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Correlation Between Depression Level and Red Blood Cell Distribution Width (RDW) and Erythrocyte Sedimentation Rate (ESR) in Chronic Kidney Disease (CKD) Patients Undergoing Regular Hemodialysis at Haji Adam Malik General Hospital Medan 棉兰哈吉亚当马利克综合医院定期血液透析的慢性肾病患者抑郁水平与红细胞分布宽度(RDW)和红细胞沉降率(ESR)的相关性
Pub Date : 2023-05-31 DOI: 10.47353/jsocmed.v2i5.49
D. Prianto, W. H. Lubis, A. T. Nasution
Introduction: Chronic Kidney Disease are related to inflammation and stress levels therefore depression is a predictor that will increase the morbidity and mortality of patients with chronic kidney disease undergoing hemodialysis.Method: This research is an analytical study with a cross-sectional design which carried out in Januari until February 2023, at Hemodialysis Installation of RSUP. H. Adam Malik. To analyze the correlation between the Depression Level and Red Blood Cell Distribution Width (RDW) and Erythrocyte Sedimentation Rate (ESR), the Pearson correlation test was used if the data was normally distributed. If the data is not normally distributed, Spearman's correlation test is performed. Statistical analysis using 95% confidence level (p<0.05).Results: In this research, demographic characteristics of 85 patients with mean age of the patients was 49.56 years old with a standard deviation of 13.46. Based on Spearman rho test it was found that there was a significant correlation between RDW and the BDI II score with p value 0.003. The degree of correlation or r value was 0.318. This indicates that there is a weak correlation between the RDW score and the BD II score. Based on Pearson test it was found that there was a significant correlation between ESR and the BDI II score with p value 0.009. The degree of correlation or r value was 0.280. This indicates that there is a weak correlation between the ESR value and the BD II score.Conclusion: Level of depression were found to be correlated with Red Blood Cell Distribution Width (RDW) and Erythrocyte Sedimentation Rate (ESR) in CKD patients whose undergoing regular hemodialysis.
慢性肾脏疾病与炎症和应激水平相关,因此抑郁是慢性肾脏疾病患者接受血液透析的发病率和死亡率增加的预测因子。方法:本研究是一项横断面设计的分析研究,于2023年1月至2月在RSUP血液透析装置进行。亚当·马利克。分析抑郁水平与红细胞分布宽度(RDW)和红细胞沉降率(ESR)的相关性,如果数据为正态分布,则采用Pearson相关检验。如果数据不是正态分布,则进行Spearman相关检验。统计学分析采用95%置信水平(p<0.05)。结果:本研究85例患者的人口学特征,患者平均年龄为49.56岁,标准差为13.46。经Spearman rho检验发现,RDW与BDI II评分存在显著相关,p值为0.003。相关程度或r值为0.318。这表明RDW评分与BD II评分之间存在弱相关性。Pearson检验发现ESR与BDI II评分存在显著相关,p值为0.009。相关程度或r值为0.280。这表明ESR值与BD II评分之间存在弱相关性。结论:定期进行血液透析的CKD患者抑郁程度与红细胞分布宽度(RDW)和红细胞沉降率(ESR)相关。
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引用次数: 0
Prognostic Value of Tricuspid Annular Plane Systolic Excursion (TAPSE), Right Ventricular Fractional Area Changes (RV FAC) and Pulses Tissue Doppler S' Wave (PTD S') at 30 Days after Care of Acute Miocardial Infarction Patients in Haji Adam Malik Hospital Haji Adam Malik医院急性心肌梗死患者术后30 d三尖瓣环平面收缩偏移(TAPSE)、右心室分数面积变化(RV FAC)和脉冲组织多普勒S波(PTD S’)的预后价值
Pub Date : 2023-05-31 DOI: 10.47353/jsocmed.v2i5.65
Fadli Ilhami, A. N. Nasution, C. A. Andra
Introduction: Echocardiography is a reliable and simple method of hemodynamic monitoring that can be used on every IMA patient. Tricuspid Annular Plane Systolic Excursion (TAPSE), Right Ventricular Fractional Aera Changes (RV FAC), and Pulses Tissue Doppler S' Wave (PTD S') are the three main parameters of ventricular electrocardiography. The purpose of this study is to understand the reliability of the right ventricle function prognostic indicators TAPSE, PTD S', and RV FAC with regard to the MACE at 30 days following the occurrence of the AMI in RSUP H. Adam Malik Medan Method: This study is an ambispective observational analytic study with sampling carried out at one time (cross-sectional study) on 88 AMI patients at the HAM Hospital who were treated from March 2022 to June 2022 and performed echocardiography in the first 24 hours and measured TAPSE, PTD S' and RV FAC. And followed for 30 days to see the MACE in patients. Bivariate test was conducted to assess the correlation between variables. To determine which independent variables were more effective at predicting MACE, a multivariate logistic regression test was then run. The effectiveness of the independent factors in predicting MACE was also assessed using ROC analysis. Results: The total subjects were 88 AMI patients consisting of 39 (44.3%) patients who experienced MACE and 49 (55.6%) patients who didn’t. The prognostic values of TAPSE, PTDS' and RV FAC on MACE at 30 days were related by bivariate analysis with P Value 0.001 but only PTD S’ showed logistic regression results that were consistent with P Value < 0.001. Based on ROC analysis obtained by PTD S' can predict MACE with AUC = 0.894 Conclusion: Echocardiographic measurement PTD S’ has a good prognostic value to predict MACE within 30 days in AMI patients.
