Pub Date : 2023-10-31DOI: 10.2174/18743722-v17-230823-2023-1
Ananda Ayu Paramita, Deryne Anggia Paramita
Introduction: Diaper dermatitis is a skin disease that commonly occurs in babies, especially whose diapers are always wet and rarely changed. It is a condition in which inflammation occurs in diaper areas, such as the perianal region, buttocks, genitals, inner thighs, and waistline. This study aims to analyze the correlation between duration of diarrhea and severity of diaper dermatitis in children aged 0 – 24 months. Methods: The design of this study was analytic observational using a cross sectional study. Data was collected through an interview with parents using structured questionnaire. Spearman correlation was used to analyze the correlation between duration of diarrhea and severity of diaper dermatitis. This study included 58 babies with diarrhea and diaper dermatitis. This study included 58 infants with a history of diarrhea. Results: The results showed that 37 babies (63.8%) had very mild diaper dermatitis, 18 babies (31.0%) had mild diaper dermatitis, and 3 babies (5.2%) had mild to moderate diaper dermatitis. There was a correlation between duration of diarrhea and severity of diaper dermatitis in children aged 0 – 24 months (p=0.0001). Conclusion: It was concluded that the longer the duration of diarrhea, more severe is the diaper dermatitis.
{"title":"Correlation between Duration of Diarrhea and Severity of Diaper Dermatitis in Children Aged 0 – 24 Months","authors":"Ananda Ayu Paramita, Deryne Anggia Paramita","doi":"10.2174/18743722-v17-230823-2023-1","DOIUrl":"https://doi.org/10.2174/18743722-v17-230823-2023-1","url":null,"abstract":"Introduction: Diaper dermatitis is a skin disease that commonly occurs in babies, especially whose diapers are always wet and rarely changed. It is a condition in which inflammation occurs in diaper areas, such as the perianal region, buttocks, genitals, inner thighs, and waistline. This study aims to analyze the correlation between duration of diarrhea and severity of diaper dermatitis in children aged 0 – 24 months. Methods: The design of this study was analytic observational using a cross sectional study. Data was collected through an interview with parents using structured questionnaire. Spearman correlation was used to analyze the correlation between duration of diarrhea and severity of diaper dermatitis. This study included 58 babies with diarrhea and diaper dermatitis. This study included 58 infants with a history of diarrhea. Results: The results showed that 37 babies (63.8%) had very mild diaper dermatitis, 18 babies (31.0%) had mild diaper dermatitis, and 3 babies (5.2%) had mild to moderate diaper dermatitis. There was a correlation between duration of diarrhea and severity of diaper dermatitis in children aged 0 – 24 months (p=0.0001). Conclusion: It was concluded that the longer the duration of diarrhea, more severe is the diaper dermatitis.","PeriodicalId":39105,"journal":{"name":"Open Dermatology Journal","volume":"157 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135977335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-07DOI: 10.2174/18743722-v17-230727-2023-3
Margo Bush, Craig G. Burkhart
UV radiation is a well-researched cause of malignant melanoma, however more than the sun may be to blame for today’s increased rates of the deadliest form of skin cancer. Pesticides and industrial pollutants are an overlooked yet major causative factor that is still being exposed to ecosystems. This article identifies documented cases of the chemical causes of melanoma stemming from a study that articulates these dangers in the year 2000. It concludes with a message that a clear risk between chemicals and melanoma exists and calls to action the need for mediation.
