，不使用造影剂增强 CT。首先，我们评估了患者随访期间肝脏和骨髓中[18F]FLT摄取的稳定性。在病灶分割方面，我们评估了三个阈值：结果：肝脏和骨髓都可以不明确地作为参考组织。一个体素被认为属于病变的 SUV 阈值用相对于患者在参考组织中摄取量的百分比来表示。发现的阈值为：肝脏，62%、33%、27%；骨髓，基线、iPET 和 fPET 阶段，分别为 35%、21% 和 22%。整个治疗过程中的相对阈值呈逐级下降趋势：根据[18F]FLT PET/CT在DLBCL患者的分期和随访中获得的结果，可以得出各期肝脏和骨髓摄取的参考值，这些参考值可用于肿瘤临床实践。

{"title":"Exploring the applicability of a lesion segmentation method on [18F]fluorothymidine PET/CT images in diffuse large B-cell lymphoma.","authors":"Germán Pitarch, Yamila Rotstein Habarnau, Roxana Chirico, Brenda Konowalik, Amalia Pérez, Alejandro Valda, María Bastianello","doi":"10.1186/s41824-023-00184-3","DOIUrl":"10.1186/s41824-023-00184-3","url":null,"abstract":"Background and purpose: The determination of the total metabolic tumour volume based on [18F]fluorothymidine ([18F]FLT) PET/CT images in diffuse large B-cell lymphoma has a potential clinical value for detecting early relapse in this type of heterogeneous lymphoproliferative tumours. Tumour segmentation is a key step in this process. For this purpose, our objective was to determine a segmentation threshold of [18F]FLT PET/CT images, based on a reference tissue uptake, on a cohort of patients with diffuse large B-cell lymphoma (DLBCL) that have been scanned at different stages of the treatment.Methods: We enrolled 23 adult patients with DLBCL confirmed in II-IV stages without nervous system compromise. All patients were scanned using [18F]FLT PET/CT at the time of diagnosis (baseline PET), interim PET (iPET), and at the end of treatment (fPET). The administered activity was 1.8-2.6 MBq/kg body weight, performed 60-70 min after injection and without use of contrast-enhanced CT. First, we assessed the [18F]FLT uptake stability in liver and bone marrow along the patient follow-up. For the lesion segmentation, three threshold values were assessed.Results: Both, liver, and bone marrow can be indistinctly taken as reference tissue. The SUV threshold for a voxel to be considered as belonging to a lesion is expressed in terms of a percentage relative to the patient's uptake in the reference tissue. Found thresholds were: for liver, 62%, 33%, 27%; and for bone marrow, 35%, 21% and 22%, for baseline, iPET and fPET stages, respectively. The relative threshold throughout the treatment has a decreasing tendency along the stages.Conclusion: Based on the results obtained with [18F]FLT PET/CT during staging and follow-up in patients with DLBCL, reference values were obtained for each stage referring to liver and bone marrow uptake that could be used in clinical practice oncology.","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"7 1","pages":"28"},"PeriodicalIF":1.7,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10749290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patients 18F-FDG 和 18F-FES PET/CT 对 ER 阳性乳腺癌患者初步分期的正面比较

IF 1.7 Q2 Computer Science

European Journal of Hybrid Imaging

Pub Date : 2023-12-18 DOI: 10.1186/s41824-023-00176-3

Peerapon Kiatkittikul, Supanida Mayurasakorn, Chetsadaporn Promteangtrong, Anchisa Kunawudhi, Dheeratama Siripongsatian, Natdanai Hirata, Attapon Jantarato, Natphimol Boonkawin, Sukanya Yaset, Pattanapong Kongsakorn, Warunya Phewnual, Chanisa Chotipanich

