World Neurosurgery: X最新文献

{"title":"Grading the damage: Prognostic significance of diffuse axonal injury severity and hemorrhagic lesions in traumatic brain injury outcomes","authors":"Nanci Estefanía Bayas-Almeida ,&nbsp;Fabricio González-Andrade","doi":"10.1016/j.wnsx.2025.100539","DOIUrl":"10.1016/j.wnsx.2025.100539","url":null,"abstract":"<div><h3>Background</h3><div>Diffuse axonal injury (DAI) is a key determinant of prognosis in traumatic brain injury (TBI), yet the interaction between DAI severity and associated hemorrhagic lesions is not well defined, especially in low- and middle-income countries (LMICs).</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of 283 adults with moderate-to-severe TBI admitted to a tertiary hospital in Ecuador (2019–2023). DAI severity was graded anatomically using CT or MRI, and patients were stratified by the presence of hemorrhagic lesions. Demographic, clinical, metabolic, and radiological variables were collected. Outcomes were evaluated at 6 months with the Glasgow Outcome Scale–Extended (GOS-E). Logistic and ordinal regression models identified predictors of mortality and disability.</div></div><div><h3>Results</h3><div>Of 283 patients, 141 had isolated DAI and 142 had DAI with hemorrhage. Baseline demographics were similar. Patients with hemorrhagic lesions had lower median Glasgow Coma Scale scores (6 vs 9, <em>p</em> &lt; 0.001), more frequent hyperglycemia (15.5 % vs 7.1 %, <em>p</em> = 0.045), and greater surgical needs (77.5 % vs 16.3 %, <em>p</em> &lt; 0.001). Complications, including pneumonia and central nervous system infections, were more frequent in the hemorrhagic group (63.9 % vs 45.7 %, <em>p</em> &lt; 0.001). At 6 months, functional outcomes were significantly worse with hemorrhage (median GOS-E 7 vs 8, <em>p</em> &lt; 0.001). Multivariable regression identified Grade III DAI as the strongest predictor of mortality (OR 20.02, 95 % CI 7.99–50.15) and disability (OR 71.59, 95 % CI 23.11–221.77). Hemorrhagic lesions predicted poor functional recovery (OR 2.08, 95 % CI 1.24–3.48) but not mortality.</div></div><div><h3>Conclusions</h3><div>DAI grading is the most powerful prognostic factor in severe TBI, while hemorrhagic lesions primarily worsen disability. In LMICs, CT-based assessment remains essential for prognostic stratification and guiding rehabilitation strategies.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100539"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of pre-stroke physical activity on the initial volume and growth of the brain infarct and the rate of recanalization: A post-hoc analysis of the rescue brain trial","authors":"B. Douma ,&nbsp;M. Ferrigno ,&nbsp;E. Drumez ,&nbsp;B. Lapergue ,&nbsp;C. Rosso ,&nbsp;E. Meseguer ,&nbsp;M.L. Chadenat ,&nbsp;M. Obadia ,&nbsp;C. Hirel ,&nbsp;D.L. Duong ,&nbsp;C. Cordonnier ,&nbsp;P. Amarenco ,&nbsp;F. Pico","doi":"10.1016/j.wnsx.2025.100534","DOIUrl":"10.1016/j.wnsx.2025.100534","url":null,"abstract":"<div><h3>Background</h3><div>– Pre-stroke physical activity is known to influence stroke severity and long-term outcomes. However, its effects on infarct volume and vascular recanalization remain unclear. Using data from the RESCUE BRAIN trial, we aimed to determine whether the beneficial effects of physical activity before stroke are associated with smaller infarct volumes at presentation, reduced infarct growth over 24 h, and/or increased rates of arterial recanalization.</div></div><div><h3>Methods</h3><div><em>–</em> This study is a post-hoc analysis of the RESCUE BRAIN trial, a multicenter, randomized, open-label, controlled trial. Patients for whom information on activity habits was available at the time of randomization were included in this analysis. Hierarchical ascendant clustering was used to define physical activity clusters based on intensity (none, walking, walking and sports), frequency (0, 1, 1–3, &gt;3 times per week), and duration (0, &lt;30, 30–60, &gt;60 min). We examined the associations between physical activity clusters and baseline infarct volume and change in infarct volume over 24 h, site of arterial occlusion, and successful recanalization (including intravenous thrombolysis and mechanical thrombectomy).