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The Use of Pressure Recording Analytical Method in Patients Undergoing Endovascular Repair for Abdominal Aortic Aneurysm: The Impact on Clinical Decisions for the Appropriate Postoperative Setting and Cost-effective Analysis 在接受腹主动脉瘤血管内修复术的患者中使用压力记录分析方法:对术后适当设置的临床决策的影响及成本效益分析
Q3 Medicine Pub Date : 2024-06-12 DOI: 10.5644/ama2006-124.442
E. Giacomelli, W. Dorigo, S. Romano, Andrea Casini, C. Giglioli, Chiara Papini, A. Fargion, N. Marchionni, C. Pratesi, R. Pulli, E. Cecchi
Objective. To analyze the use of the Pressure Recording Analytical Method (PRAM), an hemodynamic monitoring system, in evaluating intraoperative and postoperative hemodynamic instability in patients undergoing endovascular repair for abdominal aortic aneurysm, and to evaluate if the decision to refer patients to a ordinary ward or to a Cardiac Step-Down Unit (CSDU) after the intervention on the basis of intraoperative hemodynamic monitoring could be more cost-effective. Materials and Methods. After preoperative clinical evaluation, 44 patients were divided in this non-randomised study into two groups accord- ing to their postoperative destination: Group 1-ward (N=22) and Group 2-CSDU (N=22). All patients underwent monitoring with PRAM during the intervention and in the 24 postoperative hours, measuring several indices of myocardial contractility and other hemodynamic variables. Results. According to the variability of two parameters, Stroke Volume Variation and Pulse Pressure Variation, patients were classified as stable or unstable. Unstable patients showed a significant alteration in several hemodynamic indices, in comparison to stable ones. According to the intraoperative monitoring, eight high risk patients could have been sent to an ordinary ward due to their stability, with a reduction in the improper use of CSDU and, consequently, in costs. Conclusions. Hemodynamic monitoring with PRAM can be useful in these patients, both for intraoperative management and for the choice of the more appropriate postoperative setting, possibly reducing the improper use of CSDU for hemodynami- cally stable patients who are judged to be at high risk preoperatively, and re-evaluating low surgical risk patients with an unstable intraoperative pattern, with a possible reduction in costs.
目的分析血流动力学监测系统压力记录分析法(PRAM)在评估腹主动脉瘤血管内修复术患者术中和术后血流动力学不稳定性中的应用,并评估根据术中血流动力学监测结果决定将患者转入普通病房还是介入治疗后转入心脏降压病房(CSDU)是否更具成本效益。材料与方法。在这项非随机研究中,44 名患者经过术前临床评估后,根据术后去向分为两组:第一组-病房(22 人)和第二组-CSDU(22 人)。所有患者在介入治疗期间和术后 24 小时内都接受了 PRAM 监测,测量心肌收缩力的多个指标和其他血液动力学变量。 结果显示根据两个参数的变化,即卒中容量变化和脉压变化,患者被分为稳定型和不稳定型。与稳定型患者相比,不稳定型患者的几项血流动力学指标出现了显著变化。根据术中监测结果,有八名高危患者因病情稳定而被送往普通病房,从而减少了CSDU的不当使用,降低了费用。结论使用 PRAM 进行血流动力学监测对这些患者非常有用,既有助于术中管理,也有助于选择更合适的术后环境,可能会减少术前判断为高风险的血流动力学稳定患者对 CSDU 的不当使用,并对术中模式不稳定的低手术风险患者进行重新评估,从而可能减少费用。
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引用次数: 0
The Genesis of Multidisciplinary Health Professionals Teams for Pain Management. A History from the Hellenic Antiquity to Modern Palliative Medicine 多学科医护人员疼痛管理团队的起源。从希腊古代到现代姑息医学的发展史
Q3 Medicine Pub Date : 2024-05-14 DOI: 10.5644/ama2006-124.439
Heleni Karassava, Loukas Agorgianitis, Evaggelos Mavrommatis
No abstract available.
无摘要。
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引用次数: 0
Late Adverse Effects after Treatment for Childhood Acute Leukemia 儿童急性白血病治疗后的晚期不良反应
Q3 Medicine Pub Date : 2024-04-15 DOI: 10.5644/ama2006-124.438
Jelena Roganovic, Riccardo Haupt, E. Bárdi, L. Hjorth, Gisela Michel, Vesna Pavasovic, Katrin Scheinemann, H. V. D. van der Pal, L. Zadravec Zaletel, Ana E. Amariutei, Roderick Skinner, PanCare Board
The aim of this review is to raise awareness and knowledge among healthcare professionals and policymakers about late adverse effects in survivors of childhood leukemia. With contemporary treatment, over 90% of children with acute lymphoblastic leukemia (ALL) and over 60% with acute myeloid leukemia (AML) are cured. Large cohort studies demonstrate that 20% of ALL and most AML survivors have at least one chronic health condition by 20-25 years after diagnosis. These are life-changing or threatening in some survivors and contribute to increased premature mortality. We describe the frequency, causes, clinical features, and natural history of the most frequent and severe late adverse effects in childhood leukemia survivors, including subsequent malignant neoplasms, metabolic toxicity, gonadotoxicity and impaired fertility, endocrinopathy and growth disturbances, bone toxicity, central and peripheral neurotoxicity, cardiotoxicity, psychosocial late effects, accelerated ageing and late mortality. The wide range of late effects in survivors of haemopoietic stem cell transplant is highlighted. Recent developments informing the approach to long-term survivorship care are discussed, including electronic personalized patient-specific treatment summaries and care plans such as the Survivor Passport (SurPass), surveillance guidelines and models of care. The importance of ongoing vigilance is stressed given the increasing use of novel targeted drugs with limited experience of long-term outcomes. Conclusion. It is vital to raise awareness of the existence and severity of late effects of childhood leukemia therapy among parents, patients, health professionals, and policymakers. Structured long-term surveillance recommendations are necessary to standardize follow-up care.