超声心动图是一种可靠、简便的血流动力学监测方法,可用于所有IMA患者。三尖瓣环平面收缩偏移(TAPSE)、右心室分数面积变化(RV FAC)和脉冲组织多普勒S波(PTD S’)是心室心电图的三个主要参数。本研究的目的是了解右心室功能预后指标TAPSE、PTD S’和RV FAC与RSUP h患者AMI发生30天后MACE的可靠性。本研究是一项双透视观察性分析研究,对2022年3月至2022年6月在HAM医院接受治疗的88例AMI患者进行一次抽样(横断面研究),在前24小时进行超声心动图检查,测量TAPSE、PTD S'和RV FAC。随访30天,观察患者的MACE情况。采用双变量检验评估变量间的相关性。为了确定哪些自变量在预测MACE方面更有效,然后进行了多变量逻辑回归检验。使用ROC分析评估独立因素预测MACE的有效性。结果:共88例AMI患者,其中39例(44.3%)发生MACE, 49例(55.6%)未发生MACE。经双变量分析,30 d时TAPSE、PTDS’和RV FAC对MACE的预后价值具有相关性,P值为0.001,但只有PTDS’的logistic回归结果与P值< 0.001一致。结论超声心动图测量PTD S′对AMI患者30天内MACE有较好的预测价值。
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引用次数: 0
Correlation of Fatty Liver Imaging on Abdominal CT-Scan with Dyslipidemia in Haji Adam Malik General Hospital in 2020 2020年哈吉亚当马利克总医院腹部ct脂肪肝影像与血脂异常的相关性分析
Pub Date : 2023-05-31 DOI: 10.47353/jsocmed.v2i5.51
Fariz Nugraha Akbar, E. R. Daulay, T. Sungkar
Background: Fatty liver is a broad term for a condition in which there is an increase triglyceride level in hepatocyte. In Indonesia there is not much research about this condition. Fatty liver is a major health problem in West countries, and is slowly increasing in Asian countries. For many individual with fatty liver, have no specific complaint or can have no symptoms at all. This aim of this study to analyzed the relationship between fatty liver images on abdominal CT scans with dyslipidemia. Methods: This study is an observational analytic study with a case – control type of research with the aim of knowing the relationship between CT scan images of fatty liver and dsylipidemia. The data in this study were all medical records who went to the Radiology Department for abdominal CT scan at the Haji Adam Malik General Hospital for a period of one year from January 1st, 2020 to December 31st 2020. Results: The subjects on the abdominal CT scan results with fatty liver and high triglyceride is 5 peoples out of 12 (41.7%). The test results obtained p value = 0.,688 (p>0,05), in other words there is no significant relationship between fatty liver and high triglyceride level. Conclusion: No significant relationship was found between the incidence of fatty liver and the incidence of dyslipidemia.
