Pub Date : 2023-01-01DOI: 10.20953/1817-7646-2023-2-14-21
I. Khamnagadaev, I. Kovalev, A. Yakshina, S. Termosesov, V.V. Beresnitskaya, I. A. Bulavina, I. Khamnagadaev, L. Kokov, M. Shkolnikova
Objective. To study the features of the clinical duration of atrial fibrillation (AF) and the structure of concomitant cardiac arrhythmias in children. Patients and methods. The pilot retrospective controlled non-randomized two-center study included 39 children aged 3 to 17 years (tmain group) who were on inpatient treatment at the Research Clinical Institute of Pediatrics and Pediatric Surgery academician Yu.E.Veltischev in the period from 2010 to 2020. The comparison group consisted of 156 patients aged 29 to 77 years suffering from paroxysmal and persistent forms of AF, who underwent interventional treatment from 2013 to 2021 at the V.M. Buyanov City Clinical Hospital of Moscow City Health Department and the National Medical Research Endocrinology Center of the Ministry of Health of Russia. Statistical processing was performed using STATISTICA application package. Quantitative features are represented by minimum and maximum values, as well as median (Me) and interquartile range (Q1 – 25 percent quartile, Q3 – 75 percent, respectively). The criteria of Fisher, Mann–Whitney, Pearson, and Spearman were calculated. The differences were considered reliable at p < 0.05. Results. The paroxysmal form of disease was diagnosed in 24 children (61.5%) cases, in 121 adults (77.6%). Clinical manifestations of AF in children were significantly more often recorded in its paroxysmal form – in 23 (95.8%) cases versus 8 (53.3%). In the comparison group, regardless of the form of AF, all patients had severe symptoms; the severity of clinical manifestations was founded in 93 (59.6%) cases, according to the classification of the European Heart Rhythm Association, corresponding to class III and above. In the structure of concomitant cardiac arrhythmias in patients of the main group, typical atrial flutter was in 13 (33.3%) cases, and atrial extrasystole -in 9 (23.1%). Bradyarrhythmias and conduction disorders (sinus node weakness syndrome, and atrioventricular blockade of I–II degrees) were founded in 10 (25.6%) children and only in 6 (3.8%) patients from the comparison group. Antiarrhythmic therapy in the main group was received by 30 (76.9%) children; in 28 (71.8%) cases – monotherapy with antiarrhythmic drugs of IC, II and III classes; all patients in the comparison group received IC and Class III preparations. Interventional treatment was performed in 6 (15.4%) patients from the main group and all from the comparison group. Conclusion. During diagnosing AF in children we should know the possibility of a frequent asymptomatic duration of disease, as well as complaints which are not typical for tachysystolic cardiac arrhythmias, isolated or in combination with typical. Clinical manifestations were significantly more often founded in paroxysmal AF in children. In the structure of concomitant AF cardiac arrhythmias in children, as well as in adult patients, atrial flutter prevails, and atrial extrasystole in children was recorded significantly more often, as well as
{"title":"Atrial fibrillation in children: features of the clinical course, structure of concomitant cardiac arrhythmias","authors":"I. Khamnagadaev, I. Kovalev, A. Yakshina, S. Termosesov, V.V. Beresnitskaya, I. A. Bulavina, I. Khamnagadaev, L. Kokov, M. Shkolnikova","doi":"10.20953/1817-7646-2023-2-14-21","DOIUrl":"https://doi.org/10.20953/1817-7646-2023-2-14-21","url":null,"abstract":"Objective. To study the features of the clinical duration of atrial fibrillation (AF) and the structure of concomitant cardiac arrhythmias in children. Patients and methods. The pilot retrospective controlled non-randomized two-center study included 39 children aged 3 to 17 years (tmain group) who were on inpatient treatment at the Research Clinical Institute of Pediatrics and Pediatric Surgery academician Yu.E.Veltischev in the period from 2010 to 2020. The comparison group consisted of 156 patients aged 29 to 77 years suffering from paroxysmal and persistent forms of AF, who underwent interventional treatment from 2013 to 2021 at the V.M. Buyanov City Clinical Hospital of Moscow City Health Department and the National Medical Research Endocrinology Center of the Ministry of Health of Russia. Statistical processing was performed using STATISTICA application package. Quantitative features are represented by minimum and maximum values, as well as median (Me) and interquartile range (Q1 – 25 percent quartile, Q3 – 75 percent, respectively). The criteria of Fisher, Mann–Whitney, Pearson, and Spearman were calculated. The differences were considered reliable at p < 0.05. Results. The paroxysmal form of disease was diagnosed in 24 children (61.5%) cases, in 121 adults (77.6%). Clinical manifestations of AF in