本综述旨在提高医护人员和决策者对儿童白血病幸存者晚期不良反应的认识和了解。通过现代治疗方法,90% 以上的急性淋巴细胞白血病(ALL)患儿和 60% 以上的急性髓细胞白血病(AML)患儿可以治愈。大型队列研究表明,20% 的急性淋巴细胞白血病(ALL)和大多数急性髓细胞白血病(AML)幸存者在确诊后 20-25 年间至少患有一种慢性疾病。这些病症改变了一些幸存者的生活或对其构成威胁,并导致过早死亡率上升。我们描述了儿童白血病幸存者最常见和最严重的晚期不良反应的频率、原因、临床特征和自然史,包括后续恶性肿瘤、代谢毒性、性腺毒性和生育能力受损、内分泌病变和生长障碍、骨毒性、中枢和外周神经毒性、心脏毒性、心理社会晚期反应、加速衰老和晚期死亡率。重点介绍了造血干细胞移植幸存者的各种晚期效应。讨论了长期幸存者护理方法的最新进展,包括电子个性化患者治疗摘要和护理计划(如幸存者护照(SurPass))、监测指南和护理模式。鉴于新型靶向药物的使用越来越多,但长期疗效经验有限,因此强调了持续警惕的重要性。结论。提高家长、患者、医疗专业人员和政策制定者对儿童白血病治疗后期效应的存在和严重性的认识至关重要。有必要提出结构化的长期监测建议,以规范后续治疗。
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引用次数: 0
Difficulties in Accessing the List and Full Text of the Defended PhD Theses from Medical Schools: a Retrospective Case Study from Croatia. 获取医学院已答辩博士论文清单和全文的困难:克罗地亚的回顾性案例研究》(Difficulties in Accessing the List and Full Text of the Defended PhD Theses from Medical Schools: a Retrospective Case Study from Croatia)。
Q3 Medicine Pub Date : 2024-04-09 DOI: 10.5644/ama2006-124.437
Livia Puljak, Matea Tolić, Marko Sablić, Vlatko Silobrčić, Marija Heffer, Bojan Polić, O. Barcot, D. Sapunar
OBJECTIVETo conduct scientometric studies on PhD ("Doctor of Philosophy") theses (i.e., doctoral theses), researchers should be able to access the theses. We aimed to explore how to obtain a list and full text of the defended PhD theses from medical schools in Croatia over 30 years (from the beginning of 1992 to the end of 2021).METHODSWe tried to obtain information from the Croatian Bureau of Statistics, the National and University Library in Zagreb (NSK), universities, medical schools and online repositories.RESULTSWe could not find a single list (source) of all PhD theses. Based on 4 different sources (website of the University of Zagreb and Medical School in Rijeka; school administrator from Split; library catalog from Osijek), we gathered information that from the beginning of 1992 to the end of 2021, there were 2955 PhD theses defended at medical schools in Croatia - 357 in Osijek, 550 in Rijeka, 337 in Split and 1711 in Zagreb. In May 2022, the online Croatian Digital Dissertations Repository contained 631 (22%) of full-text theses in Portable Document Format (PDF). University of Zagreb School of Medicine has its own repository that holds the full text of 834 (49%) of their PhD theses. One of the three PhD programs of the University of Split School of Medicine, namely Translational Research in Biomedicine (TRIBE), published full texts of all PhD theses defended at that program on its website. NSK held 2650 (90%) of the theses in a printed version.CONCLUSIONIt was extremely challenging to access the list and full texts of doctoral theses defended in Croatia. Making PhD theses publicly available would ensure transparency and enable analyses that should improve scientific policy.
目的要对博士学位论文(即博士论文)进行科学计量学研究,研究人员必须能够获得这些论文。我们试图从克罗地亚统计局、萨格勒布国家和大学图书馆 (NSK)、大学、医学院和在线资料库获取相关信息。根据 4 个不同来源(萨格勒布大学和里耶卡医学院网站;斯普利特的学校管理员;奥西耶克的图书馆目录),我们收集到以下信息:从 1992 年初到 2021 年底,克罗地亚医学院共有 2955 篇博士论文答辩,其中奥西耶克 357 篇,里耶卡 550 篇,斯普利特 337 篇,萨格勒布 1711 篇。2022年5月,在线克罗地亚数字论文库收录了631篇(22%)可移植文件格式(PDF)的论文全文。萨格勒布大学医学院拥有自己的论文库,其中包含 834 篇(49%)博士论文全文。斯普利特大学医学院的三个博士项目之一,即生物医学转化研究(TRIBE),在其网站上公布了该项目所有答辩博士论文的全文。NSK拥有2650篇(90%)论文的印刷版。公开博士论文将确保透明度,并有助于进行分析,从而改进科学政策。
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引用次数: 0
Establishment of a Unified Register of Donor Sexual Gametes in the Republic of Kazakhstan. 在哈萨克斯坦共和国建立性配子捐献者统一登记册。
Q3 Medicine Pub Date : 2024-04-08 DOI: 10.5644/ama2006-124.436
Leila Chalova, Vyacheslav Lokshin, Vladimir Kiyan, Botagoz Turdaliyeva, A. Kinzhibayev
OBJECTIVEThe purpose of this narrative review paper was to review the state and development of the field of donor gametes in Kazakhstan, compare its legislative and technical capabilities with other countries and identify key steps towards the establishment of a unified register of donor gametes in the Republic.MATERIALS AND METHODSThe narrative review paper conducted an analysis of scientific publications and legal documents to examine the implementation of Assisted Reproductive Technologies (ART), focusing on Donor Sexual Gametes (DSG), globally. It utilized medical publications from 2019 to 2023, legal acts, and recommendations from global health organizations to analyze eligibility criteria, legal regulations, and the social aspects of ART across different regions.RESULTSIn Kazakhstan, ART is regulated by legislation, with DSG procedures governed by age limits, medical screening, and restrictions on the number of children born from donated gametes. Worldwide, practices vary, but there is growing interest in establishing a unified register of reproductive donor material to enhance transparency and accountability. However, legal gaps and ethical considerations must be addressed.CONCLUSIONThe study identifies gaps in Kazakhstan's legislation compared to Western countries, emphasizing the necessity for enhanced legal rights for donors and recipients, including options for anonymity. Ethical concerns highlight the importance of confidentiality and data security in accessing the donor registry. Overall, implementing such a register promises to enhance transparency, safety, and accountability in reproductive medicine.
本文旨在回顾哈萨克斯坦捐献配子领域的现状和发展,将其立法和技术能力与其他国家进行比较,并确定在哈萨克斯坦共和国建立统一的捐献配子登记册的关键步骤。结果在哈萨克斯坦,辅助生殖技术受法律监管,性配子捐献程序受年龄限制、医疗筛查和捐献配子生育子女数量限制的制约。世界各地的做法各不相同,但人们对建立统一的生殖捐献者材料登记册以提高透明度和问责制的兴趣与日俱增。该研究发现了哈萨克斯坦立法与西方国家相比存在的差距,强调有必要加强捐献者和受捐者的法律权利,包括匿名选择。伦理方面的问题凸显了访问捐赠者登记册时保密和数据安全的重要性。总体而言,实施这样一个登记册有望提高生殖医学的透明度、安全性和问责制。
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引用次数: 0
George Sclavunos (1869-1954): Anatomical Insights and His Contribution into the "Magenstrasse of Waldeyer". 乔治-斯克拉夫诺斯(1869-1954 年):解剖学见解及其对 "瓦尔德耶尔的马根大街 "的贡献。
Q3 Medicine Pub Date : 2024-04-01 DOI: 10.5644/ama2006-124.433
Ioanna Verzoviti, Michail Saintanis, Dimosthenis Chrysikos, Dimitrios Filippou, Dimitrios Schizas, Ioannis K Antonopoulos, Theodore Troupis