背景:脂肪肝是肝细胞中甘油三酯水平升高的一个广义术语。在印度尼西亚,关于这种情况的研究并不多。脂肪肝在西方国家是一个主要的健康问题,在亚洲国家也在缓慢增加。对于许多患有脂肪肝的人来说,没有特别的抱怨或根本没有症状。本研究的目的是分析腹部CT扫描脂肪肝图像与血脂异常的关系。方法:本研究为病例对照型观察性分析研究,目的是了解脂肪肝CT扫描图像与血脂异常的关系。本研究的数据为2020年1月1日至2020年12月31日在哈吉亚当马利克综合医院放射科进行腹部CT扫描的医疗记录,为期一年。结果:12人中腹部CT扫描结果为脂肪肝和高甘油三酯的有5人(41.7%)。得到的检验结果p值= 0。,688 (p < 0.05),即脂肪肝与高甘油三酯水平之间无显著关系。结论:脂肪肝的发病率与血脂异常的发病率无明显关系。
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引用次数: 0
Association between Coagulation Profile and Platelet Lymphocyte Ratio with Karnofsky Performance Status Scale In Brain Tumor Patients 脑肿瘤患者凝血特征、血小板淋巴细胞比值与Karnofsky功能状态量表的关系
Pub Date : 2023-05-31 DOI: 10.47353/jsocmed.v2i5.50
Khansa Salsabila, P. P. Sinurat, I. Nasution
Introduction: Patients with tumor usually show abnormal laboratory coagulation tests, indicating a subclinical hypercoagulable state that contributes to morbidity and mortality. Hematologic markers such as the platelet-lymphocyte ratio (PLR) can be used as an index of tumor progression, high PLR is associated with morbidity and mortality in patients with primary or metastatic tumors. KPS is a method that is widely used to assess the functional status of a patient. The aim of this study is to determine the relationship between coagulation profile and platelet-lymphocyte with Karnofsky Performance Status Scale in Brain Tumor Patients.Method: This study was an observational analytic study with a cross-sectional design using primary data sources taken consecutively from all brain tumor patients who were hospitalized in Inpatient Room at Haji Adam Malik General Hospital Medan who met the inclusion criteria. The parameters analyzed were Prothrombin Time (PT), Activated Partial Thromboplastin Time (aPTT), D dimer (DD), and PLR. Clinical outcome of brain tumor patients was assessed using KPS. To assess the relationship between coagulation marker factors and the ratio of platelets to lymphocytes to KPS, the Spearman and Gamma tests were used.Results: Of the 30 research subjects analyzed, the number of female subjects was comparable to that of males (50%). The highest age is in the age range of 61-70 years by 30%. The highest level of education was high school at 40%, the most research subjects were housewives at 33.3% and the most types of brain tumors were primary brain tumors at 56.7%. The highest KPS score during treatment was found in the <70 group of 76.7%. From the correlation test, it was found that there was a strong, significant relationship between the values of PT (p<0.02 r = -0.731), APTT (p<0.013 r = -0.761), D-dimer (p<0.001 r = -0.737) and PLR (p<0.001 r = 0.78) on the clinical outcome of brain tumor patients assessed by KPS.Conclusion: There is a strong relationship between PT, APTT, D-dimer and PLR values on KPS in patients with brain tumor.
导论:肿瘤患者通常显示实验室凝血检查异常,提示亚临床高凝状态,导致发病率和死亡率。血液学指标如血小板淋巴细胞比率(PLR)可作为肿瘤进展的指标,高PLR与原发性或转移性肿瘤患者的发病率和死亡率相关。KPS是一种广泛用于评估患者功能状态的方法。本研究的目的是利用Karnofsky性能状态量表确定脑肿瘤患者凝血状况与血小板淋巴细胞的关系。方法:本研究采用横断面设计的观察性分析研究,主要数据来源为棉兰Haji Adam Malik综合医院住院部所有符合纳入标准的脑肿瘤患者。分析参数为凝血酶原时间(PT)、活化部分凝血活素时间(aPTT)、D二聚体(DD)和PLR。采用KPS评价脑肿瘤患者的临床预后。为了评估凝血标志物因子与血小板/淋巴细胞/ KPS比值的关系,采用Spearman和Gamma试验。结果:在分析的30个研究对象中,女性受试者的数量与男性相当(50%)。年龄最高的是61-70岁,占30%。受教育程度最高的是高中(40%),研究对象最多的是家庭主妇(33.3%),脑肿瘤类型最多的是原发性脑肿瘤(56.7%)。治疗期间KPS评分以<70组最高,为76.7%。相关性检验发现,PT (p<0.02 r = -0.731)、APTT (p<0.013 r = -0.761)、d -二聚体(p<0.001 r = -0.737)、PLR (p<0.001 r = 0.78)值与KPS评价脑肿瘤患者的临床转归存在较强的显著相关性。结论:PT、APTT、d -二聚体和PLR值与脑肿瘤患者KPS有密切关系。
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引用次数: 0
Relationship of D-dimer Value to Mortality in Covid-19 Patients with Acute Coronary Syndrome at Haji Adam Malik Hospital Medan 棉兰哈吉亚当马利克医院新冠肺炎急性冠脉综合征患者d-二聚体值与死亡率的关系
Pub Date : 2023-04-30 DOI: 10.47353/jsocmed.v2i4.45
Dian Primadia Putri, Rahmad Isnanta Sembiring, T. Kembaren, P. Eyanoer
