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Medicina Clinica Practica最新文献

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Miositis necrosante autoinmune asociada al uso de atorvastatina: reporte de un caso y revisión de la literatura 与阿托伐他汀有关的自身免疫性坏死性肌炎：病例报告和文献综述
Q4 Medicine
Medicina Clinica Practica
Pub Date : 2026-01-26 DOI: 10.1016/j.mcpsp.2026.100534
Luis Ángel Rodríguez-Chávez, Melissa Ysabel Romero-Díaz, Christian Alberto Vargas Machuca-Carranza, José Guillermo Cabanillas-López
Statin-associated autoimmune necrotizing myositis (ANM) is a rare entity characterized by progressive proximal muscle weakness, marked and persistent elevation of creatine phosphokinase, and the presence of anti-HMGCR autoantibodies. Unlike toxic statin-induced myopathy, ANM persists even after discontinuation of the drug due to an autoimmune response directed against the HMGCR enzyme. We report the case of a 75-year-old man on long-term atorvastatin therapy who developed severe muscle weakness, dysphagia, and respiratory involvement, initially suspected to be Guillain–Barré syndrome. The autoimmune profile revealed positive anti-HMGCR antibodies, confirming the diagnosis. Treatment included discontinuation of atorvastatin, glucocorticoids, azathioprine, and intravenous immunoglobulin, with partial improvement. This case highlights the importance of timely recognition of ANM to prevent severe complications and to guide early immunosuppressive therapy that may improve functional prognosis.
他汀类药物相关自身免疫性坏死性肌炎（ANM）是一种罕见的疾病，其特征是进行性近端肌肉无力，肌酸磷酸激酶显著且持续升高，以及抗hmgcr自身抗体的存在。与毒性他汀类药物诱导的肌病不同，ANM甚至在停药后仍然存在，这是由于针对HMGCR酶的自身免疫反应。我们报告一例长期接受阿托伐他汀治疗的75岁男性，出现严重的肌肉无力、吞咽困难和呼吸受累，最初怀疑为格林-巴罗综合征。自身免疫特征显示抗hmgcr抗体阳性，证实了诊断。治疗包括停止阿托伐他汀、糖皮质激素、硫唑嘌呤和静脉注射免疫球蛋白，部分改善。该病例强调了及时识别ANM的重要性，以防止严重并发症，并指导早期免疫抑制治疗，可能改善功能预后。
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引用次数: 0
Acute pancreatitis: a rare complication of transjugular intrahepatic portosystemic shunt (TIPS) 急性胰腺炎：经颈静脉肝内门静脉系统分流术的罕见并发症
Q4 Medicine
Medicina Clinica Practica
Pub Date : 2026-01-23 DOI: 10.1016/j.mcpsp.2025.100532
Helena Font , Anna Baiges , Ángeles García-Criado , Alba Igual
{"title":"Acute pancreatitis: a rare complication of transjugular intrahepatic portosystemic shunt (TIPS)","authors":"Helena Font ,&nbsp;Anna Baiges ,&nbsp;Ángeles García-Criado ,&nbsp;Alba Igual","doi":"10.1016/j.mcpsp.2025.100532","DOIUrl":"10.1016/j.mcpsp.2025.100532","url":null,"abstract":"","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":"9 2","pages":"Article 100532"},"PeriodicalIF":0.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146026085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When diabetes strikes the muscle: a case of diabetic myonecrosis 糖尿病侵袭肌肉：糖尿病性肌坏死1例
Q4 Medicine
Medicina Clinica Practica
Pub Date : 2026-01-01 DOI: 10.1016/j.mcpsp.2025.100533
Mariem Essouri, Wiem Hlali, Imen Mariem Abbassi, Naziha Khammassi
This paper describes a rare case of diabetic myonecrosis in a 63-year-old patient with a long-standing history of type 2 diabetes. The patient presented with progressive pain in the right thigh, difficulty walking, and muscle weakness. Initial examination and imaging suggested a focal myositis, but further investigation including muscle biopsy confirmed the diagnosis of diabetic myonecrosis. The patient improved with glycemic control and pain management. Diabetic myonecrosis is a rare complication of diabetes that can mimic other conditions such as myositis, and prompt diagnosis and management are essential for a favorable short-term prognosis.