children were significantly more often recorded in its paroxysmal form – in 23 (95.8%) cases versus 8 (53.3%). In the comparison group, regardless of the form of AF, all patients had severe symptoms; the severity of clinical manifestations was founded in 93 (59.6%) cases, according to the classification of the European Heart Rhythm Association, corresponding to class III and above. In the structure of concomitant cardiac arrhythmias in patients of the main group, typical atrial flutter was in 13 (33.3%) cases, and atrial extrasystole -in 9 (23.1%). Bradyarrhythmias and conduction disorders (sinus node weakness syndrome, and atrioventricular blockade of I–II degrees) were founded in 10 (25.6%) children and only in 6 (3.8%) patients from the comparison group. Antiarrhythmic therapy in the main group was received by 30 (76.9%) children; in 28 (71.8%) cases – monotherapy with antiarrhythmic drugs of IC, II and III classes; all patients in the comparison group received IC and Class III preparations. Interventional treatment was performed in 6 (15.4%) patients from the main group and all from the comparison group. Conclusion. During diagnosing AF in children we should know the possibility of a frequent asymptomatic duration of disease, as well as complaints which are not typical for tachysystolic cardiac arrhythmias, isolated or in combination with typical. Clinical manifestations were significantly more often founded in paroxysmal AF in children. In the structure of concomitant AF cardiac arrhythmias in children, as well as in adult patients, atrial flutter prevails, and atrial extrasystole in children was recorded significantly more often, as well as","PeriodicalId":38157,"journal":{"name":"Voprosy Prakticheskoi Pediatrii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67751395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.20953/1817-7646-2023-2-91-101
G. Filippova, O. Morozova, E.Yu. Kirichek, A. A. Eliseeva, O. Efimenko, T. Raba, F. Raupov, Z. M. Kulieva, T.G. Eyvazov
This article discusses the problem of acute viral gastroenteritis (AVGE), including aspects of immunopathogenesis that are significant for effective therapy and prevention. It also summarizes the results of randomized clinical trials assessing the efficacy of technologically processed purified antibodies (Anaferon® for children, Ergoferon®). We describe our own experience with Ergoferon® evaluated in a an open-label study involving 94 AVGE patients aged 1 to 10 years. Children who received Ergoferon® demonstrated rapid resolution of symptoms and normalization of body temperature 3–3.5 days after treatment initiation. Resolution of vomiting was achieved during the first 2 days of therapy in most of the patients. Median duration of diarrhea was 3.5–4 days, with a trend to a little bit longer diarrhea period in patients in patients aged 1–3 years. None of the patients developed complications or aggravation by the moment of discharge from the hospital (day 5–6 of treatment); all children were cured. The therapy was well tolerated by patients; none of them reported adverse events. Our findings suggest that drugs based on technologically processed affine purified antibodies are effective are effective and can be used in comprehensive treatment for acute viral gastroenteritis in children to ensure active defense against viruses, support the immune system, and alleviate symptoms via the anti-inflammatory effect. Key words: acute viral gastroenteritis, Ergoferon, Anaferon for children, treatment
{"title":"Acute viral gastroenteritis: a brief review of current research and experience with antiviral drugs based on technologically processed antibodies","authors":"G. Filippova, O. Morozova, E.Yu. Kirichek, A. A. Eliseeva, O. Efimenko, T. Raba, F. Raupov, Z. M. Kulieva, T.G. Eyvazov","doi":"10.20953/1817-7646-2023-2-91-101","DOIUrl":"https://doi.org/10.20953/1817-7646-2023-2-91-101","url":null,"abstract":"This article discusses the problem of acute viral gastroenteritis (AVGE), including aspects of immunopathogenesis that are significant for effective therapy and prevention. It also summarizes the results of randomized clinical trials assessing the efficacy of technologically processed purified antibodies (Anaferon® for children, Ergoferon®). We describe our own experience with Ergoferon® evaluated in a an open-label study involving 94 AVGE patients aged 1 to 10 years. Children who received Ergoferon® demonstrated rapid resolution of symptoms and normalization of body temperature 3–3.5 days after treatment initiation. Resolution of vomiting was achieved during the first 2 days of therapy in most of the patients. Median duration of diarrhea was 3.5–4 days, with a trend to a little bit longer diarrhea period in patients in patients aged 1–3 years. None of the patients developed complications or aggravation by the moment of discharge from the hospital (day 5–6 