</div></div><div><h3>Results</h3><div><em>–</em> A total of 151 patients (mean ± standard deviation age 66.3 ± 15.9 years; 47.0 % male) were included. Patients with high levels of pre-stroke physical activity were younger and had a lower prevalence of hypertension (<em>p</em> = 0.02) and atrial fibrillation (<em>p</em> = 0.03). At baseline, infarct volume was unexpectedly larger in the walking and sports cluster (<em>p</em> = 0.01), but there was no significant difference between the three physical activity groups regarding the change in infarct volume at 24 h. We also found no evidence of a difference in baseline cerebral artery occlusion or recanalization rates.</div></div><div><h3>Conclusion</h3><div><em>–</em> This study suggests that pre-stroke physical activity does not affect the change in infarct volume or recanalization rates, despite its impact on the initial infarct size. These findings may suggest that the effects of physical activity may not operate through reducing infarcts volume or improving reperfusion, but rather through other mechanisms.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100534"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145320241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additive manufacturing for neurosurgical training: Development of patient-specific intracranial aneurysm flexible biomodels","authors":"Lorena Maria Dering ,&nbsp;Eduardo Burkot Hungria ,&nbsp;Jorge Luis Novak Filho ,&nbsp;Matheus Kahakura Franco Pedro ,&nbsp;André Giacomelli Leal ,&nbsp;Mauren Abreu de Souza","doi":"10.1016/j.wnsx.2025.100538","DOIUrl":"10.1016/j.wnsx.2025.100538","url":null,"abstract":"<div><h3>Background</h3><div>Additive manufacturing (AM) technologies have revolutionized the fabrication of three-dimensional objects by sequentially adding material layers based on digital representations. In addition to the production of medical equipment and implants, AM can reproduce precise anatomical models for the visualization of organs and structures, called 3D biomodels. The use of biomodels has the advantages of reducing costs, facilitating communication between doctor and patient, and is also a useful tool for simulation and surgical training.</div></div><div><h3>Methods</h3><div>Five rotational angiography exams of patients with aneurysms were selected. Based on these images, the modeling and 3D printing of biomodels of flexible aneurysms were customized, each model was evaluated based on manufacturing methodology, morphological fidelity compared to digital models, and usability in surgical training.</div></div><div><h3>Results</h3><div>Five IA biomodels, malleable and hollow, were obtained. On average, the production time was 176 min, with an average material cost of US$0.60. In their morphometric analysis, conducted using Geomagic Wrap® software, the biomodels did not demonstrate significant differences in relation to the three-dimensional image of the exam. In the software metrics, the differences between the printed aneurysms and their digital model did not exceed 0.57 mm. The surgical simulation with the biomodels performed by neurosurgeons still in-training and experienced neurosurgeons were positive, validating their use for resident training.</div></div><div><h3>Conclusions</h3><div>The 3D intracranial aneurysm biomodels, produced with flexible resin by 3D printing, demonstrate potential as valuable educational tools for training new professionals in clinical settings.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100538"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive surgery outcomes for intradural extramedullary tumors: a systematic review and meta-analysis","authors":"Ahmer Nasir Baig ,&nbsp;Tabinda Tahir ,&nbsp;Mohammad Hamza Bajwa ,&nbsp;Faiza Urooj ,&nbsp;Aimen Tameezuddin ,&nbsp;Saqib Kamran Bakhshi ,&nbsp;Muhammad Shahzad Shamim","doi":"10.1016/j.wnsx.2025.100544","DOIUrl":"10.1016/j.wnsx.2025.100544","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditionally, spinal intradural-extramedullary (ID-EM) tumors have been accessed via open surgery which involves significant tissue dissection, prolonged time of surgery and painful recovery. Advanced techniques of minimally invasive surgery (MIS) aim to reduce these risks and complications while achieving similar goals of surgery.