Introduction: Coronaviruses (CoVs) are single-stranded positive-sense RNA viruses, which can trigger cardiovascular disease. Inflammation caused by SARS-CoV-2 can affect atherosclerotic plaques, induced prothrombotic changes in the blood and endothelium and caused their instability and myocardial infarction. Several prospective studies have demonstrated an association between increased baseline D-dimer levels and the risk of subsequent cardiovascular events. Several studied had showed the relationship of D-dimer value to mortality in COVID-19 patients with acute coronary syndrome at H. Adam Malik Hospital Medan.Method: This study was a descriptive analytic study using medical record data from central installation patients at H. Adam Malik Hospital in the period August 2020 to August 2021. The sample was calculated using the Lemeshow formula. Then the distribution test was carried out using Shapiro Wilk test. Inferential statistical analysis was performed to assess the relationship of D-dimer to mortality in COVID-19 patients with acute coronary syndrome at H. Adam Malik Hospital Medan using chi-square test. If chi-square criteria were not met, the inferential statistical analysis used was Fisher's exact or other alternative tests. The results were statistically significant if the p value <0.05.Results: 70 subjects participated in the study and the average age of the research subjects was 58.2 years, majority were male. Most subjects experienced severe COVID-19; ECG found ST elevation and comorbid factors were mostly hypertension followed by hypertension and diabetes type 2. There was a relationship between D-dimer value and mortality in COVID-19 patients with acute coronary syndrome, with p value = 0.005.Conclusion: D-dimer values was associated with mortality in COVID-19 patients with acute coronary syndrome.
简介:冠状病毒(cov)是一种单链正义RNA病毒,可引发心血管疾病。SARS-CoV-2引起的炎症可影响动脉粥样硬化斑块,诱导血液和内皮的血栓前改变,导致其不稳定和心肌梗死。几项前瞻性研究表明,基线d -二聚体水平升高与随后心血管事件的风险之间存在关联。一些研究显示了d -二聚体值与棉兰H. Adam Malik医院COVID-19急性冠脉综合征患者死亡率的关系。方法:本研究是一项描述性分析研究,使用了2020年8月至2021年8月期间H. Adam Malik医院中心装置患者的病历数据。采用Lemeshow公式计算样品。然后采用Shapiro Wilk检验进行分布检验。采用卡方检验对棉兰H. Adam Malik医院COVID-19急性冠脉综合征患者d -二聚体与死亡率的关系进行推论统计分析。如果不符合卡方标准,则使用Fisher精确检验或其他替代检验进行推论统计分析。以p值<0.05为差异有统计学意义。结果:共纳入研究对象70人,平均年龄58.2岁,男性居多。大多数受试者经历了严重的COVID-19;心电图发现ST段抬高,合并症以高血压为主,其次为高血压和2型糖尿病。d -二聚体值与COVID-19急性冠脉综合征患者死亡率存在相关性,p值= 0.005。结论:d -二聚体值与COVID-19合并急性冠脉综合征患者的死亡率相关。
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引用次数: 0
Correlation of Kidney Volume on CT-Scan with Kidney Function Tests in Patients with Normal Kidneys at Haji Adam Malik Hospital Medan in 2020-2021 棉兰Haji Adam Malik医院2020-2021年正常肾脏患者ct扫描肾脏体积与肾功能检查的相关性
Pub Date : 2023-04-30 DOI: 10.47353/jsocmed.v2i4.46
M. Harry
Introduction: Kidneys have filtration and excretion functions; the glomerular filtration rate (GFR) is considered the best indicator of kidney function and may indicate abnormalities. Kidney volume can be an early indicator of kidney disorders before there is a decrease in kidney function. Changes in kidney volume may indicate structural and functional changes that indicate a disorder or disease progression. Radiological examination such as a CT-Scan has an important role in measuring the size and kidney volume and assessing kidney morphological changes for the diagnosis and staging of kidney disease as well as planning therapy. Objective: This study aims to find a correlation between the estimated kidney volume with the ellipsoid method through CT scanning and estimated kidney function by glomerular filtration rate in patients with normal kidneys.Method: An analytical study used a case-series design; all subjects were patients who had normal CT-Scan results and normal kidney function at the Haji Adam Malik Hospital in Medan in 2020–2021. Used the consecutive sampling technique and had 90 total samples.Results: There is a moderately positive correlation (r = 0,410-0,499) between volume and kidney function. A moderately negative correlation (r = -0,196 to -0,282) between kidney volume and age. A moderately positive correlation (r = 0,456-0,548) between kidney volume and body weight. There is a moderately negative correlation (r = -0.495) between renal function and age. A moderately positive correlation (r = 0,567) between renal function and body weight.Conclusion: there is a correlation between kidney volume and kidney function, the correlation between kidney volume and body weight, the correlation between kidney function and body weight.
