Pub Date : 2026-01-16DOI: 10.1016/j.inat.2026.102194
Plamen Penchev , Eduardo Alonso , Pablo Vega-Medina , Danna Espinoza , Daniela Milanova-Ilieva , Monyse Falcao , Raphael Wuo-Silva , Feres Chaddad-Neto , Cristian Mendieta , Cristian Palomino , Francisco Palma-Garcia , Petar-Preslav Petrov , Pavel Stanchev , Nikolai Ramadanov
Introduction
Skull base meningiomas present unique surgical challenges due to proximity to critical neurovascular structures, leading to prolonged operative time, significant blood loss, and high complication risks. Preoperative embolization (POE) is used to reduce tumor vascularity and potentially decrease blood loss and operative time. However, existing studies are limited by small samples and a general focus, particularly lacking robust evidence for skull base lesions. We aimed to perform a systematic review and meta-analysis of the efficacy of POE versus direct surgery in skull base meningiomas.
Methods
A systematic search from inception up to 30 July 2025 (PubMed, Embase, and Cochrane Central) identified studies comparing POE to direct surgery for skull base meningiomas. Outcomes included intraoperative blood loss, operative time, hemoglobin, complications, and transfusion rates. Statistical analysis used a frequentist random-effects model (Risk Ratios [RR], Mean Differences [MD]), with heterogeneity assessed via I2 and the Cochrane Q test.
Results
Twenty-one studies (n = 896; mean age 54, 65.5% females), including 349 POE patients (39%), were analyzed. Pooled analysis revealed no statistically significant differences between POE and direct surgery for intraoperative blood loss (MD −67.26; 95% CI [-265.28; 130.76]; p = 0.51; I2 = 98.4%), operative time (MD −0.30; 95% CI [-1.03; 0.42]; p = 0.42; I2 = 87.8%), hemoglobin levels (MD 0.21; 95% CI [-0.54; 0.96]; p = 0.58; I2 = 70%), blood transfusion rate (RR 0.89; 95% CI [0.65; 1.23]; p = 0.446; I2 = 21%), or complication prevalence (RR 1.12; 95% CI [0.67; 1.87]; p = 0.637; I2 = 25.7%). Subgroup analyses (Simpson grade, extent of resection) and meta-regression showed no significant effect modifiers.
Conclusion
POE of skull base meningiomas did not significantly improve perioperative outcomes compared with direct surgery. Routine use may offer limited clinical benefit. Selective use may be warranted in giant or highly vascular tumors, but further high-quality studies are needed to confirm these findings.
{"title":"Preoperative Embolization vs. Direct Surgery in Skull Base Meningiomas: A Systematic Review and Meta-Analysis with Meta-Regression","authors":"Plamen Penchev , Eduardo Alonso , Pablo Vega-Medina , Danna Espinoza , Daniela Milanova-Ilieva , Monyse Falcao , Raphael Wuo-Silva , Feres Chaddad-Neto , Cristian Mendieta , Cristian Palomino , Francisco Palma-Garcia , Petar-Preslav Petrov , Pavel Stanchev , Nikolai Ramadanov","doi":"10.1016/j.inat.2026.102194","DOIUrl":"10.1016/j.inat.2026.102194","url":null,"abstract":"<div><h3>Introduction</h3><div>Skull base meningiomas present unique surgical challenges due to proximity to critical neurovascular structures, leading to prolonged operative time, significant blood loss, and high complication risks. Preoperative embolization (POE) is used to reduce tumor vascularity and potentially decrease blood loss and operative time. However, existing studies are limited by small samples and a general focus, particularly lacking robust evidence for skull base lesions. We aimed to perform a systematic review and <em>meta</em>-analysis of the efficacy of POE versus direct surgery in skull base meningiomas.