</div></div><div><h3>Objectives</h3><div>To evaluate and compare surgical, functional, and complication-related outcomes in patients with ID-EM spine tumors receiving surgery through open approaches and MIS.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines and registered under PROSPERO (#CRD42022302574), a systematic literature search was conducted across PubMed, EBSCO, and the Cochrane Library. Eligible studies included retrospective cohorts and case series that provided comparative data on MIS and open surgical approaches for IDEM tumor excision. Meta-analysis utilized the Mantel-Haenszel random-effects model for pooled data.</div></div><div><h3>Results</h3><div>We reviewed 426 articles and included 16 for qualitative and quantitative analysis. On meta-analysis, a total of 804 patients (372 MIS and 432 open surgery) were included. MIS showed a significant reduction in operative time, intraoperative blood loss, and length of hospital stay. Gross total resection rates were comparable between the two approaches. MIS also resulted in fewer postoperative complications, including cerebrospinal fluid leaks and the need for spinal fusion.</div></div><div><h3>Conclusion</h3><div>MIS for IDEM tumors provides surgical and recovery benefits compared to traditional open surgery, including shorter operative times, reduced blood loss, and fewer postoperative complications. Although both methods achieve similar tumor resection rates, MIS is linked to enhanced patient outcomes and shorter hospital stays, underscoring its role as a viable alternative in managing IDEM tumors. Future research should aim to optimize MIS techniques to improve patient safety and outcomes further.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100544"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular management of arterial-encasing meningiomas: A case report and review of treatment strategies","authors":"Mario Benvenutti-Regato ,&nbsp;Hannia M. Macias-Cruz ,&nbsp;Hector R. Martínez ,&nbsp;Carlos D. Acevedo-Castillo ,&nbsp;Omar R. Ortega-Ruiz ,&nbsp;Uriel A. Bautista-Coronado ,&nbsp;Jose A. Moran-Guerrero ,&nbsp;Rogelio E. Flores-Salcido ,&nbsp;Misael Salazar-Alejo ,&nbsp;Jose A. Figueroa-Sanchez","doi":"10.1016/j.wnsx.2025.100533","DOIUrl":"10.1016/j.wnsx.2025.100533","url":null,"abstract":"<div><h3>Introduction</h3><div>Skull base meningiomas pose significant surgical challenges due to their proximity to and encasement of critical neurovascular structures, particularly the internal carotid artery (ICA). While surgical resection remains the standard of care, complete excision may be limited by the risk of vascular injury. Endovascular approaches such as stenting and angioplasty have emerged as potential adjuncts to mitigate ischemic complications.</div></div><div><h3>Methods</h3><div>A review using Scopus, Medline, and Web of Science was conducted according to PRISMA guidelines to evaluate the use of endovascular stenting and angioplasty in patients with intracranial meningiomas encasing arteries. Inclusion criteria targeted cases with symptomatic encasement treated with endovascular procedures.</div></div><div><h3>Results</h3><div>Among 114 studies, three patients presented with skull base meningiomas involving the ICA, with symptoms including hemiparesis, aphasia, proptosis, and visual deficits. Endovascular strategies included: (1) ICA stenting for high-grade stenosis with favorable long-term patency; (2) preoperative angioplasty to reduce perioperative ischemic risk; and (3) postoperative stenting for vasospasm due to vessel kinking. Additionally, we report the case of a 71-year-old woman with a meningioma encasing the ICA, managed with endovascular stenting and radiotherapy. No ischemic events or tumor progression were observed at 12-month follow-up.</div></div><div><h3>Discussion</h3><div>The reviewed cases highlight the potential of endovascular strategies to maintain vascular integrity and prevent ischemia in tumors with arterial encasement. This strategy may reduce intraoperative complications and expand resection options. Current evidence is limited to isolated reports, underscoring the need for prospective studies to validate efficacy and safety.