Pub Date : 2016-03-04DOI: 10.1109/BSB.2016.7552147
R. Tripathi, Pawan Sharma, P. Chakraborty, P. Varadwaj
Sequencing the coding regions or the whole cancer transcriptome can provide valuable information about the differential expression patterns of the genes. Previous researches centered on ~2% of coding human genome, assuming that the non-coding sequences were “junk” lacking significant functional information. Recent medical research show that a major percentage of the human genome (~70-90%) are non-coding, stored in the cell in the form of non-coding RNA (ncRNA) which overshadows the coding information limited only to a small percentage. These ncRNAs are composed of mostly ultraconserved elements, lacking protein-coding potential and regulating gene expression acting as enhancers whose aberrant expression may be involved in pathological process such as cancer. Here, we have described RNA-seq data analysis for the profiling of transcriptome of Breast cells and provided a generic outline of the whole pipeline from next-generation sequencing (NGS) output for quantification of differential gene expression across different conditions (e.g., control vs test). We have used tool Cufflinks-Cuffdiff to estimate transcript-level expression for gene discovery extracted from high-throughput RNA-seq data across distinct conditions that represent candidate biomarkers for future research. This study provides the survey of coding transcripts associated genes expression within a cancer system.
{"title":"Count-based transcriptome analysis to identify differentially expressed genes for breast cancer","authors":"R. Tripathi, Pawan Sharma, P. Chakraborty, P. Varadwaj","doi":"10.1109/BSB.2016.7552147","DOIUrl":"https://doi.org/10.1109/BSB.2016.7552147","url":null,"abstract":"Sequencing the coding regions or the whole cancer transcriptome can provide valuable information about the differential expression patterns of the genes. Previous researches centered on ~2% of coding human genome, assuming that the non-coding sequences were “junk” lacking significant functional information. Recent medical research show that a major percentage of the human genome (~70-90%) are non-coding, stored in the cell in the form of non-coding RNA (ncRNA) which overshadows the coding information limited only to a small percentage. These ncRNAs are composed of mostly ultraconserved elements, lacking protein-coding potential and regulating gene expression acting as enhancers whose aberrant expression may be involved in pathological process such as cancer. Here, we have described RNA-seq data analysis for the profiling of transcriptome of Breast cells and provided a generic outline of the whole pipeline from next-generation sequencing (NGS) output for quantification of differential gene expression across different conditions (e.g., control vs test). We have used tool Cufflinks-Cuffdiff to estimate transcript-level expression for gene discovery extracted from high-throughput RNA-seq data across distinct conditions that represent candidate biomarkers for future research. This study provides the survey of coding transcripts associated genes expression within a cancer system.","PeriodicalId":363820,"journal":{"name":"2016 International Conference on Bioinformatics and Systems Biology (BSB)","volume":"454 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122938079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-04DOI: 10.1109/BSB.2016.7552125
Ankita Sharma, R. Malhotra, P. Kumari, S. Biswas, G. Soundhara Rajan
Altered expression of heavy chains of inter alpha trypsin inhibitor (ITI) family along with hyaluronan have clearly been established in various chronic inflammatory diseases. In the present study, the three dimensional (3D) model construction of ITIH4 and its functional role using Ginzu server was carried out. We identified three functional domains of ITIH4 protein model and elucidated their functional role. Thus, it helped us to understand the critical role of the protein in Serum derived Hyaluronic acid Associated Protein (SHAP) complex during the inflamed condition of RA.