The purpose of this article is to present a well-known physician and highlight his contribution into an essential, but neglected anatomical feature. George Sclavunos (1869-1954) was a 20th century Greek physician, whose scientific work was a significant milestone in global medical knowledge. In 1899 he became Professor of Anatomy and Head Director of the Department of Anatomy. In 1906 Sclavunos G. published the first volume of the three volume book "Human Anatomy" (1906-1926), which is characterized by its unparalleled illustrations. For more than a century it was the most important book of medical literature in Greece. In 1926 he became a Full Member of the Academy of Athens and was named Life Partner of the International Anatomical Society. His interests included Anatomy, Physiology, Histology, as well as Osteology and Syndesmology. In his book "Human Anatomy", he described for first time the "Sialine Groove of the Stomach", which was described by Waldeyer-Hartz almost at the same time as the "Magenstrasse", a German word that means "stomach road". It is a ribbon-like path that extends along the lesser curvature of the stomach from the gastric cardia to the antrum and releases the gastric content directly into the small intestine. Its importance is confirmed by its association not only with drug delivery, but also with anti-obesity surgical techniques. The old German term has come back into common medical usage in view of the commonly performed Magenstrasse and Mill procedure, a form of bariatric surgery. CONCLUSION: Sclavunos G. managed to observe an anatomical structure that has remained of great importance until today.

