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Ethical and practical considerations arising from community consultation on implementing controlled human infection studies using Schistosoma mansoni in Uganda. 在乌干达利用曼氏血吸虫开展人类感染控制研究的社区磋商中产生的伦理和实际考虑因素。
Q1 Arts and Humanities Pub Date : 2022-07-04 eCollection Date: 2022-01-01 DOI: 10.1080/11287462.2022.2091503
Moses Egesa, Agnes Ssali, Edward Tumwesige, Moses Kizza, Emmanuella Driciru, Fiona Luboga, Meta Roestenberg, Janet Seeley, Alison M Elliott

Issues related to controlled human infection studies using Schistosoma mansoni (CHI-S) were explored to ensure the ethical and voluntary participation of potential CHI-S volunteers in an endemic setting in Uganda. We invited volunteers from a fishing community and a tertiary education community to guide the development of informed consent procedures. Consultative group discussions were held to modify educational materials on schistosomiasis, vaccines and the CHI-S model and similar discussions were held with a test group. With both groups, a mock consent process was conducted. Fourteen in-depth key informant interviews and three group discussions were held to explore perceptions towards participating in a CHI-S. Most of the participants had not heard of the CHI-S. Willingness to take part depended on understanding the study procedures and the consenting process. Close social networks were key in deciding to take part. The worry of adverse effects was cited as a possible hindrance to taking part. Volunteer time compensation was unclear for a CHI-S. Potential volunteers in these communities are willing to take part in a CHI-S. Community engagement is needed to build trust and time must be taken to share study procedures and ensure understanding of key messages.

我们探讨了使用曼氏血吸虫(CHI-S)进行控制性人类感染研究的相关问题,以确保潜在的 CHI-S 志愿者在乌干达流行病环境中的道德和自愿参与。我们邀请了来自渔业社区和高等教育社区的志愿者,以指导知情同意程序的制定。我们举行了咨询小组讨论,以修改有关血吸虫病、疫苗和 CHI-S 模式的教育材料,并与一个测试小组进行了类似的讨论。两个小组都进行了模拟同意程序。对关键信息提供者进行了 14 次深入访谈,并举行了 3 次小组讨论,以探讨他们对参与 CHI-S 的看法。大多数参与者都没有听说过 CHI-S。是否愿意参与取决于对研究程序和同意过程的理解。亲密的社交网络是决定是否参与的关键。担心不良影响可能是阻碍参与的一个因素。对 CHI-S 而言,志愿者的时间补偿并不明确。这些社区的潜在志愿者愿意参与社区健康倡议活动。社区参与需要建立信任,必须花时间分享研究程序并确保理解关键信息。
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引用次数: 0
Glocalization of bioethics 生命伦理学的全球本土化
Q1 Arts and Humanities Pub Date : 2022-03-19 DOI: 10.1080/11287462.2022.2052603
Himani Bhakuni
ABSTRACT There appears to be a conflict between global bioethical principles and the local understanding and application of these principles, but this conflict has misleadingly been characterized through the east–west dichotomy. This dichotomy portrays bioethical principles as western and as alien to non-western cultures. In this paper, I present reasons to reject the east–west dichotomy. Using the discussion around the principle of informed consent as an example, I propose that while bioethical values are common, bioethical governance must display a certain flexibility akin to Aristotle’s metaphor about the Lesbian rule. Such flexibility combined with a deeper understanding of the lived experiences of bioethical subjects might lead to the purging of tensions between global and local, giving us Glocal Bioethics.
全球生物伦理原则与当地对这些原则的理解和应用之间似乎存在冲突,但这种冲突被误导性地描述为东西方二分法。这种二分法将生物伦理原则描绘为西方文化和非西方文化的异类。在本文中,我提出了拒绝东西方二分法的理由。以关于知情同意原则的讨论为例,我提出,虽然生物伦理价值观是普遍的,但生物伦理治理必须表现出一定的灵活性,类似于亚里士多德关于女同性恋规则的比喻。这种灵活性与对生物伦理主体生活经验的更深入理解相结合,可能会消除全球与地方之间的紧张关系,给我们带来全球生物伦理学。
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引用次数: 1
Sustainable biobanks: a case study for a green global bioethics. 可持续生物银行:绿色全球生物伦理的案例研究
Q1 Arts and Humanities Pub Date : 2022-02-24 eCollection Date: 2022-01-01 DOI: 10.1080/11287462.2021.1997428
G Samuel, F Lucivero, A M Lucassen