of treatment); all children were cured. The therapy was well tolerated by patients; none of them reported adverse events. Our findings suggest that drugs based on technologically processed affine purified antibodies are effective are effective and can be used in comprehensive treatment for acute viral gastroenteritis in children to ensure active defense against viruses, support the immune system, and alleviate symptoms via the anti-inflammatory effect. Key words: acute viral gastroenteritis, Ergoferon, Anaferon for children, treatment","PeriodicalId":38157,"journal":{"name":"Voprosy Prakticheskoi Pediatrii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67752366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.20953/1817-7646-2023-1-144-152
{"title":"The Consensus of resolution on nasal obstruction in children 0 to 3 years old","authors":"","doi":"10.20953/1817-7646-2023-1-144-152","DOIUrl":"https://doi.org/10.20953/1817-7646-2023-1-144-152","url":null,"abstract":"","PeriodicalId":38157,"journal":{"name":"Voprosy Prakticheskoi Pediatrii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67749283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.20953/1817-7646-2023-3-108-115
O. Vasilyev, V. Voynov, E. Achkasov, F. Takhavieva, A. Rokhlin
Joint hypermobility is a little-studied and relatively new risk factor for Russian school medicine, leading to impaired functions of the musculoskeletal system. The study involved 50 conditionally healthy children of primary school from 7 to 8.4 years. Main group consisted of 26 students of the 1st grade (12 boys, 14 girls) of the village school "Podosinki" (Moscow region). Сomparison group consisted of 24 female athletes (engaged in rhythmic gymnastics for at least one year) from 7.7 to 8.3 years, living in Moscow and Moscow region. All children underwent a detailed study of the volume of passive movements in the wrist, elbow, knee and hip joints, as well as in the small joints of the hand; Postural changes were determined by non-invasive methods. Comparison of the results in both groups showed that all respondents equally have risk factors for the development of orthopedic diseases and pathological conditions: posture disorders (kyphoscoliotic type), valgus installation of feet and flattening of their arches of the feet (mobile flat feet), hypermobility of the joints. The results of the study questioned the adequacy of the assessment of hypermobility on the Beighton scоre in children of this age group; According to studies, further research is needed to find a measure of joint hypermobility in children. The study was conducted with the support of the Ministry of Education of Russia. Key words: joint hypermobility, children, musculoskeletal system, risk factors
{"title":"Features of screening diagnostics of joint hypermobility in primary school children","authors":"O. Vasilyev, V. Voynov, E. Achkasov, F. Takhavieva, A. Rokhlin","doi":"10.20953/1817-7646-2023-3-108-115","DOIUrl":"https://doi.org/10.20953/1817-7646-2023-3-108-115","url":null,"abstract":"Joint hypermobility is a little-studied and relatively new risk factor for Russian school medicine, leading to impaired functions of the musculoskeletal system. The study involved 50 conditionally healthy children of primary school from 7 to 8.4 years. Main group consisted of 26 students of the 1st grade (12 boys, 14 girls) of the village school \"Podosinki\" (Moscow region). Сomparison group consisted of 24 female athletes (engaged in rhythmic gymnastics for at least one year) from 7.7 to 8.3 years, living in Moscow and Moscow region. All children underwent a detailed study of the volume of passive movements in the wrist, elbow, knee and hip joints, as well as in the small joints of the hand; Postural changes were determined by non-invasive methods. Comparison of the results in both groups showed that all respondents equally have risk factors for the development of orthopedic diseases and pathological conditions: posture disorders (kyphoscoliotic type), valgus installation of feet and flattening of their arches of the feet (mobile flat feet), hypermobility of the joints. The results of the study questioned the adequacy of the assessment of hypermobility on the Beighton scоre in children of this age group; According to studies, further research is needed to find a measure of joint hypermobility in children. The study was conducted with the support of the Ministry of Education of Russia. Key words: joint hypermobility, children, musculoskeletal system, risk factors","PeriodicalId":38157,"journal":{"name":"Voprosy Prakticheskoi Pediatrii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67752169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.20953/1817-7646-2023-2-76-82
A.A. Shavrov (Jr), A. S. Koshurnikova, I. E. Starostina, S. I. Ibragimov, A. Shavrov
