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Preoperative Embolization vs. Direct Surgery in Skull Base Meningiomas: A Systematic Review and Meta-Analysis with Meta-Regression 术前栓塞与直接手术治疗颅底脑膜瘤:一项系统回顾和meta回归分析
IF 0.5 Q4 CLINICAL NEUROLOGY Pub Date : 2026-01-16 DOI: 10.1016/j.inat.2026.102194
Plamen Penchev , Eduardo Alonso , Pablo Vega-Medina , Danna Espinoza , Daniela Milanova-Ilieva , Monyse Falcao , Raphael Wuo-Silva , Feres Chaddad-Neto , Cristian Mendieta , Cristian Palomino , Francisco Palma-Garcia , Petar-Preslav Petrov , Pavel Stanchev , Nikolai Ramadanov

Introduction

Skull base meningiomas present unique surgical challenges due to proximity to critical neurovascular structures, leading to prolonged operative time, significant blood loss, and high complication risks. Preoperative embolization (POE) is used to reduce tumor vascularity and potentially decrease blood loss and operative time. However, existing studies are limited by small samples and a general focus, particularly lacking robust evidence for skull base lesions. We aimed to perform a systematic review and meta-analysis of the efficacy of POE versus direct surgery in skull base meningiomas.

Methods

A systematic search from inception up to 30 July 2025 (PubMed, Embase, and Cochrane Central) identified studies comparing POE to direct surgery for skull base meningiomas. Outcomes included intraoperative blood loss, operative time, hemoglobin, complications, and transfusion rates. Statistical analysis used a frequentist random-effects model (Risk Ratios [RR], Mean Differences [MD]), with heterogeneity assessed via I2 and the Cochrane Q test.

Results

Twenty-one studies (n = 896; mean age 54, 65.5% females), including 349 POE patients (39%), were analyzed. Pooled analysis revealed no statistically significant differences between POE and direct surgery for intraoperative blood loss (MD −67.26; 95% CI [-265.28; 130.76]; p = 0.51; I2 = 98.4%), operative time (MD −0.30; 95% CI [-1.03; 0.42]; p = 0.42; I2 = 87.8%), hemoglobin levels (MD 0.21; 95% CI [-0.54; 0.96]; p = 0.58; I2 = 70%), blood transfusion rate (RR 0.89; 95% CI [0.65; 1.23]; p = 0.446; I2 = 21%), or complication prevalence (RR 1.12; 95% CI [0.67; 1.87]; p = 0.637; I2 = 25.7%). Subgroup analyses (Simpson grade, extent of resection) and meta-regression showed no significant effect modifiers.

Conclusion

POE of skull base meningiomas did not significantly improve perioperative outcomes compared with direct surgery. Routine use may offer limited clinical benefit. Selective use may be warranted in giant or highly vascular tumors, but further high-quality studies are needed to confirm these findings.
颅底脑膜瘤由于靠近关键的神经血管结构,导致手术时间延长,大量失血和高并发症风险,给手术带来了独特的挑战。术前栓塞(POE)用于减少肿瘤血管,并可能减少失血和手术时间。然而,现有的研究受到小样本和一般焦点的限制,特别是缺乏颅底病变的有力证据。我们的目的是对POE与直接手术治疗颅底脑膜瘤的疗效进行系统回顾和荟萃分析。方法从开始到2025年7月30日(PubMed, Embase和Cochrane Central)进行系统检索,确定了将POE与颅底脑膜瘤直接手术进行比较的研究。结果包括术中出血量、手术时间、血红蛋白、并发症和输血率。统计分析采用频率随机效应模型(Risk ratio [RR], Mean Differences [MD]),通过I2和Cochrane Q检验评估异质性。结果共纳入21项研究(n = 896,平均年龄54岁,女性占65.5%),其中POE患者349例(39%)。汇集分析显示坡之间没有明显的统计学差异和直接手术术中失血(MD−67.26;95%可信区间[-265.28,130.76],p = 0.51; I2 = 98.4%),手术时间(MD−0.30;95%可信区间[-1.03,0.42],p = 0.42; I2 = 87.8%),血红蛋白水平(MD 0.21; 95%可信区间[-0.54,0.96],p = 0.58; I2 = 70%),输血率(RR 0.89; 95%可信区间[0.65,1.23],p = 0.446; I2 = 21%),或并发症患病率(RR 1.12; 95%可信区间[0.67,1.87],p = 0.637; I2 = 25.7%)。亚组分析(Simpson分级、切除程度)和meta回归显示无显著影响。结论颅底脑膜瘤poe与直接手术相比,围手术期预后无明显改善。常规使用可能提供有限的临床效益。在巨大或高血管肿瘤中选择性使用可能是合理的,但需要进一步的高质量研究来证实这些发现。
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引用次数: 0
Prevalence of burnout syndrome in Brazilian neurosurgery residents: A nationwide questionnaire-based survey 巴西神经外科住院医师倦怠综合征的患病率:一项全国性的问卷调查
IF 0.5 Q4 CLINICAL NEUROLOGY Pub Date : 2026-01-08 DOI: 10.1016/j.inat.2025.102160
Rhuann Pontes dos Santos Silva , Isadora Gomes Mesquita , Louise Makaren Oliveira , Marcia Mitie Nagumo , Julia Costa Justo , Gabriela Fernandes de Oliveira Pessoa , Eberval Gadelha , Luis Alencar Borba , Cleice Mara Goncalves Coelho , Jonas Byk , Juscimar Carneiro , Otávio da Cunha Ferreira Neto , José Marcus Rotta , Wellingson Silva Paiva , Robson Luis Oliveira de Amorim

