Acta medica academica最新文献

The aim of this historical review is to present the beliefs of the ancient Greeks related to lyssa and how the mythology surrounding this disease was created. In Greek antiquity Lyssa was a secondary goddess, a personification of a zoonotic disease which could be transmitted after an animal bite. Also named hydrophobia, the illness lyssa presented with an acute loss of mental stability, offensive frenzy and madness, and fear of water in the patient, who was seen to be possessed by a daemon as a divine punishment. In the Trojan War, lyssa was seen as a drug to Greek warriors, to demonstrate unreal power during battle. Homer was the first to refer to the hound of Orion, who was the greatest ancient Greek hunter. The hound, named Sirius, as a carrier of lyssa, was used as a bio-weapon to inflict death among the Trojans. Soranus of Ephesus and Galen gave descriptions of the disease, and proposed a sponge soaked with various herbal drugs as a therapeutic measure. The Greco-Roman physician Caelius Aurelianus noted that ancient Greeks knew about lyssa, and was the first to suggest that this was a neuro-disease. Lyssa was a figure in Greek Tragedy, depicted as a young female with a dog-like crown, related to Erinyes and Maniae. CONCLUSION: Lyssa was noted as a disease in Hellenic literature more than 2500 years ago. It was used as a bio-weapon to inflict madness. This vignette reveals Lyssa within a historical framework for the reader to understand the disease's origins.

Background: The deadliest, most dangerous subtype of breast cancer is triple-negative, which lacks treatment targets and accounts for 30% of all breast cancer-related deaths worldwide. TNBC is characterized by the expression of no estrogen, progesterone, or human epidermal growth factor 2 receptors. This suggests that new treatment modalities with fewer adverse effects are required.

Objective: The aim of the present study was to investigate the therapeutic potential of selenium compounds as an adjuvant therapy for Triple Negative Breast Cancer (TNBC), either on their own or in conjunction with nutritional supplements and chemotherapy medications.

Methods: Using the keywords "selenium" and "triple negative breast cancer", a thorough search was conducted in the PubMed database, yielding 23 articles. The following factors were taken into consideration for inclusion: studies using TNBC cell culture lines or in vivo tumors/specimens; full-text articles from the PubMed database; studies published in the English language; experiments with statistically significant results; and selenium used alone or in combination with other antioxidants or chemotherapy. This led to the evaluation of 13 articles in this review.

Results: The results show that selenium therapy increased the anti-cancer drug's effects and produced tumor cytotoxicity, while reducing the cellular features of the cancer (hyperproliferation, growth, and metastasis).

Discussion: This study evaluated the various selenium compounds tested, the cell lines and model organisms used, the assays performed, and the cellular pathways affected.

Conclusion: Examining the possible benefits of selenium in TNBC treatment highlights the need for more studies to confirm selenium compounds as viable co-therapeutic agents.

Objective: This study aimed to determine which pedagogic method, online workshops or live medical education, was the better way to teach about self-medication for middle school students.

Methods: The following groups were formed: group O (students receiving online education), group L (students participating in live medical education animated by a medical practitioner and a science teacher) and group C (students without any medical learning). To compare them, the students answered three multiple choice questions before and after the educational intervention. The students in group L were evaluated immediately after the live medical training and group O immediately after the online workshops (t1). Group C was only evaluated at t0.

Results: Group C N=195), group L (N=219) and group O (N=200, but 101 students who participated in the online workshops students dropped out before the end) were equivalent in terms of gender, but their ages and school grades were statistically different (P<0.001). A post-hoc test revealed that students in group O were older and in a higher grade than those in the other two groups (P<0.001) but the mean ages and school grades were equivalent in group L and group C. At t0, the results obtained were equivalent in the 3 groups. At t1, school students obtained better results in both groups (P<0.001) but these same results were significantly better in group L than those obtained in group O (P<0.001). Age, gender, school grade and school level had no effect on the students' results.

Conclusion: The study's findings suggest that live medical education is a superior approach for imparting self-medication knowledge to middle school students.

The purpose of this article is to present a well-known physician and highlight his contribution into an essential, but neglected anatomical feature. George Sclavunos (1869-1954) was a 20th century Greek physician, whose scientific work was a significant milestone in global medical knowledge. In 1899 he became Professor of Anatomy and Head Director of the Department of Anatomy. In 1906 Sclavunos G. published the first volume of the three volume book "Human Anatomy" (1906-1926), which is characterized by its unparalleled illustrations. For more than a century it was the most important book of medical literature in Greece. In 1926 he became a Full Member of the Academy of Athens and was named Life Partner of the International Anatomical Society. His interests included Anatomy, Physiology, Histology, as well as Osteology and Syndesmology. In his book "Human Anatomy", he described for first time the "Sialine Groove of the Stomach", which was described by Waldeyer-Hartz almost at the same time as the "Magenstrasse", a German word that means "stomach road". It is a ribbon-like path that extends along the lesser curvature of the stomach from the gastric cardia to the antrum and releases the gastric content directly into the small intestine. Its importance is confirmed by its association not only with drug delivery, but also with anti-obesity surgical techniques. The old German term has come back into common medical usage in view of the commonly performed Magenstrasse and Mill procedure, a form of bariatric surgery. CONCLUSION: Sclavunos G. managed to observe an anatomical structure that has remained of great importance until today.