Pub Date : 2023-01-01DOI: 10.1504/ijcbdd.2023.10058565
D. Hajra, Pritam Ghosh, Sanket Dan, Subhranil Mustafi, S. Mandal, Santanu Banik, Shyamal Naskar
{"title":"EyeRIS: Image-Based Identification of Goats using Iris","authors":"D. Hajra, Pritam Ghosh, Sanket Dan, Subhranil Mustafi, S. Mandal, Santanu Banik, Shyamal Naskar","doi":"10.1504/ijcbdd.2023.10058565","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.10058565","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66715470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1504/ijcbdd.2023.10058028
V. Nunia, Mansoor Ali Syed, S. Qureshi, Rakesh Sharma, Shubham Verma, Shradheya R. R. Gupta, Kavita Joshi
{"title":"Virtual screening of plant phytochemicals to discover potent Janus kinase-1 inhibitors against severe COVID-19 and sepsis","authors":"V. Nunia, Mansoor Ali Syed, S. Qureshi, Rakesh Sharma, Shubham Verma, Shradheya R. R. Gupta, Kavita Joshi","doi":"10.1504/ijcbdd.2023.10058028","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.10058028","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"1 1","pages":"391-411"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66715907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SMLBT: secure machine learning and blockchain-based telemedicine model for the remote areas of developing countries","authors":"Milon Biswas, Atanu Shome, Prodipta Promit Mukherjee, Loveleen Gaur, Zhongming Zhao","doi":"10.1504/ijcbdd.2023.134617","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.134617","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135318453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment and Validation of Emulgel Based Salicylic acid Formulation Development to Drug release and Optimization by Statistical Design","authors":"Pavani Cheekati, Kundansai Balaga, Manasa Banala, Ishwarya Bammidi, Tarakaramarao C H, Yamani Busa","doi":"10.1504/ijcbdd.2023.10058216","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.10058216","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66715460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Virtual screening of plant phytochemicals to discover potent Janus kinase-1 inhibitors against severe COVID-19 and sepsis","authors":"Kavita Joshi, Shradheya R.R. Gupta, Shubham Verma, Rakesh Sharma, Sameer Qureshi, Mansoor Ali Syed, Vandana Nunia","doi":"10.1504/ijcbdd.2023.133834","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.133834","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136004087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1504/ijcbdd.2023.134614
Ali Adel Dawood
{"title":"Simulate the agarose gel of the receptor binding domain in Omicron's spike protein inserted into the pGEM®-T Easy vector using SpeI and SacI restriction enzymes","authors":"Ali Adel Dawood","doi":"10.1504/ijcbdd.2023.134614","DOIUrl":"https://doi.org/10.1504/ijcbdd.2023.134614","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135318472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1504/ijcbdd.2022.10051680
Lokesh Kumar Agarwal N.A.
{"title":"In Silico Analysis of Multiple Targets (HER2 receptor and DNA) Inhibition by Natural Isoquinoline Derivatives for Breast Cancer Treatment","authors":"Lokesh Kumar Agarwal N.A.","doi":"10.1504/ijcbdd.2022.10051680","DOIUrl":"https://doi.org/10.1504/ijcbdd.2022.10051680","url":null,"abstract":"","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66715722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-13DOI: 10.1504/ijcbdd.2020.10029440
T. Samaha
Protein-phospholipid interactions encompass the basis of many biological processes, including host-pathogen interaction and disease progression. This study reports the interactions of Leptospiral PI-PLC (LA_1375) with PIP2 and PIP3. Molecular docking analysis was carried out to unveil the interactions of the protein with the plasma membrane phosphoinositides. The binding affinities of the interactions, most favourable protein-phospholipid binding poses, and the binding site residues were revealed. The binding energies were found to be -14.04 and -11.64 kcal/mol respectively for PIP2 and PIP3 interaction. Also, the analysis explored the high-affinity binding of the protein with the substrate PIP2. PIP2 is the precursor of intracellular second messengers DAG and IP3; responsible for the activation of pro-inflammatory mediators and other signalling events. Moreover, both PIP2 and PIP3 have been implicated in various cellular processes through the activation of lipid signalling cascades. Hence, further in-vitro confirmation of the annotated interactions may open up new dimensions in the pathogenesis of Leptospirosis.
{"title":"Interactions of Leptospiral PI-PLC with the membrane phosphoinositides: an insight of the proteinphospholipid association in the pathogenesis","authors":"T. Samaha","doi":"10.1504/ijcbdd.2020.10029440","DOIUrl":"https://doi.org/10.1504/ijcbdd.2020.10029440","url":null,"abstract":"Protein-phospholipid interactions encompass the basis of many biological processes, including host-pathogen interaction and disease progression. This study reports the interactions of Leptospiral PI-PLC (LA_1375) with PIP2 and PIP3. Molecular docking analysis was carried out to unveil the interactions of the protein with the plasma membrane phosphoinositides. The binding affinities of the interactions, most favourable protein-phospholipid binding poses, and the binding site residues were revealed. The binding energies were found to be -14.04 and -11.64 kcal/mol respectively for PIP2 and PIP3 interaction. Also, the analysis explored the high-affinity binding of the protein with the substrate PIP2. PIP2 is the precursor of intracellular second messengers DAG and IP3; responsible for the activation of pro-inflammatory mediators and other signalling events. Moreover, both PIP2 and PIP3 have been implicated in various cellular processes through the activation of lipid signalling cascades. Hence, further in-vitro confirmation of the annotated interactions may open up new dimensions in the pathogenesis of Leptospirosis.","PeriodicalId":39227,"journal":{"name":"International Journal of Computational Biology and Drug Design","volume":"13 1","pages":"200-208"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47553615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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