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A Hybrid Approach for Image Acquisition Methods Based on Feature-Based Image Registration. 基于特征图像注册的混合图像采集方法。
IF 2.7 Q3 IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY Pub Date : 2024-09-14 DOI: 10.3390/jimaging10090228
Anchal Kumawat, Sucheta Panda, Vassilis C Gerogiannis, Andreas Kanavos, Biswaranjan Acharya, Stella Manika

This paper presents a novel hybrid approach to feature detection designed specifically for enhancing Feature-Based Image Registration (FBIR). Through an extensive evaluation involving state-of-the-art feature detectors such as BRISK, FAST, ORB, Harris, MinEigen, and MSER, the proposed hybrid detector demonstrates superior performance in terms of keypoint detection accuracy and computational efficiency. Three image acquisition methods (i.e., rotation, scene-to-model, and scaling transformations) are considered in the comparison. Applied across a diverse set of remote-sensing images, the proposed hybrid approach has shown marked improvements in match points and match rates, proving its effectiveness in handling varied and complex imaging conditions typical in satellite and aerial imagery. The experimental results have consistently indicated that the hybrid detector outperforms conventional methods, establishing it as a valuable tool for advanced image registration tasks.

本文提出了一种新颖的混合特征检测方法,专门用于增强基于特征的图像注册(FBIR)。通过对 BRISK、FAST、ORB、Harris、MinEigen 和 MSER 等最先进的特征检测器进行广泛评估,所提出的混合检测器在关键点检测精度和计算效率方面表现出了卓越的性能。比较中考虑了三种图像采集方法(即旋转、场景到模型和缩放变换)。通过对各种遥感图像的应用,所提出的混合方法在匹配点和匹配率方面都有明显改善,证明了其在处理卫星和航空图像中典型的各种复杂成像条件时的有效性。实验结果一致表明,混合检测器的性能优于传统方法,使其成为高级图像配准任务的重要工具。
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引用次数: 0
Unleashing the Power of Contrastive Learning for Zero-Shot Video Summarization. 释放对比学习的力量,实现零镜头视频总结。
IF 2.7 Q3 IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY Pub Date : 2024-09-14 DOI: 10.3390/jimaging10090229
Zongshang Pang, Yuta Nakashima, Mayu Otani, Hajime Nagahara

Video summarization aims to select the most informative subset of frames in a video to facilitate efficient video browsing. Past efforts have invariantly involved training summarization models with annotated summaries or heuristic objectives. In this work, we reveal that features pre-trained on image-level tasks contain rich semantic information that can be readily leveraged to quantify frame-level importance for zero-shot video summarization. Leveraging pre-trained features and contrastive learning, we propose three metrics featuring a desirable keyframe: local dissimilarity, global consistency, and uniqueness. We show that the metrics can well-capture the diversity and representativeness of frames commonly used for the unsupervised generation of video summaries, demonstrating competitive or better performance compared to past methods when no training is needed. We further propose a contrastive learning-based pre-training strategy on unlabeled videos to enhance the quality of the proposed metrics and, thus, improve the evaluated performance on the public benchmarks TVSum and SumMe.

视频摘要的目的是选择视频中信息量最大的帧子集,以促进高效的视频浏览。以往的工作无一例外都是利用注释摘要或启发式目标来训练摘要模型。在这项工作中,我们揭示了在图像级任务中预先训练的特征包含丰富的语义信息,可随时用于量化零镜头视频摘要的帧级重要性。利用预先训练的特征和对比学习,我们提出了具有理想关键帧特征的三个指标:局部不相似性、全局一致性和唯一性。我们的研究表明,这些指标能很好地捕捉常用于无监督生成视频摘要的帧的多样性和代表性,在不需要训练的情况下,与过去的方法相比具有竞争力或更好的性能。我们进一步提出了一种基于对比学习的预训练策略,该策略可在无标记视频上提高所提指标的质量,从而提高在公共基准 TVSum 和 SumMe 上的评估性能。
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引用次数: 0
Morphological Changes of the Pituitary Gland in Patients with Irritable Bowel Syndrome Using Magnetic Resonance Imaging. 利用磁共振成像观察肠易激综合征患者垂体的形态变化
IF 2.7 Q3 IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY Pub Date : 2024-09-13 DOI: 10.3390/jimaging10090226
Jessica Abou Chaaya, Jennifer Abou Chaaya, Batoul Jaafar, Lea Saab, Jad Abou Chaaya, Elie Al Ahmar, Elias Estephan