</div></div><div><h3>Methods</h3><div>A systematic search from inception up to 30 July 2025 (PubMed, Embase, and Cochrane Central) identified studies comparing POE to direct surgery for skull base meningiomas. Outcomes included intraoperative blood loss, operative time, hemoglobin, complications, and transfusion rates. Statistical analysis used a frequentist random-effects model (Risk Ratios [RR], Mean Differences [MD]), with heterogeneity assessed via I<sup>2</sup> and the Cochrane Q test.</div></div><div><h3>Results</h3><div>Twenty-one studies (n = 896; mean age 54, 65.5% females), including 349 POE patients (39%), were analyzed. Pooled analysis revealed no statistically significant differences between POE and direct surgery for intraoperative blood loss (MD −67.26; 95% CI [-265.28; 130.76]; p = 0.51; I<sup>2</sup> = 98.4%), operative time (MD −0.30; 95% CI [-1.03; 0.42]; p = 0.42; I<sup>2</sup> = 87.8%), hemoglobin levels (MD 0.21; 95% CI [-0.54; 0.96]; p = 0.58; I<sup>2</sup> = 70%), blood transfusion rate (RR 0.89; 95% CI [0.65; 1.23]; p = 0.446; I<sup>2</sup> = 21%), or complication prevalence (RR 1.12; 95% CI [0.67; 1.87]; p = 0.637; I<sup>2</sup> = 25.7%). Subgroup analyses (Simpson grade, extent of resection) and <em>meta</em>-regression showed no significant effect modifiers.</div></div><div><h3>Conclusion</h3><div>POE of skull base meningiomas did not significantly improve perioperative outcomes compared with direct surgery. Routine use may offer limited clinical benefit. Selective use may be warranted in giant or highly vascular tumors, but further high-quality studies are needed to confirm these findings.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102194"},"PeriodicalIF":0.5,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1016/j.inat.2025.102160
Rhuann Pontes dos Santos Silva , Isadora Gomes Mesquita , Louise Makaren Oliveira , Marcia Mitie Nagumo , Julia Costa Justo , Gabriela Fernandes de Oliveira Pessoa , Eberval Gadelha , Luis Alencar Borba , Cleice Mara Goncalves Coelho , Jonas Byk , Juscimar Carneiro , Otávio da Cunha Ferreira Neto , José Marcus Rotta , Wellingson Silva Paiva , Robson Luis Oliveira de Amorim
Background
Burnout syndrome (BS) is a significant issue among neurosurgery residents, resulting from chronic emotional and interpersonal stressors. Characterized by emotional exhaustion, depersonalization, and low personal accomplishment, BS can lead to decreased productivity, interpersonal relationships, and medical errors.
Objective
This study aims to analyze the prevalence of BS among Brazilian neurosurgery residents and identify associated factors.
Methods
We conducted a cross-sectional study using the Maslach Burnout Inventory (MBI) and questionnaires covering sociodemographic information, mental health, and job satisfaction.
Results
The study surveyed all Brazilian neurosurgery residency programs, with 118 out of 600 residents (19.6 %) responding. The prevalence of BS was 64.1 %, and 94.9 % had at least one high domain. Third-year residents exhibited the highest rate of burnout (79.2 %). Gender significantly influenced burnout rates, with males showing higher levels. Additionally, dissatisfaction with personal life and insufficient physical exercise were associated with increased likelihood of burnout. They also exhibited higher dissatisfaction with their academic productivity, time for study, and balance between professional and personal life. Suicidal ideation was reported by 16.1 % of residents but was not statistically associated with BS. Multivariate analysis showed that only male sex was an independent variable of having BS (OR 2.97 95CI 1.005–8.78, p = 0.049). Also, those with BS were less likely to choose neurosurgery again (OR 0.22 95CI 0.06–0.78, p = 0.02) or recommend it as a specialty (OR 0.32 95CI 0.11–0.93, p = 0.03)
Conclusion
This study highlights the high prevalence of BS among Brazilian neurosurgery residents, indicating a need for targeted interventions to address these stressors and improve resident well-being.