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100533"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum pentraxin-3 and plaque burden predict unexplained early neurological deterioration in branch atheromatous disease","authors":"Zhiyong Cao ,&nbsp;Xiaoming Guo ,&nbsp;Mei Ding ,&nbsp;Zhuo Chen ,&nbsp;Lei Wang ,&nbsp;Qi Fang","doi":"10.1016/j.wnsx.2025.100530","DOIUrl":"10.1016/j.wnsx.2025.100530","url":null,"abstract":"<div><h3>Objective</h3><div>Pentraxin-3 (PTX-3), an inflammatory biomarker, is associated with atherosclerosis-related cerebral infarction. Plaque burden is a known predictor of poor prognosis in cerebral infarction. This study aimed to determine whether serum PTX-3 levels and plaque burden are independent risk factors for unexplained early neurological deterioration (END) in patients with branch atheromatous disease (BAD).</div></div><div><h3>Methods</h3><div>This prospective observational cohort study included 289 consecutive BAD patients. END was evaluated within 72 h after acute ischemic stroke onset. Univariate and multivariate regression analyses were used to assess the relationships between PTX-3, plaque burden, and END. Receiver operating characteristic (ROC) curves were generated to evaluate the predictive performance of PTX-3, plaque burden, and their combination for unexplained END.</div></div><div><h3>Results</h3><div>Among the 289 patients, 82 (28.4 %) developed END. END was associated with higher PTX-3, oxLDL, and LDL levels; older age; hypertension; higher NIHSS scores after END; and greater plaque burden. After adjusting for confounders, both the highest PTX-3 quartile (OR = 1.256, 95 % CI: 1.032–29.930) and plaque burden (OR = 1.568, 95 % CI: 0.918–2.926) were independent predictors of END. The ROC analysis demonstrated that the combination of PTX-3(AUC = 0.742, 95 % CI: 0.680–0.804) and plaque burden (AUC = 0.758, 95 % CI: 0.697–0.818) yielded the highest predictive value (AUC = 0.785, 95 % CI: 0.727–0.844, p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Elevated serum PTX-3 levels and increased plaque burden were independently associated with unexplained END in BAD patients. Their combination showed superior predictive performance, indicating potential clinical utility for risk stratification.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100530"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seizure control after surgical resection of low-grade Gliomas: A Regional retrospective analysis","authors":"Saqib Kamran Bakhshi ,&nbsp;Rabeet Tariq ,&nbsp;Faiza Urooj ,&nbsp;Safwan Masood ,&nbsp;Farhan Arshad Mirza ,&nbsp;Syed Ather Enam","doi":"10.1016/j.wnsx.2025.100548","DOIUrl":"10.1016/j.wnsx.2025.100548","url":null,"abstract":"<div><h3>Introduction</h3><div>Seizures occur in 60–75 % of patients with low-grade gliomas (LGGs). 60–90 % of patients attain seizure freedom after resection. Seizure control varies with histopathology, the extent of resection (EOR), and the type of seizures. There is an inconsistency in the literature regarding the utility of anti-epileptic drugs (AED) after tumor resection. We aimed to determine factors associated with seizure control in patients after LGG resection.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using the medical records of all patients who underwent LGG resection at our center from 2018 to 2021. 77 patients fulfilled the selection criteria and were contacted via phone calls to collect information about their seizure control as per Engel Classification. The data was analyzed using SPSSv21.</div></div><div><h3>Results</h3><div>The mean age was 34.9 ± 11.3 years, and there was male predominance (62; 80.5 %). Generalized seizures were the most common type (54; 70 %), and Levetiracetam was the most commonly prescribed AED (60; 77.9 %). The median duration of pre-operative AED use was 4 (IQR: 1–24) months. The frontal lobe was the most common location of tumor (36; 46.8 %). Most of the patients had their surgery under general anesthesia (51; 61.4 %), while 29 (37.7 %) underwent awake craniotomy. Nearly half of the patients had a gross total resection (31; 40.3 %), and another 15 (19.5 %) had near-total resection. Sixteen patients (20.8 %) had their AEDs stopped within the first 6 months post-operatively (at variable intervals), and all of them had Engel Class IA to ID control at the time of follow-up (<em>p</em> = 0.008). The 12 patients with Grade I glioma also had optimum seizure control (<em>p</em> = 0.032).