Background

Burnout syndrome (BS) is a significant issue among neurosurgery residents, resulting from chronic emotional and interpersonal stressors. Characterized by emotional exhaustion, depersonalization, and low personal accomplishment, BS can lead to decreased productivity, interpersonal relationships, and medical errors.

Objective

This study aims to analyze the prevalence of BS among Brazilian neurosurgery residents and identify associated factors.

Methods

We conducted a cross-sectional study using the Maslach Burnout Inventory (MBI) and questionnaires covering sociodemographic information, mental health, and job satisfaction.

Results

The study surveyed all Brazilian neurosurgery residency programs, with 118 out of 600 residents (19.6 %) responding. The prevalence of BS was 64.1 %, and 94.9 % had at least one high domain. Third-year residents exhibited the highest rate of burnout (79.2 %). Gender significantly influenced burnout rates, with males showing higher levels. Additionally, dissatisfaction with personal life and insufficient physical exercise were associated with increased likelihood of burnout. They also exhibited higher dissatisfaction with their academic productivity, time for study, and balance between professional and personal life. Suicidal ideation was reported by 16.1 % of residents but was not statistically associated with BS. Multivariate analysis showed that only male sex was an independent variable of having BS (OR 2.97 95CI 1.005–8.78, p = 0.049). Also, those with BS were less likely to choose neurosurgery again (OR 0.22 95CI 0.06–0.78, p = 0.02) or recommend it as a specialty (OR 0.32 95CI 0.11–0.93, p = 0.03)

Conclusion

This study highlights the high prevalence of BS among Brazilian neurosurgery residents, indicating a need for targeted interventions to address these stressors and improve resident well-being.
职业倦怠综合征(BS)是神经外科住院医师中一个重要的问题,由慢性情绪和人际压力源引起。BS的特点是情绪耗竭、人格解体和个人成就感低,可能导致生产力下降、人际关系下降和医疗差错。目的分析巴西神经外科住院医师BS患病率及相关因素。方法采用Maslach职业倦怠量表(MBI)和社会人口统计信息、心理健康和工作满意度问卷进行横断面研究。结果该研究调查了巴西所有的神经外科住院医师项目,600名住院医师中有118人(19.6%)做出了回应。BS患病率为64.1%,其中94.9%至少有一个高域。第三年住院医师的倦怠率最高(79.2%)。性别显著影响倦怠率,男性表现出更高的水平。此外,对个人生活的不满和缺乏体育锻炼与倦怠的可能性增加有关。此外,他们对学业成绩、学习时间、职业与个人生活平衡的不满意度也较高。16.1%的居民报告有自杀意念,但与BS无统计学关联。多因素分析显示,男性是影响BS发生的独立变量(OR 2.97 95CI 1.005-8.78, p = 0.049)。此外,患有BS的患者不太可能再次选择神经外科(OR 0.22 95CI 0.06-0.78, p = 0.02)或将其作为专科推荐(OR 0.32 95CI 0.11-0.93, p = 0.03)。结论:本研究强调了巴西神经外科住院患者中BS的高患病率,表明需要有针对性的干预措施来解决这些压力源并改善居民的幸福感。
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引用次数: 0
Trigeminal Neuralgia Secondary to Arteriovenous Malformation of the Posterior Fossa: A Case Report and Literature Review 后窝动静脉畸形继发三叉神经痛1例报告及文献复习
IF 0.5 Q4 CLINICAL NEUROLOGY Pub Date : 2026-01-03 DOI: 10.1016/j.inat.2025.102176
Hongkuan Yang, Rudong Chen, Hua Li, Jiasheng Yu, Lingcheng Zeng

