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Receipt of HPV Vaccine Associated with Increased Prevalence of High-Risk HPV Infections HPV疫苗接种与高危HPV感染增加相关
Pub Date : 2021-09-17 DOI: 10.56098/ijvtpr.v2i1.28
Gayle DeLong
Identifying possible negative side effects of vaccines helps to determine whether benefits outweigh the costs of a medical intervention that claims to prevent a disease. Such a cost-benefit analysis is essential both for vaccine policy as well as informed consent. This study seeks to determine whether the use of the human papillomavirus (HPV) vaccine is related to an increase in high-risk (HR), possibly cancer related, HPV infections. Data from the U.S. National Health and Examination Nutrition Survey reveal a statistically significantly higher percentage of women who received an HPV vaccine carried an HR-HPV than women who did not receive an HPV shot (Rao-Scott Chi-square contrast p-value of 0.002). Vaccine recipients tested positive less frequently for HPVs targeted by the vaccines, but had a higher prevalence of other HR (cancer related) HPVs. The results suggest that a thorough investigation of the effects of HPV vaccines on HR-HPV viruses (and other pathogens) not targeted by them is warranted.
确定疫苗可能产生的负面影响有助于确定一种声称可以预防疾病的医疗干预措施的收益是否大于成本。这种成本效益分析对于疫苗政策和知情同意都是至关重要的。本研究旨在确定人乳头瘤病毒(HPV)疫苗的使用是否与高危(HR)(可能与癌症相关)HPV感染的增加有关。来自美国国家健康和检查营养调查的数据显示,接种HPV疫苗的女性携带HR-HPV的比例明显高于未接种HPV疫苗的女性(Rao-Scott卡方对比p值为0.002)。疫苗接种者对疫苗靶向的hpv检测呈阳性的频率较低,但其他HR(癌症相关)hpv的患病率较高。结果表明,有必要对HPV疫苗对HR-HPV病毒(和其他非靶向病原体)的影响进行彻底调查。
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引用次数: 1
Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19 比疾病更糟糕?回顾抗COVID-19 mRNA疫苗的一些可能的意外后果
Pub Date : 2021-06-16 DOI: 10.56098/ijvtpr.v2i1.23
S. Seneff, G. Nigh
Operation Warp Speed brought to market in the United States two mRNA vaccines, produced by Pfizer and Moderna. Interim data suggested high efficacy for both of these vaccines, which helped legitimize Emergency Use Authorization (EUA) by the FDA. However, the exceptionally rapid movement of these vaccines through controlled trials and into mass deployment raises multiple safety concerns. In this review we first describe the technology underlying these vaccines in detail. We then review both components of and the intended biological response to these vaccines, including production of the spike protein itself, and their potential relationship to a wide range of both acute and long-term induced pathologies, such as blood disorders, neurodegenerative diseases and autoimmune diseases. Among these potential induced pathologies, we discuss the relevance of prion-protein-related amino acid sequences within the spike protein. We also present a brief review of studies supporting the potential for spike protein “shedding”, transmission of the protein from a vaccinated to an unvaccinated person, resulting in symptoms induced in the latter. We finish by addressing a common point of debate, namely, whether or not these vaccines could modify the DNA of those receiving the vaccination. While there are no studies demonstrating definitively that this is happening, we provide a plausible scenario, supported by previously established pathways for transformation and transport of genetic material, whereby injected mRNA could ultimately be incorporated into germ cell DNA for transgenerational transmission. We conclude with our recommendations regarding surveillance that will help to clarify the long-term effects of these experimental drugs and allow us to better assess the true risk/benefit ratio of these novel technologies.