{"title":"Pesticides and Pollutants associated with Rising Cases of Melanoma","authors":"Margo Bush, Craig G. Burkhart","doi":"10.2174/18743722-v17-230727-2023-3","DOIUrl":"https://doi.org/10.2174/18743722-v17-230727-2023-3","url":null,"abstract":"UV radiation is a well-researched cause of malignant melanoma, however more than the sun may be to blame for today’s increased rates of the deadliest form of skin cancer. Pesticides and industrial pollutants are an overlooked yet major causative factor that is still being exposed to ecosystems. This article identifies documented cases of the chemical causes of melanoma stemming from a study that articulates these dangers in the year 2000. It concludes with a message that a clear risk between chemicals and melanoma exists and calls to action the need for mediation.","PeriodicalId":39105,"journal":{"name":"Open Dermatology Journal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135999025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-06DOI: 10.2174/18743722-v17-e230505-2022-27
Sanjay Satya-Akunuri Koka, Craig G. Burkhart
Artificial Intelligence (AI) has the potential to transform medical delivery by improving patient care and provider experience. Implementing AI into health care is limited in scale, but the projected demand for health care, combined with the shortfall in practitioners, will necessitate the inclusion of AI-based technology in clinical medicine to maintain quality care. AI applications may range from enhancing clinical diagnosis to managing population health through big data. In today’s world, AI scaling in health care is at phase one: AI is either utilized for administrative tasks or imaging. Although the implementation of AI will be difficult, the need for the adoption of AI in the coming years will lead the technology to be a vital aspect of diagnosis and care in and out of the hospital. Dermatology is one medical specialty in which AI applications are in use and in which medical care will evolve. Dermatology has progressed over the years in correspondence with advancements in AI-based technologies such as imaging and medical speech recognition. To better equip future dermatologists, exposure to AI through medical education is necessary for dermatologists to utilize AI effectively. There are hurdles to overcome, but AI is necessary, and it will change health care through effective time management and clinical decision-making. This review, created in collaboration with Precision Pundits, was developed to achieve an understanding of AI in the present-day medical landscape; this project explored the impact AI technology has on dermatology and medical care.
{"title":"Artificial Intelligence in Dermatology: Current Uses, Shortfalls, and Potential Opportunities for Further Implementation in Diagnostics and Care","authors":"Sanjay Satya-Akunuri Koka, Craig G. Burkhart","doi":"10.2174/18743722-v17-e230505-2022-27","DOIUrl":"https://doi.org/10.2174/18743722-v17-e230505-2022-27","url":null,"abstract":"Artificial Intelligence (AI) has the potential to transform medical delivery by improving patient care and provider experience. Implementing AI into health care is limited in scale, but the projected demand for health care, combined with the shortfall in practitioners, will necessitate the inclusion of AI-based technology in clinical medicine to maintain quality care. AI applications may range from enhancing clinical diagnosis to managing population health through big data. In today’s world, AI scaling in health care is at phase one: AI is either utilized for administrative tasks or imaging. Although the implementation of AI will be difficult, the need for the adoption of AI in the coming years will lead the technology to be a vital aspect of diagnosis and care in and out of the hospital. Dermatology is one medical specialty in which AI applications are in use and in which medical care will evolve. Dermatology has progressed over the years in correspondence with advancements in AI-based technologies such as imaging and medical speech recognition. To better equip future dermatologists, exposure to AI through medical education is necessary for dermatologists to utilize AI effectively. There are hurdles to overcome, but AI is necessary, and it will change health care through effective time management and clinical decision-making. This review, created in collaboration with Precision Pundits, was developed to achieve an understanding of AI in the present-day medical landscape; this project explored the impact AI technology has on dermatology and medical care.","PeriodicalId":39105,"journal":{"name":"Open Dermatology Journal","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135602159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-06DOI: 10.2174/18743722-v17-e230530-2022-26
Craig G. Burkhart
The cost of health care is escalating at alarming rates in the United States. There are real issues regarding affordability and access under the system today. US health care is unsustainable in its present course, and changes are imminent. Insurance companies are forced to consider various methods to rein in these costs. It seems evident that some of these innovative measures might restrict access to non-life-threatening diseases. With these concerns, I wish to sound the alarm to my specialty of dermatology as we, and specifically the prescriptions we write, might just be pricing ourselves out of future affordable health insurance plans. I pray I am merely following the famous finger-wagger Thomas Malthus, who said that the world population would grow so large that we won't be able to feed ourselves anymore.
