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JOURNAL OF MENTAL HEALTH AND CLINICAL PSYCHOLOGY最新文献

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Concept and Results of the German Research Network on Schizophrenia 德国精神分裂症研究网络的概念和结果
Pub Date : 2018-07-01 DOI: 10.29245/2578-2959/2018/4.1152
W. Wölwer
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引用次数: 2
Commentary: Comparative Genomic Analysis of Ten Clinical Streptococcus pneumoniae Collected From a Malaysian Hospital Reveal 31 New Unique Drug-Resistant SNPs Using Whole Genome Sequencing 评论:利用全基因组测序对马来西亚一家医院收集的10种临床肺炎链球菌进行比较基因组分析,揭示了31个新的独特耐药snp
Pub Date : 2018-07-01 DOI: 10.29245/2578-2959/2018/4.1153
S. Sekaran
Despite the effort and decades of research, S. pneumoniae remains a primary cause of infectious morbidity and mortality worldwide. Although Antibiotics are lifesaving medications that offer tremendous benefits to patients with infectious diseases. Yet, several reports have revealed that the overuse and misuse of these agents had led to antibiotic resistance. Our study utilized whole genome sequencing (WGS) to reveal the pattern of antibiotic-resistance among ten pneumococcal isolates with various degree of susceptibility to antibacterial drugs. The main purpose of our study was to explore genetic variations related to drug-resistance in those ten strains. The results indicated that pneumococcal strains with resistant profile were associated with greater number of SNPs compared to susceptible ones. Out of all the SNPs identified, 31 were unique and had not been reported before. Our data propose that these SNPs could possess an important role in modifying the degree of sensitivity to different antibacterial drugs. In this article we comment on the methodology and results of our study which previously published in Journal of Biomedical Science.
尽管经过数十年的努力和研究,肺炎链球菌仍然是世界范围内传染性发病率和死亡率的主要原因。虽然抗生素是拯救生命的药物,为传染病患者提供了巨大的好处。然而,一些报告显示,这些药物的过度使用和误用已导致抗生素耐药性。本研究利用全基因组测序(WGS)揭示了10株对抗菌药物有不同程度敏感性的肺炎球菌的耐药模式。我们研究的主要目的是探索这10种菌株与耐药相关的遗传变异。结果表明,具有耐药谱的肺炎球菌菌株与易感菌株相比具有更多的snp。在鉴定出的所有snp中,有31个是独一无二的,以前没有报道过。我们的数据表明,这些snp可能在改变对不同抗菌药物的敏感性程度方面发挥重要作用。在这篇文章中,我们对之前发表在《生物医学科学杂志》上的研究方法和结果进行了评论。
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引用次数: 0
Commentary: Using Electroencephalography Measurements and High-quality Video Recording for Analyzing Visual Perception of Media Content 评论:使用脑电图测量和高质量视频记录分析媒体内容的视觉感知
Pub Date : 2018-07-01 DOI: 10.29245/2578-2959/2018/4.1163
Celia Andreu-Sánchez
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引用次数: 0
Risperidone Response in Schizophrenia: A Narrative Review of Pharmaco-Genetic Research 精神分裂症的利培酮反应:药物遗传学研究的叙述性回顾
Pub Date : 2018-07-01 DOI: 10.29245/2578-2959/2018/4.1161
J. Aneja
Background: The response to risperidone in patients with schizophrenia is influenced by many factors including the genetic ones. The innovations in biotechnology have provided essential tools for conduction of pharmacogenetic research and subsequently a number of pharmaco-dynamic and pharmaco-kinetic studies delineating the response of anti-psychotics in schizophrenia have been conducted till date. So, we may prevision that pharmaco-genetic knowledge can provide us with the tools to personalize treatment in routine psychiatric clinical practice.
背景:精神分裂症患者对利培酮的反应受多种因素影响,包括遗传因素。生物技术的创新为进行药物遗传学研究提供了必要的工具,随后进行了许多描述抗精神病药物对精神分裂症反应的药效学和药效学研究。因此,我们可以预见,药物遗传学知识可以为我们在日常精神病学临床实践中提供个性化治疗的工具。
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引用次数: 3
Improving the Methodological Quality of Single-Case Experimental Design Meta-Analysis 提高单例实验设计meta分析的方法学质量
Pub Date : 2018-07-01 DOI: 10.29245/2578-2959/2018/4.1140
L. Jamshidi
Improving the Methodological Quality of Single-Case Experimental Design Meta-Analysis Laleh Jamshidi1*, Lies Declercq1, John M. Ferron2, Mariola Moeyaert3, S. Natasha Beretvas4, and Wim Van den Noortgate1 1 Faculty of Psychology and Educational Sciences & imec-Itec, KU Leuven (University of Leuven), Belgium 2 University of South Florida, Tampa, Florida, USA 3 University at Albany – State University of New York, New York, USA 4 University of Texas at Austin, Texas, USA
Laleh Jamshidi1*, Lies declerc1, John M. Ferron2, Mariola moeyaer3, S. Natasha Beretvas4, and Wim Van den Noortgate1 1比利时鲁汶大学心理与教育科学学院及imec-Itec 2美国南佛罗里达大学坦帕分校3美国奥尔班大学-纽约州立大学纽约分校4美国德克萨斯大学奥斯汀分校
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引用次数: 0
The Use of Gardening and Green Space Therapy in Mental Health is Increasingly Important 园艺和绿地疗法在心理健康中的应用越来越重要
Pub Date : 1900-01-01 DOI: 10.29245/2578-2959/2019/1.1173
Richard Thompson
In many countries, including the United Kingdom (UK), Health Services are under increasing pressure of workload and since this will inexorably continue, even with appropriately increased funding, every attempt to improve the health of the population and prevent illness must be welcomed. Thus gardening and green care, which are forms of complementary therapy and social prescribing, are cheap, safe and effective treatments for mental and physical problems, and can help to improve the disparity between the efficacy of treatments for physical and mental health1,2,3. Such alternatives to increasingly expensive drug therapies must be studied and applied, if only to reduce the incidence of the increasingly complex side effects of drugs, and the large number of admissions to hospital and deaths that are attributed to these.
在包括联合王国在内的许多国家,保健服务部门承受着越来越大的工作量压力,由于即使适当增加资金,这种情况也将不可避免地继续下去,因此必须欢迎改善人口健康和预防疾病的一切努力。因此,园艺和绿色护理作为补充疗法和社会处方的形式,是治疗身心问题的廉价、安全和有效的方法,有助于改善身心健康治疗效果之间的差距1,2,3。必须研究和应用这些替代日益昂贵的药物疗法的方法,哪怕只是为了减少药物日益复杂的副作用的发生率,以及由此导致的大量住院和死亡人数。
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引用次数: 1
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JOURNAL OF MENTAL HEALTH AND CLINICAL PSYCHOLOGY
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