Pub Date : 2022-03-25DOI: 10.18705/1607-419x-2022-28-2-147-156
T. Brodskaya, B. Geltser, T. S. Satalkina, S. Knysh, O. I. Shekunova
{"title":"Arterial hypertension and breast cancer in women: mechanisms of comorbidity and iatrogenic disease","authors":"T. Brodskaya, B. Geltser, T. S. Satalkina, S. Knysh, O. I. Shekunova","doi":"10.18705/1607-419x-2022-28-2-147-156","DOIUrl":"https://doi.org/10.18705/1607-419x-2022-28-2-147-156","url":null,"abstract":"","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82898853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-24DOI: 10.18705/1607-419x-2022-28-1-87-95
E. Bragina, I. A. Goncharova, I. Zhalsanova, E. Nemerov, M. Nazarenko, M. Freidin, V. Puzyrev
Objective. To assess the association of single nucleotide polymorphisms of genes potentially involved in the comorbidity of bronchial asthma (BA) and essential hypertension (HTN) in patients with different time onset of the diseases.Design and methods. Genotyping of 92 SNPs was performed using MALDI-TOF mass spectrometry in patients with BA and HTN (n = 97) and healthy individuals (n = 153). The group of patients with comorbid pathology was divided into two subgroups depending on the time of onset of symptoms of BA relative to HTN, and the prevalence of all studied SNPs was compared in each subgroup relative to the control.Results. The variant rs11590807 regulating expression for UTP25, TRAF3IP3, C1orf74, HSD11B1-AS 1, IRF6 genes in the heart, blood vessels, and lung is associated with BA and HTN, regardless of the time onset of each of these diseases. Associations of other variants are specific with respect for each subgroup of comorbid diseases. The rs1010461 variant, which regulates the expression of RNASE4 and ANG genes, is linked with HTN as the first phenotype of the comorbidity. The rs769214, rs11032700, rs11032699, rs484214, and rs480575 variants, which regulate the expression of CAT gene, are associated with BA as the first phenotype of disease comorbidity.Conclusions. We found specific associations of the studied polymorphic variants in the development of comorbid phenotypes of BA and HTN, which differ in the time of manifestation of each of the diseases relative to each other.
{"title":"Genetic comorbidity of hypertension and bronchial asthma","authors":"E. Bragina, I. A. Goncharova, I. Zhalsanova, E. Nemerov, M. Nazarenko, M. Freidin, V. Puzyrev","doi":"10.18705/1607-419x-2022-28-1-87-95","DOIUrl":"https://doi.org/10.18705/1607-419x-2022-28-1-87-95","url":null,"abstract":"Objective. To assess the association of single nucleotide polymorphisms of genes potentially involved in the comorbidity of bronchial asthma (BA) and essential hypertension (HTN) in patients with different time onset of the diseases.Design and methods. Genotyping of 92 SNPs was performed using MALDI-TOF mass spectrometry in patients with BA and HTN (n = 97) and healthy individuals (n = 153). The group of patients with comorbid pathology was divided into two subgroups depending on the time of onset of symptoms of BA relative to HTN, and the prevalence of all studied SNPs was compared in each subgroup relative to the control.Results. The variant rs11590807 regulating expression for UTP25, TRAF3IP3, C1orf74, HSD11B1-AS 1, IRF6 genes in the heart, blood vessels, and lung is associated with BA and HTN, regardless of the time onset of each of these diseases. Associations of other variants are specific with respect for each subgroup of comorbid diseases. The rs1010461 variant, which regulates the expression of RNASE4 and ANG genes, is linked with HTN as the first phenotype of the comorbidity. The rs769214, rs11032700, rs11032699, rs484214, and rs480575 variants, which regulate the expression of CAT gene, are associated with BA as the first phenotype of disease comorbidity.Conclusions. We found specific associations of the studied polymorphic variants in the development of comorbid phenotypes of BA and HTN, which differ in the time of manifestation of each of the diseases relative to each other.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83552119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.18705/1607-419x-2022-28-2-188-197
D. A. Shimanski, I. Nesterovich, O. Inamova, S. Lapin, O. Galkina, E. Levykina, V. I. Trophimov, T. Vlasov