Objective

The objective of this study is to analyze a case of trigeminal neuralgia (TN) secondary to intracranial arteriovenous malformation (AVM), summarize reported cases of TN associated with cerebral vascular malformations, and discuss the experience with endovascular and other therapeutic modalities.

Methods

We analyzed our institutional case of cerebral AVM-induced TN and reviewed relevant literature on trigeminal neuralgia and AVM published between 1968 and 2022. A total of 47 consecutive cases of brain arteriovenous malformations (bAVMs) complicated by TN were identified through retrospective analysis of 47 treated bAVM cases. Clinical data, angiographic findings, and outcomes following endovascular and other treatments were evaluated.

Results

Among the 47 patients with TN associated with bAVMs, 11 underwent endovascular embolization: 10 achieved pain relief, and 1 showed initial symptomatic remission. Arterialization and ectasia of the superior petrosal vein (SPV) and its tributaries, which could explain trigeminal nerve compression, were observed in 24 cases. Venous hypertension in the ponto-trigeminal vein (a tributary of the SPV) appears to be one of the etiological factors of TN.

Conclusions

Consistent with previous publications, we propose that venous reflux into tributaries of the SPV—particularly the ponto-trigeminal vein—represents a key mechanism of TN caused by nerve compression. Currently, there is no consensus on the optimal treatment for cerebellar AVM-related TN; however, partial interventional embolization of the AVM nidus is considered a viable strategy to reduce blood flow and alleviate symptoms.
目的分析1例颅内动静脉畸形(AVM)继发三叉神经痛(TN),总结报道的三叉神经痛合并脑血管畸形的病例,探讨血管内治疗及其他治疗方法的经验。方法分析我院收治的脑动静脉畸形诱发TN病例,回顾1968 ~ 2022年三叉神经痛和动静脉畸形的相关文献。回顾性分析47例已治疗的脑动静脉畸形(bAVMs)合并TN的连续47例。评估临床资料、血管造影结果以及血管内治疗和其他治疗后的结果。结果47例TN合并bAVMs患者中,11例行血管内栓塞术,10例疼痛缓解,1例初步症状缓解。24例观察到岩上静脉(SPV)及其分支动脉化和扩张,可以解释三叉神经压迫。桥-三叉静脉(SPV的一条分支)的静脉高压似乎是TN的病因之一。结论与先前的出版物一致,我们提出静脉回流到SPV的分支,特别是桥-三叉静脉,是神经压迫引起TN的关键机制。目前,小脑avm相关TN的最佳治疗方法尚未达成共识;然而,AVM病灶的部分介入栓塞被认为是减少血流量和缓解症状的可行策略。
{"title":"Trigeminal Neuralgia Secondary to Arteriovenous Malformation of the Posterior Fossa: A Case Report and Literature Review","authors":"Hongkuan Yang,&nbsp;Rudong Chen,&nbsp;Hua Li,&nbsp;Jiasheng Yu,&nbsp;Lingcheng Zeng","doi":"10.1016/j.inat.2025.102176","DOIUrl":"10.1016/j.inat.2025.102176","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study is to analyze a case of trigeminal neuralgia (TN) secondary to intracranial arteriovenous malformation (AVM), summarize reported cases of TN associated with cerebral vascular malformations, and discuss the experience with endovascular and other therapeutic modalities.</div></div><div><h3>Methods</h3><div>We analyzed our institutional case of cerebral AVM-induced TN and reviewed relevant literature on trigeminal neuralgia and AVM published between 1968 and 2022. A total of 47 consecutive cases of brain arteriovenous malformations (bAVMs) complicated by TN were identified through retrospective analysis of 47 treated bAVM cases. Clinical data, angiographic findings, and outcomes following endovascular and other treatments were evaluated.</div></div><div><h3>Results</h3><div>Among the 47 patients with TN associated with bAVMs, 11 underwent endovascular embolization: 10 achieved pain relief, and 1 showed initial symptomatic remission. Arterialization and ectasia of the superior petrosal vein (SPV) and its tributaries, which could explain trigeminal nerve compression, were observed in 24 cases. Venous hypertension in the ponto-trigeminal vein (a tributary of the SPV) appears to be one of the etiological factors of TN.</div></div><div><h3>Conclusions</h3><div>Consistent with previous publications, we propose that venous reflux into tributaries of the SPV—particularly the ponto-trigeminal vein—represents a key mechanism of TN caused by nerve compression. Currently, there is no consensus on the optimal treatment for cerebellar AVM-related TN; however, partial interventional embolization of the AVM nidus is considered a viable strategy to reduce blood flow and alleviate symptoms.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102176"},"PeriodicalIF":0.5,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collagen synthesis and MicroRNA interaction in degenerative lumbar canal stenosis 退行性腰椎管狭窄的胶原合成和MicroRNA相互作用
IF 0.5 Q4 CLINICAL NEUROLOGY Pub Date : 2026-01-03 DOI: 10.1016/j.inat.2025.102172
İsa İsaoğlu , Özlem Delen , Zeynep Banu Doğanlar , Oğuzhan Doğanlar , Emre Delen