{"title":"Sequelae from Financial Toxicity of Biologics and JAK Inhibitors in the United States: Health Insurance Companies May Eliminate Dermatology from the List of Specialists in their Physician Panels","authors":"Craig G. Burkhart","doi":"10.2174/18743722-v17-e230530-2022-26","DOIUrl":"https://doi.org/10.2174/18743722-v17-e230530-2022-26","url":null,"abstract":"The cost of health care is escalating at alarming rates in the United States. There are real issues regarding affordability and access under the system today. US health care is unsustainable in its present course, and changes are imminent. Insurance companies are forced to consider various methods to rein in these costs. It seems evident that some of these innovative measures might restrict access to non-life-threatening diseases. With these concerns, I wish to sound the alarm to my specialty of dermatology as we, and specifically the prescriptions we write, might just be pricing ourselves out of future affordable health insurance plans. I pray I am merely following the famous finger-wagger Thomas Malthus, who said that the world population would grow so large that we won't be able to feed ourselves anymore.","PeriodicalId":39105,"journal":{"name":"Open Dermatology Journal","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135602160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The disease, regardless of its nosology, involves the child in a different deficient social situation. It creates two restraint conditions for the sick child: restriction of motions or restriction of cognitive activity. The interview with paediatric patients with psoriasis showed that 65% of them were stigmatised in the form of bullying, insults, and humiliation. Concerns about constant skin peeling and odour affect leisurely activity in 15-30% of children with psoriasis. This stigmatisation can lead to changes in behaviour, depression, anxiety, and apprehension. In adolescents with psoriasis, apprehension is increasingly mediated by the features of the attitude toward oneself and is of a contradictory, conflicting nature during this period. A persistently high anxiety level in childhood leads to a wide range of problems, the consequence of which can be impaired development of individual structures and functions and, ultimately, impaired formation of the personality structure as a whole. Objective: The article aims to determine the psychological characteristics of children with psoriasis aged 8–12 years. Materials and Methods: Characterological and behavioural traits were studied in 54 children with psoriasis aged 8–12 years using R. Cattell's multi-factor test (junior version). Characteristics of personality traits in terms of factor scoring were carried out by grouping them by communicative and emotional-volitional components. Results: It was determined that the majority of 8–12-year-old children with psoriasis have an average scoring of the basic factors by both communicative and emotional-volitional components. In addition, half of the children were found to have a low score of factor A “outgoingness” and factor Q3 “self-control”, while a third of the children had a low score of factors C “self-confidence” and F “risk proneness”. High scores were revealed for factors D “excitability” and O “apprehension”. The correlation analysis revealed a significant number of correlations between the bipolar factor indicators. Conclusion: The analysis using R. Cattell's Children's Personality Questionnaire identified the characteristic personality traits of children aged 8 to 12 years with psoriasis. The children are fairly adapted to society, showing activity and moderate sensitivity, and the ability to observe moral standards of behaviour. However, the disease's impact on the formation of psychological characteristics can already be traced: 50% of children with psoriasis have hyperexcitability and lack of self-control; one-third of patients have depressed moods, increased apprehension, seclusiveness, resentfulness, mistrustfulness and nervous tension, increased responsibility for their own actions and deeds, and lack of self-confidence; every fifth patient has a poor concentration of attention, fatigue and a simplified approach to problem-solving. The determined significant number of correlational pleiads between the bipolar factor scores in
{"title":"Psychological Characteristics of Children with Psoriasis","authors":"Elvina Murzina, Oleksandr Litus, Liudmyla Piankivska, Yulianna Rokhletsova, Kateryna Bardova, Svitlana Vozianova","doi":"10.2174/18743722-v16-e221227-2022-14","DOIUrl":"https://doi.org/10.2174/18743722-v16-e221227-2022-14","url":null,"abstract":"Background: The disease, regardless of its nosology, involves the child in a different deficient social situation. It creates two restraint conditions for the sick child: restriction of motions or restriction of cognitive activity. The interview with paediatric patients with psoriasis showed that 65% of them were stigmatised in the form of bullying, insults, and humiliation. Concerns about constant skin peeling and odour affect leisurely activity in 15-30% of children with psoriasis. This stigmatisation can lead to changes in behaviour, depression, anxiety, and apprehension. In adolescents with psoriasis, apprehension is increasingly mediated by the features of the attitude toward oneself and is of a contradictory, conflicting nature during this period. A persistently high anxiety level in childhood leads to a wide range of problems, the consequence of which can be impaired development of individual