To compare the diagnostic performance of 18F-fluorodeoxyglucose (18F-FDG) and 18F-fluoroestradiol (18F-FES) positron emission tomography/computed tomography (PET/CT) for initial staging of estrogen receptor (ER) positive breast cancer. Twenty-eight patients with ER-positive breast cancer underwent 18F-FDG and 18F-FES PET/CT for initial staging. Diagnostic performance and concordance rates were analyzed for both radiotracers. Semiquantitative parameters of maximum standardized uptake value (SUVmax) and tumor-to-normal ratio (T/N ratio) were compared using Wilcoxon signed-rank test. Factors potentially affecting the degree of radiotracer uptake were analyzed by multi-level linear regression analysis. The overall diagnostic performance of 18F-FES was comparable to 18F-FDG, except for higher specificity and NPV, with sensitivity, specificity, PPV, NPV, and accuracy of 87.56%, 100%, 100%, 35.14%, and 88.35%, respectively, for 18F-FES and 83.94%, 30.77%, 94.74%, 11.43%, and 95.37%, respectively, for 18F-FDG. Diagnostic performance of strong ER expression was better in 18F-FES but worse for 18F-FDG. There was a correlation of mucinous cell type and Allred score 7–8 with 18F-FES uptake, with correlation coefficients of 26.65 (19.28, 34.02), 5.90 (− 0.005, 11.81), and p-value of < 0.001, 0.05, respectively. Meanwhile, luminal B and Ki-67 were related to 18F-FDG uptake, with correlation coefficients of 2.76 (1.10, 0.20), 0.11 (0.01, 0.2), and p-value of 0.018, 0.025, respectively. Diagnostic performance of 18F-FES is comparable to 18F-FDG, but better for strongly ER-positive breast cancer. Combination of 18F-FES and 18F-FDG would potentially overcome the limitations of each tracer with more accurate staging.

目的：比较18F-氟脱氧葡萄糖（18F-FDG）和18F-氟雌二醇（18F-FES）正电子发射断层扫描/计算机断层扫描（PET/CT）对雌激素受体（ER）阳性乳腺癌初步分期的诊断效果。28名ER阳性乳腺癌患者接受了18F-FDG和18F-FES PET/CT进行初步分期。分析了两种放射性核素的诊断性能和吻合率。使用Wilcoxon符号秩检验比较了最大标准化摄取值（SUVmax）和肿瘤与正常比（T/N比）的半定量参数。对可能影响放射性示踪剂摄取程度的因素进行了多级线性回归分析。18F-FES的敏感性、特异性、PPV、NPV和准确性分别为87.56%、100%、100%、35.14%和88.35%，而18F-FDG的敏感性、特异性、PPV、NPV和准确性分别为83.94%、30.77%、94.74%、11.43%和95.37%。18F-FES 对强 ER 表达的诊断效果较好，而 18F-FDG 则较差。粘液细胞类型和 Allred 评分 7-8 与 18F-FES 摄取存在相关性，相关系数分别为 26.65（19.28，34.02）、5.90（- 0.005，11.81），P 值分别小于 0.001、0.05。同时，管腔 B 和 Ki-67 与 18F-FDG 摄取相关，相关系数分别为 2.76（1.10，0.20）、0.11（0.01，0.2），P 值分别为 0.018、0.025。18F-FES 的诊断效果与 18F-FDG 相当，但对 ER 强阳性乳腺癌的诊断效果更好。将 18F-FES 和 18F-FDG 结合使用可能会克服每种示踪剂的局限性，分期更准确。

