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A24. HEART AND LUNGS: "BETTER TOGETHER"最新文献

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Who's Responsible? Diffuse Alveolar Hemorrhage with Multiple Potential Culprits 谁该对此负责呢?弥漫性肺泡出血有多种潜在的罪魁祸首
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1129
R. Puthumana, C. J. Trujillo
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引用次数: 0
Pneumonitis Due to "Dabbing" Successfully Managed via Extracorporeal Membrane Oxygenation 经体外膜氧合成功治疗轻敷所致肺炎
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1130
L. Meece, J. P. Morán, H.M. McConville, S. Velani
INTRODUCTION: E-cigarette or vaping associated lung injury (EVALI) is an uncommon complication of e-cigarettes or vaping. 96% of these cases require hospitalization. The condition is especially associated with tetrahydrocannabinol (THC) products, frequent use, and is found primarily in young adults. “Dabbing” refers to the process of heating THC containing oils or waxes with butane solvents to vaporize cannabinoids for inhalation. CASE REPORT: An obese 20-year-old college male with a history of prematurity and anxiety presented with cough, dyspnea, nausea, vomiting and diarrhea that began 3 days prior. He reported smoking marijuana, but denied vaping. Multiple PCR tests for SARS-CoV-2 were negative. Initial chest radiograph demonstrated multifocal pneumonia. He was hypoxic on presentation requiring two liters of oxygen via nasal cannula. Broad spectrum antibiotics for pneumonia and steroids were initiated. Oxygen requirements rapidly increased and humidified high flow oxygen was instituted and escalated to 60 liters per minute and 90 % FiO2. He remained hypoxic, prompting intubation 48 hours from presentation. His ventilatory settings were steadily escalated to a positive end expiratory pressure of 15 cm H2O with 100% FiO2. Despite this, the patient had oxygenation saturations as low as 57% requiring transition to venovenous extracorporeal membrane oxygenation (VV-ECMO). Computed tomography angiography ruled out pulmonary embolism but redemonstrated extensive alveolar and interstitial infiltrates bilaterally. Bronchoscopy with alveolar lavage was performed with negative cultures and cytology. Blood cultures were also negative and antibiotic therapy was stopped. Extensive laboratory investigation for autoimmune vasculitis was performed and found to be negative. Discussion with family revealed that the patient regularly inhaled concentrated THC wax with butane as a solvent. Treatment continued with high dose intravenous steroids and supportive care. The patient received a total of 5 days of ventilator support after which he was extubated, and an additional 5 days of VV-ECMO. At discharge, the patient required 2 liters of continuous oxygen at rest and 4 liters with activity. He was otherwise asymptomatic and at his baseline level of function. He was discharged on daily steroids with taper and close outpatient follow up. DISCUSSION: While the majority of hospitalized patients with EVALI require intubation, the necessity of VV-ECMO utilization represents a rare severe presentation. Dabbing remains a rare cause of acute respiratory distress syndrome and EVALI, however, dabbing is emerging as a trend among young adults and represents an under-investigated cause of severe inhalational lung injury.