structures and functions and, ultimately, impaired formation of the personality structure as a whole. Objective: The article aims to determine the psychological characteristics of children with psoriasis aged 8–12 years. Materials and Methods: Characterological and behavioural traits were studied in 54 children with psoriasis aged 8–12 years using R. Cattell's multi-factor test (junior version). Characteristics of personality traits in terms of factor scoring were carried out by grouping them by communicative and emotional-volitional components. Results: It was determined that the majority of 8–12-year-old children with psoriasis have an average scoring of the basic factors by both communicative and emotional-volitional components. In addition, half of the children were found to have a low score of factor A “outgoingness” and factor Q3 “self-control”, while a third of the children had a low score of factors C “self-confidence” and F “risk proneness”. High scores were revealed for factors D “excitability” and O “apprehension”. The correlation analysis revealed a significant number of correlations between the bipolar factor indicators. Conclusion: The analysis using R. Cattell's Children's Personality Questionnaire identified the characteristic personality traits of children aged 8 to 12 years with psoriasis. The children are fairly adapted to society, showing activity and moderate sensitivity, and the ability to observe moral standards of behaviour. However, the disease's impact on the formation of psychological characteristics can already be traced: 50% of children with psoriasis have hyperexcitability and lack of self-control; one-third of patients have depressed moods, increased apprehension, seclusiveness, resentfulness, mistrustfulness and nervous tension, increased responsibility for their own actions and deeds, and lack of self-confidence; every fifth patient has a poor concentration of attention, fatigue and a simplified approach to problem-solving. The determined significant number of correlational pleiads between the bipolar factor scores in ","PeriodicalId":39105,"journal":{"name":"Open Dermatology Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136136383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anterior cervical hypertrichosis (ACH) may be only an isolated aesthetic finding, but it may also be associated with other underlying conditions, including neurological and ocular disorders. In order to recognize this uncommon entity, it is imperative to provide detailed physical examination and clinical history to exclude the possible associated abnormalities in patients with ACH. In those cases that ACH represents only a cosmetic problem for the patient, laser hair removal is recommended. We hereby presented 2 cases of ACH in two young girls and discussed about all the differential diagnoses and how to rule out associated anomalies. The most useful workout to rule out associated underlying conditions are described, and cosmetic treatment with laser hair removal devices is also commented.
{"title":"Clinical Cases of Anterior Cervical Hypertrichosis","authors":"M. Cutrone, E. Valerio, R. Grimalt","doi":"10.17140/drmtoj-7-148","DOIUrl":"https://doi.org/10.17140/drmtoj-7-148","url":null,"abstract":"Anterior cervical hypertrichosis (ACH) may be only an isolated aesthetic finding, but it may also be associated with other underlying conditions, including neurological and ocular disorders. In order to recognize this uncommon entity, it is imperative to provide detailed physical examination and clinical history to exclude the possible associated abnormalities in patients with ACH. In those cases that ACH represents only a cosmetic problem for the patient, laser hair removal is recommended. We hereby presented 2 cases of ACH in two young girls and discussed about all the differential diagnoses and how to rule out associated anomalies. The most useful workout to rule out associated underlying conditions are described, and cosmetic treatment with laser hair removal devices is also commented.","PeriodicalId":39105,"journal":{"name":"Open Dermatology Journal","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88688270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Dicko, Ilias Sow, K. Tall, Yannick M. Nkesu, B. Guindo, Gassama Mamadou, Y. Karabinta, O. Faye
This 33-year-old lady was hospitalised for systemic lupus and received corticosteroid therapy; upper limb edoema developed as a result. The interview revealed a theory of trauma related to a fall in the bathroom. During the examination, it was discovered that the patient’s overall health was quite poor and that her left upper limb was edematous, unpleasant to the touch, and covered in an erythematous plaque with blisters and a necrosis area. After 72-hours, ciprofloxacin, gentamycin, and amoxicillin antibiotic treatment had no noticeable effects. A bacteriological examination of the ulcer indicated the presence of Providencia stuartii, which is susceptible to cefotaxime but resistant to ciprofloxacin and amoxicillin. The biological evaluation revealed hyperleukocytosis (12,800 white blood cells/L), thrombocytopenia (103,000/L), and anaemia (9.1 g/dL). Following the administration of cefotaxime together with surgical debridement, apyrexia set in within 24-hours, and full recovery occurred three-weeks later. The search for atypical germs and the performance of an antibiogram must be mandated in front of an acute necrotizing dermohypodermatitis (AND) due to the odd location, the circumstances of the occurrence, and the clinical component.