{"title":"Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patients","authors":"Peerapon Kiatkittikul, Supanida Mayurasakorn, Chetsadaporn Promteangtrong, Anchisa Kunawudhi, Dheeratama Siripongsatian, Natdanai Hirata, Attapon Jantarato, Natphimol Boonkawin, Sukanya Yaset, Pattanapong Kongsakorn, Warunya Phewnual, Chanisa Chotipanich","doi":"10.1186/s41824-023-00176-3","DOIUrl":"https://doi.org/10.1186/s41824-023-00176-3","url":null,"abstract":"To compare the diagnostic performance of 18F-fluorodeoxyglucose (18F-FDG) and 18F-fluoroestradiol (18F-FES) positron emission tomography/computed tomography (PET/CT) for initial staging of estrogen receptor (ER) positive breast cancer. Twenty-eight patients with ER-positive breast cancer underwent 18F-FDG and 18F-FES PET/CT for initial staging. Diagnostic performance and concordance rates were analyzed for both radiotracers. Semiquantitative parameters of maximum standardized uptake value (SUVmax) and tumor-to-normal ratio (T/N ratio) were compared using Wilcoxon signed-rank test. Factors potentially affecting the degree of radiotracer uptake were analyzed by multi-level linear regression analysis. The overall diagnostic performance of 18F-FES was comparable to 18F-FDG, except for higher specificity and NPV, with sensitivity, specificity, PPV, NPV, and accuracy of 87.56%, 100%, 100%, 35.14%, and 88.35%, respectively, for 18F-FES and 83.94%, 30.77%, 94.74%, 11.43%, and 95.37%, respectively, for 18F-FDG. Diagnostic performance of strong ER expression was better in 18F-FES but worse for 18F-FDG. There was a correlation of mucinous cell type and Allred score 7–8 with 18F-FES uptake, with correlation coefficients of 26.65 (19.28, 34.02), 5.90 (− 0.005, 11.81), and p-value of < 0.001, 0.05, respectively. Meanwhile, luminal B and Ki-67 were related to 18F-FDG uptake, with correlation coefficients of 2.76 (1.10, 0.20), 0.11 (0.01, 0.2), and p-value of 0.018, 0.025, respectively. Diagnostic performance of 18F-FES is comparable to 18F-FDG, but better for strongly ER-positive breast cancer. Combination of 18F-FES and 18F-FDG would potentially overcome the limitations of each tracer with more accurate staging.","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"7 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138717445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of two timepoints on [18F]FAPI-42 PET/CT in various cancers 各种癌症中[18F]FAPI-42 PET/CT 两个时间点的对比分析

IF 1.7 Q2 Computer Science

European Journal of Hybrid Imaging

Pub Date : 2023-12-11 DOI: 10.1186/s41824-023-00186-1

Xingyu Mu, Biyun Mo, Jie Qin, Zuguo Li, Weixia Chong, Yulong Zeng, Lu Lu, Lei Zhang, Wei Fu

This study aimed to assess the biodistribution, detection rate, and uptake of the [18F]FAPI-42 at two distinct time intervals. This prospective study enrolled 60 consecutive patients (median age 59; range 35–74) referred to [18F]FAPI-42 PET/CT. [18F]FAPI-42 PET/CT was performed early and late timepoint after tracer injection for staging or restaging. Positive lesions specified for anatomic locations (primary or recurrent tumor, LN metastasis and other metastasis) by visual analysis at both timepoints. Semiquantitative analysis of the tracer activity in lesions as well as normal tissues at both time points were measured and compared. In a subgroup analysis, eleven patients underwent 2-[18F]FDG PET/CT within 1 week, the detection rate and uptake of lesion were compared between early [18F]FAPI-42 and 2-[18F]FDG. Uptake of [18F]FAPI-42 in the late timepoint was significantly lower than the early timepoint in most organs (all p < 0.05), except for bone (SUVmean 0.88 vs. 0.85; p = 0.218). Tracer retention at biliary system showed less frequent at early timepoint than late timepoint. A total of 194 lesions were detected in 60 patients. One lesion was only seen at early timepoint but not at late timepoint. Lesions on early [18F]FAPI-42 PET/CT had higher visual score than that of late image(23 vs. 6). The uptake of lesion decreased significantly from early to late timepoint (all p < 0.05). In subgroup analysis, early [18F]FAPI-42 illustrated higher detection rate, visual score, and uptake of lesion than that of 2-[18F]FDG PET/CT. Early [18F]FAPI-42 PET/CT provided consistent detection rates and lesion uptake, but less tracer retention in the biliary system compared to late images. Therefore, acquisition at early timepoint could be a feasible strategy for improving acquisition protocols of [18F]FAPI-42 PET/CT. Trial registration: ChiCTR2200063441. Registered 28 September 2022—Retrospectively registered, https://www.chictr.org.cn/bin/project/edit?pid=149714 .