电子烟或电子烟相关肺损伤(EVALI)是一种罕见的电子烟或电子烟并发症。其中96%的病例需要住院治疗。这种情况与四氢大麻酚(THC)产品的频繁使用特别相关,主要发生在年轻人身上。“涂抹”是指用丁烷溶剂加热含四氢大麻酚的油或蜡,使大麻素蒸发以供吸入的过程。病例报告:一名肥胖的20岁大学男性,有早产和焦虑史,3天前开始出现咳嗽、呼吸困难、恶心、呕吐和腹泻。他说自己吸食大麻,但否认吸电子烟。SARS-CoV-2多重PCR检测均为阴性。最初胸片显示多灶性肺炎。他入院时缺氧需要通过鼻插管吸入两升氧气。开始使用广谱抗生素治疗肺炎和类固醇。氧气需求迅速增加,湿化高流量氧气被建立并升级到每分钟60升和90%的FiO2。他仍然缺氧,在出现48小时后需要插管。他的呼吸设置稳步上升到呼气末正压15 cm H2O和100% FiO2。尽管如此,患者的氧合饱和度低至57%,需要过渡到静脉-静脉体外膜氧合(VV-ECMO)。计算机断层血管造影排除肺栓塞,但再次显示广泛的肺泡和间质浸润双侧。支气管镜及肺泡灌洗行阴性培养及细胞学检查。血培养也呈阴性,并停止抗生素治疗。对自身免疫性血管炎进行了广泛的实验室调查,结果为阴性。与家人讨论后发现,患者经常吸入以丁烷为溶剂的浓缩四氢大麻酚蜡。治疗继续给予大剂量静脉注射类固醇和支持性护理。患者总共接受了5天的呼吸机支持,之后拔管,并额外接受了5天的VV-ECMO。出院时,患者静息时需连续供氧2升,活动时需连续供氧4升。其他方面无症状,功能处于基线水平。出院时每日服用类固醇,逐渐减少剂量,门诊随访密切。讨论:虽然大多数EVALI住院患者需要插管,但使用VV-ECMO的必要性代表了罕见的严重表现。轻拍仍然是一种罕见的急性呼吸窘迫综合征和EVALI的原因,然而,轻拍在年轻人中正在成为一种趋势,并且代表了一种未充分研究的严重吸入性肺损伤的原因。
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引用次数: 1
A Case of Acute Interstitial Pneumonia (AIP) 急性间质性肺炎1例
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1137
S. Jarrett, A. Matta, S. Benzaquen
Introduction: Acute interstitial pneumonia (AIP) also known as Hamman-Rich Syndrome is an uncommon, acute, and rapidly progressive idiopathic pulmonary disease that often leads to acute respiratory distress syndrome (ARDS). We present a case of a 52-year-old male who developed this condition. Case: A 52-year-old male with no past medical history presented to the emergency department with a 3-day history of progressively worsening dyspnea, dry cough, and chills. Prior to symptom onset, he was in his usual state of health but did report having polyarthralgia mainly involving large joints with no other associated symptoms. He denied a history of sick contacts including COVID exposure, sexually transmitted infections, incarceration, intravenous drug abuse, or travel to tuberculosis endemic countries. He denied tobacco use and any other form of illicit drug use. On physical examination, he was afebrile, tachycardic, and hypoxic on room air. He appeared to be in no respiratory distress and chest was clear to auscultation. There were no joint abnormalities, skin rashes, or lymphadenopathy. Lab workup revealed elevated D-Dimer (2140 ng/mL), CRP (50 mg/L), lactate dehydrogenase (296 IU/L), ferritin (578 ng/mL). His SARSCoV2 PCR was negative. Chest X-ray and CT chest both revealed right pleural effusion and diffuse reticular and ground-glass opacities. He underwent thoracentesis and fluid analysis revealed lymphocytic exudate with negative cultures. Antibiotics and steroids were initiated. He underwent a complete rheumatologic workup including myositis panel, due to concern for possible autoimmune etiologies and it was negative. His respiratory status worsened, and he eventually required intubation. At this point given unclear etiology, he underwent bronchoscopy with transbronchial cryobiopsy. Cryobiopsy revealed evidence of organizing phase of diffuse alveolar damage (Figure 1) and in the setting of negative cultures, COVID-19 and autoimmune panel, there was a growing concern for acute interstitial pneumonia. The patient was started on pulse dose of steroids and transferred to a transplant center for lung transplantation evaluation. Discussion: Acute interstitial pneumonia is a rare idiopathic clinicopathological condition that is characterized clinically by rapid onset of respiratory failure in patients with no past medical history of pre-existing lung disease. Histopathological findings are identical to those of diffuse alveolar damage. Closely resembling ARDS, it is frequently confused with other clinical entities characterized by rapidly progressive interstitial pneumonia. Considering this a high index of suspicion is required to diagnose these patients and institute appropriate management as mortality is as high as 70%. (Figure Presented).