“曲速行动”向美国市场推出了两种mRNA疫苗,分别由辉瑞和Moderna生产。中期数据表明,这两种疫苗都有很高的疗效,这有助于FDA批准紧急使用授权(EUA)。然而,这些疫苗通过对照试验并进入大规模部署的速度异常之快,引发了多重安全问题。在这篇综述中,我们首先详细描述了这些疫苗背后的技术。然后,我们回顾了这些疫苗的组成部分和预期的生物反应,包括刺突蛋白本身的产生,以及它们与各种急性和长期诱导病理(如血液疾病、神经退行性疾病和自身免疫性疾病)的潜在关系。在这些潜在的诱导病理中,我们讨论了刺突蛋白中朊蛋白相关氨基酸序列的相关性。我们还简要回顾了支持刺突蛋白“脱落”可能性的研究,即蛋白质从接种疫苗的人传播到未接种疫苗的人,导致后者引起症状。最后,我们将讨论一个共同的争论点,即,这些疫苗是否可以修改接种疫苗者的DNA。虽然没有研究明确地证明这种情况正在发生,但我们提供了一个合理的场景,支持先前建立的遗传物质转化和运输途径,即注射的mRNA最终可以整合到生殖细胞DNA中进行跨代传播。最后,我们提出了关于监测的建议,这将有助于澄清这些实验性药物的长期影响,并使我们能够更好地评估这些新技术的真正风险/收益比。
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引用次数: 38
Messianic Mad Men, Medicine, and the Media War on Empirical Reality 弥赛亚广告狂人,医学,和经验现实的媒体战争
Pub Date : 2021-03-31 DOI: 10.56098/ijvtpr.v2i1.22
D. Broudy, Darwin Hoop
This article critically examines the emerging global war on pathogens mimicking the Global War on Terror (GWOT). We draw upon the history of recent wars and the fear-driven narratives aimed at nudging the public toward uncritical acceptance of the new emerging social and economic global order. We adopt Edward Herman and Noam Chomsky’s ‘Propaganda Model’ to describe how mainstream media perform in manufacturing consent to policies that tighten control over populations and degrade rights, agency, and sovereignty. Here we consider the efforts of globalist political actors who seek to co-opt or influence political institutions around the world and position themselves as unelected rulers of an emerging authoritarian order. We argue that agenda-setting media are predisposed to serve elite interests that shape news coverage, bound public debate, and obscure new forms of warfare behind the smokescreen of a manufactured Global War on Pathogens (GWOP). We introduce critical analysis and alternative perspectives, largely marginalized by the mainstream, on the hidden conflicts of interest involved in the demands for full social compliance.
本文批判性地考察了模仿全球反恐战争(GWOT)的新兴全球病原体战争。我们借鉴了最近几次战争的历史和恐惧驱动的叙事,旨在推动公众不加批判地接受新兴的社会和经济全球秩序。我们采用爱德华·赫尔曼(Edward Herman)和诺姆·乔姆斯基(Noam Chomsky)的“宣传模型”(Propaganda Model)来描述主流媒体在制造对加强对人口控制、降低权利、机构和主权的政策的同意方面的表现。在这里,我们考虑全球主义政治行动者的努力,他们试图在世界各地的政治机构中进行合作或影响,并将自己定位为新兴威权秩序的未经选举的统治者。我们认为,议程设定媒体倾向于为精英利益服务,这些利益塑造了新闻报道,束缚了公众辩论,并在制造的全球病原体战争(GWOP)的烟幕背后掩盖了新形式的战争。我们介绍了主要被主流边缘化的批判性分析和其他观点,讨论了在要求全面遵守社会的过程中所涉及的潜在利益冲突。
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引用次数: 3
Vaccine Practice Payment Schedules Create Perverse Incentives for Unnecessary Medical Procedures – at What Cost to Patients? 疫苗实践支付计划为不必要的医疗程序创造了不正当的激励——对患者来说代价是什么?
Pub Date : 2021-03-31 DOI: 10.56098/ijvtpr.v2i1.21
James Lyons-Weiler, Paul Thomas
No published assessment of revenue variation associated with variance in pediatric vaccine uptake exists. Using data from patients in a pediatric practice that provides full-service with informed consent, we provide a detailed analysis of the financial realities of respecting informed consent and allowing parents to exercise their legal right to refuse some or all pediatric vaccines. The data from a 30-day period of billing were tracked and analyzed via superbills, noting vaccines that were ordered and those that were refused. Considering that other practice income covered all operating expenses; these numbers reflect actual profits (from vaccines given) and losses (from vaccines refused). Patients in the practice exhibited increased refusal of some or all vaccines over a period of approximately ten years.  These real-world data show losses would exceed one million US dollars for a practice that bills out just over 3 million (gross revenue). With pediatric administrative overhead running 60–80%, it becomes clear that the financial incentives to vaccinate are now a matter of survival for pediatric practices.