本研究旨在评估[18F]FAPI-42在两个不同时间间隔的生物分布、检出率和摄取量。这项前瞻性研究连续收治了60名转诊至[18F]FAPI-42 PET/CT的患者（中位年龄59岁；范围35-74岁）。[18F]FAPI-42 PET/CT 在示踪剂注射后的早期和晚期时间点进行，用于分期或重新分期。两个时间点的阳性病灶通过肉眼分析确定解剖位置（原发或复发肿瘤、LN转移灶和其他转移灶）。在两个时间点对病灶和正常组织中的示踪剂活性进行测量和比较，并进行半定量分析。在一项亚组分析中，11 名患者在 1 周内接受了 2-[18F]FDG PET/CT，比较了早期[18F]FAPI-42 和 2-[18F]FDG 的检出率和病灶摄取率。在大多数器官中，晚期时间点的[18F]FAPI-42摄取量明显低于早期时间点（均 p < 0.05），骨除外（SUV meanan 0.88 vs. 0.85; p = 0.218）。胆道系统的示踪剂滞留在早期时间点的频率低于晚期时间点。60 名患者共检测到 194 个病灶。有一个病灶只在早期时间点出现，而在晚期时间点没有出现。早期[18F]FAPI-42 PET/CT 图像的病灶视觉评分高于晚期图像（23 分对 6 分）。从早期到晚期，病灶的摄取量明显下降（均 p < 0.05）。在亚组分析中，早期[18F]FAPI-42的检出率、视觉评分和病灶摄取率均高于2-[18F]FDG PET/CT。与晚期图像相比，早期[18F]FAPI-42 PET/CT 的检出率和病灶摄取率一致，但胆道系统中的示踪剂滞留较少。因此，在早期时间点采集图像是改进[18F]FAPI-42 PET/CT采集方案的可行策略。试验注册：ChiCTR2200063441。注册日期：2022 年 9 月 28 日-回顾性注册，https://www.chictr.org.cn/bin/project/edit?pid=149714 。

{"title":"Comparative analysis of two timepoints on [18F]FAPI-42 PET/CT in various cancers","authors":"Xingyu Mu, Biyun Mo, Jie Qin, Zuguo Li, Weixia Chong, Yulong Zeng, Lu Lu, Lei Zhang, Wei Fu","doi":"10.1186/s41824-023-00186-1","DOIUrl":"https://doi.org/10.1186/s41824-023-00186-1","url":null,"abstract":"This study aimed to assess the biodistribution, detection rate, and uptake of the [18F]FAPI-42 at two distinct time intervals. This prospective study enrolled 60 consecutive patients (median age 59; range 35–74) referred to [18F]FAPI-42 PET/CT. [18F]FAPI-42 PET/CT was performed early and late timepoint after tracer injection for staging or restaging. Positive lesions specified for anatomic locations (primary or recurrent tumor, LN metastasis and other metastasis) by visual analysis at both timepoints. Semiquantitative analysis of the tracer activity in lesions as well as normal tissues at both time points were measured and compared. In a subgroup analysis, eleven patients underwent 2-[18F]FDG PET/CT within 1 week, the detection rate and uptake of lesion were compared between early [18F]FAPI-42 and 2-[18F]FDG. Uptake of [18F]FAPI-42 in the late timepoint was significantly lower than the early timepoint in most organs (all p < 0.05), except for bone (SUVmean 0.88 vs. 0.85; p = 0.218). Tracer retention at biliary system showed less frequent at early timepoint than late timepoint. A total of 194 lesions were detected in 60 patients. One lesion was only seen at early timepoint but not at late timepoint. Lesions on early [18F]FAPI-42 PET/CT had higher visual score than that of late image(23 vs. 6). The uptake of lesion decreased significantly from early to late timepoint (all p < 0.05). In subgroup analysis, early [18F]FAPI-42 illustrated higher detection rate, visual score, and uptake of lesion than that of 2-[18F]FDG PET/CT. Early [18F]FAPI-42 PET/CT provided consistent detection rates and lesion uptake, but less tracer retention in the biliary system compared to late images. Therefore, acquisition at early timepoint could be a feasible strategy for improving acquisition protocols of [18F]FAPI-42 PET/CT. Trial registration: ChiCTR2200063441. Registered 28 September 2022—Retrospectively registered, https://www.chictr.org.cn/bin/project/edit?pid=149714 .","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"60 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138566744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Added value of regional ¹⁸F-FDG PET/MRI-assisted whole-body ¹⁸F-FDG PET/CT in malignant ascites with unknown primary origin. 局部18F-FDG PET/ mri辅助全身18F-FDG PET/CT在原发原因不明的恶性腹水中的附加价值。

IF 1.7 Q2 Computer Science

European Journal of Hybrid Imaging

Pub Date : 2023-12-04 DOI: 10.1186/s41824-023-00179-0

Yiru Fu, Weiwei Ruan, Xun Sun, Fan Hu, Xiaoli Lan, Fang Liu

Background: Comparing to PET/CT, integrative PET/MRI imaging provides superior soft tissue resolution. This study aims to evaluate the added value of regional delayed ¹⁸F-FDG PET/MRI-assisted whole-body ¹⁸F-FDG PET/CT in diagnosing malignant ascites patients.