本文旨在介绍一位著名的医生,并强调他对一个重要但被忽视的解剖学特征所做的贡献。乔治-斯克拉夫诺斯(George Sclavunos,1869-1954 年)是 20 世纪的希腊医生,他的科研成果是全球医学知识的重要里程碑。1899 年,他成为解剖学教授和解剖学系主任。1906 年,斯克拉夫诺斯-G.出版了三卷本《人体解剖学》(1906-1926 年)的第一卷,其特点是插图无与伦比。一个多世纪以来,该书一直是希腊最重要的医学著作。1926 年,他成为雅典科学院正式院士,并被任命为国际解剖学会终身合伙人。他的研究领域包括解剖学、生理学、组织学以及骨骼学和综合病理学。他在《人体解剖学》一书中首次描述了 "胃的膳食纤维沟",瓦尔德耶-哈茨几乎在同一时间将其描述为 "Magenstrasse"(德语,意为 "胃路")。它是沿着胃小弯从胃贲门延伸到胃窦的一条带状路径,将胃内容物直接释放到小肠中。其重要性不仅体现在药物输送方面,还体现在抗肥胖外科技术方面。鉴于 Magenstrasse 和 Mill 手术是一种常见的减肥手术,这一古老的德语术语又重新成为医学界的常用术语。结论:Sclavunos G. 成功地观察到了一种解剖结构,这种结构直到今天仍具有重要意义。
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引用次数: 0
Prejudice and Fear as Influences in Relation to a Successful Organ Donation - Experiences of Immigrants Living in Sweden. 偏见和恐惧对成功捐献器官的影响--生活在瑞典的移民的经历。
Q3 Medicine Pub Date : 2024-04-01 DOI: 10.5644/ama2006-124.432
Ferid Krupic, Melissa Krupic, Jelena Kovacevic-Prstojevic, Svemir Custovic, Lutvo Sporisevic, Parvaneh Lindström