This paper argues that as we move to redefine global bioethics, there is a need to be attentive to the ethical issues associated with the environmental sustainability of data and digital infrastructures in global health systems. We show that these infrastructures have thus far featured little in environmental impact discussions in the context of health, and we use a case study approach of biobanking to illustrate this. We argue that this missing discussion is problematic because biobanks have environmental impacts associated with data and digital infrastructures. We consider several ethical questions to consider these impacts: what ethical work does the concept of environmental sustainability add to the debate; how should this concept be prioritised in decision-making; and who should be responsible for doing so? We call on global bioethics to play a role in advancing this dialogue and addressing these questions.

摘要本文认为,在我们重新定义全球生物伦理的过程中,有必要关注与全球卫生系统中数据和数字基础设施的环境可持续性相关的伦理问题。我们表明,到目前为止,这些基础设施在健康背景下的环境影响讨论中几乎没有出现,我们使用生物库的案例研究方法来说明这一点。我们认为,这种缺失的讨论是有问题的,因为生物库对环境的影响与数据和数字基础设施有关。我们考虑了几个伦理问题来考虑这些影响:环境可持续性的概念在辩论中增加了什么伦理工作;如何在决策中优先考虑这一概念;谁应该对此负责?我们呼吁全球生物伦理学在推动对话和解决这些问题方面发挥作用。
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引用次数: 0
Towards a feminist global ethics. 走向女权主义全球伦理
Q1 Arts and Humanities Pub Date : 2022-02-10 eCollection Date: 2022-01-01 DOI: 10.1080/11287462.2021.2011002
Rosemarie Tong

In this article, I explain what makes a global bioethics "feminist" and why I think this development makes a better bioethics. Before defending this assertion explicitly, I engage in some preliminary work. First, I attempt to define global bioethics, showing why the so-called feminist sameness-difference debate [are men and women fundamentally the same or fundamentally different?] is of relevance to this attempt. I then discuss the difference between rights-based feminist approaches to global bioethics and care-based feminist approaches to global bioethics. Next, I agree with a significant number of feminist bioethicists that care is a more fundamental moral value and practice than justice. Finally, I conclude that feminists' insights about care, even more than rights, can bring us closer to achieving an inclusive, diverse, and fair feminist global bioethics.