{"title":"Analysis of clinical and anamnestic factors affecting endothelial glycocalyx condition in patients with active rheumatoid arthritis","authors":"D. A. Shimanski, I. Nesterovich, O. Inamova, S. Lapin, O. Galkina, E. Levykina, V. I. Trophimov, T. Vlasov","doi":"10.18705/1607-419x-2022-28-2-188-197","DOIUrl":"https://doi.org/10.18705/1607-419x-2022-28-2-188-197","url":null,"abstract":"","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75257710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.18705/1607-419x-2022-28-2-157-166
M. S. Litvinova, L. Khaisheva, S. Shlyk, I. Aboyan
{"title":"Vascular calcification and fibroblast growth factor in resistant hypertension","authors":"M. S. Litvinova, L. Khaisheva, S. Shlyk, I. Aboyan","doi":"10.18705/1607-419x-2022-28-2-157-166","DOIUrl":"https://doi.org/10.18705/1607-419x-2022-28-2-157-166","url":null,"abstract":"","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75845178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.18705/1607-419x-2022-28-2-108-125
M. Ionov, A. Konradi
{"title":"Telehealth in hypertensive patients: to whom, how and for how long?","authors":"M. Ionov, A. Konradi","doi":"10.18705/1607-419x-2022-28-2-108-125","DOIUrl":"https://doi.org/10.18705/1607-419x-2022-28-2-108-125","url":null,"abstract":"","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82264074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-18DOI: 10.18705/1607-419x-2022-28-1-17-26
S. Povetkin, A. A. Kornilov
This article is an analysis of current data on arterial hypertension (HTN) as a leading risk factor for premature death. We discuss the reasons of the failure to achieve target levels of blood pressure, and the available approaches to HTN pharmacological treatment by the main classes of antihypertensive drugs in accordance with current clinical guidelines. We show the advantages of fixed combinations (FC) of antihypertensive drugs and the ways to optimize antihypertensive treatment by administration of a triple FC, containing amlodipine, indapamide and perindopril.
{"title":"Fixed drug combinations as a way of complex antihypertensive therapy optimization: focus on the combination of amlodipine, indapamide, perindopril","authors":"S. Povetkin, A. A. Kornilov","doi":"10.18705/1607-419x-2022-28-1-17-26","DOIUrl":"https://doi.org/10.18705/1607-419x-2022-28-1-17-26","url":null,"abstract":"This article is an analysis of current data on arterial hypertension (HTN) as a leading risk factor for premature death. We discuss the reasons of the failure to achieve target levels of blood pressure, and the available approaches to HTN pharmacological treatment by the main classes of antihypertensive drugs in accordance with current clinical guidelines. We show the advantages of fixed combinations (FC) of antihypertensive drugs and the ways to optimize antihypertensive treatment by administration of a triple FC, containing amlodipine, indapamide and perindopril. ","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84530043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-18DOI: 10.18705/1607-419x-2022-28-2-178-187
A. Polupanov, A. Mamatov, A. Kontsevaya, M. T. Duishenalieva, E. Y. Amelin, I. Bebezov, S. Akhunbaev, E. D. Djyshambaev, A. Jumagulova
{"title":"Association of abdominal obesity with the development of fatal and non-fatal cardiovascular events in a cohort of rural residents of the Kyrgyz Republic: gender and ethnic characteristics","authors":"A. Polupanov, A. Mamatov, A. Kontsevaya, M. T. Duishenalieva, E. Y. Amelin, I. Bebezov, S. Akhunbaev, E. D. Djyshambaev, A. Jumagulova","doi":"10.18705/1607-419x-2022-28-2-178-187","DOIUrl":"https://doi.org/10.18705/1607-419x-2022-28-2-178-187","url":null,"abstract":"","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78677460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-18DOI: 10.18705/1607-419x-2021-27-6-706-712
A. Avagimyan, L. Mkrtchyan, N. B. Kononchuk, L. V. Kaktursky, L. Agati
{"title":"Chemotherapy as a possible trigger for the myocardial lipomatosis development","authors":"A. Avagimyan, L. Mkrtchyan, N. B. Kononchuk, L. V. Kaktursky, L. Agati","doi":"10.18705/1607-419x-2021-27-6-706-712","DOIUrl":"https://doi.org/10.18705/1607-419x-2021-27-6-706-712","url":null,"abstract":"","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82722951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-18DOI: 10.18705/1607-419x-2021-27-6-683-695
S. G. Manasyan, S. Ermolov, A. G. Apresyan, A. V. Arutyunyan