{"title":"In-silico structure prediction and domain characterization of inter alpha trypsin inhibitor heavy chain 4","authors":"Ankita Sharma, R. Malhotra, P. Kumari, S. Biswas, G. Soundhara Rajan","doi":"10.1109/BSB.2016.7552125","DOIUrl":"https://doi.org/10.1109/BSB.2016.7552125","url":null,"abstract":"Altered expression of heavy chains of inter alpha trypsin inhibitor (ITI) family along with hyaluronan have clearly been established in various chronic inflammatory diseases. In the present study, the three dimensional (3D) model construction of ITIH4 and its functional role using Ginzu server was carried out. We identified three functional domains of ITIH4 protein model and elucidated their functional role. Thus, it helped us to understand the critical role of the protein in Serum derived Hyaluronic acid Associated Protein (SHAP) complex during the inflamed condition of RA.","PeriodicalId":363820,"journal":{"name":"2016 International Conference on Bioinformatics and Systems Biology (BSB)","volume":"95 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127989484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-04DOI: 10.1109/BSB.2016.7552126
D. Nigam, Puneet Kumar Kadimi, Sanjeev Kumar, D. Mishra, P. Pandey, Manoj Kumar singh, A. Rai, Subodh Kumar Sinha
MicroRNAs (miRNAs) are the key modulators implicated in the regulation of virtually every biological process found in multicellular eukaryotes. Wheat (Triticum aestivum) is one of the most important cereal crops worldwide. To date, only a few conserved miRNAs have been reported in wheat and their association with different metabolic process is still in dark. Therefore, the present study we attempt to predict miRNA and their association with metabolic pathways in wheat. Total 39 potential mature miRNA's were predicted using 1287279 ESTs of wheat and 8496 known mature miRNA's, along with their precursor sequences, of Viridiplantae. Overall, 11380 genome wise target genes across 21 chromosomes were identified and functionally characterized via meta-analysis. As a result, genome wise miRNA-targets signatures under different conditions and their regulatory pathways along with network structures were examined. Here, a concept of “miRNA community” was proposed and a miRNA community linked with nitrogen metabolism was identified. Top two potential miRNA's from this community were verified by stem loop pulsed RT-PCR for their expression in root and leaf tissue under nitrogen starvation. Exploration of such type of miRNAs communities will provide in depth understanding of metabolic processes that may leads to improved genotypes.
{"title":"Meta-analysis of potential miRNA in Triticum astivum reveals their genome biased association with different metabolisms EST based potential miRNA identification in wheat","authors":"D. Nigam, Puneet Kumar Kadimi, Sanjeev Kumar, D. Mishra, P. Pandey, Manoj Kumar singh, A. Rai, Subodh Kumar Sinha","doi":"10.1109/BSB.2016.7552126","DOIUrl":"https://doi.org/10.1109/BSB.2016.7552126","url":null,"abstract":"MicroRNAs (miRNAs) are the key modulators implicated in the regulation of virtually every biological process found in multicellular eukaryotes. Wheat (Triticum aestivum) is one of the most important cereal crops worldwide. To date, only a few conserved miRNAs have been reported in wheat and their association with different metabolic process is still in dark. Therefore, the present study we attempt to predict miRNA and their association with metabolic pathways in wheat. Total 39 potential mature miRNA's were predicted using 1287279 ESTs of wheat and 8496 known mature miRNA's, along with their precursor sequences, of Viridiplantae. Overall, 11380 genome wise target genes across 21 chromosomes were identified and functionally characterized via meta-analysis. As a result, genome wise miRNA-targets signatures under different conditions and their regulatory pathways along with network structures were examined. Here, a concept of “miRNA community” was proposed and a miRNA community linked with nitrogen metabolism was identified. Top two potential miRNA's from this community were verified by stem loop pulsed RT-PCR for their expression in root and leaf tissue under nitrogen starvation. Exploration of such type of miRNAs communities will provide in depth understanding of metabolic processes that may leads to improved genotypes.","PeriodicalId":363820,"journal":{"name":"2016 International Conference on Bioinformatics and Systems Biology (BSB)","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114786886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-04DOI: 10.1109/BSB.2016.7552134
A. Tripathi, K. Misra
Some stilbene analogues are essentially important for inhibiting the expression of P-glycoprotein in cancer stem cells. P-glycoprotein is a ATP binding cassette (ABC) transporter that mediates efflux process through ATP hydrolysis. This protein is composed of nucleotide binding and transmembrane domains. The expression level of P-glycoprotein is reported to be high in the cancer stem cell population. Stilbenes are phenylpropanoid-derived naturally occurring secondary metabolites of plants, reported as third generation inhibitors of P-glycoprotein. Based on biological activities of stilbenes against breast cancer cell line, the 3D quantitative structure-activity relationship and docking simulation study was carried out to predict the pharmacophoric features of these compounds. This study is likely to enable researchers to design and synthesize novel therapeutic analogues for reducing the growth of breast cancer stem cells by inhibiting the expression level of P-glycoprotein.