Results: The final diagnosis included 22 patients with ovarian cancer (n = 11), peritoneal cancer (n = 3), colon cancer (n = 2), liver cancer (n = 2), pancreatic cancer (n = 2), gastric cancer (n = 1), and fallopian tube cancer (n = 1). The diagnosis of the primary tumor using whole-body PET/CT was correct in 11 cases. Regional PET/MRI-assisted whole-body PET/CT diagnosis was correct in 18 cases, including 6 more cases of ovarian cancer and 1 more case of fallopian tube cancer. Among 4 cases that were not diagnosed correctly, 1 case had the primary tumor outside of the PET/MRI scan area, 2 cases were peritoneal cancer, and 1 case was colon cancer. The diagnostic accuracy of regional PET/MRI-assisted whole-body PET/CT was higher than PET/CT alone (81.8% vs. 50.0%, κ ² = 5.14, p = 0.023). The primary tumor conspicuity score of PET/MRI was higher than PET/CT (3.67 ± 0.66 vs. 2.76 ± 0.94, P < 0.01). In the same scan area, more metastases were detected in PET/MRI than in PET/CT (156 vs. 86 in total, and 7.43 ± 5.17 vs. 4.10 ± 1.92 per patient, t = 3.89, P < 0.01). Lesion-to-background ratio in PET/MRI was higher than that in PET/CT (10.76 ± 5.16 vs. 6.56 ± 3.45, t = 13.02, P < 0.01).

Conclusion: Comparing to whole-body PET/CT alone, additional delayed regional PET/MRI with high soft tissue resolution is helpful in diagnosing the location of the primary tumor and identifying more metastases in patients with malignant ascites. Yet larger sample size in multicenter and prospective clinical researches is still needed.

背景:与PET/CT相比，PET/MRI综合成像提供了更好的软组织分辨率。本研究旨在评价局部延迟18F-FDG PET/ mri辅助全身18F-FDG PET/CT在诊断恶性腹水患者中的附加价值。结果:最终诊断为卵巢癌(11例)、腹膜癌(3例)、结肠癌(2例)、肝癌(2例)、胰腺癌(2例)、胃癌(1例)、输卵管癌(1例)22例。全身PET/CT对原发肿瘤的诊断正确11例。局部PET/ mri辅助全身PET/CT诊断正确18例，其中卵巢癌多6例，输卵管癌多1例。在4例误诊病例中，原发肿瘤在PET/MRI扫描区外1例，腹膜癌2例，结肠癌1例。局部PET/ mri辅助全身PET/CT诊断正确率高于单独PET/CT (81.8% vs. 50.0%， κ 2 = 5.14, p = 0.023)。PET/MRI对原发肿瘤的显著性评分高于PET/CT(3.67±0.66 vs. 2.76±0.94,P)结论:与单独进行全身PET/CT相比，附加软组织分辨率较高的延迟区域性PET/MRI对恶性腹水患者原发肿瘤的位置诊断和转移灶的发现更有帮助。然而，在多中心和前瞻性临床研究中仍需要更大的样本量。