Objective. The purpose of the work was to assess the application of modified ways of polyhepatography (PHG) and peripheral arterial tonometry (PAT) in the evaluation of regulation of peripheral circulation (capillary blood flow).Design and methods. We included 150 people, divided into four groups. The first group (n = 40) includes patients with stage II hypertension, moderate and high risk of cardiovascular complications. The second group (n = 40) includes patients with stable forms of coronary heart disease in combination with hypertension. The third group (n = 40) includes patients with chronic liver diseases. The fourth group (n = 30) consisted of subjects without anamnestic and objective data of pathology. All subjects underwent a comprehensive clinical and laboratory examination, an assessment of intrahepatic hemodynamics by the PGG method, an assessment of the endothelial function by the PAT method. A modified method of PAT was used to evaluate the central reaction of the peripheral blood flow regulation system (endothelium-independent vasodilation).Results. Endothelial dysfunction was found in patients with cardiovascular pathology and in patients with chronic liver diseases. A modified method of PAT showed a multidirectional reaction of peripheral blood flow to the test with local ischemia. A number of features were identified in the study groups when assessing disorders of intrahepatic microcirculation. Patients of group I had multidirectional disorders of arteriovenous inflow (45% cases, confidence interval (CI) from 27 % to 63 %) and outflow (37,5 %, CI from 22 % to 56 %) in the liver, while in patients of group II and group III, disorders of arteriovenous inflow were more common, 85 % (CI from 70 % to 95%) and 90% (82 % to 94%), respectively. Rheographic signs of bile passage disorders were more common in groups II and III. A significant negative relationship was established between endothelial dysfunction and the severity of intrahepatic microcirculation disorders (r = –0,35, p < 0,001).Conclusions. Modified methods of peripheral arterial tone and PHG enable assessment of local and central mechanisms of blood flow regulation at the microvascular level in patients with hypertension, coronary heart disease and chronic liver diseases. The relationship between impaired endothelial function and intrahepatic microcirculation allows us to consider the liver as a target organ in cardiovascular pathology.
{"title":"Modified methods of polygepatography and peripheral arterial tonometry in the assessment of peripheral circulation regulation","authors":"S. G. Manasyan, S. Ermolov, A. G. Apresyan, A. V. Arutyunyan","doi":"10.18705/1607-419x-2021-27-6-683-695","DOIUrl":"https://doi.org/10.18705/1607-419x-2021-27-6-683-695","url":null,"abstract":"Objective. The purpose of the work was to assess the application of modified ways of polyhepatography (PHG) and peripheral arterial tonometry (PAT) in the evaluation of regulation of peripheral circulation (capillary blood flow).Design and methods. We included 150 people, divided into four groups. The first group (n = 40) includes patients with stage II hypertension, moderate and high risk of cardiovascular complications. The second group (n = 40) includes patients with stable forms of coronary heart disease in combination with hypertension. The third group (n = 40) includes patients with chronic liver diseases. The fourth group (n = 30) consisted of subjects without anamnestic and objective data of pathology. All subjects underwent a comprehensive clinical and laboratory examination, an assessment of intrahepatic hemodynamics by the PGG method, an assessment of the endothelial function by the PAT method. A modified method of PAT was used to evaluate the central reaction of the peripheral blood flow regulation system (endothelium-independent vasodilation).Results. Endothelial dysfunction was found in patients with cardiovascular pathology and in patients with chronic liver diseases. A modified method of PAT showed a multidirectional reaction of peripheral blood flow to the test with local ischemia. A number of features were identified in the study groups when assessing disorders of intrahepatic microcirculation. Patients of group I had multidirectional disorders of arteriovenous inflow (45% cases, confidence interval (CI) from 27 % to 63 %) and outflow (37,5 %, CI from 22 % to 56 %) in the liver, while in patients of group II and group III, disorders of arteriovenous inflow were more common, 85 % (CI from 70 % to 95%) and 90% (82 % to 94%), respectively. Rheographic signs of bile passage disorders were more common in groups II and III. A significant negative relationship was established between endothelial dysfunction and the severity of intrahepatic microcirculation disorders (r = –0,35, p < 0,001).Conclusions. Modified methods of peripheral arterial tone and PHG enable assessment of local and central mechanisms of blood flow regulation at the microvascular level in patients with hypertension, coronary heart disease and chronic liver diseases. The relationship between impaired endothelial function and intrahepatic microcirculation allows us to consider the liver as a target organ in cardiovascular pathology.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87108209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-18DOI: 10.18705/1607-419x-2022-28-1-58-66