本文报告一例罕见的糖尿病性肌坏死病例，患者63岁，长期患有2型糖尿病。患者表现为右大腿进行性疼痛，行走困难，肌肉无力。最初的检查和影像学提示局灶性肌炎，但进一步的检查包括肌肉活检证实了糖尿病性肌坏死的诊断。患者血糖控制和疼痛管理均有所改善。糖尿病性肌坏死是一种罕见的糖尿病并发症，它可以模仿其他疾病，如肌炎，及时诊断和治疗对于良好的短期预后至关重要。
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引用次数: 0
Sinonasal schwannoma: A rare cause of unilateral nasal mass 鼻窦神经鞘瘤：单侧鼻肿块的罕见病因
Q4 Medicine
Medicina Clinica Practica
Pub Date : 2025-12-24 DOI: 10.1016/j.mcpsp.2025.100529
Alexandra Cortés-Arciniegas , Inés Tortajada-Torralba , Santiago Almanzo , Alfonso García-Piñero , Miguel Armengot-Carceller
{"title":"Sinonasal schwannoma: A rare cause of unilateral nasal mass","authors":"Alexandra Cortés-Arciniegas ,&nbsp;Inés Tortajada-Torralba ,&nbsp;Santiago Almanzo ,&nbsp;Alfonso García-Piñero ,&nbsp;Miguel Armengot-Carceller","doi":"10.1016/j.mcpsp.2025.100529","DOIUrl":"10.1016/j.mcpsp.2025.100529","url":null,"abstract":"","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":"9 1","pages":"Article 100529"},"PeriodicalIF":0.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pleomorphic adenoma of the parapharyngeal space: A common tumor at an uncommon location 咽旁间隙多形性腺瘤：一种不常见部位的常见肿瘤
Q4 Medicine
Medicina Clinica Practica
Pub Date : 2025-12-24 DOI: 10.1016/j.mcpsp.2025.100531
Alexandra Cortés-Arciniegas , Saúl Astray-Gómez , Germán Martín-Viguer , Diego Collado-Martín , José María Perolada-Valmaña , Miguel Armengot-Carceller
{"title":"Pleomorphic adenoma of the parapharyngeal space: A common tumor at an uncommon location","authors":"Alexandra Cortés-Arciniegas ,&nbsp;Saúl Astray-Gómez ,&nbsp;Germán Martín-Viguer ,&nbsp;Diego Collado-Martín ,&nbsp;José María Perolada-Valmaña ,&nbsp;Miguel Armengot-Carceller","doi":"10.1016/j.mcpsp.2025.100531","DOIUrl":"10.1016/j.mcpsp.2025.100531","url":null,"abstract":"","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":"9 1","pages":"Article 100531"},"PeriodicalIF":0.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous leishmaniasis 皮肤利什曼病
Q4 Medicine
Medicina Clinica Practica
Pub Date : 2025-12-22 DOI: 10.1016/j.mcpsp.2025.100530
María G. Moreno Treviño , Julio C. Salas-Alanis , Mauricio Salas-Garza , Raúl Rubio-Moreno , David I. Loera-Menchaca , Gerardo Rivera-Silva
{"title":"Cutaneous leishmaniasis","authors":"María G. Moreno Treviño ,&nbsp;Julio C. Salas-Alanis ,&nbsp;Mauricio Salas-Garza ,&nbsp;Raúl Rubio-Moreno ,&nbsp;David I. Loera-Menchaca ,&nbsp;Gerardo Rivera-Silva","doi":"10.1016/j.mcpsp.2025.100530","DOIUrl":"10.1016/j.mcpsp.2025.100530","url":null,"abstract":"","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":"9 1","pages":"Article 100530"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abordaje ecográfico en el diagnóstico de atelectasias pulmonares: un caso clínico 用超声扫描诊断肺毛细血管扩张：一个临床案例
Q4 Medicine
Medicina Clinica Practica
Pub Date : 2025-12-01 DOI: 10.1016/j.mcpsp.2025.100526
Jorge Cumarín Solórzano, Diana García Portillo
{"title":"Abordaje ecográfico en el diagnóstico de atelectasias pulmonares: un caso clínico","authors":"Jorge Cumarín Solórzano,&nbsp;Diana García Portillo","doi":"10.1016/j.mcpsp.2025.100526","DOIUrl":"10.1016/j.mcpsp.2025.100526","url":null,"abstract":"","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":"9 1","pages":"Article 100526"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilidad del test de Tzanck en el diagnóstico de herpes cutáneo Tzanck检测在诊断皮肤疱疹方面的作用
Q4 Medicine