职业倦怠综合征(BS)是神经外科住院医师中一个重要的问题,由慢性情绪和人际压力源引起。BS的特点是情绪耗竭、人格解体和个人成就感低,可能导致生产力下降、人际关系下降和医疗差错。目的分析巴西神经外科住院医师BS患病率及相关因素。方法采用Maslach职业倦怠量表(MBI)和社会人口统计信息、心理健康和工作满意度问卷进行横断面研究。结果该研究调查了巴西所有的神经外科住院医师项目,600名住院医师中有118人(19.6%)做出了回应。BS患病率为64.1%,其中94.9%至少有一个高域。第三年住院医师的倦怠率最高(79.2%)。性别显著影响倦怠率,男性表现出更高的水平。此外,对个人生活的不满和缺乏体育锻炼与倦怠的可能性增加有关。此外,他们对学业成绩、学习时间、职业与个人生活平衡的不满意度也较高。16.1%的居民报告有自杀意念,但与BS无统计学关联。多因素分析显示,男性是影响BS发生的独立变量(OR 2.97 95CI 1.005-8.78, p = 0.049)。此外,患有BS的患者不太可能再次选择神经外科(OR 0.22 95CI 0.06-0.78, p = 0.02)或将其作为专科推荐(OR 0.32 95CI 0.11-0.93, p = 0.03)。结论:本研究强调了巴西神经外科住院患者中BS的高患病率,表明需要有针对性的干预措施来解决这些压力源并改善居民的幸福感。
{"title":"Prevalence of burnout syndrome in Brazilian neurosurgery residents: A nationwide questionnaire-based survey","authors":"Rhuann Pontes dos Santos Silva , Isadora Gomes Mesquita , Louise Makaren Oliveira , Marcia Mitie Nagumo , Julia Costa Justo , Gabriela Fernandes de Oliveira Pessoa , Eberval Gadelha , Luis Alencar Borba , Cleice Mara Goncalves Coelho , Jonas Byk , Juscimar Carneiro , Otávio da Cunha Ferreira Neto , José Marcus Rotta , Wellingson Silva Paiva , Robson Luis Oliveira de Amorim","doi":"10.1016/j.inat.2025.102160","DOIUrl":"10.1016/j.inat.2025.102160","url":null,"abstract":"<div><h3>Background</h3><div>Burnout syndrome (BS) is a significant issue among neurosurgery residents, resulting from chronic emotional and interpersonal stressors. Characterized by emotional exhaustion, depersonalization, and low personal accomplishment, BS can lead to decreased productivity, interpersonal relationships, and medical errors.</div></div><div><h3>Objective</h3><div>This study aims to analyze the prevalence of BS among Brazilian neurosurgery residents and identify associated factors.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study using the Maslach Burnout Inventory (MBI) and questionnaires covering sociodemographic information, mental health, and job satisfaction.</div></div><div><h3>Results</h3><div>The study surveyed all Brazilian neurosurgery residency programs, with 118 out of 600 residents (19.6 %) responding. The prevalence of BS was 64.1 %, and 94.9 % had at least one high domain. Third-year residents exhibited the highest rate of burnout (79.2 %). Gender significantly influenced burnout rates, with males showing higher levels. Additionally, dissatisfaction with personal life and insufficient physical exercise were associated with increased likelihood of burnout. They also exhibited higher dissatisfaction with their academic productivity, time for study, and balance between professional and personal life. Suicidal ideation was reported by 16.1 % of residents but was not statistically associated with BS. Multivariate analysis showed that only male sex was an independent variable of having BS (OR 2.97 95CI 1.005–8.78, p = 0.049). Also, those with BS were less likely to choose neurosurgery again (OR 0.22 95CI 0.06–0.78, p = 0.02) or recommend it as a specialty (OR 0.32 95CI 0.11–0.93, p = 0.03)</div></div><div><h3>Conclusion</h3><div>This study highlights the high prevalence of BS among Brazilian neurosurgery residents, indicating a need for targeted interventions to address these stressors and improve resident well-being.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102160"},"PeriodicalIF":0.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The objective of this study is to analyze a case of trigeminal neuralgia (TN) secondary to intracranial arteriovenous malformation (AVM), summarize reported cases of TN associated with cerebral vascular malformations, and discuss the experience with endovascular and other therapeutic modalities.
Methods
We analyzed our institutional case of cerebral AVM-induced TN and reviewed relevant literature on trigeminal neuralgia and AVM published between 1968 and 2022. A total of 47 consecutive cases of brain arteriovenous malformations (bAVMs) complicated by TN were identified through retrospective analysis of 47 treated bAVM cases. Clinical data, angiographic findings, and outcomes following endovascular and other treatments were evaluated.