{"title":"Added value of regional 18F-FDG PET/MRI-assisted whole-body 18F-FDG PET/CT in malignant ascites with unknown primary origin.","authors":"Yiru Fu, Weiwei Ruan, Xun Sun, Fan Hu, Xiaoli Lan, Fang Liu","doi":"10.1186/s41824-023-00179-0","DOIUrl":"10.1186/s41824-023-00179-0","url":null,"abstract":"Background: Comparing to PET/CT, integrative PET/MRI imaging provides superior soft tissue resolution. This study aims to evaluate the added value of regional delayed 18F-FDG PET/MRI-assisted whole-body 18F-FDG PET/CT in diagnosing malignant ascites patients.Results: The final diagnosis included 22 patients with ovarian cancer (n = 11), peritoneal cancer (n = 3), colon cancer (n = 2), liver cancer (n = 2), pancreatic cancer (n = 2), gastric cancer (n = 1), and fallopian tube cancer (n = 1). The diagnosis of the primary tumor using whole-body PET/CT was correct in 11 cases. Regional PET/MRI-assisted whole-body PET/CT diagnosis was correct in 18 cases, including 6 more cases of ovarian cancer and 1 more case of fallopian tube cancer. Among 4 cases that were not diagnosed correctly, 1 case had the primary tumor outside of the PET/MRI scan area, 2 cases were peritoneal cancer, and 1 case was colon cancer. The diagnostic accuracy of regional PET/MRI-assisted whole-body PET/CT was higher than PET/CT alone (81.8% vs. 50.0%, κ 2 = 5.14, p = 0.023). The primary tumor conspicuity score of PET/MRI was higher than PET/CT (3.67 ± 0.66 vs. 2.76 ± 0.94, P < 0.01). In the same scan area, more metastases were detected in PET/MRI than in PET/CT (156 vs. 86 in total, and 7.43 ± 5.17 vs. 4.10 ± 1.92 per patient, t = 3.89, P < 0.01). Lesion-to-background ratio in PET/MRI was higher than that in PET/CT (10.76 ± 5.16 vs. 6.56 ± 3.45, t = 13.02, P < 0.01).Conclusion: Comparing to whole-body PET/CT alone, additional delayed regional PET/MRI with high soft tissue resolution is helpful in diagnosing the location of the primary tumor and identifying more metastases in patients with malignant ascites. Yet larger sample size in multicenter and prospective clinical researches is still needed.","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"7 1","pages":"22"},"PeriodicalIF":1.7,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138478774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signet cell rectal carcinoma with prostatic involvement detected by FAPI-04 PET-MRI fusion. FAPI-04 PET-MRI融合检测累及前列腺的印细胞直肠癌。

IF 1.7 Q2 Computer Science

European Journal of Hybrid Imaging

Pub Date : 2023-12-01 DOI: 10.1186/s41824-023-00183-4

K Arun Prashanth, Deepti Jain, R Manikandan, Suman Kalyan, Vimalraj Velayutham, R Surendran

A 60-year-old male patient diagnosed with mucinous adenocarcinoma of lower third of rectum underwent abdominoperineal resection and permanent colostomy followed by adjuvant chemotherapy. Response evaluation with F-18 FDG PET-CT showed a complete metabolic response. After 6 months, CEA levels started increasing and clinically a recurrence was suspected. A restaging FDG PET-CT showed no obvious malignant disease. Patient presented again within a month with complaints of urinary retention and haematuria. CEA levels were further elevated, and Ga-68 FAPI-04 (FAPI) PET-CT was performed. FAPI PET-CT revealed prostatic and seminal vesicle disease involvement. Additionally, an MRI of pelvis was done and fused with FAPI PET for confirmation of prostatic involvement.

一位60岁男性患者诊断为直肠下三分之一的粘液腺癌，接受了腹部会阴切除术和永久性结肠造口术，并辅以化疗。F-18 FDG PET-CT反应评估显示完全代谢反应。6个月后，CEA水平开始升高，临床怀疑复发。复诊FDG PET-CT未见明显恶性病变。患者在一个月内再次出现尿潴留和血尿。CEA水平进一步升高，行Ga-68 FAPI-04 (FAPI) PET-CT检查。FAPI PET-CT显示前列腺及精囊病变累及。此外，骨盆MRI检查并与FAPI PET融合以确认前列腺受累。

引用次数: 0

[¹⁸F]PSMA-1007 PET is comparable to [^99mTc]Tc-DMSA SPECT for renal cortical imaging. [18F]PSMA-1007 PET在肾皮质成像方面与[99mTc]Tc-DMSA SPECT相当。

IF 1.7 Q2 Computer Science

European Journal of Hybrid Imaging

Pub Date : 2023-11-24 DOI: 10.1186/s41824-023-00185-2

Kristian Valind, David Minarik, Sabine Garpered, Eva Persson, Jonas Jögi, Elin Trägårdh