Irritable bowel syndrome (IBS) is a gastrointestinal functional disorder characterized by unclear underlying mechanisms. Several theories propose that hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis leads to elevated cortisol levels and increased sensitivity of gut wall receptors. Given the absence of prior literature on this topic, our study aimed to investigate the potential for diagnosing IBS based on morphological changes in the pituitary gland, specifically its volume and grayscale intensity. Additionally, we aimed to assess whether factors such as gender, age, and body mass index influence these parameters. This retrospective study involved 60 patients, examining the volume and grayscale characteristics of their pituitary glands in the presence of IBS. Our findings revealed a positive correlation between pituitary gland volume and IBS diagnosis, although no significant correlation was observed with grayscale intensity. Due to the limited existing research and the small sample size of our study, further investigation with a larger cohort is warranted to validate these results.

肠易激综合征(IBS)是一种胃肠功能紊乱,其发病机制尚不清楚。有几种理论认为,下丘脑-垂体-肾上腺(HPA)轴的过度激活导致皮质醇水平升高,肠壁受体的敏感性增加。鉴于之前没有相关文献,我们的研究旨在根据垂体的形态学变化,特别是垂体的体积和灰度强度,研究诊断肠易激综合征的可能性。此外,我们还旨在评估性别、年龄和体重指数等因素是否会影响这些参数。这项回顾性研究涉及 60 名患者,研究了他们在肠易激综合征时垂体的体积和灰度特征。我们的研究结果表明,垂体体积与肠易激综合征的诊断呈正相关,但与灰度强度无明显相关性。由于现有研究有限,而且我们的研究样本量较小,因此有必要对更大范围的人群进行进一步调查,以验证这些结果。
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引用次数: 0
Altered Movement Coordination during Functional Reach Tasks in Patients with Chronic Low Back Pain and Its Relationship to Numerical Pain Rating Scores. 慢性腰痛患者在完成功能性前伸任务时运动协调性的改变及其与数字疼痛评分的关系。
IF 2.7 Q3 IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY Pub Date : 2024-09-12 DOI: 10.3390/jimaging10090225
Susanne M van der Veen, Christopher R France, James S Thomas

Identifying the effects of pain catastrophizing on movement patterns in people with chronic low back pain (CLBP) has important clinical implications for treatment approaches. Prior research has shown people with CLBP have decreased lumbar-hip ratios during trunk flexion movements, indicating a decrease in the contribution of lumbar flexion relative to hip flexion during trunk flexion. In this study, we aim to explore the relationship between pain catastrophizing and movement patterns during trunk flexion in a CLBP population. Participants with CLBP (N = 98, male = 59, age = 39.1 ± 13.0) completed a virtual reality standardized reaching task that necessitated a progressively larger amount of trunk flexion. Specifically, participants reached for four virtual targets to elicit 15°, 30°, 45°, and 60° trunk flexion in the mid-sagittal plane. Lumbar flexion was derived from the motion data. Self-report measures of numerical pain ratings, kinesiophobia, and pain catastrophizing were obtained. Pain catastrophizing leads to decreased lumbar flexion angles during forward reaching. This effect is greater in females than males.

确定疼痛灾难化对慢性腰背痛(CLBP)患者运动模式的影响对治疗方法具有重要的临床意义。先前的研究表明,慢性腰背痛患者在躯干屈曲运动时腰部与臀部的比率会降低,这表明在躯干屈曲过程中,腰部屈曲相对于臀部屈曲的贡献会减少。在本研究中,我们旨在探讨 CLBP 患者在躯干屈曲时疼痛灾难化与运动模式之间的关系。患有慢性肢体麻痹症的参与者(人数 = 98,男性 = 59,年龄 = 39.1 ± 13.0)完成了一项虚拟现实标准化伸手任务,该任务要求参与者逐渐加大躯干屈曲的幅度。具体来说,参与者伸手去够四个虚拟目标,在中矢状面上引起 15°、30°、45° 和 60°的躯干弯曲。腰部屈曲由运动数据得出。研究人员对数字疼痛评分、运动恐惧和疼痛灾难化进行了自我报告测量。疼痛灾难化会导致前伸时腰椎屈曲角度减小。女性比男性受到的影响更大。
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引用次数: 0
Quantitative Evaluation of White Matter Injury by Cranial Ultrasound to Detect the Effects of Parenteral Nutrition in Preterm Babies: An Observational Study. 通过头颅超声定量评估白质损伤以检测早产儿肠外营养的影响:一项观察性研究
IF 2.7 Q3 IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY Pub Date : 2024-09-10 DOI: 10.3390/jimaging10090224
Gianluigi Laccetta, Maria Chiara De Nardo, Raffaella Cellitti, Maria Di Chiara, Monica Tagliabracci, Pasquale Parisi, Flavia Gloria, Giuseppe Rizzo, Alberto Spalice, Gianluca Terrin