Results
Among the 47 patients with TN associated with bAVMs, 11 underwent endovascular embolization: 10 achieved pain relief, and 1 showed initial symptomatic remission. Arterialization and ectasia of the superior petrosal vein (SPV) and its tributaries, which could explain trigeminal nerve compression, were observed in 24 cases. Venous hypertension in the ponto-trigeminal vein (a tributary of the SPV) appears to be one of the etiological factors of TN.
Conclusions
Consistent with previous publications, we propose that venous reflux into tributaries of the SPV—particularly the ponto-trigeminal vein—represents a key mechanism of TN caused by nerve compression. Currently, there is no consensus on the optimal treatment for cerebellar AVM-related TN; however, partial interventional embolization of the AVM nidus is considered a viable strategy to reduce blood flow and alleviate symptoms.
{"title":"Trigeminal Neuralgia Secondary to Arteriovenous Malformation of the Posterior Fossa: A Case Report and Literature Review","authors":"Hongkuan Yang, Rudong Chen, Hua Li, Jiasheng Yu, Lingcheng Zeng","doi":"10.1016/j.inat.2025.102176","DOIUrl":"10.1016/j.inat.2025.102176","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study is to analyze a case of trigeminal neuralgia (TN) secondary to intracranial arteriovenous malformation (AVM), summarize reported cases of TN associated with cerebral vascular malformations, and discuss the experience with endovascular and other therapeutic modalities.</div></div><div><h3>Methods</h3><div>We analyzed our institutional case of cerebral AVM-induced TN and reviewed relevant literature on trigeminal neuralgia and AVM published between 1968 and 2022. A total of 47 consecutive cases of brain arteriovenous malformations (bAVMs) complicated by TN were identified through retrospective analysis of 47 treated bAVM cases. Clinical data, angiographic findings, and outcomes following endovascular and other treatments were evaluated.</div></div><div><h3>Results</h3><div>Among the 47 patients with TN associated with bAVMs, 11 underwent endovascular embolization: 10 achieved pain relief, and 1 showed initial symptomatic remission. Arterialization and ectasia of the superior petrosal vein (SPV) and its tributaries, which could explain trigeminal nerve compression, were observed in 24 cases. Venous hypertension in the ponto-trigeminal vein (a tributary of the SPV) appears to be one of the etiological factors of TN.</div></div><div><h3>Conclusions</h3><div>Consistent with previous publications, we propose that venous reflux into tributaries of the SPV—particularly the ponto-trigeminal vein—represents a key mechanism of TN caused by nerve compression. Currently, there is no consensus on the optimal treatment for cerebellar AVM-related TN; however, partial interventional embolization of the AVM nidus is considered a viable strategy to reduce blood flow and alleviate symptoms.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102176"},"PeriodicalIF":0.5,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.inat.2025.102172
İsa İsaoğlu , Özlem Delen , Zeynep Banu Doğanlar , Oğuzhan Doğanlar , Emre Delen
Background
To investigate the potential interaction between collagen synthesis and microRNAs in ligamentum flavum (LF) obtained from patients with degenerative lumbar canal stenosis (DLCS).
Methods
A total of thirty-two human LF specimens were divided into two groups, each based on the diagnosis as follows: 20 from patients with DLCS and 12 from patients those with lumbar disc herniation (LDH). Fibrosis was graded into four levels according to the accumulation of decreased elastin fibres and increased collagen fibres, which can be observed using the Masson’s trichrome staining. Expression of the collagens (COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL6A1, COL8A1), associated proteins (extracellular matrix protein tenascin XB-TNXB, solute carrier family 39 member 13-SLC39A13, and procollagen N proteinase ADAMTS-2; and micro-ribonucleic acids (miR-27B, miR-29B, miR-143, and miR-221) were measured by quantitative real-time polymerase chain reaction (qRT-PCR) analysis. Western blot analysis was performed to determine the levels of COL1, COL3, COL5, COL6A1, and COL8A1. DLCS patients have higher fibrosis score than the LDH patients.