V. Chulkov, E. Gavrilova, V. Chulkov, E. Pankova, S. Martynov, V. I. Manzhos
Background. The increased prevalence of obesity and associated cardiometabolic diseases attract attention worldwide. Renin-angiotensin system can link obesity and cardiovascular and metabolic diseases.Objective. To access a comprehensive assessment of cardiometabolic risk factors and gene polymorphisms of the renin-angiotensin system in metabolic phenotypes among young individuals.Design and methods. The sample consisted of 251 individuals, who were divided into four groups: group 1 — metabolically healthy individuals with normal body mass index (BMI) (n = 62); group 2 — metabolically unhealthy individuals with normal BMI (n = 57); group 3 — metabolically healthy overweight/obese individuals (n = 16); group 4— metabolically unhealthy overweight/ obese individuals (n = 116). All participants answered a questionnaire designed for this study. Anthropometric, clinical and biochemical parameters were assessed. The following polymorphisms were evaluated:, A1166C polymorphism of the angiotensin II type 1 receptor gene (rs5186), M235T polymorphism of the angiotensinogen gene (rs699), T174M polymorphism of the angiotensinogen gene (rs4762), I/D polymorphism of the angiotensinconverting enzyme gene (rs4340).Results. In young individuals with metabolically unhealthy overweight/ obesity, a higher frequency of coexistent abdominal obesity and hypertension was found in combination with a higher frequency of the allele T of AGT 235M/T. The greater differences in carbohydrate and lipid metabolism in combination with a higher serum levels of leptin and low serum concentrations of adiponectin were also found in young individuals with metabolically unhealthy overweight/obesity.
{"title":"Cardiometabolic risk factors and renin-angiotensin system polymorphisms in young individuals with various metabolic phenotypes","authors":"V. Chulkov, E. Gavrilova, V. Chulkov, E. Pankova, S. Martynov, V. I. Manzhos","doi":"10.18705/1607-419x-2022-28-1-58-66","DOIUrl":"https://doi.org/10.18705/1607-419x-2022-28-1-58-66","url":null,"abstract":"Background. The increased prevalence of obesity and associated cardiometabolic diseases attract attention worldwide. Renin-angiotensin system can link obesity and cardiovascular and metabolic diseases.Objective. To access a comprehensive assessment of cardiometabolic risk factors and gene polymorphisms of the renin-angiotensin system in metabolic phenotypes among young individuals.Design and methods. The sample consisted of 251 individuals, who were divided into four groups: group 1 — metabolically healthy individuals with normal body mass index (BMI) (n = 62); group 2 — metabolically unhealthy individuals with normal BMI (n = 57); group 3 — metabolically healthy overweight/obese individuals (n = 16); group 4— metabolically unhealthy overweight/ obese individuals (n = 116). All participants answered a questionnaire designed for this study. Anthropometric, clinical and biochemical parameters were assessed. The following polymorphisms were evaluated:, A1166C polymorphism of the angiotensin II type 1 receptor gene (rs5186), M235T polymorphism of the angiotensinogen gene (rs699), T174M polymorphism of the angiotensinogen gene (rs4762), I/D polymorphism of the angiotensinconverting enzyme gene (rs4340).Results. In young individuals with metabolically unhealthy overweight/ obesity, a higher frequency of coexistent abdominal obesity and hypertension was found in combination with a higher frequency of the allele T of AGT 235M/T. The greater differences in carbohydrate and lipid metabolism in combination with a higher serum levels of leptin and low serum concentrations of adiponectin were also found in young individuals with metabolically unhealthy overweight/obesity. ","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81422778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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