Nutrition in early life has an impact on white matter (WM) development in preterm-born babies. Quantitative analysis of pixel brightness intensity (PBI) on cranial ultrasound (CUS) scans has shown a great potential in the evaluation of periventricular WM echogenicity in preterm newborns. We aimed to investigate the employment of this technique to objectively verify the effects of parenteral nutrition (PN) on periventricular WM damage in preterm infants. Prospective observational study including newborns with gestational age at birth ≤32 weeks and/or birth weight ≤1500 g who underwent CUS examination at term-equivalent age. The echogenicity of parieto-occipital periventricular WM relative to that of homolateral choroid plexus (RECP) was calculated on parasagittal scans by means of quantitative analysis of PBI. Its relationship with nutrient intake through enteral and parenteral routes in the first postnatal week was evaluated. The study included 42 neonates for analysis. We demonstrated that energy and protein intake administered through the parenteral route positively correlated with both right and left RECP values (parenteral energy intake vs. right RECP: r = 0.413, p = 0.007; parenteral energy intake vs. left RECP: r = 0.422, p = 0.005; parenteral amino acid intake vs. right RECP: r = 0.438, p = 0.004; parenteral amino acid intake vs. left RECP: r = 0.446, p = 0.003). Multivariate linear regression analysis confirmed these findings. Quantitative assessment of PBI could be considered a simple, risk-free, and repeatable method to investigate the effects of PN on WM development in preterm neonates.

早产儿的早期营养会影响其白质(WM)的发育。头颅超声(CUS)扫描的像素亮度强度(PBI)定量分析在评估早产新生儿脑室周围白质回声方面显示出巨大的潜力。我们的目的是研究如何利用这一技术来客观验证肠外营养(PN)对早产儿脑室周围 WM 损伤的影响。前瞻性观察研究包括胎龄小于 32 周和/或出生体重小于 1500 克的新生儿,他们在足月时接受了 CUS 检查。通过PBI定量分析,计算了副矢状面扫描中顶枕周WM相对于同侧脉络丛(RECP)的回声性。研究还评估了其与出生后第一周通过肠道和肠外途径摄入营养物质的关系。该研究共分析了 42 名新生儿。我们发现,通过肠外途径摄入的能量和蛋白质与右侧和左侧 RECP 值均呈正相关(肠外能量摄入量与右侧 RECP 值对比:r = 0.413,p = 0.007;肠外能量摄入量与左侧 RECP 值对比:r = 0.422,p = 0.005;肠外氨基酸摄入量与右侧 RECP 值对比:r = 0.438,p = 0.004;肠外氨基酸摄入量与左侧 RECP 值对比:r = 0.446,p = 0.003)。多变量线性回归分析证实了这些发现。PBI的定量评估可被视为一种简单、无风险且可重复的方法,用于研究PN对早产新生儿WM发育的影响。
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引用次数: 0
Peripheral Non-Contrast MR Angiography Using FBI: Scan Time and T2 Blurring Reduction with 2D Parallel Imaging. 使用 FBI 进行外周非对比 MR 血管造影:利用二维平行成像减少扫描时间和 T2 模糊。
IF 2.7 Q3 IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY Pub Date : 2024-09-09 DOI: 10.3390/jimaging10090223
Won C Bae, Lewis Hahn, Vadim Malis, Anya Mesa, Diana Vucevic, Mitsue Miyazaki