Background

To investigate the potential interaction between collagen synthesis and microRNAs in ligamentum flavum (LF) obtained from patients with degenerative lumbar canal stenosis (DLCS).

Methods

A total of thirty-two human LF specimens were divided into two groups, each based on the diagnosis as follows: 20 from patients with DLCS and 12 from patients those with lumbar disc herniation (LDH). Fibrosis was graded into four levels according to the accumulation of decreased elastin fibres and increased collagen fibres, which can be observed using the Masson’s trichrome staining. Expression of the collagens (COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL6A1, COL8A1), associated proteins (extracellular matrix protein tenascin XB-TNXB, solute carrier family 39 member 13-SLC39A13, and procollagen N proteinase ADAMTS-2; and micro-ribonucleic acids (miR-27B, miR-29B, miR-143, and miR-221) were measured by quantitative real-time polymerase chain reaction (qRT-PCR) analysis. Western blot analysis was performed to determine the levels of COL1, COL3, COL5, COL6A1, and COL8A1. DLCS patients have higher fibrosis score than the LDH patients.

Results

DLCS patients have higher fibrosis score than the LDH patients. qRT-PCR analysis demonstrated that strongly upregulated mRNA levels of COL1A, COL1A2, COL3A1, ADAMTS2, miR-29B, and miR-143. However, protein expressions of COL1, COL3, COL6A, and COL8A1 is also upregulated.