{"title":"Stilbene analogues as inhibitors of breast cancer Stem cells through P-glycoprotein efflux; A 3D quantitative structure-activity relationship study (Inhibitory activity of stilbenes analogues on breast cancer stem cells)","authors":"A. Tripathi, K. Misra","doi":"10.1109/BSB.2016.7552134","DOIUrl":"https://doi.org/10.1109/BSB.2016.7552134","url":null,"abstract":"Some stilbene analogues are essentially important for inhibiting the expression of P-glycoprotein in cancer stem cells. P-glycoprotein is a ATP binding cassette (ABC) transporter that mediates efflux process through ATP hydrolysis. This protein is composed of nucleotide binding and transmembrane domains. The expression level of P-glycoprotein is reported to be high in the cancer stem cell population. Stilbenes are phenylpropanoid-derived naturally occurring secondary metabolites of plants, reported as third generation inhibitors of P-glycoprotein. Based on biological activities of stilbenes against breast cancer cell line, the 3D quantitative structure-activity relationship and docking simulation study was carried out to predict the pharmacophoric features of these compounds. This study is likely to enable researchers to design and synthesize novel therapeutic analogues for reducing the growth of breast cancer stem cells by inhibiting the expression level of P-glycoprotein.","PeriodicalId":363820,"journal":{"name":"2016 International Conference on Bioinformatics and Systems Biology (BSB)","volume":"28 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130779894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wheat seed germination directly affects wheat yield and quality. Embryo and endosperm are two main parts of wheat seed and plays crucial role in seed germination and subsequent plant growth and other development. In the process of seed germination a systematic bi-directional molecular interactions are major component and that got affected by the means of abiotic stresses. A variety of proteomic and transcriptomic approaches have been used so far to investigate seed germination process in response to abiotic stresses. In this study, we have investigated deferentially expressed genes/transcripts (DEGs) of embryo and endosperm in response to ABA and H2O2 stress by the means of stress systems biology approaches using microarray data. Further, role of DEGs in response to each stress was explored, which identify biological and molecular functions of genes during seed germination embryo and endosperm. Our results provide the insight into comparative transcriptomic mechanism of the embryo and endosperm in response to ABA and H2O2 treatment during seed germination process.
{"title":"Embryo and endosperm specific comparative transcriptome analysis of triticum aestivum in response to ABA and H2O2 stress","authors":"Saurabh Gupta, Utkarsh Raj, Himansu Kumar, Pritish Kumar Varadwaj, Adhyana Gupta","doi":"10.1109/BSB.2016.7552157","DOIUrl":"https://doi.org/10.1109/BSB.2016.7552157","url":null,"abstract":"Wheat seed germination directly affects wheat yield and quality. Embryo and endosperm are two main parts of wheat seed and plays crucial role in seed germination and subsequent plant growth and other development. In the process of seed germination a systematic bi-directional molecular interactions are major component and that got affected by the means of abiotic stresses. A variety of proteomic and transcriptomic approaches have been used so far to investigate seed germination process in response to abiotic stresses. In this study, we have investigated deferentially expressed genes/transcripts (DEGs) of embryo and endosperm in response to ABA and H2O2 stress by the means of stress systems biology approaches using microarray data. Further, role of DEGs in response to each stress was explored, which identify biological and molecular functions of genes during seed germination embryo and endosperm. Our results provide the insight into comparative transcriptomic mechanism of the embryo and endosperm in response to ABA and H2O2 treatment during seed germination process.","PeriodicalId":363820,"journal":{"name":"2016 International Conference on Bioinformatics and Systems Biology (BSB)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131139908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-04DOI: 10.1109/BSB.2016.7552160
Noopur Singh, S. Srivastava, Ashok Sharma
microRNAs are small, endogenous, noncoding RNA, work at post-transcriptional level and control the gene regulation in animals and plants. Turmeric is an Asian medicinal plant known for its medicinal properties. The present work focused on identification of the miRNAs take part in the developmental process of turmeric. Eight miRNA families (miR156, miR157, miR159, miR170, miR171, miR319, miR396 and miR5015) were identified by using bioinformatics approach. Phylogenetic analysis of selective miRNAs was performed. Six miRNA families were observed to regulate eighty-six target transcripts. Our results further indicated their role in binding, reproduction, stress and other developmental process. Gene annotation and pathway analysis illustrate the biological function of the targets regulated by the putative miRNAs. Involvement of miR156 and miR5015 in the regulation of rhizome development was also observed. Other miRNAs were found to be involved in the growth and developmental process of turmeric. To the best of our knowledge, this is the first report on miRNA prediction and regulation in turmeric.