Objectives: The purpose of this study was to determine whether fear and prejudice in relation to organ donation and the transplantation of organs may influence the decision to become an organ donor.

Materials and methods: Data were collected through four group interviews using open-ended questions and qualitative content analysis. Forty participants, 16 males and 24 females from seven countries, participated in the focus group interviews.

Results: The analysis resulted in three main categories, and nine subcategories. Fears and prejudice caused by tradition and customs, approval of organ donation by family members, perception of the body as a gift from parents, the influence of religious leaders, knowledge about the religious understanding of organ donation, influence of social ambience on respondents, knowledge of the donation process in the healthcare system, including knowing about life after eventual organ donation, were some of predictors in the decision to agree to organ donation.

Conclusion: More education on the factors that influence organ donation, more information in schools, health institutions and through the media, as well as more research with the aim of "dispelling" fears and prejudice about organ donation would significantly improve the current situation and result in a larger number of potential organ donors.

研究目的本研究旨在确定与器官捐献和器官移植有关的恐惧和偏见是否会影响器官捐献者的决定:采用开放式问题和定性内容分析法,通过四次小组访谈收集数据。来自 7 个国家的 40 名参与者(16 名男性和 24 名女性)参加了焦点小组访谈:分析得出三个主要类别和九个子类别。传统和习俗造成的恐惧和偏见、家庭成员对器官捐献的认可、将身体视为父母的礼物、宗教领袖的影响、对器官捐献的宗教理解的了解、社会氛围对受访者的影响、对医疗系统捐献程序的了解,包括对最终器官捐献后生活的了解,都是影响受访者是否同意器官捐献的一些预测因素:结论:就影响器官捐献的因素开展更多教育,在学校、医疗机构和通过媒体提供更多信息,以及开展更多旨在 "消除 "对器官捐献的恐惧和偏见的研究,将极大地改善目前的状况,并使潜在的器官捐献者人数增加。
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引用次数: 0
An X across the Chest: A Rare Case of a Criss-crossed Sternalis Muscle. 胸前的 "X":胸骨肌十字交叉的罕见病例
Q3 Medicine Pub Date : 2024-04-01 DOI: 10.5644/ama2006-124.420
Swapna Ramakrishnan, Ishan Mahajan, T Nikitha, Robert Kevin Fernandez, Minnie Pillay

Objective: The present case study aims at drawing attention to a very rare presentation of the sternalis muscle noticed during routine dissection, and is intended to highlight the clinical significance and usefulness of this unique muscle in reconstructive surgeries, especially of the breast.

Case report: Though many morphological variants of the muscle have been reported, we came across a unique bilateral sternalis muscle during routine dissection for undergraduate medical teaching, in an 80-year-old male cadaver. The muscle originates on both sides from the external oblique aponeurosis from the fleshy belly, and after becom-ing tendinous, converges in the midline to form a common tendon at the level of the sternal angle, and then splits again into two tendons which become continuous with the ipsilateral sternocleidomastoid.

Conclusion: Notwithstanding the fact that the presence of a sternalis can be misdiagnosed as a wide range of anterior chest wall lesions and tumors, especially with misdiag-nosis of breast masses in routine mammograms, it has great use as a muscular flap for reconstructive surgeries of the anterior chest wall, head, neck and breast.

目的:本病例研究旨在提请人们注意在常规解剖过程中发现的胸骨肌的一种非常罕见的表现形式,并旨在强调这种独特肌肉在整形手术(尤其是乳房整形手术)中的临床意义和作用:尽管胸骨肌的形态变异已被报道过很多次,但我们在一具 80 岁男性尸体上例行解剖进行医学本科教学时,发现了一块独特的双侧胸骨肌。该肌肉起源于两侧肉腹的外斜肌腱膜,变成肌腱后在中线汇合,在胸骨角水平形成一条共同的肌腱,然后再次分裂成两条肌腱,与同侧胸锁乳突肌连续:尽管胸锁乳突肌可能被误诊为多种前胸壁病变和肿瘤,尤其是在常规乳房 X 光检查中被误诊为乳房肿块,但它作为一种肌肉瓣,在前胸壁、头颈部和乳房的重建手术中仍有很大的用途。
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引用次数: 0
Response to Letter to the Editor by Josef Finsterer, MD, PhD: "The More Intensive the Diagnostic Workup, the More Likely It Is That the Cause of Coccygodynia Can Be Clarified". 对医学博士 Josef Finsterer 致编辑的信的回复:"诊断工作越深入,越有可能明确尾骨神经痛的病因"。
Q3 Medicine Pub Date : 2024-04-01 DOI: 10.5644/ama2006-124.431
Spyridon P Galanakos, Nikolaos D Karakousis, George Bablekos, Sophia Fontara
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引用次数: 0
Autonomic Dysfunction in Amyotrophic Lateral Sclerosis - A Case-Control Study. 肌萎缩侧索硬化症的自主神经功能障碍--一项病例对照研究。
Q3 Medicine Pub Date : 2024-04-01 DOI: 10.5644/ama2006-124.440
Mehedi Hasan, Sk Mahbub Alam, Hasan Zahidur Rahman, Md Abdullah Saeed Khan, Muhammad Rezeul Huq

Introduction: This study aimed to explore autonomic nervous system involvement in amyotrophic lateral sclerosis (ALS) patients by evaluating sympathetic skin response (SSR).