{"title":"Acute Necrotizing Dermohypodermatitis Due to an Unusual Germ: Providencia Stuartii","authors":"A. Dicko, Ilias Sow, K. Tall, Yannick M. Nkesu, B. Guindo, Gassama Mamadou, Y. Karabinta, O. Faye","doi":"10.17140/drmtoj-7-151","DOIUrl":"https://doi.org/10.17140/drmtoj-7-151","url":null,"abstract":"This 33-year-old lady was hospitalised for systemic lupus and received corticosteroid therapy; upper limb edoema developed as a result. The interview revealed a theory of trauma related to a fall in the bathroom. During the examination, it was discovered that the patient’s overall health was quite poor and that her left upper limb was edematous, unpleasant to the touch, and covered in an erythematous plaque with blisters and a necrosis area. After 72-hours, ciprofloxacin, gentamycin, and amoxicillin antibiotic treatment had no noticeable effects. A bacteriological examination of the ulcer indicated the presence of Providencia stuartii, which is susceptible to cefotaxime but resistant to ciprofloxacin and amoxicillin. The biological evaluation revealed hyperleukocytosis (12,800 white blood cells/L), thrombocytopenia (103,000/L), and anaemia (9.1 g/dL). Following the administration of cefotaxime together with surgical debridement, apyrexia set in within 24-hours, and full recovery occurred three-weeks later. The search for atypical germs and the performance of an antibiogram must be mandated in front of an acute necrotizing dermohypodermatitis (AND) due to the odd location, the circumstances of the occurrence, and the clinical component.","PeriodicalId":39105,"journal":{"name":"Open Dermatology Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81324353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. A. Al Hawsawi, Bashair Al Zahrani, Hawazin D. Jan, Duaa Babkoor, Razan Alluhaibi, E. Alharbi, Waseem K. Alhawsawi, A. Siddique, Abeer Ashary
Background Omalizumab is a recombinant humanized monoclonal antibody against immunoglobulin E (IgE). It is approved for the treatment of chronic spontaneous urticaria (CSU) in patients ≥12-years of age. Objective We carried out a retrospective cross-sectional study in 25 patients with CSU to evaluate the characteristics of response of CSU to omalizumab treatment. Method A retrospective cross-sectional study of a convenient sample of all patients diagnosed as CSU who have been using omalizumab treatment during the study period from January 2018 to January 2020 in the Dermatology Department in King Abdulaziz Hospital, Makkah, Saudi Arabia. Results A total of 25 patients have participated in this study. The average age of patients was 40-years. Majority of the patients were female (52.0%, n=15). The average duration of illness was 1.32-years. Majority of the patients (72.0%, n=18) received two courses of omalizumab treatment. Minority of patients (28.0%, n=7) received one course of omalizumab treatment which was statistically significant (p value<0.01). Number of patients who have been using oral 2nd generation antihistamine during the first course and 2nd course was (72%, n=18 out of 25) and (50%, n=9 out of 18) respectively. Number of flare-ups during 2nd course (1.72 flares up per patient, n=31 flare-ups among 18 patients) was less than the number of flares-up during 1st course (2.96 flares-up per patient, n=74 flare-ups among 25 patients) which was statistically significant (p value<0.01). Number of patients who showed no flare-ups during the 1st and 2nd course of omalizumab treatment was (16%, n=4 out of 25 patients) and (27.77%, n=5 out of 18 patients) respectively. The average intensity of flares-up during 2nd course of omalizumab treatment was less than the average intensity of flares-up during first course of omalizumab treatment as the following; during 2nd course ( 33.33%, n=6 out of 18 patients), (27.77% n=5 out of 18 patients), (11.11%, n=2 out of 18 patients) mild, moderate and severe flares-up respectively and the severity during 1st course was (40.0%, n=10 out of 25 patients), (28.0%, n=7 out of 25 patients), (16.0%, n=4 out of 25 patients) mild, moderate and severe flares-up respectively. Conclusion According to expert’s guidelines, CSU of ≥3-years would be treated with omalizumab for a minimum of one-year. In our study, in spite of the short duration of CSU (average duration was 1.32-years), the majority of patients (72.0%, n=18) received omalizumab for 1-year (two courses of omalizumab treatment) suggesting that the majority of patients with CSU in general requires omalizumab ≥1-year. Our study also showed 5 patients who were free of any flare-up and they were not using 2nd generation antihistamines suggesting that omalizumab alone as monotherapy can be effective