{"title":"A bioinformatics study of miRNAs and their regulating targets in Curcuma longa (turmeric)","authors":"Noopur Singh, S. Srivastava, Ashok Sharma","doi":"10.1109/BSB.2016.7552160","DOIUrl":"https://doi.org/10.1109/BSB.2016.7552160","url":null,"abstract":"microRNAs are small, endogenous, noncoding RNA, work at post-transcriptional level and control the gene regulation in animals and plants. Turmeric is an Asian medicinal plant known for its medicinal properties. The present work focused on identification of the miRNAs take part in the developmental process of turmeric. Eight miRNA families (miR156, miR157, miR159, miR170, miR171, miR319, miR396 and miR5015) were identified by using bioinformatics approach. Phylogenetic analysis of selective miRNAs was performed. Six miRNA families were observed to regulate eighty-six target transcripts. Our results further indicated their role in binding, reproduction, stress and other developmental process. Gene annotation and pathway analysis illustrate the biological function of the targets regulated by the putative miRNAs. Involvement of miR156 and miR5015 in the regulation of rhizome development was also observed. Other miRNAs were found to be involved in the growth and developmental process of turmeric. To the best of our knowledge, this is the first report on miRNA prediction and regulation in turmeric.","PeriodicalId":363820,"journal":{"name":"2016 International Conference on Bioinformatics and Systems Biology (BSB)","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133795873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-04DOI: 10.1109/BSB.2016.7552121
D. Arora, V. Singh, Ajeet Singh
Bacteria have the tendency to acquire resistance and develop defense from drug which makes pharmaceutical industries to work and develop new strategies for producing effective antibiotics against them. With molecular advancement and better understanding to their pathway architecture, channel for developing better antibiotics is open. Here we try to understand the enzyme kinetics of each protein and system biology of Salmonella typhi and infected host cell by its virulence factors. With taking in consideration, we have identified expressed protein CDC42, HiLD, and Arp2/3 complex protein in disease state when pathogen attacks the host. This study opens target for developing future drugs against salmonella typhi infection.
{"title":"Modeling and simulation analysis of Salmonella typhimurium inside human epithelial cells: Host-pathogen relationship analysis by system biology","authors":"D. Arora, V. Singh, Ajeet Singh","doi":"10.1109/BSB.2016.7552121","DOIUrl":"https://doi.org/10.1109/BSB.2016.7552121","url":null,"abstract":"Bacteria have the tendency to acquire resistance and develop defense from drug which makes pharmaceutical industries to work and develop new strategies for producing effective antibiotics against them. With molecular advancement and better understanding to their pathway architecture, channel for developing better antibiotics is open. Here we try to understand the enzyme kinetics of each protein and system biology of Salmonella typhi and infected host cell by its virulence factors. With taking in consideration, we have identified expressed protein CDC42, HiLD, and Arp2/3 complex protein in disease state when pathogen attacks the host. This study opens target for developing future drugs against salmonella typhi infection.","PeriodicalId":363820,"journal":{"name":"2016 International Conference on Bioinformatics and Systems Biology (BSB)","volume":"162 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131669717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-04DOI: 10.1109/BSB.2016.7552117
Prashanthi Dharanipragada, N. Parekh
In the last decade, discovery of copy number variations (CNVs) have dramatically changed our understanding of differences between individuals. CNVs include both additional copies of sequence (duplications) and loss of genetic material (deletions) and provide an alternate paradigm for the genetic basis of human diseases. Genome-wide CNV detection is now possible using high-throughput, low-cost next generation sequencing (NGS) methods. Nature of NGS data demands various preprocessing and pretreatment steps before extracting any meaningful information. Among the plethora of variant calling methods available, R-based methods offer flexible environment, facilitating choice of various methods depending on the type of data or type of analysis to be performed. Here we give a pipeline for various steps involved in CNV detection in NGS data using R-based algorithms and packages.