Objective. To study the influence of constipation in the anamnesis, diet as risk factors for inadequate bowel preparation for colonoscopy in children, after bowel preparation with sodium picosulfate with magnesium citrate , cleansing enemas or with combination of both. Patients and methods. Children (1 year – 17 years 11 months) were referred for routine colonoscopy to two children's hospitals in Moscow and were randomly assigned three types of preparation for the research. Exclusion criteria were the need for an emergency colonoscopy, kidney disease, or colectomy. All patients were prescribed low-fiber diet during three days before the procedure. Endoscopists did not know about the method of preparation and evaluated the effectiveness of preparation according to the Boston Bowel Preparation Scale (BBPS ), noting the maximum depth of insertion of device (intubation of the cecum, ileum, etc.). Tolerability of methods and adherence of diet were assessed using the questionnaire for patients, as well as by the incidence of undesirable effects. The BBPS of ≥2 in 3 segments of the colon (left, transverse, right) was considered satisfactory, while BBPS <2 in more than 1 segment was considered unsatisfactory. Results. 440 children (mean age 12 years) were randomly assigned to bowel preparation with sodium picosulfate with magnesium citrate (n = 135), cleansing enemas (n = 79) or combination (n = 226) . The satisfactory result of preparation was achieved in 127 (94.1%) patients in the bowel preparation with sodium picosulfate group, in 71 (90%) in the group with cleansing enemas and in 201 (89%) using the combined method (BBPC value for bowel preparation with sodium picosulfate 7.0 (6.0–8.0), Cleansing enemas 7.0 (5.0–8.0), Combination 6.5 (6.0–8.0), p = 0.009). Analysis of logistic regression showed that age, body mass index and the presence of a diagnosis of constipation in the anamnesis did not affect (p > 0.05)to success of achieving the satisfactory result of bowel preparation in all groups (p > 0.05). However, constipation was associated with depth of insertion and intubation of the cecum and/or terminal ileum, which was 6.8 times less likely in patients with constipation (OR = 0.146; 95% CI: 0.036–0.602, p = 0.014). In patients who followed the diet, inadequate bowel preparation was observed with a probability of 7.4 times less (OR = 0.135; 95% CI: 0.053–0.345, p < 0.001). In children who followed the dosage, the probability of inadequate bowel preparation was also 7.393 times lower, regardless of the method of preparation (OR = 0.135; 95% CI: 0.053–0.345, p < 0.001). Frequency of undesirable effects between the groups was almost the same, there was no statistically significant difference (sodium picosulfate 29%, cleansing enemas 27%, combination 39%, p = 0.03). Conclusion. The results of our study show that in children without constipation on diet and adequate doses of medicines makes it easier to tolerate preparation, qualitatively prepare the in
目标。研究便秘对儿童结肠镜前肠道准备不足、pico硫酸钠联合柠檬酸镁、清洁灌肠或两者联合进行肠道准备后便秘的影响，饮食作为危险因素。患者和方法。儿童(1岁- 17岁11个月)被转介到莫斯科的两家儿童医院进行常规结肠镜检查，并随机分配三种类型的研究准备。排除标准为需要紧急结肠镜检查、肾脏疾病或结肠切除术。所有患者在手术前三天内均给予低纤维饮食。内镜医师不了解准备方法，根据波士顿肠准备量表(Boston Bowel preparation Scale, BBPS)评估准备效果，注意装置的最大插入深度(插管盲肠、回肠等)。方法的耐受性和饮食的依从性通过对患者的问卷调查来评估，以及不良反应的发生率。3段结肠(左、横、右)BBPS≥2为满意，BBPS≥0.05为各组肠准备成功(p < 0.05)。然而，便秘与盲肠和/或回肠末端的插入和插管深度有关，便秘患者的可能性低6.8倍(or = 0.146;95% CI: 0.036-0.602, p = 0.014)。在遵循该饮食的患者中，观察到肠道准备不足的概率为7.4倍(OR = 0.135;95% CI: 0.053-0.345, p < 0.001)。在按剂量服药的儿童中，无论采用何种准备方法，肠道准备不充分的概率也降低了7.393倍(OR = 0.135;95% CI: 0.053-0.345, p < 0.001)。两组不良反应发生频率基本相同，差异无统计学意义(picosulfate 29%， cleansing灌肠27%，combination 39%， p = 0.03)。结论。我们的研究结果表明，在没有便秘的儿童中，饮食和适当剂量的药物更容易耐受准备，定性准备肠道并进行完整的结肠镜检查。我们认为这些标准对于儿童的肠道清洁和结肠镜检查的质量是最重要的，无论结肠准备的方法是什么。关键词:结肠镜检查;儿童;儿科学
{"title":"Risk factors for inadequate bowel preparation for colonoscopy and comparison of bowel preparation methods in pediatrics","authors":"A.A. Shavrov (Jr), A. S. Koshurnikova, I. E. Starostina, S. I. Ibragimov, A. Shavrov","doi":"10.20953/1817-7646-2023-2-76-82","DOIUrl":"https://doi.org/10.20953/1817-7646-2023-2-76-82","url":null,"abstract":"Objective. To study the influence of constipation in the anamnesis, diet as risk factors for inadequate bowel preparation for colonoscopy in children, after bowel preparation with sodium picosulfate with magnesium citrate , cleansing enemas or with combination of both. Patients and methods. Children (1 year – 17 years 11 months) were referred for routine colonoscopy to two children's hospitals in Moscow and were randomly assigned three types of preparation for the research. Exclusion criteria were the need for an emergency colonoscopy, kidney disease, or colectomy. All patients were prescribed low-fiber diet during three days before the procedure. Endoscopists did not know about the method of preparation and evaluated the effectiveness of preparation according to the Boston Bowel Preparation Scale (BBPS ), noting the maximum depth of insertion of device (intubation of the cecum, ileum, etc.). Tolerability of methods and adherence of diet were assessed using the questionnaire for patients, as well as by the incidence of undesirable effects. The BBPS of ≥2 in 3 segments of the colon (left, transverse, right) was considered satisfactory, while BBPS <2 in more than 1 segment was considered unsatisfactory. Results. 