Results
DLCS patients have higher fibrosis score than the LDH patients. qRT-PCR analysis demonstrated that strongly upregulated mRNA levels of COL1A, COL1A2, COL3A1, ADAMTS2, miR-29B, and miR-143. However, protein expressions of COL1, COL3, COL6A, and COL8A1 is also upregulated.
Conclusions
Our results identified miR-29B and miR-143 regulation of COL synthesis of the LF fibrosis.
{"title":"Collagen synthesis and MicroRNA interaction in degenerative lumbar canal stenosis","authors":"İsa İsaoğlu , Özlem Delen , Zeynep Banu Doğanlar , Oğuzhan Doğanlar , Emre Delen","doi":"10.1016/j.inat.2025.102172","DOIUrl":"10.1016/j.inat.2025.102172","url":null,"abstract":"<div><h3>Background</h3><div>To investigate the potential interaction between collagen synthesis and microRNAs in ligamentum flavum (LF) obtained from patients with degenerative lumbar canal stenosis (DLCS).</div></div><div><h3>Methods</h3><div>A total of thirty-two human LF specimens were divided into two groups, each based on the diagnosis as follows: 20 from patients with DLCS and 12 from patients those with lumbar disc herniation (LDH). Fibrosis was graded into four levels according to the accumulation of decreased elastin fibres and increased collagen fibres, which can be observed using the Masson’s trichrome staining. Expression of the collagens (COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL6A1, COL8A1), associated proteins (extracellular matrix protein tenascin XB-TNXB, solute carrier family 39 member 13-SLC39A13, and procollagen N proteinase ADAMTS-2; and micro-ribonucleic acids (miR-27B, miR-29B, miR-143, and miR-221) were measured by quantitative real-time polymerase chain reaction (qRT-PCR) analysis. Western blot analysis was performed to determine the levels of COL1, COL3, COL5, COL6A1, and COL8A1. DLCS patients have higher fibrosis score than the LDH patients.</div></div><div><h3>Results</h3><div>DLCS patients have higher fibrosis score than the LDH patients. qRT-PCR analysis demonstrated that strongly upregulated mRNA levels of COL1A, COL1A2, COL3A1, ADAMTS2, miR-29B, and miR-143. However, protein expressions of COL1, COL3, COL6A, and COL8A1 is also upregulated.</div></div><div><h3>Conclusions</h3><div>Our results identified miR-29B and miR-143 regulation of COL synthesis of the LF fibrosis.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102172"},"PeriodicalIF":0.5,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.inat.2025.102191
Matthew Aceto , Scott Gronowicz , Michael S. Barnum , Maahir Haque
Background
Pars defects affect up to 7 % of adults. Patients with pars defects often experience progressively worsening pain and some develop spinal deformity due to the development of lytic spondylolisthesis. In symptomatic pars fractures who have failed non-operative management and have only mild deformity and degeneration, a decision can be made to fuse the affected motion segment or perform a direct pars repair. The purpose of this study is to describe a novel technique for direct pars repair using a novel radiation-free stereotactic navigation. We further describe the clinical outcomes in two cases managed with this technique.
Case
Two adult patients with L5 spondylolysis and spina bifida occulta − a 33-year-old male and a 41-year-old male who also had sacral dysraphism − underwent direct pars repair using radiation-free 7D Navigation.
Outcome
Both cases demonstrated clinical improvement and good radiographic outcomes at more than 1 year follow-up.
Conclusion
Direct pars repair using radiation-free stereotactic navigation offers a safe, effective, and more efficient means for the surgical treatment of symptomatic spondylolysis. This is especially true for patients with lumbosacral anatomical variability, in whom conventional techniques may lead to screw malpositioning, a need for revision surgery, and poor outcomes.