肾脏具有过滤和排泄功能;肾小球滤过率(GFR)被认为是肾功能的最佳指标,可能提示异常。在肾功能下降之前,肾脏体积可以作为肾脏疾病的早期指标。肾脏体积的变化可能表明结构和功能的改变,表明疾病或疾病进展。ct扫描等放射学检查在测量肾脏大小和体积、评估肾脏形态学变化、肾脏疾病的诊断和分期以及计划治疗方面具有重要作用。目的:本研究旨在探讨正常肾脏患者CT扫描椭球法估算肾脏体积与肾小球滤过率估算肾功能的相关性。方法:采用病例系列设计进行分析研究;所有受试者均为2020-2021年棉兰Haji Adam Malik医院ct扫描结果正常且肾功能正常的患者。采用连续抽样技术,共90个样本。结果:体积与肾功能之间存在中度正相关(r = 0,410-0,499)。肾体积与年龄呈中度负相关(r = -0,196 ~ -0,282)。肾体积与体重呈中度正相关(r = 0,456-0,548)。肾功能与年龄呈中度负相关(r = -0.495)。肾功能与体重呈中度正相关(r = 0.567)。结论:肾脏体积与肾功能、肾脏体积与体重、肾脏功能与体重存在相关性。
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引用次数: 0
The Association between Waist Hip Ratio and Severity of Diabetic Peripheral Neuropaty in Diabetes Melitus Type 2 by Using Toronto Clinical Scoring System 应用多伦多临床评分系统研究腰臀比与2型糖尿病周围神经病变严重程度的关系
Pub Date : 2023-04-30 DOI: 10.47353/jsocmed.v2i4.47
S. Dhillon, A. Fithrie, C. A. Batubara
Introduction: Diabetic neuropathy is a common and progressive microvascular complication of diabetes, so early detection and prevention is very important. Other modifiable risk factors such as hypertension, dyslipidemia, or central obesity can be managed. Central obesity with insulin resistance is a key pathophysiological factor in the metabolic syndrome. Waist hip ratio (WHR) has been proposed as a tool for detecting central obesity. Toronto Clinical Scoring System (TCSS) is a diabetic neuropathy scoring system that has high sensitivity and specificity. The aim of this study was to determine the relationship between waist hip ratio and the severity of peripheral diabetic neuropathy in type 2 Diabetes Melitus (DM) according to the Toronto Clinical Scoring System (TCSS).Method: This study used a cross-sectional design. Sampling was conducted at the Endocrinology Polyclinic and Neurology Polyclinic Hospital H. Adam Malik Medan. The research sample was taken as many as 45 subjects consecutively. TCSS examination is performed to diagnose and determine the severity of diabetic neuropathy Therefore, waist hip ratio was calculated to assess central obesity. Data analysis using Chi Square test.Results: On the demographic characteristics of the research subjects were male, age range 51-60 years, high school education level, not working, history of DM 5-10 years. The mean value of WHR is 0.87±0.051. Median TCSS Score 10 (6-16). The majority of subjects had mild diabetic peripheral neuropathy. Patients with central obesity had a grading of neuropathy that was classified as severe as many as 13 people (56.5%), moderate as many as 7 people (30.4%), and mild as many as 3 people (13.0%). While patients who are not obese have a grading of neuropathy that is classified as severe as many as 1 person (4.5%), moderate as many as 5 people (22.7%), mild as many as 16 people (72.7%). Based on the Chi Square test, it was found that there was a significant association between the waist hip ratio and the severity of diabetic peripheral neuropathy in type 2 DM patients with p<0.01.Conclusion: There is a statistically significant association between waist hip ratio and the severity of diabetic neuropathy in type 2 DM with p < 0.01.