在本文中,我将解释全球生命伦理学 "女性主义 "的内涵,以及为什么我认为这种发展会带来更好的生命伦理学。在为这一论断明确辩护之前,我做了一些初步工作。首先,我试图给全球生命伦理学下一个定义,说明为什么所谓的女权主义 "同一性-差异性 "辩论(男女在本质上是相同的还是不同的?然后,我讨论了以权利为基础的女权主义全球生命伦理学研究方法与以关爱为基础的女权主义全球生命伦理学研究方法之间的区别。接下来,我同意许多女性主义生命伦理学家的观点,即关爱是比正义更基本的道德价值和实践。最后,我得出结论,女性主义者对关爱的洞察力,甚至比对权利的洞察力,能够使我们更接近于实现一种包容、多样和公平的女性主义全球生命伦理学。
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引用次数: 0
Global bioethics: it's past and future. 全球生物伦理学:过去和未来。
Q1 Arts and Humanities Pub Date : 2022-02-08 eCollection Date: 2022-01-01 DOI: 10.1080/11287462.2021.2011009
Cheryl Macpherson
A google scholar search for “global bioethics” returns citations situating ethical analyses within the evolving social and physical features of the global environment. Such work is consistent with Van Rensselaer Potter’s “Global Bioethics” (1988) and its application of bioethics to global issues of health and human survival such as nuclear war and what he called “global warming”. Ruth Macklin, in this special issue (SI), offers the Covid-19 pandemic as such an issue and delineates global bioethics from “international bioethics” which address countryspecific issues isolated from wider global influences. A search for “global bioethics” in non-academic search engines returns items about international bioethics, and not global bioethics. This editorial concludes this special issue (SI) by underscoring links between its contents and the history of global bioethics, offering a view to the future of global bioethics as a field and future aims and scope of this journal. It turns out that the field contributed to the establishment of this journal although it’s contents shifted over time into Macklin’s international bioethics. This SI examines what global bioethics might bring to the often distressing global environments of the 2020’s and associated animosities, misinformation, and information overload. It’s authors show how globalization influences health and increases dependence of individuals and populations on global systems for essential resources: food, water, shelter, air, and more. Globalization seems driven primarily by industrial and corporate entities that have wealth and power. In maximizing growth and profit for their shareholders, they may choose to embrace health-promoting or health-harming strategies and policies. Authors herein suggest that examining competing interests like these in a global (as well as international and local) context may increase transparency and better inform decision-making and policies to protect human health and survival long into the future. Several things surprised me in the process of reading the contents of this SI. One was Rosemary Tong’s explicit wish that she had paid more attention to Potter’s views early in her career. Another was something she and others herein state that I had not known that Potter’s views contributed to establishing the International Association for Bioethics (IAB), International Association for Feminist Approaches to Bioethics (FAB), and International Bioethics Committee (IBC). Like Macklin, Tong turns to pandemic planning and cooperation while offering some history. Tong hopes “for a future, care-based feminist global bioethics... [because] unless we human beings learn how to care for each other...we cannot hope to respect each other’s rights” or protect and share resources essential for human health and survival. Macklin pragmatically concludes that diplomacy is “a necessary ingredient” in engaging with “ethical aspects of relations between and among nations or regions”. Effective dip
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引用次数: 1
Introduction 介绍
Q1 Arts and Humanities Pub Date : 2022-02-06 DOI: 10.1080/11287462.2021.2011000
C. Richie
Eva Feder Kittay's characterization of "rights/justice-based ethics/bioethics on the one hand and relationships/care-based ethics/bioethics on the other hand", noted in Tong's essay, could be both inward or outward in application. Taken in aggregate, the articles which were solicited for our thematic issue, which attempts to re-define global bioethics and "deepen understandings of what "global bioethics" is and does" simply does just that. Yet, as Gustavo Ortiz Millán's commentary on Macklin's article suggests, "a more globalized world presents bioethics with new challenges;cases that call for a global response and also a global bioethics.". [Extracted from the article]
在童的文章中,伊娃·费德·基泰对“一方面是权利/基于正义的伦理/生物伦理,另一方面是关系/基于关怀的伦理/生命伦理”的描述既可以是内在的,也可以是外在的。总的来说,为我们的主题问题征集的文章试图重新定义全球生物伦理学,并“加深对“全球生物伦理学”是什么和做什么的理解”,只是做了这件事。然而,正如Gustavo Ortiz Millán对Macklin文章的评论所表明的那样,“一个更加全球化的世界给生物伦理学带来了新的挑战;需要全球应对的案例,也需要全球生物伦理学。”
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引用次数: 0
Bioethics, globalization and pandemics. 生物伦理学、全球化和流行病。
Q1 Arts and Humanities Pub Date : 2022-02-06 eCollection Date: 2022-01-01 DOI: 10.1080/11287462.2021.2011006
Gustavo Ortiz-Millán

Bioethics should pay more attention to globalization and some of its consequences than it has done so far. The COVID-19 pandemic would not have been possible without globalization, which has also increased some of its negative consequences. Globalization has intensified wildlife trade in the world. One of the main hypotheses about the origin of this pandemic is that it originated in illegal forms of wildlife trade in China. In the last 30 or 40 years, there have been zoonotic outbreaks at a much frequent pace than before, many of those have been related to wildlife trade. Legal and illegal wildlife trade has grown in the shadow of globalization. Second, globalization has had a huge impact on the redistribution of wealth in the world. Since 1990 income inequality has increased in most high- and in many middle- and low-income countries. A country's level of pre-COVID income inequality is the best predictor of the COVID death rate. These two issues are not unrelated. People living in poverty in LMIC tend to suffer more from infectious diseases and tend to be marginalized from the health sector. Additionally, poverty tends to reproduce the conditions under which zoonotic diseases can more easily spread.