440 children (mean age 12 years) were randomly assigned to bowel preparation with sodium picosulfate with magnesium citrate (n = 135), cleansing enemas (n = 79) or combination (n = 226) . The satisfactory result of preparation was achieved in 127 (94.1%) patients in the bowel preparation with sodium picosulfate group, in 71 (90%) in the group with cleansing enemas and in 201 (89%) using the combined method (BBPC value for bowel preparation with sodium picosulfate 7.0 (6.0–8.0), Cleansing enemas 7.0 (5.0–8.0), Combination 6.5 (6.0–8.0), p = 0.009). Analysis of logistic regression showed that age, body mass index and the presence of a diagnosis of constipation in the anamnesis did not affect (p > 0.05)to success of achieving the satisfactory result of bowel preparation in all groups (p > 0.05). However, constipation was associated with depth of insertion and intubation of the cecum and/or terminal ileum, which was 6.8 times less likely in patients with constipation (OR = 0.146; 95% CI: 0.036–0.602, p = 0.014). In patients who followed the diet, inadequate bowel preparation was observed with a probability of 7.4 times less (OR = 0.135; 95% CI: 0.053–0.345, p < 0.001). In children who followed the dosage, the probability of inadequate bowel preparation was also 7.393 times lower, regardless of the method of preparation (OR = 0.135; 95% CI: 0.053–0.345, p < 0.001). Frequency of undesirable effects between the groups was almost the same, there was no statistically significant difference (sodium picosulfate 29%, cleansing enemas 27%, combination 39%, p = 0.03). Conclusion. The results of our study show that in children without constipation on diet and adequate doses of medicines makes it easier to tolerate preparation, qualitatively prepare the in","PeriodicalId":38157,"journal":{"name":"Voprosy Prakticheskoi Pediatrii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67752246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.20953/1817-7646-2023-3-83-99
I.D. Gordienko, O. I. Admakin, N. S. Morozova, Yu.A. Kozlitina, U.Yu. Chugaeva, T. Rumyantseva, E.A. Maslikova
The aim of this study was is the performance evaluation of Emdogain for direct pulp capping, partial pulpotomy, and pulpotomy in comparison with other materials, used in such methods. After raising a PICO question, the PRISMA guideline was adopted to carry out an electronic search through the Scopus, PubMed, Cochrane Library database to identify comparative studies A systematic search using keywords was conducted using seven databases up to November 11, 2020. The search resulted in 509 records. The success rate of Endogain (93.3%) was higher than that of formocresol (66.7%). The authors reported the absence of any significant difference in clinical results of the Emdogain group and calcium hydroxide after a year upon treatment. After reviewing articles it is evident that the Emdogain is a perspective material for pulp capping. Key wоrds: pulpitis, pulp capping, pulpotomy, Emdogain
{"title":"Эффективность Emdogain для обработки пульпы","authors":"I.D. Gordienko, O. I. Admakin, N. S. Morozova, Yu.A. Kozlitina, U.Yu. Chugaeva, T. Rumyantseva, E.A. Maslikova","doi":"10.20953/1817-7646-2023-3-83-99","DOIUrl":"https://doi.org/10.20953/1817-7646-2023-3-83-99","url":null,"abstract":"The aim of this study was is the performance evaluation of Emdogain for direct pulp capping, partial pulpotomy, and pulpotomy in comparison with other materials, used in such methods. After raising a PICO question, the PRISMA guideline was adopted to carry out an electronic search through the Scopus, PubMed, Cochrane Library database to identify comparative studies A systematic search using keywords was conducted using seven databases up to November 11, 2020. The search resulted in 509 records. The success rate of Endogain (93.3%) was higher than that of formocresol (66.7%). The authors reported the absence of any significant difference in clinical results of the Emdogain group and calcium hydroxide after a year upon treatment. After reviewing articles it is evident that the Emdogain is a perspective material for pulp capping. Key wоrds: pulpitis, pulp capping, pulpotomy, Emdogain","PeriodicalId":38157,"journal":{"name":"Voprosy Prakticheskoi Pediatrii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67753094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.20953/1817-7646-2023-3-13-17
E. V. Plotnikova, L. V. Kochorova, N. Vishnyakov, P. I. Konstantinova