Background: Scintigraphy using technetium-99m labelled dimercaptosuccinic acid ([^99mTc]Tc-DMSA), taken up in the proximal tubules, is the standard in functional imaging of the renal cortex. Recent guidelines recommend performing [^99mTc]Tc-DMSA scintigraphy with single photon emission computed tomography (SPECT). Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) is used for staging and localization of recurrence in prostate cancer. A high renal uptake is often seen on PSMA PET, concordant with known PSMA expression in proximal tubules. This suggests PSMA PET could be used analogous to [^99mTc]Tc-DMSA scintigraphy for renal cortical imaging. [¹⁸F]PSMA-1007 is a promising radiopharmaceutical for this purpose due to low urinary clearance. In this study, we aimed to compare [¹⁸F]PSMA-1007 PET to [^99mTc]Tc-DMSA SPECT regarding split renal uptake and presence of renal uptake defects, in patients with prostate cancer. Three readers interpreted PET and SPECT images regarding presence of renal uptake defects, with each kidney split into cranial, mid and caudal segments. Kidneys were segmented in PET and SPECT images, and left renal uptake as a percentage of total renal uptake was measured.

Results: Twenty patients with prostate cancer were included. 2 participants had single kidneys; thus 38 kidneys were evaluated. A total of 29 defects were found on both [^99mTc]Tc-DMSA SPECT and [¹⁸F]PSMA-1007 PET. Cohen's kappa for concordance regarding presence of any defect was 0.76 on a per-segment basis and 0.67 on a per-kidney basis. Spearman's r for left renal uptake percentage between [^99mTc]Tc-DMSA SPECT and [¹⁸F]PSMA-1007 PET was 0.95.

Conclusions: [¹⁸F]PSMA-1007 PET is comparable to [^99mTc]Tc-DMSA SPECT for detection of uptake defects in this setting. Measurements of split renal function made using [¹⁸F]PSMA-1007 PET are valid and strongly correlated to measurements made with [^99mTc]Tc-DMSA SPECT.

背景:近端小管采用锝-99m标记二巯基琥珀酸([99mTc]Tc-DMSA)的闪烁成像是肾皮质功能成像的标准。最近的指南推荐使用[99mTc]Tc-DMSA闪烁成像与单光子发射计算机断层扫描(SPECT)。前列腺特异性膜抗原(PSMA)靶向正电子发射断层扫描(PET)用于前列腺癌复发的分期和定位。PSMA PET常可见高肾摄取，与已知的近端小管PSMA表达一致。这表明PSMA PET可以类似于[99mTc]Tc-DMSA显像用于肾皮质成像。[18F]由于尿清除率低，PSMA-1007是一种很有前途的放射性药物。在这项研究中，我们旨在比较[18F]PSMA-1007 PET与[99mTc]Tc-DMSA SPECT在前列腺癌患者肾摄取分裂和存在肾摄取缺陷方面的差异。三位读者解释了肾脏摄取缺陷存在的PET和SPECT图像，每个肾脏分为颅、中、尾段。在PET和SPECT图像中对肾脏进行分割，并测量左肾摄取占肾脏总摄取的百分比。结果:纳入20例前列腺癌患者。2例为单肾;38个肾脏被评估。在[99mTc]Tc-DMSA SPECT和[18F]PSMA-1007 PET上共发现29个缺陷。关于任何缺陷存在的一致性的Cohen kappa在每个节段的基础上为0.76，在每个肾脏的基础上为0.67。[99mTc]Tc-DMSA SPECT与[18F]PSMA-1007 PET左肾摄取百分率的Spearman’s r为0.95。结论:在这种情况下，[18F]PSMA-1007 PET与[99mTc]Tc-DMSA SPECT在检测摄取缺陷方面是相当的。使用[18F]PSMA-1007 PET进行的分裂肾功能测量是有效的，并且与[99mTc]Tc-DMSA SPECT进行的测量高度相关。

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引用次数: 0

Association between body mass index (BMI) and [¹²³I]Ioflupane (DaTSCAN) availabilities in patients with parkinsonism using single-photon emission computed tomography-computed tomography (SPECT-CT). 使用单光子发射计算机断层扫描(SPECT-CT)研究帕金森病患者身体质量指数(BMI)与[123I]碘氟烷(DaTSCAN)可用性之间的关系