Non-contrast magnetic resonance angiography (NC-MRA), including fresh blood imaging (FBI), is a suitable choice for evaluating patients with peripheral artery disease (PAD). We evaluated standard FBI (sFBI) and centric ky-kz FBI (cFBI) acquisitions, using 1D and 2D parallel imaging factors (PIFs) to assess the trade-off between scan time and image quality due to blurring. The bilateral legs of four volunteers (mean age 33 years, two females) were imaged in the coronal plane using a body array coil with a posterior spine coil. Two types of sFBI and cFBI sequences with 1D PIF factor 5 in the phase encode (PE) direction (in-plane) and 2D PIF 3 (PE) × 2 (slice encode (SE)) (in-plane, through-slice) were studied. Image quality was evaluated by a radiologist, the vessel's signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured, and major vessel width was measured on the coronal maximum intensity projection (MIP) and 80-degree MIP. Results showed significant time reductions from 184 to 206 s on average when using sFBI down to 98 to 162 s when using cFBI (p = 0.003). Similar SNRs (averaging 200 to 370 across all sequences and PIF) and CNRs (averaging 190 to 360) for all techniques (p > 0.08) were found. There was no significant difference in the image quality (averaging 4.0 to 4.5; p > 0.2) or vessel width (averaging 4.1 to 4.9 mm; p > 0.1) on coronal MIP due to sequence or PIF. However, vessel width measured using 80-degree MIP demonstrated a significantly wider vessel in cFBI (5.6 to 6.8 mm) compared to sFBI (4.5 to 4.7 mm) (p = 0.022), and in 1D (4.7 to 6.8 mm) compared to 2D (4.5 to 5.6 mm) (p < 0.05) PIF. This demonstrated a trade-off in T2 blurring between 1D and 2D PIF: 1D using a PIF of 5 shortened the acquisition window, resulting in sharper arterial blood vessels in coronal images but significant blur in the 80-degree MIP. Two-dimensional PIF for cFBI provided a good balance between shorter scan time (relative to sFBI) and good sharpness in both in- and through-plane, while no benefit of 2D PIF was seen for sFBI. In conclusion, this study demonstrated the usefulness of FBI-based techniques for peripheral artery imaging and underscored the need to strike a balance between scan time and image quality in different planes through the use of 2D parallel imaging.

非对比磁共振血管成像(NC-MRA),包括新鲜血液成像(FBI),是评估外周动脉疾病(PAD)患者的合适选择。我们使用一维和二维平行成像因子(PIF)评估了标准联邦调查局(sFBI)和中心 ky-kz 联邦调查局(cFBI)采集,以评估扫描时间与模糊导致的图像质量之间的权衡。使用带脊柱后部线圈的体阵线圈对四名志愿者(平均年龄 33 岁,两名女性)的双侧腿部进行冠状面成像。研究了相位编码(PE)方向(平面内)的 1D PIF 因子 5 和 2D PIF 3(PE)×2(切片编码(SE))(平面内,穿透切片)的两种 sFBI 和 cFBI 序列。放射科医生对图像质量进行了评估,测量了血管的信噪比(SNR)和对比信噪比(CNR),并在冠状最大强度投影(MIP)和 80 度 MIP 上测量了主要血管的宽度。结果显示,使用 sFBI 时的平均时间从 184 秒到 206 秒大幅缩短到使用 cFBI 时的 98 秒到 162 秒(p = 0.003)。所有技术的信噪比(在所有序列和 PIF 中平均为 200 至 370)和 CNR(平均为 190 至 360)相似(p > 0.08)。冠状 MIP 的图像质量(平均 4.0 至 4.5;p > 0.2)或血管宽度(平均 4.1 至 4.9 毫米;p > 0.1)因序列或 PIF 而无明显差异。然而,使用 80 度 MIP 测量的血管宽度显示,与 sFBI(4.5 至 4.7 毫米)(p = 0.022)相比,cFBI(5.6 至 6.8 毫米)的血管明显更宽;与二维(4.5 至 5.6 毫米)(p < 0.05)PIF 相比,一维(4.7 至 6.8 毫米)的血管明显更宽(p < 0.05)。这表明一维和二维 PIF 在 T2 模糊方面有所权衡:一维 PIF 为 5 时缩短了采集窗口,从而使冠状图像中的动脉血管更加清晰,但 80 度 MIP 则明显模糊。用于 cFBI 的二维 PIF 很好地平衡了扫描时间(相对于 sFBI)的缩短和平面内及通透平面的清晰度,而用于 sFBI 的二维 PIF 则没有任何益处。总之,这项研究证明了基于 FBI 的外周动脉成像技术的实用性,并强调了通过使用二维平行成像在不同平面的扫描时间和图像质量之间取得平衡的必要性。
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引用次数: 0
Spectral Reflectance Estimation from Camera Response Using Local Optimal Dataset and Neural Networks. 利用局部最优数据集和神经网络从相机响应估算光谱反射率
IF 2.7 Q3 IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY Pub Date : 2024-09-09 DOI: 10.3390/jimaging10090222
Shoji Tominaga, Hideaki Sakai