Conclusions

Our results identified miR-29B and miR-143 regulation of COL synthesis of the LF fibrosis.
背景:研究退行性腰椎管狭窄(DLCS)患者黄韧带(LF)中胶原合成与microrna之间的潜在相互作用。方法32例人LF标本根据诊断分为2组:DLCS患者20例,LDH患者12例。根据弹性蛋白纤维减少和胶原纤维增加的累积,纤维化分为四个级别,可以用马松三色染色观察。通过定量实时聚合酶链式反应(qRT-PCR)分析,检测胶原(COL1A1、COL1A2、COL3A1、COL5A1、COL5A2、COL6A1、COL8A1)、相关蛋白(细胞外基质蛋白tenascin XB-TNXB、溶质载体家族39成员13-SLC39A13、前胶原N蛋白酶ADAMTS-2)和微核糖核酸(miR-27B、miR-29B、miR-143和miR-221)的表达。Western blot检测COL1、COL3、COL5、COL6A1和COL8A1的表达水平。dlc患者纤维化评分高于LDH患者。结果dlc患者纤维化评分高于LDH患者。qRT-PCR分析显示COL1A、COL1A2、COL3A1、ADAMTS2、miR-29B和miR-143的mRNA水平明显上调。然而,COL1、COL3、COL6A和COL8A1的蛋白表达也上调。结论miR-29B和miR-143在LF纤维化中调节COL合成。
{"title":"Collagen synthesis and MicroRNA interaction in degenerative lumbar canal stenosis","authors":"İsa İsaoğlu ,&nbsp;Özlem Delen ,&nbsp;Zeynep Banu Doğanlar ,&nbsp;Oğuzhan Doğanlar ,&nbsp;Emre Delen","doi":"10.1016/j.inat.2025.102172","DOIUrl":"10.1016/j.inat.2025.102172","url":null,"abstract":"<div><h3>Background</h3><div>To investigate the potential interaction between collagen synthesis and microRNAs in ligamentum flavum (LF) obtained from patients with degenerative lumbar canal stenosis (DLCS).</div></div><div><h3>Methods</h3><div>A total of thirty-two human LF specimens were divided into two groups, each based on the diagnosis as follows: 20 from patients with DLCS and 12 from patients those with lumbar disc herniation (LDH). Fibrosis was graded into four levels according to the accumulation of decreased elastin fibres and increased collagen fibres, which can be observed using the Masson’s trichrome staining. Expression of the collagens (COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL6A1, COL8A1), associated proteins (extracellular matrix protein tenascin XB-TNXB, solute carrier family 39 member 13-SLC39A13, and procollagen N proteinase ADAMTS-2; and micro-ribonucleic acids (miR-27B, miR-29B, miR-143, and miR-221) were measured by quantitative real-time polymerase chain reaction (qRT-PCR) analysis. Western blot analysis was performed to determine the levels of COL1, COL3, COL5, COL6A1, and COL8A1. DLCS patients have higher fibrosis score than the LDH patients.</div></div><div><h3>Results</h3><div>DLCS patients have higher fibrosis score than the LDH patients. qRT-PCR analysis demonstrated that strongly upregulated mRNA levels of COL1A, COL1A2, COL3A1, ADAMTS2, miR-29B, and miR-143. However, protein expressions of COL1, COL3, COL6A, and COL8A1 is also upregulated.</div></div><div><h3>Conclusions</h3><div>Our results identified miR-29B and miR-143 regulation of COL synthesis of the LF fibrosis.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102172"},"PeriodicalIF":0.5,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel radiation-free technique for navigated direct pars repair in patients with spondylolysis and congenital vertebral anomalies: A report of two cases 一种新的无辐射技术用于峡部裂和先天性椎体畸形患者的导航直接修复:附两例报告
IF 0.5 Q4 CLINICAL NEUROLOGY Pub Date : 2026-01-03 DOI: 10.1016/j.inat.2025.102191
Matthew Aceto , Scott Gronowicz , Michael S. Barnum , Maahir Haque

Background

Pars defects affect up to 7 % of adults. Patients with pars defects often experience progressively worsening pain and some develop spinal deformity due to the development of lytic spondylolisthesis. In symptomatic pars fractures who have failed non-operative management and have only mild deformity and degeneration, a decision can be made to fuse the affected motion segment or perform a direct pars repair. The purpose of this study is to describe a novel technique for direct pars repair using a novel radiation-free stereotactic navigation. We further describe the clinical outcomes in two cases managed with this technique.

Case

Two adult patients with L5 spondylolysis and spina bifida occulta − a 33-year-old male and a 41-year-old male who also had sacral dysraphism − underwent direct pars repair using radiation-free 7D Navigation.

Outcome

Both cases demonstrated clinical improvement and good radiographic outcomes at more than 1 year follow-up.