{"title":"Omalizumab in Chronic Spontaneous Urticaria: Assessment of Response in Twenty-Five Patients","authors":"K. A. Al Hawsawi, Bashair Al Zahrani, Hawazin D. Jan, Duaa Babkoor, Razan Alluhaibi, E. Alharbi, Waseem K. Alhawsawi, A. Siddique, Abeer Ashary","doi":"10.17140/drmtoj-7-147","DOIUrl":"https://doi.org/10.17140/drmtoj-7-147","url":null,"abstract":"Background Omalizumab is a recombinant humanized monoclonal antibody against immunoglobulin E (IgE). It is approved for the treatment of chronic spontaneous urticaria (CSU) in patients ≥12-years of age. Objective We carried out a retrospective cross-sectional study in 25 patients with CSU to evaluate the characteristics of response of CSU to omalizumab treatment. Method A retrospective cross-sectional study of a convenient sample of all patients diagnosed as CSU who have been using omalizumab treatment during the study period from January 2018 to January 2020 in the Dermatology Department in King Abdulaziz Hospital, Makkah, Saudi Arabia. Results A total of 25 patients have participated in this study. The average age of patients was 40-years. Majority of the patients were female (52.0%, n=15). The average duration of illness was 1.32-years. Majority of the patients (72.0%, n=18) received two courses of omalizumab treatment. Minority of patients (28.0%, n=7) received one course of omalizumab treatment which was statistically significant (p value<0.01). Number of patients who have been using oral 2nd generation antihistamine during the first course and 2nd course was (72%, n=18 out of 25) and (50%, n=9 out of 18) respectively. Number of flare-ups during 2nd course (1.72 flares up per patient, n=31 flare-ups among 18 patients) was less than the number of flares-up during 1st course (2.96 flares-up per patient, n=74 flare-ups among 25 patients) which was statistically significant (p value<0.01). Number of patients who showed no flare-ups during the 1st and 2nd course of omalizumab treatment was (16%, n=4 out of 25 patients) and (27.77%, n=5 out of 18 patients) respectively. The average intensity of flares-up during 2nd course of omalizumab treatment was less than the average intensity of flares-up during first course of omalizumab treatment as the following; during 2nd course ( 33.33%, n=6 out of 18 patients), (27.77% n=5 out of 18 patients), (11.11%, n=2 out of 18 patients) mild, moderate and severe flares-up respectively and the severity during 1st course was (40.0%, n=10 out of 25 patients), (28.0%, n=7 out of 25 patients), (16.0%, n=4 out of 25 patients) mild, moderate and severe flares-up respectively. Conclusion According to expert’s guidelines, CSU of ≥3-years would be treated with omalizumab for a minimum of one-year. In our study, in spite of the short duration of CSU (average duration was 1.32-years), the majority of patients (72.0%, n=18) received omalizumab for 1-year (two courses of omalizumab treatment) suggesting that the majority of patients with CSU in general requires omalizumab ≥1-year. Our study also showed 5 patients who were free of any flare-up and they were not using 2nd generation antihistamines suggesting that omalizumab alone as monotherapy can be effective","PeriodicalId":39105,"journal":{"name":"Open Dermatology Journal","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86115600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Chittoria, Marenika Manisekaran, J. A. Chakiath
Aim The aim of the study is the application of delayed Keystone flap in the management of post-electrical burn squamous cell carcinoma. Materials and Methods In our study, a delayed staged type 3 keystone flap was performed as first stage procedure. Result In our study, by doing a delayed staged type 3 keystone flap we were able to successfully reduce the size of the defect by 40% without necrosis of the inset flap. Conclusion Delaying of the flap is a useful method when the vascularity of the keystone flap is doubtful especially in the case of post electrical burn.