生物伦理学应当比迄今为止更加关注全球化及其某些后果。如果没有全球化,COVID-19 大流行病就不可能发生,而全球化也增加了它的一些负面后果。全球化加剧了世界野生动植物贸易。关于这一大流行病的起源,一个主要的假设是它起源于中国的非法野生动物贸易。在过去的三四十年里,人畜共患病的爆发比以前频繁得多,其中许多都与野生动物贸易有关。合法和非法的野生动物贸易在全球化的阴影下愈演愈烈。其次,全球化对世界财富的再分配产生了巨大影响。自 1990 年以来,大多数高收入国家和许多中低收入国家的收入不平等现象加剧。一个国家 COVID 前的收入不平等水平是 COVID 死亡率的最佳预测指标。这两个问题并非毫无关联。在低收入和中等收入国家,生活在贫困中的人们往往更容易患上传染病,而且往往被卫生部门边缘化。此外,贫困往往使人畜共患病更容易传播。
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引用次数: 0
The Role of Care. 关爱的作用。
Q1 Arts and Humanities Pub Date : 2022-02-04 eCollection Date: 2022-01-01 DOI: 10.1080/11287462.2021.2011007
Christine Overall

"The Role of Care" is a commentary on "Towards a Feminist Global Ethics," by Rosemarie Tong.

"关爱的作用 "是对 Rosemarie Tong 所著《迈向女权主义全球伦理》的评论。
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引用次数: 0
The challenges of global bioethics. 全球生物伦理学的挑战。
Q1 Arts and Humanities Pub Date : 2022-02-04 eCollection Date: 2022-01-01 DOI: 10.1080/11287462.2021.2011008
Henk Ten Have

The Covid-19 pandemic is associated with an increase in ethics publications and an upsurge of interest in global bioethics. This commentary argues that global bioethics is broader than international bioethics, as defined by Macklin, because the nature of moral problems is determined by processes and practices of globalization, and because a broader theoretical perspective is required. Such perspective acknowledges the connectedness and relationality of human beings, as assumed in the care-based feminist bioethics defended by Tong. The commentary finally claims that a rights-based approach is not opposed to but reinforces a care-based global bioethics.

2019冠状病毒病大流行与伦理学出版物的增加和对全球生物伦理学的兴趣高涨有关。这篇评论认为,全球生物伦理学比麦克林所定义的国际生物伦理学更广泛,因为道德问题的本质是由全球化的过程和实践决定的,因为需要更广泛的理论视角。这种观点承认了人类的联系和关系,正如Tong所捍卫的基于关怀的女性主义生命伦理学所假设的那样。评论最后声称,以权利为基础的方法并不反对而是加强了以护理为基础的全球生物伦理。
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引用次数: 2
A new definition for global bioethics: COVID-19, a case study. 全球生物伦理学的新定义:COVID-19案例研究
Q1 Arts and Humanities Pub Date : 2022-02-04 eCollection Date: 2022-01-01 DOI: 10.1080/11287462.2021.2011001
Ruth Macklin

A truly global bioethics involves cooperation and collaboration among countries. Most of the articles published in bioethics journals address a problem that exists in one or more countries, but the articles typically do not discuss solutions that require collaboration or cooperation. COVAX is one example of proposed international cooperation related to the current COVID-19. pandemic. Yet it is evident that nations have been proceeding on their own with little, if any collaboration. Despite international research ethics guidance from the World Health Organization (WHO), an article published under WHO auspices violates an ethical principle rejecting "double standards" in the conduct of global research. The COVID pandemic provides an opportunity for countries to learn from the recent lack of international cooperation and employ a multi-national strategy in future global health crises.

真正的全球生物伦理涉及国家间的合作与协作。发表在生物伦理学期刊上的大多数文章都涉及存在于一个或多个国家的问题,但这些文章通常不讨论需要协作或合作的解决方案。COVID-19全球获取疫苗计划是与当前COVID-19有关的拟议国际合作的一个例子。大流行。然而,很明显,各国一直在各自为政,几乎没有合作。尽管世界卫生组织(世卫组织)提供了国际研究伦理指导,但在世卫组织主持下发表的一篇文章违反了在开展全球研究时拒绝“双重标准”的伦理原则。COVID - 19大流行为各国提供了一个机会,可以从最近缺乏国际合作的情况中吸取教训,并在未来的全球卫生危机中采用多国战略。
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引用次数: 2
期刊
Global Bioethics
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