没有发表的与儿童疫苗摄取差异相关的收入差异评估。我们利用在知情同意的情况下提供全面服务的儿科实践中的患者数据,详细分析了尊重知情同意和允许父母行使其合法权利拒绝部分或全部儿科疫苗的财务现实。通过超级账单跟踪和分析了30天的账单数据,记录了订购和拒绝接种的疫苗。考虑到其他执业收入已涵盖所有经营费用;这些数字反映了实际利润(来自接种疫苗)和损失(来自拒绝接种疫苗)。在实践中,患者在大约十年的时间里表现出对部分或全部疫苗的拒绝增加。这些真实世界的数据显示,对于一个总收入只有300多万美元的诊所来说,损失将超过100万美元。由于儿科管理费用占60-80%,很明显,接种疫苗的财政激励现在是儿科实践的生存问题。
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引用次数: 0
Balance of Risk in COVID-19 Reveals the Extreme Cost of False Positives 2019冠状病毒病的风险平衡揭示了假阳性的极端代价
Pub Date : 2021-01-06 DOI: 10.56098/ijvtpr.v1i2.15
James Lyons-Weiler
COVID-19 public health responses, including lockdowns and diagnostic testing strategies, have had consequences. Economic costs (see the CHD paper in this issue) could reach $16 trillion dollars, 90% of the US annual GDP. While harm to small businesses, unemployment, worsening poverty, death from cancer, increased suicides, social isolation, and restriction of freedom all increase the perceived need for drastic responses from the top, flawed measures are costly. A diagnostic assay[1] of tests for COVID-19 depends for its validity on its sensitivity and specificity assessed in terms of the true positive rate (TPR), false positive rate (FPR), true negative rate (TNR), and false negative rate (FNR) of the assays. In this pandemic, Real Time — Polymerase Chain Reaction (RT-PCR) testing has been relied on for drastic top-down responses (as in shutting down the economy of whole nations or the entire world). Here I focus on false positive results where RT-PCR testing suggests many infections by SARS-CoV-2 where there are none. I show by mathematical modeling how reporting positive results of RT-PCR testing, ones known to be false in a measurable percentage of instances, is at least 40 times more impactful (in a detrimental way) than increasing or decreasing the number of tests conducted. To balance the risks of errors in diagnosis, false positive results must be minimized by validating nucleotide sequences and estimates of viremia to avoid flagging individuals as contagious when they are not.
COVID-19公共卫生应对措施,包括封锁和诊断检测策略,已经产生了后果。经济成本可能达到16万亿美元,相当于美国年GDP的90%。虽然对小企业的伤害、失业、贫困加剧、癌症死亡、自杀率上升、社会孤立和自由限制都增加了人们对高层采取激烈应对措施的需求,但有缺陷的措施代价高昂。新冠肺炎诊断检测方法[1]的有效性取决于检测方法的真阳性率(TPR)、假阳性率(FPR)、真阴性率(TNR)和假阴性率(FNR)评估的敏感性和特异性。在这次大流行中,实时聚合酶链反应(RT-PCR)检测一直依赖于激烈的自上而下的应对措施(如关闭整个国家或整个世界的经济)。这里我关注的是假阳性结果,即RT-PCR检测显示许多SARS-CoV-2感染,而实际上没有感染。我通过数学模型表明,报告RT-PCR检测的阳性结果(在可测量的百分比中已知是错误的结果)的影响(以有害的方式)至少是增加或减少进行的检测数量的40倍。为了平衡诊断错误的风险,必须通过验证核苷酸序列和病毒血症估计来最大限度地减少假阳性结果,以避免在没有传染性的情况下将个体标记为传染性。
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引用次数: 1
Vitamin C Mitigating and Rescuing from Synergistic Toxicity: Sodium Fluoride, Silicofluorides, Aluminum Salts, Electromagnetic Pollution, and SARS-CoV-2 维生素C减轻和挽救协同毒性:氟化钠、氟化硅、铝盐、电磁污染和SARS-CoV-2
Pub Date : 2021-01-05 DOI: 10.56098/ijvtpr.v1i2.12
R. Davidson, T. Winey