导语:糖尿病神经病变是糖尿病常见的进行性微血管并发症,早期发现和预防十分重要。其他可改变的危险因素如高血压、血脂异常或中心性肥胖是可以控制的。中心性肥胖伴胰岛素抵抗是代谢综合征的关键病理生理因素。腰臀比(WHR)已被提出作为检测中心性肥胖的工具。多伦多临床评分系统(TCSS)是一种具有高敏感性和特异性的糖尿病神经病变评分系统。本研究的目的是根据多伦多临床评分系统(TCSS)确定腰臀比与2型糖尿病(DM)周围糖尿病神经病变严重程度之间的关系。方法:本研究采用横断面设计。抽样在内分泌科综合诊所和神经病学综合诊所H. Adam Malik Medan医院进行。研究样本连续抽取多达45名受试者。通过TCSS检查来诊断和确定糖尿病神经病变的严重程度,因此计算腰臀比来评估中心性肥胖。数据分析采用卡方检验。结果:研究对象的人口学特征为男性,年龄51 ~ 60岁,高中学历,无工作,糖尿病病史5 ~ 10年。WHR平均值为0.87±0.051。TCSS得分中位数为10(6-16)。大多数受试者有轻度糖尿病周围神经病变。中枢性肥胖患者的神经病变分级为重度13人(56.5%),中度7人(30.4%),轻度3人(13.0%)。而非肥胖患者的神经病变分级为重度1人(4.5%),中度5人(22.7%),轻度16人(72.7%)。经卡方检验发现,腰臀比与2型DM患者糖尿病周围神经病变严重程度有显著相关性,p<0.01。结论:腰臀比与2型DM患者糖尿病神经病变严重程度有统计学意义(p < 0.01)。
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引用次数: 0
The Relationship Between Serum Apolipoprotein B Levels and Severity of Coronary Lesions Using The Syntax Score in Non-St Segment Elevation Acute Myocardial Infarction Patients at Haji Adam Malik General Hospital Medan 棉兰哈吉亚当马利克总医院非st段抬高急性心肌梗死患者血清载脂蛋白B水平与冠状动脉病变严重程度的句法评分关系
Pub Date : 2023-04-30 DOI: 10.47353/jsocmed.v2i4.32
E. S. Kesumawardani, Z. Safri, H. Hasan, R. Hasan, C. A. Andra, T. Ardini
Introduction: Acute coronary syndrome mainly occurs as a result of plaque rupture of atherosclerosis. Apolipoprotein B (apoB) is a large glycoprotein, playing a role in lipoprotein metabolism and human lipid transport reflecting the number of circulating atherogenic particles. The purpose of this study was to assess the relationship of serum apoB levels with coronary lesion severity.Method: This is a cross-sectional study involving patients who was diagnosed with Non-ST Elevation Myocardial Infarction (NSTEMI) who underwent coronary angiography in November 2021 to July 2022. The NSTEMI criteria follow the Universal Definition of Myocardial Infarction and coronary severity is assessed using a SYNTAX score. Bivariate analysis was conducted looking for the relationship between apoB with SYNTAX scores with p<0.05 considered statistically significant.Results: The subjects of the study is 70 people, dominated by male 50 patients (71.4%). The median age of the subjects was 56 (38-77) years. Median levels of apoB was 107 (32-150) mg/dL. The average SYNTAX score was 25.66 ± 10.83. Using the Pearson correlation test, it was shown that there is a significant correlation between apoB and coronary lesion severity obtained r=0.442 (p<0.001).Conclusion: There is a significant correlation between apoB and coronary lesion severity using SYNTAX scores in NSTEMI patients.
简介:急性冠脉综合征主要是动脉粥样硬化斑块破裂的结果。载脂蛋白B (apoB)是一种大糖蛋白,在脂蛋白代谢和人体脂质转运中起作用,反映了循环中致动脉粥样硬化颗粒的数量。本研究的目的是评估血清载脂蛋白ob水平与冠状动脉病变严重程度的关系。方法:这是一项横断面研究,涉及2021年11月至2022年7月接受冠状动脉造影的非st段抬高型心肌梗死(NSTEMI)患者。NSTEMI标准遵循心肌梗死的通用定义,冠状动脉严重程度使用SYNTAX评分进行评估。采用双变量分析寻找apoB与SYNTAX评分之间的关系,p<0.05认为有统计学意义。结果:研究对象70人,以男性50例(71.4%)为主。受试者的中位年龄为56岁(38-77岁)。载脂蛋白ob的中位水平为107 (32-150)mg/dL。SYNTAX平均评分为25.66±10.83。Pearson相关检验显示,apoB与冠状动脉病变严重程度有显著相关性,r=0.442 (p<0.001)。结论:在NSTEMI患者中,apoB与冠状动脉病变严重程度之间存在显著相关性。
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引用次数: 0
The Association Between Degree of Severity and Number of Medications with Quality of Life in Parkinson's Disease Patients 帕金森病患者的严重程度和用药数量与生活质量的关系
Pub Date : 2023-04-30 DOI: 10.47353/jsocmed.v2i4.48
Marisa Heidiyana, K. Surbakti, Haflin Soraya Hutagalung
Introduction: Quality of life is an important parameter to be assessed, especially in progressive chronic diseases such as patients with Parkinson's Disease (PD). Parkinson's Disease Questionnaire-39 (PDQ-39) is the most widely used measurement tool in assessing the quality of life of PD patients. In PD, a series of features can affect the quality of life including the degree of disease severity and the number of medications. The aim of this study is to determine the relationship between the severity of the disease and the number of medications with the quality of life of people with PD so that it is hoped that it can help improve the quality of life of PD patients.Method: This study used a cross-sectional design. The research subjects