Objective. To analyze the incidence of perinatal pathology in different regions of the Russian Federation between 2016 and 2021. Materials and methods. We analyzed official statistical documents reporting cases of perinatal pathology between 2016 and 2021. We calculated incidence and prevalence of perinatal abnormalities and evaluated their dynamics over 6 years. Results. The absolute number of children with diseases developing in the perinatal period remains unacceptably high. The incidence of these diseases varies significantly across different regions of the Russian Federation. In 2021, the highest incidence of perinatal pathology was observed in the Ural and Far Eastern Federal Districts (17.9‰ and 16.4‰, respectively). In general, the incidence of congenital anomalies (malformations), deformities, and chromosomal abnormalities in Russia between 2016 to 2021 tended to decrease by 16.5% (from 10.9‰ to 9.1‰). Conclusion. The increasing incidence of malformations in children necessitates an improvement of specialized medical care, including rehabilitation for such patients. Key words: analysis of incidence, pediatric population, perinatal pathology
{"title":"Incidence of perinatal pathology in the Russian Federation","authors":"E. V. Plotnikova, L. V. Kochorova, N. Vishnyakov, P. I. Konstantinova","doi":"10.20953/1817-7646-2023-3-13-17","DOIUrl":"https://doi.org/10.20953/1817-7646-2023-3-13-17","url":null,"abstract":"Objective. To analyze the incidence of perinatal pathology in different regions of the Russian Federation between 2016 and 2021. Materials and methods. We analyzed official statistical documents reporting cases of perinatal pathology between 2016 and 2021. We calculated incidence and prevalence of perinatal abnormalities and evaluated their dynamics over 6 years. Results. The absolute number of children with diseases developing in the perinatal period remains unacceptably high. The incidence of these diseases varies significantly across different regions of the Russian Federation. In 2021, the highest incidence of perinatal pathology was observed in the Ural and Far Eastern Federal Districts (17.9‰ and 16.4‰, respectively). In general, the incidence of congenital anomalies (malformations), deformities, and chromosomal abnormalities in Russia between 2016 to 2021 tended to decrease by 16.5% (from 10.9‰ to 9.1‰). Conclusion. The increasing incidence of malformations in children necessitates an improvement of specialized medical care, including rehabilitation for such patients. Key words: analysis of incidence, pediatric population, perinatal pathology","PeriodicalId":38157,"journal":{"name":"Voprosy Prakticheskoi Pediatrii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67752601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-10DOI: 10.20953/1817-7646-2022-1-213-221
A. Gorelov, I. Zakharova, A. Khavkin, L. Kafarskaya, D. Usenko, S. Belmer, E. Kornienko, V. F. Privorotsky, V. V. Krasnov, E. Kondyurina, V. N. Panfilova, N. Tkhakushinova, A. N. Plaksina, O. Rychkova, D. Pechkurov, A. A. Nizhevich, R. Fayzullina, E. Yablokova
The appearance of new high-tech microbiological research methods has significantly changed the understanding of the human microbiome. The purpose of the meeting of the Council of Experts "Dysbiosis. The immediate and long-term consequences of microbiome disorders and options for their correction with probiotics" was the definition of modern positions about possible methods of studying the intestinal microbiome, the possibilities of correcting dysbiosis, the use of Saccharomyces Boulardii CNCM I-745 to correct microbiome disorders in various clinical situations. The microbiota of the large intestine is represented by more than 1000 species of 7 different phyla of the Bacteriae domain, up to 160 numerically prevailing species are detected in one individual. The criteria of the microbiological "norm" for the intestinal microbiome have not been definitively established. To study the microbiome, a set of methods is used that combine cultural and molecular genetic methods that complement each other. Currently, none of the methods is widely available in clinical practice. To study the functional state of the intestinal microbiota, the most accessible is breath testing. Currently, there are no clinical markers of dysbiosis, and laboratory markers of dysbiosis require modification. There is an insignificant spectrum of diseases with such markers: acute intestinal infections, antibiotic-associated C. difficile-diarrhea, IBD, IBS. Probiotics can provide restoration of the intestinal microbiota. The effectiveness and safety of the use of S. boulardii CNCM I-745 for this purpose has been proven. In the case of acute intestinal infection, antibiotic-associated diarrhea, and the consequences of HP infection eradication, studies have a high level of evidence, and the use of Sb CNCM I-745 for treating IBS and IBD in children is promising.