A supramolecular paradigm for mitigation and rescue from SARS-COV2 infection is proposed. Similarities between the Sanarelli-Shwartzman phenomenon and biological responses to viral pathogens are considered. Non-enzymatic group transfer catalysis (NGTC) by L-ascorbic acid, the L-ascorbic acid free radical and the 2-O-phosphate substituted L-ascorbic acid derivative are proposed under the ascorbolysis hypothesis to provide a supramolecular basis for mitigating the synergistic toxicity and catalytic mimicry by the environmental toxicants, sodium fluoride, aluminum salts, and silicofluorides in public water supplies. Ascorbolysis is the term we adopt to describe a redox active, hyperconjugated, vinylogous variant of acidolysis. The objective of this paper is to provide a plausible supramolecular basis for mitigation and rescue from well-known environmental toxicity represented by the presence of sodium fluoride, aluminum salts, and silicofluoride species in public water supplies. An overview of the conceptual basis for NGTC by vitamin C during inflammatory states is provided. Controversies concerning the initial oxidation steps and pH-dependent speciation of L-ascorbic acid are addressed. Non-skeletal fluorosis is a serious systemic malady which we propose arises from disruption of hydrogen bond networks and hydrogen bond cooperativity resulting from the marked electronegativity and hydrogen bond accepting ability of fluoride atoms found in NaF and AlFx species. AlFx species have been previously shown to arise in situ spontaneously from NaF, aluminum salts, and silicofluorides often found in toothpastes and “fluoridated” drinking water. AlFx species are thought to act as isosteric mimics of biophosphates during group transfers of phosphoryl moieties. We propose that catalytic mimicry by AlFx species inhibits postulated non-enzymatic kinase-like and RNA polymerase-like function of the AA-2P derivative during inflammatory states. We describe how NGTC by L-ascorbic acid is likely to be disrupted by AlFx and sodium fluoride of a specific H3-O2 intramolecular hydrogen bond in L-ascorbic acid, the L-ascorbic acid free radical, and their 2-O-substituted derivatives, which are necessary for NGTC in the moderately acidic, mildly oxidative, relatively hydrophobic microenvironment which typify inflammatory states. Suggestions are made to achieve less variation in results of large randomized clinical trials (RCTs) seeking to validate use of high-dose intravenous vitamin C in critical care and cancer settings.
提出了一种缓解和拯救SARS-COV2感染的超分子范式。Sanarelli-Shwartzman现象和对病毒病原体的生物反应之间的相似性被考虑。在抗坏血酸分解假说下,提出了l -抗坏血酸、l -抗坏血酸自由基和2- o -磷酸取代l -抗坏血酸衍生物的非酶基转移催化(NGTC),为减轻公共供水中环境毒物、氟化钠、铝盐和氟化硅的协同毒性和催化模仿提供了超分子基础。抗坏血溶解是我们用来描述酸解的氧化还原活性,高共轭,葡萄状变体的术语。本文的目的是提供一个合理的超分子基础,以减轻和拯救众所周知的环境毒性,以公共供水中氟化钠、铝盐和氟化硅的存在为代表。本文概述了炎症状态下维生素C介导NGTC的概念基础。关于l -抗坏血酸的初始氧化步骤和ph依赖性物种的争议被解决。非骨性氟中毒是一种严重的全身性疾病,我们认为它是由于NaF和AlFx中氟原子的明显电负性和氢键接受能力导致氢键网络和氢键协同性的破坏而引起的。先前已经证明,氟化铝是由NaF、铝盐和氟化硅在牙膏和“氟化”饮用水中自然产生的。在磷酸基基团转移过程中,AlFx物种被认为是生物磷酸盐的等构模拟物。我们提出,在炎症状态下,AlFx物种的催化模仿抑制了假设的AA-2P衍生物的非酶激酶样和RNA聚合酶样功能。我们描述了AlFx和氟化钠如何破坏l -抗坏血酸中特定的H3-O2分子内氢键、l -抗坏血酸自由基及其2- o取代衍生物,这是NGTC在中酸性、轻度氧化、相对疏水的微环境中所必需的,这些微环境是典型的炎症状态。为了验证在重症监护和癌症环境中使用大剂量静脉注射维生素C的有效性,建议在大型随机临床试验(rct)中减少结果差异。
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引用次数: 3
Planned Surveillance and Control by Global Technocrats: A Big-Picture Look at the Current Pandemic Beneficiaries 全球技术官僚有计划的监测和控制:当前大流行受益者的全局观
Pub Date : 2021-01-05 DOI: 10.56098/ijvtpr.v1i2.7