{"title":"A novel radiation-free technique for navigated direct pars repair in patients with spondylolysis and congenital vertebral anomalies: A report of two cases","authors":"Matthew Aceto , Scott Gronowicz , Michael S. Barnum , Maahir Haque","doi":"10.1016/j.inat.2025.102191","DOIUrl":"10.1016/j.inat.2025.102191","url":null,"abstract":"<div><h3>Background</h3><div>Pars defects affect up to 7 % of adults. Patients with pars defects often experience progressively worsening pain and some develop spinal deformity due to the development of lytic spondylolisthesis. In symptomatic pars fractures who have failed non-operative<!--> <!-->management and have only mild deformity and degeneration, a decision can be made to fuse the affected motion segment or perform a direct pars repair.<!--> <!-->The purpose of this study is to describe a novel technique for direct pars repair using a novel radiation-free stereotactic navigation. We further describe the clinical outcomes in two cases managed with this technique.</div></div><div><h3>Case</h3><div>Two adult patients with L5 spondylolysis and spina bifida occulta − a 33-year-old male and a 41-year-old male who also had sacral dysraphism − underwent direct pars repair using radiation-free 7D Navigation.</div></div><div><h3>Outcome</h3><div>Both cases demonstrated clinical improvement and good radiographic outcomes at more than 1 year follow-up.</div></div><div><h3>Conclusion</h3><div>Direct pars repair using radiation-free stereotactic navigation offers a safe, effective, and more efficient means for the surgical treatment of symptomatic spondylolysis. This is especially true for patients with lumbosacral anatomical variability, in whom conventional techniques may lead to screw malpositioning, a need for revision surgery, and poor outcomes.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102191"},"PeriodicalIF":0.5,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.inat.2025.102187
Oualid Mohammed Hmamouche, Marouane Hammoud, Faycal Lakhdar, Mohammed Benzagmout, Khalid Chakour, Mohammed El Faiz Chaoui
Background
Spinal trauma during pregnancy is rare and technically challenging due to maternal–fetal risks. Positioning for posterior fixation in advanced gestation is problematic because prone positioning risks aortocaval compression.
Case/Technique: We report emergency posterior fixation for a burst fracture of L1 in a 40-year-old woman at 24 weeks’ gestation. Short-segment fixation was performed from D12 to L2 in the left lateral decubitus position to avoid vena cava compression. Free-hand pedicle screws were placed using anatomical landmarks and tactile feedback, with limited laminectomy and single-shot fluoroscopy under abdominal shielding.
Outcome: Recovery was uneventful. Urinary retention resolved within 6 days. The patient delivered vaginally at term, and 36-month follow-up confirmed stable fixation without maternal or neonatal complications.
Conclusion
The left lateral decubitus position is a feasible and safe alternative to prone positioning for lumbar fixation in advanced pregnancy. Multidisciplinary collaboration, radiation minimization, and precise free-hand technique are essential for achieving favorable outcomes.
{"title":"The left lateral decubitus position as a safe and effective alternative for posterior lumbar fixation in Pregnancy: A technical Note","authors":"Oualid Mohammed Hmamouche, Marouane Hammoud, Faycal Lakhdar, Mohammed Benzagmout, Khalid Chakour, Mohammed El Faiz Chaoui","doi":"10.1016/j.inat.2025.102187","DOIUrl":"10.1016/j.inat.2025.102187","url":null,"abstract":"<div><h3>Background</h3><div>Spinal trauma during pregnancy is rare and technically challenging due to maternal–fetal risks. Positioning for posterior fixation in advanced gestation is problematic because prone positioning risks aortocaval compression.</div><div><strong>Case/Technique:</strong> We report emergency posterior fixation for a burst fracture of L1 in a 40-year-old woman at 24 weeks’ gestation. Short-segment fixation was performed from D12 to L2 in the left lateral decubitus position to avoid vena cava compression. Free-hand pedicle screws were placed using anatomical landmarks and tactile feedback, with limited laminectomy and single-shot fluoroscopy under abdominal shielding.</div><div><strong>Outcome:</strong> Recovery was uneventful. Urinary retention resolved within 6 days. The patient delivered vaginally at term, and 36-month follow-up confirmed stable fixation without maternal or neonatal complications.</div></div><div><h3>Conclusion</h3><div>The left lateral decubitus position is a feasible and safe alternative to prone positioning for lumbar fixation in advanced pregnancy. Multidisciplinary collaboration, radiation minimization, and precise free-hand technique are essential for achieving favorable outcomes.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102187"},"PeriodicalIF":0.5,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.inat.2025.102182
Abbas Amitrjamshidi
{"title":"Re-considering the “Systematic review of traumatic intracranial aneurysms”","authors":"Abbas Amitrjamshidi","doi":"10.1016/j.inat.2025.102182","DOIUrl":"10.1016/j.inat.2025.102182","url":null,"abstract":"","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102182"},"PeriodicalIF":0.5,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30DOI: 10.1016/j.inat.2025.102181
Hasan Ali Aydin , Emrah Keskin , Murat Kalayci
Background: Spinal meningiomas are typically solitary and histologically uniform. The coexistence of two distinct histological subtypes at the same spinal level is extremely rare.
