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Frontiers in Clinical Drug Research: Anti-Infectives最新文献

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Monoclonal Antibodies as Therapeutic Agents for Inflammatory Diseases 单克隆抗体作为炎性疾病的治疗剂
Frontiers in Clinical Drug Research: Anti-Infectives
Pub Date : 2021-12-07 DOI: 10.2174/9789815039412121080003
Jéssica Bairos, Emanuel V. Capela, Ana P. M. Tavares, M. Freire
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引用次数: 0
Anthelmintic Drug Discovery: Current Situation and Future Perspectives 驱虫药的发现:现状与未来展望
Frontiers in Clinical Drug Research: Anti-Infectives
Pub Date : 2021-12-07 DOI: 10.2174/9789815039412121080007
M. G. Blanco, M. J. De Rosa, D. Rayes
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引用次数: 0
Anti-infectives to Combat Leishmaniasis 抗利什曼病的抗感染药物
Frontiers in Clinical Drug Research: Anti-Infectives
Pub Date : 2021-12-07 DOI: 10.2174/9789815039412121080006
Shalini Roy, Anindita Ukil, P. Das
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引用次数: 1
Therapeutic Targets for Emerging Zika Virus Infection and Vaccines in Clinical Trials 新发寨卡病毒感染的治疗靶点和临床试验中的疫苗
Frontiers in Clinical Drug Research: Anti-Infectives
Pub Date : 2021-12-07 DOI: 10.2174/9789815039412121080008
Deepthi Ramesh, B. Vijayakumar, T. Kannan
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引用次数: 0
Agro-Industrial Waste: New Source of Raw Material for the Control of American Foulbrood in Honey Bees 农工废弃物:防治蜜蜂美洲臭蝇的新原料来源
Frontiers in Clinical Drug Research: Anti-Infectives
Pub Date : 2021-12-07 DOI: 10.2174/9789815039412121080009
Pablo Giménez-Martínez, C. Ramírez, Florencia Fangio, A. Iglesias, Sandra Churio, M. Maggi, S. Fuselli
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引用次数: 0
Frontiers in Clinical Drug Research: Anti-Infectives: Volume 8 临床药物研究前沿:抗感染:第8卷
Frontiers in Clinical Drug Research: Anti-Infectives
Pub Date : 2021-12-07 DOI: 10.2174/97898150394121210801
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引用次数: 0
Antiviral Activity of Vitamin D and COVID 19: Current Understanding 维生素D与COVID - 19的抗病毒活性:目前的认识
Frontiers in Clinical Drug Research: Anti-Infectives
Pub Date : 2021-12-07 DOI: 10.2174/9789815039412121080005
Mahmood A Al-Azzawi, Moustafa A. Sakr
Innate and adaptive immune responses, which are intimately related to the evolution of many infectious diseases, are influenced by the biologically active form of vitamin D. From a mechanical perspective, there are several rationales to assume that vitamin D positively modifies host responses to SARS-CoV-2, either in the early infection or subsequent hyper-inflammatory stages of COVID-19. It has been long known that vitamin D metabolites induce antiviral effects through indirect and direct mechanisms via antimicrobial peptides, immune modulation, the interaction between major viral and cellular particles, initiation of apoptosis and autophagy, and diversity of hereditary and epigenetic aspects. The remarkable overlap between the deficiency of vitamin D and risk factors for severe COVID-19, including obesity, aging, and Black or Asian ethnicity, has motivated researchers to assume that supplementation of vitamin D can be promising as a preventive or treatment agent for COVID-19. Since the outset of the pandemic, researchers have integrated literature searches and cross-sectional statistical studies to appraise the vitamin D level impact of COVID-19, whereby nearly 30 observational studies have confirmed that the incidence, severity, and mortality of COVID-19 are inversely related to the serum 25OHD concentrations. Also, some recently announced clinical trials indicated that vitamin D supplementation has a positive effect on the severity of COVID-19;however, other studies, including clinical trials, have not supported that, especially if we take into account what was revealed in a recent clinical trial, i.e., airway diseases are related to the irregular metabolism of vitamin D increasing the potential of developing vitamin D deficiency due to pulmonary inflammation. Therefore, more dedicated studies are required without critical limitations to ascertain the actual effect of vitamin D in preventing and treating COVID-19, and if its effectiveness is proven, the effective dose must be determined. © 2021 Bentham Science Publishers. All rights reserved.
先天免疫反应和适应性免疫反应与许多传染病的进化密切相关，它们受到维生素D生物活性形式的影响。从力学角度来看，有几个理由可以假设维生素D在COVID-19的早期感染或随后的高炎症阶段积极改变宿主对SARS-CoV-2的反应。人们早就知道，维生素D代谢物通过抗菌肽、免疫调节、主要病毒与细胞颗粒之间的相互作用、细胞凋亡和自噬的启动以及遗传和表观遗传的多样性等间接和直接机制诱导抗病毒作用。维生素D缺乏与严重COVID-19的风险因素(包括肥胖、衰老、黑人或亚洲种族)之间存在显著的重叠，这促使研究人员认为补充维生素D有望成为COVID-19的预防或治疗药物。自大流行开始以来，研究人员通过文献检索和横断面统计研究来评估COVID-19对维生素D水平的影响，其中近30项观察性研究证实，COVID-19的发病率、严重程度和死亡率与血清25OHD浓度呈负相关。此外，最近公布的一些临床试验表明，补充维生素D对COVID-19的严重程度有积极影响;然而，包括临床试验在内的其他研究并不支持这一点，特别是如果我们考虑到最近的一项临床试验所揭示的结果，即气道疾病与维生素D的不规则代谢有关，增加了肺部炎症导致维生素D缺乏症的可能性。因此，需要更多的专门研究来确定维生素D在预防和治疗COVID-19方面的实际效果，如果其有效性得到证实，则必须确定有效剂量。©2021边沁科学出版社。版权所有。
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引用次数: 0
Pharmacotherapy of Emerging Antiviral Agents 新兴抗病毒药物的药物治疗
Frontiers in Clinical Drug Research: Anti-Infectives
Pub Date : 2021-12-07 DOI: 10.2174/9789815039412121080004
G. Doshi, H. Ved, Ami Thakkar, N. Bhatia, Prachi Pimple
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引用次数: 0
Frontiers in Clinical Drug Research: Anti-Infectives: Volume 7 临床药物研究前沿:抗感染:第7卷
Frontiers in Clinical Drug Research: Anti-Infectives
Pub Date : 2021-07-02 DOI: 10.2174/97898149980931210701
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引用次数: 0
Host-Directed, Antibiotic-Adjuvant Combination, and Antibiotic-Antibiotic Combination for Treating Multidrug-Resistant (MDR) Gram- Negative Pathogens 宿主导向，抗生素-佐剂联合，抗生素-抗生素联合治疗多重耐药(MDR)革兰氏阴性病原体
Frontiers in Clinical Drug Research: Anti-Infectives
Pub Date : 2021-07-02 DOI: 10.2174/9789814998093121070004
W. Leowattana, Pathomthep Leowattana, Tawithep Leowattana
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引用次数: 0
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