</div></div><div><h3>Conclusion</h3><div>Pilocytic Astrocytomas have better seizure control as compared to Grade II Astrocytomas and Oligodendrogliomas. Further studies are required with larger samples to establish guidelines on achieving adequate postoperative seizure control in LGG patients.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100548"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gazi Yaşargil: A minimalist genius in neurosurgery in parallel with the minimalism movement in art","authors":"Ali İhsan Ökten ,&nbsp;Saygı Uygur","doi":"10.1016/j.wnsx.2025.100537","DOIUrl":"10.1016/j.wnsx.2025.100537","url":null,"abstract":"<div><div>Prof. Dr. Gazi Yaşargil passed away at the age of 100 with the title of “Neurosurgeon of the Century”, leaving numerous invented neurosurgical instruments and techniques as well as trained neurosurgeons behind as his legacy. What mattered most to Yaşargil was finishing a surgery without causing harm to normal tissue. To this end, he introduced microscope into neurosurgery for the first time and developed many instruments to enhance his new techniques. Yaşargil's minimalist studies dating back to 1960s paved the road to modern, more advanced minimally invasive techniques. Notably, emergence of minimalist art movement coincides with Yaşargil's initial studies. Even though art, science and philosophy are distinct disciplines, it cannot be denied that they influence, pass through, and converge with each other throughout the history. One can observe how movements from different disciplines are embraced by others, fostering mutual empowerment while allowing each to pursue its own course. Similar pattern is apparent in minimalist art movement and minimally invasive surgical approaches. The idea of telling more with less by avoiding unnecessary materials and minimizing the number of objects to enhance the expression in minimalist art, has transformed into performing surgery with minimal harm through less invasive techniques that optimally preserve normal tissue and promote rapid patient recovery. Gazi Yaşargil pioneered the development of minimally invasive techniques in neurosurgery, simultaneously, with the emergence of the minimalist art movement, science and art reunited after a long hiatus.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100537"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Examining the correlation between hemoglobin-red blood cell distribution width ratio and hospital mortality in spontaneous intracerebral hemorrhage","authors":"Parth Aphale,&nbsp;Shashank Dokania,&nbsp;Himanshu Shekhar","doi":"10.1016/j.wnsx.2025.100536","DOIUrl":"10.1016/j.wnsx.2025.100536","url":null,"abstract":"","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100536"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professor Mahmut Gazi Yaşargil (1925–2025): The pioneer and architect of modern neurosurgery","authors":"Cumhur Kaan Yaltırık ,&nbsp;Murat Şakir Ekşi","doi":"10.1016/j.wnsx.2025.100501","DOIUrl":"10.1016/j.wnsx.2025.100501","url":null,"abstract":"<div><div>Through his work on microsurgical tools and techniques, Professor Mahmut Gazi Yaşargil revolutionized neurosurgery by making it a safer and more successful area of brain surgery. Mahmut Gazi Yaşargil, a Turkish-born neurosurgeon, died in Switzerland in 2025 after being born in 1925. The medical world recognized him as the “Father of Modern Neurosurgery” because he devoted his life to precision, education, and the upbringing of future surgeons. This article examines his life history, scientific discoveries, academic achievements, and his lasting impact on neurosurgery practices around the world.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100501"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}