were PD patients at the Neurology Polyclinic at Haji Adam Malik Hospital Medan from April - November 2020 who met the inclusion criteria. Assessing the severity of the disease using the Hoehn and Yahr and measuring the quality of life using the PDQ 39. Data analysis used the Spearman correlation test for the degree of severity and the Mann- Whitney test for the number of medications.Results: Of the 47 subjects who met the inclusion criteria, most were males (68.1%), with a mean age of 64.82 ± 9.52 years old, with University graduates as the majority of education level (46.8%) and the civil servant as the majority of a profession (34.0%). Stage 2 on Hoehn and Yahr Scales is the most common severity level of disease (55.3%), and polytherapy is the majority of the number of medications (74.5%). The median value of quality of life is 35, with the lowest score being 10 and the highest score being 98. From the results of the bivariate analysis, it was found that there was a very strong, significant association between the degree of disease severity and the quality of life (p <0.001 r=0.872), and there was a significant difference between the number of medications with the quality of life of Parkinson's disease patients (p=0.041).Conclusion: There is a very strong association between the degree of severity and the quality of life of people with Parkinson's disease and there is a difference in the quality of life of PD patients between those who receive monotherapy and polytherapy so there is an effect of the number of medication given on the quality of life of Parkinson's disease patients.
生活质量是一个重要的评估参数,特别是在进行性慢性疾病,如帕金森病(PD)患者中。帕金森病问卷-39 (PDQ-39)是目前应用最广泛的帕金森病患者生活质量评估工具。在PD中,一系列的特征会影响生活质量,包括疾病的严重程度和药物的数量。本研究的目的是确定疾病严重程度和用药次数与PD患者生活质量之间的关系,以期对改善PD患者的生活质量有所帮助。方法:本研究采用横断面设计。研究对象为2020年4月至11月在棉兰Haji Adam Malik医院神经病学综合诊所符合纳入标准的PD患者。用Hoehn和Yahr评估疾病的严重程度,用pdq39衡量生活质量。数据分析使用Spearman相关检验来检测严重程度,使用Mann- Whitney检验来检测药物数量。结果:47例符合纳入标准的受试者中,男性居多(68.1%),平均年龄64.82±9.52岁,学历以大学毕业生为主(46.8%),职业以公务员为主(34.0%)。Hoehn和Yahr量表的2期是最常见的疾病严重程度(55.3%),综合治疗是大多数药物治疗(74.5%)。生活质量中位数为35分,最低为10分,最高为98分。双变量分析结果发现,疾病严重程度与生活质量之间存在非常强的显著相关性(p <0.001 r=0.872),帕金森病患者服药次数与生活质量之间存在显著差异(p=0.041)。结论:帕金森病的严重程度与患者的生活质量之间存在非常强的相关性,并且接受单一治疗和综合治疗的帕金森病患者的生活质量存在差异,因此给予的药物数量对帕金森病患者的生活质量有影响。
{"title":"The Association Between Degree of Severity and Number of Medications with Quality of Life in Parkinson's Disease Patients","authors":"Marisa Heidiyana, K. Surbakti, Haflin Soraya Hutagalung","doi":"10.47353/jsocmed.v2i4.48","DOIUrl":"https://doi.org/10.47353/jsocmed.v2i4.48","url":null,"abstract":"Introduction: Quality of life is an important parameter to be assessed, especially in progressive chronic diseases such as patients with Parkinson's Disease (PD). Parkinson's Disease Questionnaire-39 (PDQ-39) is the most widely used measurement tool in assessing the quality of life of PD patients. In PD, a series of features can affect the quality of life including the degree of disease severity and the number of medications. The aim of this study is to determine the relationship between the severity of the disease and the number of medications with the quality of life of people with PD so that it is hoped that it can help improve the quality of life of PD patients.\u0000Method: This study used a cross-sectional design. The research subjects were PD patients at the Neurology Polyclinic at Haji Adam Malik Hospital Medan from April - November 2020 who met the inclusion criteria. Assessing the severity of the disease using the Hoehn and Yahr and measuring the quality of life using the PDQ 39. Data analysis used the Spearman correlation test for the degree of severity and the Mann- Whitney test for the number of medications.