{"title":"Copy number variation detection workflow using next generation sequencing data","authors":"Prashanthi Dharanipragada, N. Parekh","doi":"10.1109/BSB.2016.7552117","DOIUrl":"https://doi.org/10.1109/BSB.2016.7552117","url":null,"abstract":"In the last decade, discovery of copy number variations (CNVs) have dramatically changed our understanding of differences between individuals. CNVs include both additional copies of sequence (duplications) and loss of genetic material (deletions) and provide an alternate paradigm for the genetic basis of human diseases. Genome-wide CNV detection is now possible using high-throughput, low-cost next generation sequencing (NGS) methods. Nature of NGS data demands various preprocessing and pretreatment steps before extracting any meaningful information. Among the plethora of variant calling methods available, R-based methods offer flexible environment, facilitating choice of various methods depending on the type of data or type of analysis to be performed. Here we give a pipeline for various steps involved in CNV detection in NGS data using R-based algorithms and packages.","PeriodicalId":363820,"journal":{"name":"2016 International Conference on Bioinformatics and Systems Biology (BSB)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125933219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-04DOI: 10.1109/BSB.2016.7552130
Ayon Pal, A. K. Bothra, Subhasis Mukhopadhyay
The archaea represents primitive earth dwellers confined mostly to very specialized and extreme habitats, and probably have evolved very early in the history of earth. Glycolysis is an excellent example of convergent evolution in archaea whereby a diversity of glucose degradation schemes exist. This study aims to unravel the strategies employed by different extremophilic species of archaea at the nucleotide and amino acid level to structure a genome as well as proteome, emphasizing particularly, on the glycolytic pathway of monosaccharide oxidation considering its antiquity and early appearance in evolution. We have tried to find out if linear sugar oxidation pathways like glycolysis in all its modified versions have somehow directed genome structuring in the extremophilic archaea. The study of comparative codon usage blueprint and codon pair preference might enable us to scrutinize the fact whether these organisms share any common codon or amino acid utilization outline or, this is entirely a function of their niche specific lifestyle.
{"title":"Glycolysis as a determinant of genome and proteome composition of different extremophilic archaea species","authors":"Ayon Pal, A. K. Bothra, Subhasis Mukhopadhyay","doi":"10.1109/BSB.2016.7552130","DOIUrl":"https://doi.org/10.1109/BSB.2016.7552130","url":null,"abstract":"The archaea represents primitive earth dwellers confined mostly to very specialized and extreme habitats, and probably have evolved very early in the history of earth. Glycolysis is an excellent example of convergent evolution in archaea whereby a diversity of glucose degradation schemes exist. This study aims to unravel the strategies employed by different extremophilic species of archaea at the nucleotide and amino acid level to structure a genome as well as proteome, emphasizing particularly, on the glycolytic pathway of monosaccharide oxidation considering its antiquity and early appearance in evolution. We have tried to find out if linear sugar oxidation pathways like glycolysis in all its modified versions have somehow directed genome structuring in the extremophilic archaea. The study of comparative codon usage blueprint and codon pair preference might enable us to scrutinize the fact whether these organisms share any common codon or amino acid utilization outline or, this is entirely a function of their niche specific lifestyle.","PeriodicalId":363820,"journal":{"name":"2016 International Conference on Bioinformatics and Systems Biology (BSB)","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126991996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.1109/BSB.2016.7552165
Kuntal Ghosh
A new excitatory-inhibitory neural network model for the extended classical receptive field (ECRF) of Parvo (P), and Magno (M) cells in the lateral geniculate nucleus (LGN) is proposed. The model is based upon various well-known findings in neurophysiology, anatomy and psychophysics. The top-down linking of the proposed model to the feed-forward pathways, that is able to explain the simple, yet intriguing problem of brightness perception, may have implication in developing robust visual capturing and display systems, as well as in overall accurate representation of images as has been demonstrated in recent works.
{"title":"A neural network based model of M and P LGN cells","authors":"Kuntal Ghosh","doi":"10.1109/BSB.2016.7552165","DOIUrl":"https://doi.org/10.1109/BSB.2016.7552165","url":null,"abstract":"A new excitatory-inhibitory neural network model for the extended classical receptive field (ECRF) of Parvo (P), and Magno (M) cells in the lateral geniculate nucleus (LGN) is proposed. The model is based upon various well-known findings in neurophysiology, anatomy and psychophysics. The top-down linking of the proposed model to the feed-forward pathways, that is able to explain the simple, yet intriguing problem of brightness perception, may have implication in developing robust visual capturing and display systems, as well as in overall accurate representation of images as has been demonstrated in recent works.","PeriodicalId":363820,"journal":{"name":"2016 International Conference on Bioinformatics and Systems Biology (BSB)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123646915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：