In this study, a novel method is proposed to estimate surface-spectral reflectance from camera responses that combine model-based and training-based approaches. An imaging system is modeled using the spectral sensitivity functions of an RGB camera, spectral power distributions of multiple light sources, unknown surface-spectral reflectance, additive noise, and a gain parameter. The estimation procedure comprises two main stages: (1) selecting the local optimal reflectance dataset from a reflectance database and (2) determining the best estimate by applying a neural network to the local optimal dataset only. In stage (1), the camera responses are predicted for the respective reflectances in the database, and the optimal candidates are selected in the order of lowest prediction error. In stage (2), most reflectance training data are obtained by a convex linear combination of local optimal data using weighting coefficients based on random numbers. A feed-forward neural network with one hidden layer is used to map the observation space onto the spectral reflectance space. In addition, the reflectance estimation is repeated by generating multiple sets of random numbers, and the median of a set of estimated reflectances is determined as the final estimate of the reflectance. Experimental results show that the estimation accuracies exceed those of other methods.

本研究提出了一种新方法,结合基于模型和基于训练的方法,从相机响应估算表面光谱反射率。利用 RGB 摄像机的光谱灵敏度函数、多个光源的光谱功率分布、未知表面光谱反射率、加法噪声和增益参数对成像系统进行建模。估计过程包括两个主要阶段:(1) 从反射率数据库中选择局部最优反射率数据集;(2) 仅对局部最优数据集应用神经网络来确定最佳估计值。在第(1)阶段,针对数据库中的各反射率预测摄像机的响应,并按照预测误差最小的顺序选出最佳候选。在第(2)阶段,通过使用基于随机数的加权系数对局部最优数据进行凸线性组合,获得大部分反射率训练数据。使用带有一个隐藏层的前馈神经网络将观测空间映射到光谱反射空间。此外,通过生成多组随机数重复进行反射率估计,并确定一组估计反射率的中值作为反射率的最终估计值。实验结果表明,估计精度超过了其他方法。
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引用次数: 0
Impact of Display Sub-Pixel Arrays on Perceived Gloss and Transparency. 显示器子像素阵列对感知光泽度和透明度的影响
IF 2.7 Q3 IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY Pub Date : 2024-09-08 DOI: 10.3390/jimaging10090221
Midori Tanaka, Kosei Aketagawa, Takahiko Horiuchi

In recent years, improvements in display image quality have made it easier to perceive rich object information, such as gloss and transparency, from images, known as shitsukan. Do the different display specifications in the world affect their appearance? Clarifying the effects of differences in pixel structure on shitsukan perception is necessary to realize shitsukan management for displays with different hardware structures, which has not been fully clarified before. In this study, we experimentally investigated the effects of display pixel arrays on the perception of glossiness and transparency. In a visual evaluation experiment, we investigated the effects of three types of sub-pixel arrays (RGB, RGBW, and PenTile) on the perception of glossiness and transparency using natural images. The results confirmed that sub-pixel arrays affect the appearance of glossiness and transparency. A general relationship of RGB > PenTile > RGBW for glossiness and RGB > RGBW > PenTile for transparency was found; however, detailed analysis, such as cluster analysis, confirmed that the relative superiority of these sub-pixel arrays may vary depending on the observer and image content.

近年来,显示图像质量的提高使人们更容易从图像中感知丰富的物体信息,如光泽度和透明度,这些信息被称为 "shitsukan"。世界上不同的显示规格是否会影响其外观?澄清像素结构差异对 "屎壳郎 "感知的影响对于实现不同硬件结构显示器的 "屎壳郎 "管理非常必要,而这一点之前尚未完全澄清。在本研究中,我们通过实验研究了显示器像素阵列对光泽度和透明度感知的影响。在视觉评估实验中,我们使用自然图像研究了三种类型的子像素阵列(RGB、RGBW 和 PenTile)对光泽度和透明度感知的影响。结果证实,子像素阵列会影响光泽度和透明度的外观。在光泽度方面,发现了 RGB > PenTile > RGBW 的一般关系;在透明度方面,发现了 RGB > RGBW > PenTile 的一般关系;但是,聚类分析等详细分析证实,这些子像素阵列的相对优势可能因观察者和图像内容的不同而不同。
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引用次数: 0
Reducing Training Data Using Pre-Trained Foundation Models: A Case Study on Traffic Sign Segmentation Using the Segment Anything Model. 使用预训练基础模型减少训练数据:使用 Segment Anything 模型进行交通标志分割的案例研究。
IF 2.7 Q3 IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY Pub Date : 2024-09-07 DOI: 10.3390/jimaging10090220
Sofia Henninger, Maximilian Kellner, Benedikt Rombach, Alexander Reiterer