{"title":"Resolution of the Council of Experts “Dysbiosis. Immediate and long-term consequences of microbiome disorders and options for their correction with probiotics”","authors":"A. Gorelov, I. Zakharova, A. Khavkin, L. Kafarskaya, D. Usenko, S. Belmer, E. Kornienko, V. F. Privorotsky, V. V. Krasnov, E. Kondyurina, V. N. Panfilova, N. Tkhakushinova, A. N. Plaksina, O. Rychkova, D. Pechkurov, A. A. Nizhevich, R. Fayzullina, E. Yablokova","doi":"10.20953/1817-7646-2022-1-213-221","DOIUrl":"https://doi.org/10.20953/1817-7646-2022-1-213-221","url":null,"abstract":"The appearance of new high-tech microbiological research methods has significantly changed the understanding of the human microbiome. The purpose of the meeting of the Council of Experts \"Dysbiosis. The immediate and long-term consequences of microbiome disorders and options for their correction with probiotics\" was the definition of modern positions about possible methods of studying the intestinal microbiome, the possibilities of correcting dysbiosis, the use of Saccharomyces Boulardii CNCM I-745 to correct microbiome disorders in various clinical situations. The microbiota of the large intestine is represented by more than 1000 species of 7 different phyla of the Bacteriae domain, up to 160 numerically prevailing species are detected in one individual. The criteria of the microbiological \"norm\" for the intestinal microbiome have not been definitively established. To study the microbiome, a set of methods is used that combine cultural and molecular genetic methods that complement each other. Currently, none of the methods is widely available in clinical practice. To study the functional state of the intestinal microbiota, the most accessible is breath testing. Currently, there are no clinical markers of dysbiosis, and laboratory markers of dysbiosis require modification. There is an insignificant spectrum of diseases with such markers: acute intestinal infections, antibiotic-associated C. difficile-diarrhea, IBD, IBS. Probiotics can provide restoration of the intestinal microbiota. The effectiveness and safety of the use of S. boulardii CNCM I-745 for this purpose has been proven. In the case of acute intestinal infection, antibiotic-associated diarrhea, and the consequences of HP infection eradication, studies have a high level of evidence, and the use of Sb CNCM I-745 for treating IBS and IBD in children is promising.","PeriodicalId":38157,"journal":{"name":"Voprosy Prakticheskoi Pediatrii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48788323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.20953/1817-7646-2022-1-122-127
S. Todorova
Overweight and obesity among adolescents is one of the most serious public health problems of the 21st century. They play a potential role in the development of a number of socially significant non-communicable conditions and diseases. Objective. The aim of the study was to determine the prevelance of overweight and obesity among Bulgarian teenagers of both sexes and age range from 13 to 18 years based on anthropometric parameters – height, weight, and body mass index. Methods. It was conducted a survey of anthropometric indicators on a representative sample of region Stara Zagora, Bulgaria in September-October 2016. The study population included 481 school students aged 13-18 years. The classification of overweight and obesity status was determined by body mass index (BMI) for age and sex according to the WHO Growth Reference for children aged 5–19 years. Results. The results of the transversal study showed increased levels of overweight and obesity among adolescents – 14.96% and 3.74%, respectively. The percentage of overweight in the individual age groups ranged from 10.52% to 19.54%. The leaders in the sample on this indicator were 18-year-old male students – 11.49%. The prevalence of obesity among different age groups varied from 1.13% to 6.25%. The highest values of obesity were found in 13- and 14-year-old school students – 6.00% and 6.25%, respectively. Conclusion. The research found increased prevalence of overweight and obesity among Bulgarian adolescents aged 13–18 years. It requires effective health programs, active civic self-awareness, and personal participation to limit this extremely harmful process that has already reached a pandemic spread. Key words: adolescents, obesity, overweight, general practice, BMI
{"title":"Prevalence of overweight and obesity among adolescents in Bulgaria","authors":"S. Todorova","doi":"10.20953/1817-7646-2022-1-122-127","DOIUrl":"https://doi.org/10.20953/1817-7646-2022-1-122-127","url":null,"abstract":"Overweight and obesity among adolescents is one of the most serious public health problems of the 21st century. They play a potential role in the development of a number of socially significant non-communicable conditions and diseases. Objective. The aim of the study was to determine the prevelance of overweight and obesity among Bulgarian teenagers of both sexes and age range from 13 to 18 years based on anthropometric parameters – height, weight, and body mass index. Methods. It was conducted a survey of anthropometric indicators on a representative sample of region Stara Zagora, Bulgaria in September-October 2016. The study population included 481 school students aged 13-18 years. The classification of overweight and obesity status was determined by body mass index (BMI) for age and sex according to the WHO Growth Reference for children aged 5–19 years. Results. The results of the transversal study showed increased levels of overweight and obesity among adolescents – 14.96% and 3.74%, respectively. The percentage of overweight in the individual age groups ranged from 10.52% to 19.54%. The leaders in the sample on this indicator were 18-year-old male students – 11.49%. The prevalence of obesity among different age groups varied from 1.13% to 6.25%. The highest values of obesity were found in 13- and 14-year-old school students – 6.00% and 6.25%, respectively. Conclusion. The research found increased prevalence of overweight and obesity among Bulgarian adolescents aged 13–18 years. It requires effective health programs, active civic self-awareness, and personal participation to limit this extremely harmful process that has already reached a pandemic spread. Key words: adolescents, obesity, overweight, general practice, BMI","PeriodicalId":38157,"journal":{"name":"Voprosy Prakticheskoi Pediatrii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67741105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.20953/1817-7646-2022-1-150-156