Medicina Clinica Practica
Pub Date : 2025-12-01 DOI: 10.1016/j.mcpsp.2025.100527
Carlos Eduardo Solórzano Flores , Abner Bladimir Baquedano Ordoñez , Allan Daniel Maradiaga Mejía , Juan José Flores Perez
{"title":"Utilidad del test de Tzanck en el diagnóstico de herpes cutáneo","authors":"Carlos Eduardo Solórzano Flores ,&nbsp;Abner Bladimir Baquedano Ordoñez ,&nbsp;Allan Daniel Maradiaga Mejía ,&nbsp;Juan José Flores Perez","doi":"10.1016/j.mcpsp.2025.100527","DOIUrl":"10.1016/j.mcpsp.2025.100527","url":null,"abstract":"","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":"9 1","pages":"Article 100527"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare skeletal manifestations of sarcoidosis: diagnostic challenge 结节病罕见的骨骼表现：诊断挑战
Q4 Medicine
Medicina Clinica Practica
Pub Date : 2025-12-01 DOI: 10.1016/j.mcpsp.2025.100528
Mariem Essouri , Arij Soli , Imen Mariem Abbassi , Neirouz Toujeni , Zeineb Teyeb , Naziha Khammassi
Sarcoidosis is a systemic inflammatory disease characterized by non-caseating granulomas. Thoracic involvement is the most common site of the disease, observed in approximately 90% of cases. Extra-thoracic involvement occurs in 50%, but bone involvement remains rare (3–13%). There is no codified therapeutic management.
Case 1: A 30-year-old woman presented with dyspnea and fever. Imaging revealed mediastinal adenomegaly and a lytic femoral neck lesion. Biopsies confirmed granulomatous disease, leading to a diagnóstico of type 2 medullary-pulmonary sarcoidosis with bone involvement. She was treated with corticosteroids and required surgical intervention due to a fracture risk.
Case 2: A 57-year-old woman with systemic sarcoidosis experienced relapse after corticosteroid treatment, presenting with new osteolytic lesions and lymphadenopathy. Biopsy confirmed osseous sarcoidosis. High-dose corticosteroids, combined with methotrexate, led to significant clinical improvement and stabilization of lytic lesions on imaging.
Skeletal lesions are rare and can mimic malignancies. Diagnosis requires histological confirmation. Treatment primarily involves corticosteroids, and it may necessitate further immunosuppressive strategies.
结节病是一种以非干酪化肉芽肿为特征的全身性炎症性疾病。胸部受累是最常见的病变部位，约90%的病例可见。胸外受累发生率为50%，但骨受累仍很少见（3-13%）。没有成文的治疗管理。病例1：一名30岁女性，表现为呼吸困难和发烧。影像显示纵隔腺肿大及股骨颈溶解性病变。活检证实肉芽肿性疾病，导致diagnóstico 2型髓样肺结节病伴骨累及。她接受了皮质类固醇治疗，由于骨折风险需要手术干预。病例2：一名57岁女性系统性结节病患者在皮质类固醇治疗后复发，出现新的溶骨性病变和淋巴结病。活检证实骨性结节病。大剂量皮质类固醇联合甲氨蝶呤可显著改善临床和稳定溶解性病变的影像学表现。骨骼病变是罕见的，可以模仿恶性肿瘤。诊断需要组织学证实。治疗主要涉及皮质类固醇，可能需要进一步的免疫抑制策略。
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引用次数: 0
Lupus miliaris disseminatus faciei
Q4 Medicine
Medicina Clinica Practica
Pub Date : 2025-11-08 DOI: 10.1016/j.mcpsp.2025.100525
María G. Moreno-Treviño , Julio C. Salas-Alanis , Mauricio Salas-Garza , Raúl Rubio-Moreno , Ma. G. Treviño-Alanís , Gerardo Rivera-Silva
{"title":"Lupus miliaris disseminatus faciei","authors":"María G. Moreno-Treviño ,&nbsp;Julio C. Salas-Alanis ,&nbsp;Mauricio Salas-Garza ,&nbsp;Raúl Rubio-Moreno ,&nbsp;Ma. G. Treviño-Alanís ,&nbsp;Gerardo Rivera-Silva","doi":"10.1016/j.mcpsp.2025.100525","DOIUrl":"10.1016/j.mcpsp.2025.100525","url":null,"abstract":"","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":"9 1","pages":"Article 100525"},"PeriodicalIF":0.0,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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