Children's Health Defense Team
Global financial patterns and pronouncements point to a seismic overhaul of governance and financial systems that is playing out beneath the surface of the Covid-19 pandemic, reaching far beyond the health domain. Increased centralized control has the potential to create an unbridgeable chasm between a tiny handful of winners and a majority of losers. To foster an integrated analysis of the technocratic and financial forces and agendas at play, this rapid review identifies some of the pandemic’s principal beneficiaries across the interwoven financial, tech, biopharmaceutical, and military-intelligence sectors, assessing developments in the context of the accelerating global push for technocratic consolidation and control. The evidence suggests that Trojan horse coronavirus vaccines may challenge bodily integrity and informed consent in entirely new ways, transporting invasive technologies into people’s brains and bodies. Technologies such as brain-machine interfaces, digital identity tracking devices, and cryptocurrency-compatible chips would contribute to the central banking goal of replacing currencies with digital transaction and identification systems and creating a global control grid that connects the world population to the military-pharma-intelligence cloud of the global technocrats. Moreover, using vaccines as a delivery vehicle for surveillance technologies cancels any legal liability.
全球金融模式和声明表明,在2019冠状病毒病大流行的表象下,治理和金融体系正在发生翻天覆地的变化,影响范围远远超出卫生领域。加强集中控制有可能在少数赢家和大多数输家之间造成不可逾越的鸿沟。为了促进对发挥作用的技术官僚和金融力量及议程的综合分析,本快速审查确定了金融、科技、生物制药和军事情报等相互交织的部门中疫情大流行的一些主要受益者,并在全球加速推动技术官僚巩固和控制的背景下评估事态发展。有证据表明,特洛伊木马冠状病毒疫苗可能会以全新的方式挑战身体完整性和知情同意,将侵入性技术输送到人们的大脑和身体中。脑机接口、数字身份跟踪设备和加密货币兼容芯片等技术将有助于实现央行的目标,即用数字交易和身份识别系统取代货币,并创建一个全球控制网格,将世界人口与全球技术官僚的军事-制药-智能云连接起来。此外,使用疫苗作为监测技术的运载工具可以免除任何法律责任。
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引用次数: 6
Excitotoxicity (Immunoexcitotoxicity) as a Critical Component of the Cytokine Storm Reaction in Pulmonary Viral Infections, Including SARS-Cov-2 兴奋性毒性(免疫兴奋性毒性)是肺病毒感染(包括SARS-Cov-2)中细胞因子风暴反应的关键组成部分
Pub Date : 2021-01-05 DOI: 10.56098/ijvtpr.v1i2.14
R. L. Blaylock
A hyperimmune state secondary to dysregulation of the immune system during lower pulmonary viral infections, sepsis and in some cases non-infectious disorders, is now considered to be the principle event leading to clinical deterioration and eventual death in these patients. While most studies have attributed the pathological damage to the lung to be primarily due to high levels of cytokines and chemokines along with massive infiltration of principally neutrophils and macrophages, there is compelling evidence that overactivation of glutamate receptors is also playing a significant, if not critical role in this process. Functional glutamate receptors, along with two important glutamate transport systems, have now been described in epithelial and endothelial cells in the pulmonary airways as well as all involved immune cells. Experimental studies using cytokine models have shown considerable protection against pathological damage to pulmonary tissues by reducing the activation of these glutamate receptors.