V. Yankova, I. Udyanskaya, T. Slonskaya, A. Zhukova, V. Grigoryeva, S. Gribanova, K. Gryaznov, A. Kirichenko, O. Plakhotnaya, A.B. Karpyn
Enterosorbents based on lignin hydrolised are able to adsorb in the intestine different kinds of toxins, drugs, salts of heavy metals etc. Nowadays, such drugs are widely applied during the treatment of the adults and children from the first year of life due to its safety and proven efficacy. Objective. To study the morphology and the adsorption centers on the surface of the enterosorbent "Filtrum-STI" based on lignin hydrolised. To develop a methodology for determination the adsorption activity of the drug "Filtrum-STI" and to measure qualitatively and quantitatively its adsorption activity to low molecular weight toxins and heavy metals. Materials and methods. The morphology of the sample’s surface was investigated on an Olympus BX-51 optical microscope. IR spectra were obtained using a Thermo Nicolet Nexus 470 FT-IR infrared Fourier spectrometer. Visual identification of the adsorption activity of the enterosorbent was carried out using methylene blue and methyl orange, recommended by the RF SPh as models of low molecular weight toxins. The methodology of determination the adsorption activity to heavy metal cations was developed and the measurements of this activity were carried out using reverse complexometric titration towards Pb2+ cation. Results. Micrographs of the sample "Filtrum-STI" demonstrate the heterogeneity of its surface morphology, the tablet consists of small particles. IR spectroscopy confirmed the presence of active adsorption centers on the surface of lignin hydrolysed. Adsorption of low molecular weight toxins from aqueous solutions was obviously revealed after 15 minutes for all toxins. It is estimated that the adsorption activity of the drug is preserved at physiological pH. The mass content of adsorbed Pb2+ cations was determined by the method of reverse complexometric titration, was demonstrated that w = 19.44 ± 0.92% of cations were adsorbed. Conclusion. A methodology of the determination the adsorption activity of the enterosorbent "Filtrum-STI" was developed and successfully tested, it allowed to confirm the high adsorption properties of the studied drug to a wide range of markers in various media. Key words: enterosorbent, lignin hydrolysed, "Filtrum-STI", adsorption activity, toxins, adsorption centers
{"title":"Adsorption activity of an enterosorbent containing hydrolyzed lignin","authors":"V. Yankova, I. Udyanskaya, T. Slonskaya, A. Zhukova, V. Grigoryeva, S. Gribanova, K. Gryaznov, A. Kirichenko, O. Plakhotnaya, A.B. Karpyn","doi":"10.20953/1817-7646-2022-1-150-156","DOIUrl":"https://doi.org/10.20953/1817-7646-2022-1-150-156","url":null,"abstract":"Enterosorbents based on lignin hydrolised are able to adsorb in the intestine different kinds of toxins, drugs, salts of heavy metals etc. Nowadays, such drugs are widely applied during the treatment of the adults and children from the first year of life due to its safety and proven efficacy. Objective. To study the morphology and the adsorption centers on the surface of the enterosorbent \"Filtrum-STI\" based on lignin hydrolised. To develop a methodology for determination the adsorption activity of the drug \"Filtrum-STI\" and to measure qualitatively and quantitatively its adsorption activity to low molecular weight toxins and heavy metals. Materials and methods. The morphology of the sample’s surface was investigated on an Olympus BX-51 optical microscope. IR spectra were obtained using a Thermo Nicolet Nexus 470 FT-IR infrared Fourier spectrometer. Visual identification of the adsorption activity of the enterosorbent was carried out using methylene blue and methyl orange, recommended by the RF SPh as models of low molecular weight toxins. The methodology of determination the adsorption activity to heavy metal cations was developed and the measurements of this activity were carried out using reverse complexometric titration towards Pb2+ cation. Results. Micrographs of the sample \"Filtrum-STI\" demonstrate the heterogeneity of its surface morphology, the tablet consists of small particles. IR spectroscopy confirmed the presence of active adsorption centers on the surface of lignin hydrolysed. Adsorption of low molecular weight toxins from aqueous solutions was obviously revealed after 15 minutes for all toxins. It is estimated that the adsorption activity of the drug is preserved at physiological pH. The mass content of adsorbed Pb2+ cations was determined by the method of reverse complexometric titration, was demonstrated that w = 19.44 ± 0.92% of cations were adsorbed. Conclusion. A methodology of the determination the adsorption activity of the enterosorbent \"Filtrum-STI\" was developed and successfully tested, it allowed to confirm the high adsorption properties of the studied drug to a wide range of markers in various media. Key words: enterosorbent, lignin hydrolysed, \"Filtrum-STI\", adsorption activity, toxins, adsorption centers","PeriodicalId":38157,"journal":{"name":"Voprosy Prakticheskoi Pediatrii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67741686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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