Case Presentation: We report a 65-year-old female with bilateral lower extremity weakness. MRI revealed two enhancing intradural extramedullary tumors at T12–L1—one right anterolateral and one left posterolateral. Both were completely resected through a single laminectomy. Histopathology confirmed meningothelial and psammomatous meningiomas (WHO Grade I).
Conclusion (Clinical Utility)
This case highlights the importance of considering multiple lesions with differing histopathologies, even at the same level, in surgical planning. Awareness of this rare coexistence helps achieve total resection in a single session and avoid unnecessary extended exposure.
{"title":"Dual meningiomas with different pathology at the same spinal level: a rare case report","authors":"Hasan Ali Aydin , Emrah Keskin , Murat Kalayci","doi":"10.1016/j.inat.2025.102181","DOIUrl":"10.1016/j.inat.2025.102181","url":null,"abstract":"<div><div><strong>Background</strong>: Spinal meningiomas are typically solitary and histologically uniform. The coexistence of two distinct histological subtypes at the same spinal level is extremely rare.</div><div>Case Presentation: We report a 65-year-old female with bilateral lower extremity weakness. MRI revealed two enhancing intradural extramedullary tumors at T12–L1—one right anterolateral and one left posterolateral. Both were completely resected through a single laminectomy. Histopathology confirmed meningothelial and psammomatous meningiomas (WHO Grade I).</div><div>Conclusion (Clinical Utility)</div><div>This case highlights the importance of considering multiple lesions with differing histopathologies, even at the same level, in surgical planning. Awareness of this rare coexistence helps achieve total resection in a single session and avoid unnecessary extended exposure.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102181"},"PeriodicalIF":0.5,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30DOI: 10.1016/j.inat.2025.102189
Ao Chen, JianXian Li, Rong Xiang, Bin Tan , RenHui Zhou
Background
Lhermitte-Duclos disease (LDD), also known as dysplastic cerebellar gangliocytoma, which is a rare posterior fossa benign tumor, has a possible association with Cowden disease, a rare autosomal dominant disorder caused by germline mutations in the phosphatase and tensin homolog (PTEN) tumor suppressor gene on chromosome 10, with an estimated incidence of 1/200,000–1/250,000. Combined Cowden disease and LDD cases are rarely reported in the literature.
Case presentation: We report two male patients with LDD who exhibited the typical “tiger-stripe sign” on imaging. Upon retrospective review after surgery, we found that they also had nodular goiter and extensive facial trichilemmomas. These clinical features met the diagnostic criteria for Cowden disease.
Conclusion
LDD in adult patients is highly associated with Cowden disease. Although LDD exhibits characteristics of a benign tumor, given the potential of Cowden disease as a precancerous condition, we recommend initiating a comprehensive preoperative evaluation for all adult patients with LDD.
