Background and objectives: Pediatric neuroinflammatory disorders (NIDs) pose significant health and financial challenges, yet comprehensive cost estimates are lacking. These conditions likely contribute disproportionately to health care expenditures. To assess the burden of NID-related hospitalizations, we analyzed Texas hospital administrative records.
Methods: We used the Texas Health Care Information Collection Inpatient Public Use Data File (2016-2023) to explore drivers of inpatient resource use for NIDs. Pediatric hospitalizations with a primary diagnosis of acute disseminated encephalomyelitis, encephalitis and encephalomyelitis (E/EM), multiple sclerosis/neuromyelitis optica spectrum disorders, and other demyelinating disorders, or acute transverse myelitis and other myelitis were included. Charges were converted to costs using hospital-level annual average cost-to-charge ratios and then inflated to 2023 costs. Statistical analysis was implemented to predict the likelihood of having a high-cost or a longer length of stay (LOS) hospitalization and a hospitalization that involved intensive care.
Results: There were 2155 hospitalizations involving pediatric patients with a primary diagnosis of NIDs. The most common diagnoses were E/EM. The median total cost of these hospitalizations was $31 365.49, with a median LOS of 6 days. More than half (59.1%) required intensive care unit (ICU) admission and were associated with a higher cost. After adjusting for patient and facility characteristics, the primary diagnostic group remained a significant independent predictor of whether hospitalization was classified as high-cost or long-LOS or involved an ICU stay.
Conclusions: These findings align with clinical observations, highlighting the significant burden of NIDs, which often require longer hospital stays, intensive care, and higher costs compared with most pediatric conditions.
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