\u0000Results: Of the 47 subjects who met the inclusion criteria, most were males (68.1%), with a mean age of 64.82 ± 9.52 years old, with University graduates as the majority of education level (46.8%) and the civil servant as the majority of a profession (34.0%). Stage 2 on Hoehn and Yahr Scales is the most common severity level of disease (55.3%), and polytherapy is the majority of the number of medications (74.5%). The median value of quality of life is 35, with the lowest score being 10 and the highest score being 98. From the results of the bivariate analysis, it was found that there was a very strong, significant association between the degree of disease severity and the quality of life (p <0.001 r=0.872), and there was a significant difference between the number of medications with the quality of life of Parkinson's disease patients (p=0.041).\u0000Conclusion: There is a very strong association between the degree of severity and the quality of life of people with Parkinson's disease and there is a difference in the quality of life of PD patients between those who receive monotherapy and polytherapy so there is an effect of the number of medication given on the quality of life of Parkinson's disease patients.","PeriodicalId":370087,"journal":{"name":"Journal of Society Medicine","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133373473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Triglyceride/High Density Lipoprotein Cholesterol Ratio and Coronary Lesion Severity in Acute Myocardial Infarction Patients at Adam Malik Hospital, Medan 棉兰亚当马利克医院急性心肌梗死患者甘油三酯/高密度脂蛋白胆固醇比值与冠状动脉病变严重程度的关系
Pub Date : 2023-03-31 DOI: 10.47353/jsocmed.v2i3.30
Akbar Sinaga, R. Hasan, A. Raynaldo, H. Hasan, N. Akbar, C. A. Andra
Introduction: Coronary heart disease is the leading cause of worldwide death. A number of markers have been identified in terms of the atherogenic potential of the lipid profile.The TG/HDL-C ratio is an easy and economical non-invasive examination method as a predictor of coronary heart disease severity. The aim of this study is to assess the relationship of the TG/HDL ratio with the severity of coronary lesions.Method: This cross-sectional study included 53 acute myocardial infarction patients undergoing coronary angiography. Exclusion criteria include (1)AMI patients receiving fibrinolytic therapy, (2) Patients who have routinely consumed lipid lowering drug for 6 weeks,(3) Incomplete coronary angiography and medical records. The TG/HDL ratio is the result of dividing the triglyceride value by HDL. The TG/HDL ratio was divided into 2 groups, namely the TG/HDL ratio <4 group and the TG/HDL ratio >4 group. The severity of coronary lesions was described by the SYNTAX score, which was divided into two: the low SYNTAX score group (≤22) and patients with a low SYNTAX score (≤22) and medium-high SYNTAX score (≥23). Bivariate analysis was performed to find the relationship between the TG/HDL ratio and the SYNTAX score. The value of p<0.05 was considered statistically significant.Results: From 53 patients, 26 patients (49.1%) had a SYNTAX score ≥ 23 and 27 patients (50.9%) had a SYNTAX score < 23. Patients with NSTEMI, DM risk factors, and obesity were higher in the SYNTAX score group ≥23. From the results of statistical analysis, there was a significant relationship between the TG/HDL ratio with coronary lesion severity (p = 0,004).Conclusion: Enhancement of TG/HDL ratio is correlated with coronary lesion severity in acute myocardial infarction patients using the SYNTAX score.
导读:冠心病是世界范围内死亡的主要原因。许多标志物已被确定在血脂的动脉粥样硬化的潜力方面。TG/HDL-C比值是一种简便、经济、无创的预测冠心病严重程度的检查方法。本研究的目的是评估TG/HDL比值与冠状动脉病变严重程度的关系。方法:横断面研究包括53例急性心肌梗死患者行冠状动脉造影。排除标准包括(1)接受纤溶治疗的AMI患者;(2)常规服用降脂药物6周的患者;(3)冠状动脉造影和病历不完整的患者。TG/HDL比值是甘油三酯值除以HDL的结果。TG/HDL比率分为2组,即TG/HDL比率4组。冠状动脉病变的严重程度用SYNTAX评分来描述,分为低SYNTAX评分组(≤22)和低SYNTAX评分组(≤22)和中高SYNTAX评分组(≥23)。双变量分析发现TG/HDL比值与SYNTAX评分之间的关系。p<0.05为差异有统计学意义。结果:53例患者中,SYNTAX评分≥23的有26例(49.1%),SYNTAX评分< 23的有27例(50.9%)。SYNTAX评分≥23的NSTEMI、DM危险因素和肥胖患者较高。从统计分析结果来看,TG/HDL比值与冠状动脉病变严重程度有显著相关(p = 0.004)。结论:SYNTAX评分表明急性心肌梗死患者TG/HDL比值升高与冠脉病变严重程度相关。
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引用次数: 0
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Journal of Society Medicine
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