Materials and methods: The study included 35 sporadic (ALS) patients (cases), and 35 healthy age and sex-matched participants (controls) aged <60 years. SSR was recorded in the electrophysiology lab of the Neurology Department of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Patients with diseases associated with peripheral or autonomic neuropathy were excluded. Prolonged latency (delayed SSR) or an absent response was considered abnormal SSR.

Results: SSR was found to be abnormal in 17 (48.6 %) ALS cases, with an absent response in the upper limbs of six cases (17.1%). Abnormal SSR was more prevalent in the lower limbs, with 33 (94.3%) and 20 (57.1%) cases having a delayed or absent response, respectively. In comparison, SSR was normal in all control participants (P-value <0.05). Abnormal SSR was significantly more common in the lower limbs of ALS cases with bulbar palsy than those without bulbar palsy (P-value=0.04). There was no association of SSR with disease severity and duration.

Conclusion: ALS is significantly associated with abnormal SSR, indicating autonomic nervous system involvement. There could also be an association between bulbar palsy and abnormal SSR among ALS patients. Further studies should be carried out to determine the association of abnormal SSR with disease severity, duration, and type.

导言:本研究旨在通过评估交感神经皮肤反应(SSR),探讨肌萎缩性脊髓侧索硬化症(ALS)患者的自主神经系统受累情况:研究对象包括 35 名散发性(ALS)患者(病例)和 35 名年龄和性别匹配的健康参与者(对照组):发现 17 例 ALS 患者(48.6%)的 SSR 异常,其中 6 例患者(17.1%)的上肢无反应。下肢的 SSR 异常更为普遍,分别有 33 例(94.3%)和 20 例(57.1%)患者出现反应延迟或无反应。相比之下,所有对照组参与者的 SSR 均正常(P 值 结论:ALS 与 SSR 异常显著相关:肌萎缩性脊髓侧索硬化症与 SSR 异常明显相关,表明自律神经系统受累。ALS 患者的球麻痹与 SSR 异常之间也可能存在关联。应进一步研究确定 SSR 异常与疾病严重程度、病程和类型的关系。
{"title":"Autonomic Dysfunction in Amyotrophic Lateral Sclerosis - A Case-Control Study.","authors":"Mehedi Hasan, Sk Mahbub Alam, Hasan Zahidur Rahman, Md Abdullah Saeed Khan, Muhammad Rezeul Huq","doi":"10.5644/ama2006-124.440","DOIUrl":"10.5644/ama2006-124.440","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to explore autonomic nervous system involvement in amyotrophic lateral sclerosis (ALS) patients by evaluating sympathetic skin response (SSR).</p><p><strong>Materials and methods: </strong>The study included 35 sporadic (ALS) patients (cases), and 35 healthy age and sex-matched participants (controls) aged <60 years. SSR was recorded in the electrophysiology lab of the Neurology Department of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Patients with diseases associated with peripheral or autonomic neuropathy were excluded. Prolonged latency (delayed SSR) or an absent response was considered abnormal SSR.</p><p><strong>Results: </strong>SSR was found to be abnormal in 17 (48.6 %) ALS cases, with an absent response in the upper limbs of six cases (17.1%). Abnormal SSR was more prevalent in the lower limbs, with 33 (94.3%) and 20 (57.1%) cases having a delayed or absent response, respectively. In comparison, SSR was normal in all control participants (P-value <0.05). Abnormal SSR was significantly more common in the lower limbs of ALS cases with bulbar palsy than those without bulbar palsy (P-value=0.04). There was no association of SSR with disease severity and duration.</p><p><strong>Conclusion: </strong>ALS is significantly associated with abnormal SSR, indicating autonomic nervous system involvement. There could also be an association between bulbar palsy and abnormal SSR among ALS patients. Further studies should be carried out to determine the association of abnormal SSR with disease severity, duration, and type.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"53 1","pages":"24-34"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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