Pub Date : 2022-07-09DOI: 10.1007/s40139-022-00231-x
Zeyu Liu, E. Andraska, David Akinbode, W. Mars, R. M. Alvidrez
{"title":"LRP1 in the Vascular Wall","authors":"Zeyu Liu, E. Andraska, David Akinbode, W. Mars, R. M. Alvidrez","doi":"10.1007/s40139-022-00231-x","DOIUrl":"https://doi.org/10.1007/s40139-022-00231-x","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"10 1","pages":"23 - 34"},"PeriodicalIF":0.0,"publicationDate":"2022-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48937114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1007/s40139-022-00230-y
Michael A Kochen, Steven S Andrews, H Steven Wiley, Song Feng, Herbert M Sauro
Purpose of review: Signaling pathways serve to communicate information about extracellular conditions into the cell, to both the nucleus and cytoplasmic processes to control cell responses. Genetic mutations in signaling network components are frequently associated with cancer and can result in cells acquiring an ability to divide and grow uncontrollably. Because signaling pathways play such a significant role in cancer initiation and advancement, their constituent proteins are attractive therapeutic targets. In this review, we discuss how signaling pathway modeling can assist with identifying effective drugs for treating diseases, such as cancer. An achievement that would facilitate the use of such models is their ability to identify controlling biochemical parameters in signaling pathways, such as molecular abundances and chemical reaction rates, because this would help determine effective points of attack by therapeutics.
Recent findings: We summarize the current state of understanding the sensitivity of phosphorylation cycles with and without sequestration. We also describe some basic properties of regulatory motifs including feedback and feedforward regulation.
Summary: Although much recent work has focused on understanding the dynamics and particularly the sensitivity of signaling networks in eukaryotic systems, there is still an urgent need to build more scalable models of signaling networks that can appropriately represent their complexity across different cell types and tumors.
{"title":"Dynamics and Sensitivity of Signaling Pathways.","authors":"Michael A Kochen, Steven S Andrews, H Steven Wiley, Song Feng, Herbert M Sauro","doi":"10.1007/s40139-022-00230-y","DOIUrl":"https://doi.org/10.1007/s40139-022-00230-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Signaling pathways serve to communicate information about extracellular conditions into the cell, to both the nucleus and cytoplasmic processes to control cell responses. Genetic mutations in signaling network components are frequently associated with cancer and can result in cells acquiring an ability to divide and grow uncontrollably. Because signaling pathways play such a significant role in cancer initiation and advancement, their constituent proteins are attractive therapeutic targets. In this review, we discuss how signaling pathway modeling can assist with identifying effective drugs for treating diseases, such as cancer. An achievement that would facilitate the use of such models is their ability to identify controlling biochemical parameters in signaling pathways, such as molecular abundances and chemical reaction rates, because this would help determine effective points of attack by therapeutics.</p><p><strong>Recent findings: </strong>We summarize the current state of understanding the sensitivity of phosphorylation cycles with and without sequestration. We also describe some basic properties of regulatory motifs including feedback and feedforward regulation.</p><p><strong>Summary: </strong>Although much recent work has focused on understanding the dynamics and particularly the sensitivity of signaling networks in eukaryotic systems, there is still an urgent need to build more scalable models of signaling networks that can appropriately represent their complexity across different cell types and tumors.</p>","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"10 2","pages":"11-22"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035447/pdf/nihms-1878426.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9199493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.1007/s40139-022-00229-5
Nishith M. Shrimali, Sakshi Agarwal, A. Tiwari, P. Guchhait
{"title":"Platelet-Neutrophil Interactions and Thrombo-inflammatory Complications in Type 2 Diabetes Mellitus","authors":"Nishith M. Shrimali, Sakshi Agarwal, A. Tiwari, P. Guchhait","doi":"10.1007/s40139-022-00229-5","DOIUrl":"https://doi.org/10.1007/s40139-022-00229-5","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"10 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46688725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-20DOI: 10.1007/s40139-021-00225-1
Biji Balakrishnan
{"title":"Role of Nanoscale Delivery Systems in Tissue Engineering","authors":"Biji Balakrishnan","doi":"10.1007/s40139-021-00225-1","DOIUrl":"https://doi.org/10.1007/s40139-021-00225-1","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"119 - 132"},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-021-00225-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46734388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-25DOI: 10.1007/s40139-021-00222-4
Kritika Sood, A. Shanavas
{"title":"The Role of Gold Nanoclusters as Emerging Theranostic Agents for Cancer Management","authors":"Kritika Sood, A. Shanavas","doi":"10.1007/s40139-021-00222-4","DOIUrl":"https://doi.org/10.1007/s40139-021-00222-4","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"33 - 42"},"PeriodicalIF":0.0,"publicationDate":"2021-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-021-00222-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43960023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-03DOI: 10.1007/s40139-021-00223-3
S. Manivannan, S. Nagaraj, S. Narayan
{"title":"A Reflection on the Mechanism of the Role of Nanoparticles in Increasing the Efficacy of Anti-tumour Properties of Docetaxel","authors":"S. Manivannan, S. Nagaraj, S. Narayan","doi":"10.1007/s40139-021-00223-3","DOIUrl":"https://doi.org/10.1007/s40139-021-00223-3","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"79 - 91"},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-021-00223-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47691735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-13DOI: 10.1007/s40139-021-00220-6
P. Nayak, N. S., Anoop Narayanan, A. K. Badekila, S. Kini
{"title":"Nanomedicine in Cancer Clinics: Are We There Yet?","authors":"P. Nayak, N. S., Anoop Narayanan, A. K. Badekila, S. Kini","doi":"10.1007/s40139-021-00220-6","DOIUrl":"https://doi.org/10.1007/s40139-021-00220-6","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"43-55"},"PeriodicalIF":0.0,"publicationDate":"2021-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-021-00220-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46152512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-06DOI: 10.1007/s40139-021-00221-5
A. Shetty, Priyal Chikhaliwala, J. Suryawanshi, S. Chandra
{"title":"Understanding Physico-chemical Interactions of Dendrimers with Guest Molecules for Efficient Drug and Gene Delivery","authors":"A. Shetty, Priyal Chikhaliwala, J. Suryawanshi, S. Chandra","doi":"10.1007/s40139-021-00221-5","DOIUrl":"https://doi.org/10.1007/s40139-021-00221-5","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"57-70"},"PeriodicalIF":0.0,"publicationDate":"2021-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-021-00221-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41924301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-06DOI: 10.1007/s40139-020-00218-6
El Bethel Hmar, Sujata Paul, Nayanmoni Boruah, P. Sarkar, Sudarshana Borah, H. Sharma
{"title":"Apprehending Ulcerative Colitis Management With Springing Up Therapeutic Approaches: Can Nanotechnology Play a Nascent Role?","authors":"El Bethel Hmar, Sujata Paul, Nayanmoni Boruah, P. Sarkar, Sudarshana Borah, H. Sharma","doi":"10.1007/s40139-020-00218-6","DOIUrl":"https://doi.org/10.1007/s40139-020-00218-6","url":null,"abstract":"","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"9 1","pages":"9-32"},"PeriodicalIF":0.0,"publicationDate":"2021-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-020-00218-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46514199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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