The utilization of robust, pre-trained foundation models enables simple adaptation to specific ongoing tasks. In particular, the recently developed Segment Anything Model (SAM) has demonstrated impressive results in the context of semantic segmentation. Recognizing that data collection is generally time-consuming and costly, this research aims to determine whether the use of these foundation models can reduce the need for training data. To assess the models' behavior under conditions of reduced training data, five test datasets for semantic segmentation will be utilized. This study will concentrate on traffic sign segmentation to analyze the results in comparison to Mask R-CNN: the field's leading model. The findings indicate that SAM does not surpass the leading model for this specific task, regardless of the quantity of training data. Nevertheless, a knowledge-distilled student architecture derived from SAM exhibits no reduction in accuracy when trained on data that have been reduced by 95%.

利用稳健的预训练基础模型,可以简单地适应正在进行的特定任务。特别是最近开发的 "任意分割模型"(Segment Anything Model,SAM)在语义分割方面取得了令人印象深刻的成果。由于数据收集通常耗时且成本高昂,本研究旨在确定使用这些基础模型能否减少对训练数据的需求。为了评估模型在训练数据减少的条件下的表现,将使用五个语义分割测试数据集。本研究将集中于交通标志分割,以分析与该领域领先模型 Mask R-CNN 相比的结果。研究结果表明,无论训练数据的数量如何,SAM 在这一特定任务中都没有超越领先模型。不过,从 SAM 衍生出的知识蒸馏学生架构在训练减少了 95% 的数据时,准确率并没有降低。
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引用次数: 0
Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Examination. 大鼠心脏超声的现实意义:改进检查的实用技巧。
IF 2.7 Q3 IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY Pub Date : 2024-09-06 DOI: 10.3390/jimaging10090219
Jessica Silva, Tiago Azevedo, Mário Ginja, Paula A Oliveira, José Alberto Duarte, Ana I Faustino-Rocha

Echocardiography is a reliable and non-invasive method for assessing cardiac structure and function in both clinical and experimental settings, offering valuable insights into disease progression and treatment efficacy. The successful application of echocardiography in murine models of disease has enabled the evaluation of disease severity, drug testing, and continuous monitoring of cardiac function in these animals. However, there is insufficient standardization of echocardiographic measurements for smaller animals. This article aims to address this gap by providing a guide and practical tips for the appropriate acquisition and analysis of echocardiographic parameters in adult rats, which may also be applicable in other small rodents used for scientific purposes, like mice. With advancements in technology, such as ultrahigh-frequency ultrasonic transducers, echocardiography has become a highly sophisticated imaging modality, offering high temporal and spatial resolution imaging, thereby allowing for real-time monitoring of cardiac function throughout the lifespan of small animals. Moreover, it allows the assessment of cardiac complications associated with aging, cancer, diabetes, and obesity, as well as the monitoring of cardiotoxicity induced by therapeutic interventions in preclinical models, providing important information for translational research. Finally, this paper discusses the future directions of cardiac preclinical ultrasound, highlighting the need for continued standardization to advance research and improve clinical outcomes to facilitate early disease detection and the translation of findings into clinical practice.

超声心动图是在临床和实验环境中评估心脏结构和功能的一种可靠、无创的方法,可为了解疾病进展和治疗效果提供宝贵的信息。在小鼠疾病模型中成功应用超声心动图后,就能对这些动物的疾病严重程度进行评估、进行药物测试和持续监测心脏功能。然而,对小型动物的超声心动图测量还不够标准化。本文旨在弥补这一不足,为成年大鼠超声心动图参数的适当采集和分析提供指南和实用技巧,这些指南和技巧可能也适用于其他用于科研目的的小型啮齿类动物,如小鼠。随着超高频超声换能器等技术的进步,超声心动图已成为一种高度复杂的成像方式,可提供高时间和空间分辨率的成像,从而可对小动物整个生命周期的心脏功能进行实时监测。此外,它还能评估与衰老、癌症、糖尿病和肥胖有关的心脏并发症,以及监测临床前模型中治疗干预引起的心脏毒性,为转化研究提供重要信息。最后,本文讨论了心脏临床前超声的未来发展方向,强调了持续标准化的必要性,以推动研究和改善临床结果,促进早期疾病检测和将研究结果转化为临床实践。
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引用次数: 0
期刊
Journal of Imaging
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