{"title":"Lhermitte–Duclos disease with Cowden disease: Two cases report","authors":"Ao Chen, JianXian Li, Rong Xiang, Bin Tan , RenHui Zhou","doi":"10.1016/j.inat.2025.102189","DOIUrl":"10.1016/j.inat.2025.102189","url":null,"abstract":"<div><h3>Background</h3><div>Lhermitte-Duclos disease (LDD), also known as dysplastic cerebellar gangliocytoma, which is a rare posterior fossa benign tumor, has a possible association with Cowden disease, a rare autosomal dominant disorder caused by germline mutations in the phosphatase and tensin homolog (PTEN) tumor suppressor gene on chromosome 10, with an estimated incidence of 1/200,000–1/250,000. Combined Cowden disease and LDD cases are rarely reported in the literature.</div><div><strong>Case presentation:</strong> <!-->We report two male patients with LDD who exhibited the typical “tiger-stripe sign” on imaging. Upon retrospective review after surgery, we found that they also had nodular goiter and extensive facial trichilemmomas. These clinical features met the diagnostic criteria for Cowden disease.</div></div><div><h3>Conclusion</h3><div>LDD in adult patients is highly associated with Cowden disease. Although LDD exhibits characteristics of a benign tumor, given the potential of Cowden disease as a precancerous condition, we recommend initiating a comprehensive preoperative evaluation for all adult patients with LDD.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102189"},"PeriodicalIF":0.5,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Direct microsurgical treatment of basilar tip aneurysms is technically challenging due to the deep location and critical surrounding vasculature. Although endovascular treatment is increasingly preferred, vascular access can be problematic in elderly patients with tortuous or stenotic vessels.
Case Description.
An 86-year-old woman developed a subarachnoid hemorrhage due to a ruptured basilar tip aneurysm. Conventional femoral and radial artery approaches failed due to severe tortuosity and a type III aortic arch. We attempted endovascular access via direct puncture of the right vertebral artery (VA) V1 segment. A viable puncture site proximal to the C6 transverse process was confirmed on preoperative three-dimensional computed tomography angiography. Through a supraclavicular incision, the right VA V1 segment was exposed and punctured. A guiding sheath was advanced; however, angiography revealed flow stagnation, possibly caused by compression or exacerbation of preexisting stenosis. We discontinued the procedure to avoid ischemic complications. The patient recovered gradually with conservative management and was discharged to a rehabilitation facility with a modified Rankin Scale score of 3.
Conclusion
Direct puncture of the vertebral artery V1 segment is a feasible alternative for endovascular access when standard routes are inaccessible. However, cervical surgical manipulation may transiently cause dysphagia; therefore, careful postoperative management is required. Moreover, careful device selection is crucial to avoid vascular flow compromise, and smaller profile systems may reduce the risk of ischemia.
{"title":"Endovascular treatment for a ruptured basilar tip aneurysm via direct puncture of the V1 segment of the vertebral Artery: A case report","authors":"Yusuke Mochida , Tsubasa Okuyama , Hiromichi Oishi , Satoshi Ishige , Toshio Machida","doi":"10.1016/j.inat.2025.102180","DOIUrl":"10.1016/j.inat.2025.102180","url":null,"abstract":"<div><h3>Background</h3><div>Direct microsurgical treatment of basilar tip aneurysms is technically challenging due to the deep location and critical surrounding vasculature. Although endovascular treatment is increasingly preferred, vascular access can be problematic in elderly patients with tortuous or stenotic vessels.</div><div>Case Description.</div><div>An 86-year-old woman developed a subarachnoid hemorrhage due to a ruptured basilar tip aneurysm. Conventional femoral and radial artery approaches failed due to severe tortuosity and a type III aortic arch. We attempted endovascular access via direct puncture of the right vertebral artery (VA) V1 segment. A viable puncture site proximal to the C6 transverse process was confirmed on preoperative three-dimensional computed tomography angiography. Through a supraclavicular incision, the right VA V1 segment was exposed and punctured. A guiding sheath was advanced; however, angiography revealed flow stagnation, possibly caused by compression or exacerbation of preexisting stenosis. We discontinued the procedure to avoid ischemic complications. The patient recovered gradually with conservative management and was discharged to a rehabilitation facility with a modified Rankin Scale score of 3.</div></div><div><h3>Conclusion</h3><div>Direct puncture of the vertebral artery V1 segment is a feasible alternative for endovascular access when standard routes are inaccessible. However, cervical surgical manipulation may transiently cause dysphagia; therefore, careful postoperative management is required. Moreover, careful device selection is crucial to avoid vascular flow compromise, and smaller profile systems may reduce the risk of ischemia.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"43 ","pages":"Article 102180"},"PeriodicalIF":0.5,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}