简介:急性间质性肺炎(AIP)也称为哈曼-里奇综合征,是一种罕见的急性、快速进展的特发性肺部疾病,常导致急性呼吸窘迫综合征(ARDS)。我们提出一个52岁的男性谁发展这种情况的情况。病例:52岁男性,无既往病史,因呼吸困难、干咳和发冷3天进行性加重就诊于急诊科。在症状出现之前,他的健康状况正常,但确实报告有多关节痛,主要累及大关节,无其他相关症状。他否认有患病史,包括接触新冠病毒、性传播感染、监禁、静脉注射药物滥用或前往结核病流行国家。他否认使用烟草和任何其他形式的非法药物。经体格检查,他有发热、心动过速和室内空气缺氧症状。他似乎没有呼吸窘迫,听诊胸廓清晰。没有关节异常、皮疹或淋巴结病。实验室检查显示d -二聚体(2140 ng/mL)、CRP (50 mg/L)、乳酸脱氢酶(296 IU/L)、铁蛋白(578 ng/mL)升高。SARSCoV2 PCR阴性。胸部x线及CT均显示右侧胸腔积液及弥漫性网状及磨玻璃样混浊。他接受了胸腔穿刺和液体分析,发现淋巴细胞渗出,培养阴性。开始使用抗生素和类固醇。他接受了完整的风湿病检查,包括肌炎小组,由于担心可能的自身免疫性病因,结果为阴性。他的呼吸状况恶化,最终需要插管。由于病因不明,他接受了支气管镜检查和经支气管冷冻活检。低温活检显示弥漫性肺泡损伤的组织期证据(图1),在阴性培养、COVID-19和自身免疫组的情况下,急性间质性肺炎的担忧日益增加。患者开始使用脉冲剂量的类固醇,并转移到移植中心进行肺移植评估。讨论:急性间质性肺炎是一种罕见的特发性临床病理疾病,其临床特征是在没有既往肺部疾病病史的患者中快速发作呼吸衰竭。组织病理学结果与弥漫性肺泡损伤相同。与急性呼吸窘迫综合征非常相似,它经常与其他以快速进展的间质性肺炎为特征的临床实体混淆。考虑到这一点,诊断这些患者并采取适当的管理需要高度的怀疑指数,因为死亡率高达70%。(图)。
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引用次数: 0
Acute Monocytic Leukemia: A Rare but Devastating Cause of ARDS 急性单核细胞白血病:急性呼吸窘迫综合征的罕见但毁灭性的原因
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1141
A. Soleiman, G. Eman, M. Islam
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引用次数: 0
Plastic Bronchitis After Minimally Invasive Mitral Valve Replacement: An Unusual Etiology of Acute Respiratory Failure After Cardiac Surgery 微创二尖瓣置换术后的塑性支气管炎:心脏手术后急性呼吸衰竭的一种不寻常的病因
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1143
J.M. Zapata -Canivilo, F. Amin, E. Belley‐Cote, A. Alsagheir, A. Fox-Robichaud, V. Chu, S. Tang
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引用次数: 0
A Rare Cause of Acute Throat Pain: Acute Aortic Dissection 急性咽喉痛的一个罕见原因:急性主动脉夹层
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1133
I.A. Martinez Avalos, V. Hoytfox
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引用次数: 0
Use of Perfluorocarbon for Pediatric Pulmonary Hemorrhage 全氟碳化合物在儿童肺出血中的应用
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1120
K. Nelson McMillan, V. Dorsey, F. Yousaf, S. Kane, A. Waas, C. Urbas, C. E. El Zein, N. Hibino, J. Sherman, L. Vricella
{"title":"Use of Perfluorocarbon for Pediatric Pulmonary Hemorrhage","authors":"K. Nelson McMillan, V. Dorsey, F. Yousaf, S. Kane, A. Waas, C. Urbas, C. E. El Zein, N. Hibino, J. Sherman, L. Vricella","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1120","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1120","url":null,"abstract":"","PeriodicalId":364486,"journal":{"name":"A24. HEART AND LUNGS: \"BETTER TOGETHER\"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133957635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hidden Between the Lines: Acute Eosinophilic Pneumonia Masquerading as Heart Failure 隐藏在字里行间:伪装成心力衰竭的急性嗜酸性肺炎
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1122
A. Davis, J. Kanne, H. Faust
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引用次数: 0
Cardiac Tamponade - A Rare Complication of Sjogren's Syndrome 心脏填塞——干燥综合征的一种罕见并发症
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1126
Y. Medik, C. Schooff, W. Khan
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引用次数: 2
A Rare Case of Left-Sided Unilateral Pulmonary Edema in Acute Mitral Regurgitation 急性二尖瓣返流致左侧单侧肺水肿1例
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1131
C. Kang, P. Khamooshi, V. Reyes Pinzon, N. Haghani Rad
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引用次数: 0
期刊
A24. HEART AND LUNGS: "BETTER TOGETHER"
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