IF 1.7 Q2 Computer Science

European Journal of Hybrid Imaging

Pub Date : 2023-11-20 DOI: 10.1186/s41824-023-00181-6

Puja Parekh, Patrick Begley, Maryam Jessop, Mark Aplin, Elena Missir, Helena McMeekin, Gosia Raczek, Nitasha Singh, Sabina Dizdarevic

Aim: [¹²³I]Ioflupane (DaTSCAN) has a high binding affinity to the dopamine (DA) transporter (DaT) and tenfold less affinity to serotonin (5-HT) transporter (SERT). Both neurotransmitters are considered to contribute to body weight regulation. This study assesses the association between body mass index (BMI) and DaTSCAN availability in brain.

Method: Scans from 74 consecutive patients who had undergone DaTSCAN single-photon emission computed tomography-computed tomography (SPECT-CT) were used to obtain semi- and absolute quantitative data in several volumes of interest (VOIs). Relative semi-quantitative specific binding ratios (SBRs) from Chang attenuated SPECT were obtained from GE DaTQUANT. Absolute normalised concentration (NC) was calculated from attenuation/scatter corrected SPECT-CT images, using an adapted version of the EARL Ltd (European Association of Nuclear Medicine (EANM) Research 4 Life) template. Scans were subdivided into either degenerative parkinsonism (abnormal = 49), borderline (n = 14) or scan without evidence of dopaminergic deficit (SWEDD = 11) using visual assessment and SBR values by two nuclear medicine consultants.

Results: SBRs did not correlate with BMI. However, NC values correlated negatively in the entire cohort, with the strongest correlation in the frontal (r = - 0.649. p = 0.000), occipital (r = - 0.555, p = 0.000) regions and pons (r = - 0.555, p = 0.000). In the abnormal (n = 49) and SWEDD group (n = 11), NC of the frontal region was the most correlated with BMI (r = - 0.570, p = 0.000; r = - 0.813, p = 0.002, respectively). In the borderline group (n = 14), the left posterior putamen displayed the strongest correlation (r = - 0.765, p = 0.001).

Conclusion: Absolute NC values demonstrate a strong inverse correlation with BMI, strongest in the extrastriatal regions. Due to the predominately non-overlapping distribution of DaT and SERT, this study suggests greater involvement of SERT in obesity with possible interplay with DA transmission.

目的:[123I]碘氟烷(DaTSCAN)对多巴胺(DA)转运体(DaT)具有高结合亲和力，而对血清素(5-羟色胺(SERT))转运体(SERT)的亲和力低10倍。这两种神经递质都被认为有助于体重调节。本研究评估了身体质量指数(BMI)与大脑中DaTSCAN可用性之间的关系。方法:对74例连续接受DaTSCAN单光子发射计算机断层扫描(SPECT-CT)的患者进行扫描，在几个感兴趣的体积(voi)中获得半定量和绝对定量数据。从GE DaTQUANT获得Chang衰减SPECT的相对半定量特异性结合比(sbr)。绝对归一化浓度(NC)由衰减/散射校正的SPECT-CT图像计算，使用EARL Ltd(欧洲核医学协会(EANM)研究4生命)模板的改编版本。两名核医学顾问根据视觉评估和SBR值将扫描结果细分为退行性帕金森(异常= 49)、边缘性帕金森(n = 14)或无多巴胺能缺陷证据的扫描(SWEDD = 11)。结果:sbr与BMI无相关性。然而，NC值在整个队列中呈负相关，其中前额叶相关性最强(r = - 0.649)。p = 0.000),枕(r = - 0.555, p = 0.000)地区和脑桥(r = - 0.555, p = 0.000)。在异常组(n = 49)和SWEDD组(n = 11)中，额叶区NC与BMI的相关性最高(r = - 0.570, p = 0.000;R = - 0.813, p = 0.002)。在边缘组(n = 14)中，左侧后壳核的相关性最强(r = - 0.765, p = 0.001)。结论:绝对NC值与BMI呈强烈的负相关，在肠外区域最强。由于DaT和SERT的分布主要是不重叠的，本研究表明SERT在肥胖中有更大的参与，可能与DA的传播相互作用。

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引用次数: 0