Conclusion

Direct pars repair using radiation-free stereotactic navigation offers a safe, effective, and more efficient means for the surgical treatment of symptomatic spondylolysis. This is especially true for patients with lumbosacral anatomical variability, in whom conventional techniques may lead to screw malpositioning, a need for revision surgery, and poor outcomes.
高达7%的成年人患有自闭症。伴有部部缺损的患者通常会经历逐渐加重的疼痛,一些患者会由于滑脱性椎体滑移而发展为脊柱畸形。对于非手术治疗失败且仅有轻度畸形和退变的有症状的部分骨折,可决定融合受影响的运动节段或直接进行部分修复。本研究的目的是描述一种使用新型无辐射立体定向导航的直接局部修复新技术。我们进一步描述了用这种技术管理的两个病例的临床结果。2例L5椎弓峡部裂和隐性脊柱裂的成年患者(一名33岁男性和一名41岁男性,同时患有骶骨畸形)采用无辐射7D导航进行直接局部修复。结果在1年多的随访中,两例患者均表现出临床改善和良好的影像学结果。结论无辐射立体定向导航直接修复是一种安全、有效、高效的治疗症状性峡部裂的手术方法。对于腰骶解剖结构变异的患者尤其如此,传统技术可能导致螺钉错位,需要翻修手术,结果不佳。
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引用次数: 0
The left lateral decubitus position as a safe and effective alternative for posterior lumbar fixation in Pregnancy: A technical Note 左侧卧位作为妊娠期腰椎后路固定安全有效的替代方法:技术说明
IF 0.5 Q4 CLINICAL NEUROLOGY Pub Date : 2026-01-03 DOI: 10.1016/j.inat.2025.102187
Oualid Mohammed Hmamouche, Marouane Hammoud, Faycal Lakhdar, Mohammed Benzagmout, Khalid Chakour, Mohammed El Faiz Chaoui

Background

Spinal trauma during pregnancy is rare and technically challenging due to maternal–fetal risks. Positioning for posterior fixation in advanced gestation is problematic because prone positioning risks aortocaval compression.
Case/Technique: We report emergency posterior fixation for a burst fracture of L1 in a 40-year-old woman at 24 weeks’ gestation. Short-segment fixation was performed from D12 to L2 in the left lateral decubitus position to avoid vena cava compression. Free-hand pedicle screws were placed using anatomical landmarks and tactile feedback, with limited laminectomy and single-shot fluoroscopy under abdominal shielding.
Outcome: Recovery was uneventful. Urinary retention resolved within 6 days. The patient delivered vaginally at term, and 36-month follow-up confirmed stable fixation without maternal or neonatal complications.