{"title":"Application of Delayed Keystone Flap in Management of Post-Electrical Burn Squamous Cell Carcinoma","authors":"R. Chittoria, Marenika Manisekaran, J. A. Chakiath","doi":"10.17140/drmtoj-7-149","DOIUrl":"https://doi.org/10.17140/drmtoj-7-149","url":null,"abstract":"Aim The aim of the study is the application of delayed Keystone flap in the management of post-electrical burn squamous cell carcinoma. Materials and Methods In our study, a delayed staged type 3 keystone flap was performed as first stage procedure. Result In our study, by doing a delayed staged type 3 keystone flap we were able to successfully reduce the size of the defect by 40% without necrosis of the inset flap. Conclusion Delaying of the flap is a useful method when the vascularity of the keystone flap is doubtful especially in the case of post electrical burn.","PeriodicalId":39105,"journal":{"name":"Open Dermatology Journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77327162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Dicko, Adam Konandji, Yannick M. Nkesu, K. Tall, B. Guindo, Gassama Mamadou, Y. Karabinta, A. Traor, M. Sissoko, O. Faye
Background This was a descriptive and prospective study that focused on 73 cases of delirium of skin infestation (DSI) from January 1st to December 31st, 2018, in the dermatology department of the Bamako Dermatology Hospital (HDB). Aim The aim of this work was to describe the epidemiological and clinical profile of delusions of infestation (Ekbom syndrome), to deepen our knowledge of the disease in order to improve its overall management. Methods We carried out a descriptive cross-sectional study of cases of identity document (ID) seen in dermatological consultation in the HDB dermatology department between January 1st and December 31st, 2018. Now, this department is the largest dermatological reference center in the country. In our study, we have included any patient with delirium of parasitic infestation (defined as an unshakeable conviction that small vermin, insects, lice, maggots, proliferate in the skin and sometimes in the body without biological proof). Results Delirium of skin infestation constituted 0.3% of consultations in the service. The average age was 52-years with extremes ranging from 12 to 85-years. They were 45 female (62%) and 28 male (45%). The age group (25-64) was the most represented. Out-ofschool patients represented 65% of the sample. Among them, 6 cases (8%) were known in psychiatry. The agents incriminated by the patients were mainly ants, earthworms and cicadas. The specimen sign was found in 89% of cases. Insomnia was the most frequent associated sign, at 75%. The types of lesion complications observed in our patients were mainly lichenification, ulceration and excoriation. Seventy-two percent (72%) of patients have refused referral to the mental health service. The profile of Ekbom syndrome was the one of the adult women, described in the previous work. Conclusion Delirium of skin infestation is generally considered as rare disease, increasingly observed during our dermatology consultations. Its frequency is probably underestimated.
{"title":"elirium of Skin Infestation: Epidemiological and Clinical Profile of 73 Patients","authors":"A. Dicko, Adam Konandji, Yannick M. Nkesu, K. Tall, B. Guindo, Gassama Mamadou, Y. Karabinta, A. Traor, M. Sissoko, O. Faye","doi":"10.17140/drmtoj-7-150","DOIUrl":"https://doi.org/10.17140/drmtoj-7-150","url":null,"abstract":"Background This was a descriptive and prospective study that focused on 73 cases of delirium of skin infestation (DSI) from January 1st to December 31st, 2018, in the dermatology department of the Bamako Dermatology Hospital (HDB). Aim The aim of this work was to describe the epidemiological and clinical profile of delusions of infestation (Ekbom syndrome), to deepen our knowledge of the disease in order to improve its overall management. Methods We carried out a descriptive cross-sectional study of cases of identity document (ID) seen in dermatological consultation in the HDB dermatology department between January 1st and December 31st, 2018. Now, this department is the largest dermatological reference center in the country. In our study, we have included any patient with delirium of parasitic infestation (defined as an unshakeable conviction that small vermin, insects, lice, maggots, proliferate in the skin and sometimes in the body without biological proof). Results Delirium of skin infestation constituted 0.3% of consultations in the service. The average age was 52-years with extremes ranging from 12 to 85-years. They were 45 female (62%) and 28 male (45%). The age group (25-64) was the most represented. Out-ofschool patients represented 65% of the sample. Among them, 6 cases (8%) were known in psychiatry. The agents incriminated by the patients were mainly ants, earthworms and cicadas. The specimen sign was found in 89% of cases. Insomnia was the most frequent associated sign, at 75%. The types of lesion complications observed in our patients were mainly lichenification, ulceration and excoriation. Seventy-two percent (72%) of patients have refused referral to the mental health service. The profile of Ekbom syndrome was the one of the adult women, described in the previous work. Conclusion Delirium of skin infestation is generally considered as rare disease, increasingly observed during our dermatology consultations. Its frequency is probably underestimated.","PeriodicalId":39105,"journal":{"name":"Open Dermatology Journal","volume":"344 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72435910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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