在下肺病毒感染、败血症和某些非感染性疾病期间继发于免疫系统失调的高免疫状态,现在被认为是导致这些患者临床恶化和最终死亡的主要事件。虽然大多数研究认为肺的病理损伤主要是由于高水平的细胞因子和趋化因子以及主要是中性粒细胞和巨噬细胞的大量浸润,但有令人信服的证据表明,谷氨酸受体的过度激活在这一过程中也起着重要的作用,如果不是关键的作用。功能性谷氨酸受体,以及两个重要的谷氨酸运输系统,现已在肺气道上皮细胞和内皮细胞以及所有相关的免疫细胞中被描述。使用细胞因子模型的实验研究表明,通过减少这些谷氨酸受体的激活,对肺组织的病理损伤具有相当大的保护作用。
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引用次数: 6
The Age of COVID-19: Fear, Loathing, and the “New Normal” COVID-19时代:恐惧、厌恶和“新常态”
Pub Date : 2021-01-05 DOI: 10.56098/ijvtpr.v1i2.11
Christopher A. Shaw
In this article, I give some of the history of COVID-19, and review some of the unanswered questions about what is being represented as an extraordinary “pandemic”. Foremost among them is whether those “fashioning the narrative”, to borrow a phrase from the Stanford mathematician Richard Moore, also had a hand in fashioning the “pandemic” itself. I also introduce the articles in the rest of this issue that follow my own.
在本文中,我将介绍COVID-19的一些历史,并回顾一些关于什么是非同寻常的“大流行”的悬而未决的问题。其中最重要的是,借用斯坦福大学数学家理查德•摩尔(Richard Moore)的话来说,那些“塑造叙事”的人是否也参与了塑造“流行病”本身。我还介绍了本期文章之后的其他文章。
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引用次数: 3
Weaponized Pathogens and the SARS-CoV-2 Pandemic 武器化病原体与SARS-CoV-2大流行
Pub Date : 2021-01-05 DOI: 10.56098/ijvtpr.v1i2.16
John W. Oller, Jr.
This review zeros in on the aspect of vaccine theory, practice, and research that is the most dangerous, the most controversial, and that is at the epicenter of the alleged SARS-CoV-2 “pandemic”. Regardless whether the “pandemic” itself is real or an illusion manufactured out of fear by vested interests, it is central to ethics and policy discussions seeking to understand bioweapons research in general. The official involvement of the USA in civilian bioweapons research dates at least from World War II under President Franklin Delano Roosevelt. The historical records, cloaked in secrecy until after the Anthrax mailing of 2001, reveal an intimate connection to vaccine research and development, its governmental protection from public scrutiny, and from citizen initiated lawsuits. It is an industry that has released dangerous weaponized pathogens by accident and by sinister designs supposedly compensated in the peace-loving nations by unrealistic hopes in non-existent counter-measures for outbreaks, including epidemiological tracking after the fact, vaccines being researched to counter the weaponization of pathogens being studied, immunity enhancing drugs, and downstream hoped for blood sera containing antibodies. Critical questions concern the ratio of real-risks to hoped-for-benefits, the “mitigating” measures “governments” (especially in the USA) have supposedly established to prevent pandemic outbreaks from bioweapons research, and how all that has played out in the instance of SARS-CoV-2.
这篇综述的重点是疫苗理论、实践和研究中最危险、最具争议的方面,也是所谓的SARS-CoV-2“大流行”的中心。无论“大流行”本身是真实的还是既得利益者出于恐惧而制造的幻觉,它都是寻求从总体上理解生物武器研究的伦理和政策讨论的核心。美国官方对民用生物武器研究的参与至少可以追溯到富兰克林·德拉诺·罗斯福总统领导的第二次世界大战。在2001年炭疽邮件事件发生之前,这些历史记录一直处于保密状态,揭示了与疫苗研发的密切联系,以及政府对其的保护,使其免受公众监督和公民发起的诉讼。这个行业无意中释放了危险的武器化病原体,并通过邪恶的设计在爱好和平的国家中被不切实际的希望所补偿,这些希望是对不存在的爆发对策的不切实际的希望,包括事后的流行病学追踪,正在研究的疫苗以对抗正在研究的武器化病原体,增强免疫力的药物,以及下游希望含有抗体的血清。关键问题涉及实际风险与期望收益的比例,“政府”(尤其是美国)为防止生物武器研究引发的大流行而制定的“缓解”措施,以及所有这些措施在SARS-CoV-2的情况下是如何发挥作用的。
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引用次数: 4
期刊
International Journal of Vaccine Theory, Practice, and Research
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