Conclusion

The left lateral decubitus position is a feasible and safe alternative to prone positioning for lumbar fixation in advanced pregnancy. Multidisciplinary collaboration, radiation minimization, and precise free-hand technique are essential for achieving favorable outcomes.
背景:由于母胎风险,妊娠期脊柱损伤是罕见且技术上具有挑战性的。妊娠晚期后路固定的定位是有问题的,因为俯卧位有压迫腹主动脉的风险。病例/技术:我们报告一例妊娠24周的40岁女性L1爆裂性骨折的紧急后路固定。左侧卧位从D12至L2行短节段固定以避免腔静脉受压。利用解剖标志和触觉反馈放置徒手椎弓根螺钉,在腹部遮挡下进行有限椎板切除术和单次透视检查。结果:恢复平稳。尿潴留在6天内消失。患者足月顺产,36个月随访证实固定稳定,无产妇或新生儿并发症。结论左侧卧位可替代俯卧位用于妊娠晚期腰椎固定。多学科合作、辐射最小化和精确的徒手技术是获得良好结果的必要条件。
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引用次数: 0
Re-considering the “Systematic review of traumatic intracranial aneurysms” 对“外伤性颅内动脉瘤系统综述”的再思考
IF 0.5 Q4 CLINICAL NEUROLOGY Pub Date : 2026-01-03 DOI: 10.1016/j.inat.2025.102182
Abbas Amitrjamshidi
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引用次数: 0
Dual meningiomas with different pathology at the same spinal level: a rare case report 在同一脊柱水平有不同病理的双脑膜瘤:一个罕见的病例报告
IF 0.5 Q4 CLINICAL NEUROLOGY Pub Date : 2025-12-30 DOI: 10.1016/j.inat.2025.102181
Hasan Ali Aydin , Emrah Keskin , Murat Kalayci
Background: Spinal meningiomas are typically solitary and histologically uniform. The coexistence of two distinct histological subtypes at the same spinal level is extremely rare.
Case Presentation: We report a 65-year-old female with bilateral lower extremity weakness. MRI revealed two enhancing intradural extramedullary tumors at T12–L1—one right anterolateral and one left posterolateral. Both were completely resected through a single laminectomy. Histopathology confirmed meningothelial and psammomatous meningiomas (WHO Grade I).
Conclusion (Clinical Utility)
This case highlights the importance of considering multiple lesions with differing histopathologies, even at the same level, in surgical planning. Awareness of this rare coexistence helps achieve total resection in a single session and avoid unnecessary extended exposure.
背景:脊髓脑膜瘤通常是孤立的,组织学上是均匀的。两种不同的组织学亚型在同一脊柱水平共存是极其罕见的。病例介绍:我们报告一位65岁女性双侧下肢无力。MRI显示在t12 - l1两个强化硬膜内髓外肿瘤,一个右前外侧,一个左后外侧。两例均通过单次椎板切除术完全切除。组织病理学证实为脑膜上皮性和沙粒性脑膜瘤(WHO分级I级)。结论(临床应用)本病例强调了在手术计划中考虑具有不同组织病理学的多个病变的重要性,即使是在同一水平。意识到这种罕见的共存有助于在一次治疗中实现全切除,避免不必要的长时间暴露。
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引用次数: 0
Lhermitte–Duclos disease with Cowden disease: Two cases report Lhermitte-Duclos病合并coden病2例报告
IF 0.5 Q4 CLINICAL NEUROLOGY Pub Date : 2025-12-30 DOI: 10.1016/j.inat.2025.102189
Ao Chen, JianXian Li, Rong Xiang, Bin Tan , RenHui Zhou

Background

Lhermitte-Duclos disease (LDD), also known as dysplastic cerebellar gangliocytoma, which is a rare posterior fossa benign tumor, has a possible association with Cowden disease, a rare autosomal dominant disorder caused by germline mutations in the phosphatase and tensin homolog (PTEN) tumor suppressor gene on chromosome 10, with an estimated incidence of 1/200,000–1/250,000. Combined Cowden disease and LDD cases are rarely reported in the literature.
Case presentation: We report two male patients with LDD who exhibited the typical “tiger-stripe sign” on imaging. Upon retrospective review after surgery, we found that they also had nodular goiter and extensive facial trichilemmomas. These clinical features met the diagnostic criteria for Cowden disease.

Conclusion

LDD in adult patients is highly associated with Cowden disease. Although LDD exhibits characteristics of a benign tumor, given the potential of Cowden disease as a precancerous condition, we recommend initiating a comprehensive preoperative evaluation for all adult patients with LDD.
lhermitte - duclos病(LDD),也称为发育不良小脑神经节细胞瘤,是一种罕见的后窝良性肿瘤,可能与coden病有关,coden病是一种罕见的常染色体显性遗传病,由10号染色体上磷酸酶和紧张素同源物(PTEN)肿瘤抑制基因的种系突变引起,估计发病率为1/20万- 1/25万。文献中很少报道合并考登病和LDD的病例。病例介绍:我们报告了两例男性LDD患者,他们在影像学上表现出典型的“虎纹征”。在手术后的回顾性检查中,我们发现他们也有结节性甲状腺肿和广泛的面部毛瘤。这些临床特征符合考登病的诊断标准。结论成年患者ldd与考登病高度相关。尽管LDD表现出良性肿瘤的特征,但考虑到考登病作为癌前病变的可能性,我们建议对所有成年LDD患者进行全面的术前评估。
{"title":"Lhermitte–Duclos disease with Cowden disease: Two cases report","authors":"Ao Chen,&nbsp;JianXian Li,&nbsp;Rong Xiang,&nbsp;Bin Tan ,&nbsp;RenHui Zhou","doi":"10.1016/j.inat.2025.102189","DOIUrl":"10.1016/j.inat.2025.102189","url":null,"abstract":"<div><h3>Background</h3><div>Lhermitte-Duclos disease (LDD), also known as dysplastic cerebellar gangliocytoma, which is a rare posterior fossa benign tumor, has a possible association with Cowden disease, a rare autosomal dominant disorder caused by germline mutations in the phosphatase and tensin homolog (PTEN) tumor suppressor gene on chromosome 10, with an estimated incidence of 1/200,000–1/250,000. Combined Cowden disease and LDD cases are rarely reported in the literature.</div><div><strong>Case presentation:</strong> <!-->We report two male patients with LDD who exhibited the typical “tiger-stripe sign” on imaging. Upon retrospective review after surgery, we found that they also had nodular goiter and extensive facial trichilemmomas. These clinical features met the diagnostic criteria for Cowden disease.</div></div><div><h3>Conclusion</h3><div>LDD in adult patients is highly associated with Cowden disease. Although LDD exhibits characteristics of a benign tumor, given the potential of Cowden disease as a precancerous condition, we recommend initiating a comprehensive preoperative evaluation for all adult patients with LDD.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102189"},"PeriodicalIF":0.5,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endovascular treatment for a ruptured basilar tip aneurysm via direct puncture of the V1 segment of the vertebral Artery: A case report 直接穿刺椎动脉V1段血管内治疗基底动脉瘤破裂1例
IF 0.5 Q4 CLINICAL NEUROLOGY Pub Date : 2025-12-29 DOI: 10.1016/j.inat.2025.102180
Yusuke Mochida , Tsubasa Okuyama , Hiromichi Oishi , Satoshi Ishige , Toshio Machida

Background

Direct microsurgical treatment of basilar tip aneurysms is technically challenging due to the deep location and critical surrounding vasculature. Although endovascular treatment is increasingly preferred, vascular access can be problematic in elderly patients with tortuous or stenotic vessels.
Case Description.
An 86-year-old woman developed a subarachnoid hemorrhage due to a ruptured basilar tip aneurysm. Conventional femoral and radial artery approaches failed due to severe tortuosity and a type III aortic arch. We attempted endovascular access via direct puncture of the right vertebral artery (VA) V1 segment. A viable puncture site proximal to the C6 transverse process was confirmed on preoperative three-dimensional computed tomography angiography. Through a supraclavicular incision, the right VA V1 segment was exposed and punctured. A guiding sheath was advanced; however, angiography revealed flow stagnation, possibly caused by compression or exacerbation of preexisting stenosis. We discontinued the procedure to avoid ischemic complications. The patient recovered gradually with conservative management and was discharged to a rehabilitation facility with a modified Rankin Scale score of 3.

Conclusion

Direct puncture of the vertebral artery V1 segment is a feasible alternative for endovascular access when standard routes are inaccessible. However, cervical surgical manipulation may transiently cause dysphagia; therefore, careful postoperative management is required. Moreover, careful device selection is crucial to avoid vascular flow compromise, and smaller profile systems may reduce the risk of ischemia.
背景:由于基底尖动脉瘤位置较深,且周围血管状况危急,直接显微手术治疗在技术上具有挑战性。尽管血管内治疗越来越受青睐,但对于血管迂曲或狭窄的老年患者,血管通路可能存在问题。案例描述。一个86岁的妇女发展蛛网膜下腔出血由于破裂的基底动脉瘤。由于严重扭曲和III型主动脉弓,传统的股动脉和桡动脉入路失败。我们尝试通过直接穿刺右椎动脉(VA) V1段进入血管内。术前三维计算机断层血管造影证实了C6横突近端的可行穿刺点。通过锁骨上切口,暴露并穿刺右VA V1节。一个引导鞘被推进;然而,血管造影显示血流停滞,可能是由于压迫或先前存在的狭窄加剧引起的。为了避免缺血性并发症,我们停止了手术。患者在保守治疗下逐渐康复,出院至康复机构,修正Rankin量表评分为3分。结论直接穿刺椎动脉V1段是一种可行的血管内通路。然而,颈椎手术操作可能会短暂地引起吞咽困难;因此,需要谨慎的术后管理。此外,谨慎的设备选择对于避免血管流动的损害至关重要,较小的轮廓系统可以降低缺血的风险。
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Interdisciplinary Neurosurgery: Advanced Techniques and Case Management
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