Pub Date : 2020-04-10DOI: 10.46791/ujmds.2020.080102
B. Durgadevi, Jimsha Vk, Srinivasan Sv, M JonathanDaniel
Distribution and severity of apical root resorption in inflammatory periapical pathologies amongst diabetic and non diabetic
糖尿病和非糖尿病患者根尖周围炎症病理中根尖吸收的分布和严重程度
{"title":"DISTRIBUTION AND SEVERITY OF APICAL ROOT RESORPTION IN INFLAMMATORY PERIAPICAL PATHOLOGIES AMONGST DIABETIC AND NON DIABETIC PATIENTS – A PILOT STUDY","authors":"B. Durgadevi, Jimsha Vk, Srinivasan Sv, M JonathanDaniel","doi":"10.46791/ujmds.2020.080102","DOIUrl":"https://doi.org/10.46791/ujmds.2020.080102","url":null,"abstract":"Distribution and severity of apical root resorption in inflammatory periapical pathologies amongst diabetic and non diabetic","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"1 1","pages":"5-8"},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45878034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-10DOI: 10.46791/ujmds.2020.080103
Gaikwad Sanjay R, Kakde Vishwanath B
{"title":"IRRITABLE BOWEL SYNDROME (IBS) - A LITERARY REVIEW","authors":"Gaikwad Sanjay R, Kakde Vishwanath B","doi":"10.46791/ujmds.2020.080103","DOIUrl":"https://doi.org/10.46791/ujmds.2020.080103","url":null,"abstract":"","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"8 1","pages":"9-11"},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45882805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-10DOI: 10.46791/ujmds.2020.080101
Keerthi Kl, P AravindKumar, M. NarendraBabu, Kalapala Raviraj
{"title":"BUTTON POUCH TECHNIQUE WITH LASER TREATED PRF FOR TREATMENT OF MULTIPLE GINGIVAL RECESSIONS - A CASE REPORT","authors":"Keerthi Kl, P AravindKumar, M. NarendraBabu, Kalapala Raviraj","doi":"10.46791/ujmds.2020.080101","DOIUrl":"https://doi.org/10.46791/ujmds.2020.080101","url":null,"abstract":"","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"8 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42416151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-10DOI: 10.46791/ujmds.2020.080105
M. K. Sagar, T. Priyanka, M. Satish, Shinde Christopher Vinay, Dubey Ashutosh, N. Babita
{"title":"MANAGEMENT OF ELLIS CLASS VIII FRACTURE - A SURGICAL APPROACH","authors":"M. K. Sagar, T. Priyanka, M. Satish, Shinde Christopher Vinay, Dubey Ashutosh, N. Babita","doi":"10.46791/ujmds.2020.080105","DOIUrl":"https://doi.org/10.46791/ujmds.2020.080105","url":null,"abstract":"","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"8 1","pages":"14-16"},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45500047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-09DOI: 10.21203/rs.3.rs-21533/v1
Kiyotaka Horiuchi, M. Mizuno, H. Katano, Kentaro Endo, Nobutale Ozeki, K. Tsuji, H. Koga, I. Sekiya
Background Synovial mesenchymal stem cell (MSC) transplantation improved clinical outcomes in knees with cartilage defects and after repairs of degenerative torn menisci. For these, nucleated cells were cultured with 10% autologous serum for 14 days. Importantly, nucleated cell number and serum volume practically varied by patient, and initial cell density and dish number affected yield/donor. Our purpose was to examine the effect of plating density within range in clinical studies on fold increase and to estimate the MSC yield/donor, which are affected by the nucleated cell number and serum volume.Methods We obtained the data of the autologous serum volume, nucleated cell number, and initial plating cell density from 10 patients who participated in our previous clinical studies. Experimentally, synovial nucleated cells harvested from three patients with osteoarthritis during total knee arthroplasty were cultured with 10% mixed allogenic human serum for 14 days to examine the effect of initial cell density on fold increase. We used both our previous clinical data and our current experimental data to predict the yields of synovial MSCs in nine cases within the range of clinical studies.Results In the clinical studies, collected serum ranged between 87 and 186 ml, harvested nucleated cells ranged between 6.2 and 23 million, and the top five total MSC yields were obtained from donors when the initial plating cell density ranged from 919 to 1905 cells/cm2. Experimentally, fold increase significantly decreased between 700 and 1,900 cells/cm2. In cases where the cell number was low and the serum volume was high, the estimated yield/donor decreased along with the initial density, while in cases where the cell number was high and the serum volume was low, the estimated yield/donor increased along with the initial density. In cases both where some nucleated cells were discarded at low density and no cells were discarded at high density, the maximum yield/donor were obtained when the initial density was the lowest density that does not discard cells.Conclusions There was an optimal initial density that yields the highest number of primary MSCs in a clinical setting when cell numbers and human serum volumes are limited.
{"title":"Optimal Initial Cell Density that Yields the Highest Number of Primary Synovial Mesenchymal Stem Cells in a Clinical Setting","authors":"Kiyotaka Horiuchi, M. Mizuno, H. Katano, Kentaro Endo, Nobutale Ozeki, K. Tsuji, H. Koga, I. Sekiya","doi":"10.21203/rs.3.rs-21533/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-21533/v1","url":null,"abstract":"\u0000 Background Synovial mesenchymal stem cell (MSC) transplantation improved clinical outcomes in knees with cartilage defects and after repairs of degenerative torn menisci. For these, nucleated cells were cultured with 10% autologous serum for 14 days. Importantly, nucleated cell number and serum volume practically varied by patient, and initial cell density and dish number affected yield/donor. Our purpose was to examine the effect of plating density within range in clinical studies on fold increase and to estimate the MSC yield/donor, which are affected by the nucleated cell number and serum volume.Methods We obtained the data of the autologous serum volume, nucleated cell number, and initial plating cell density from 10 patients who participated in our previous clinical studies. Experimentally, synovial nucleated cells harvested from three patients with osteoarthritis during total knee arthroplasty were cultured with 10% mixed allogenic human serum for 14 days to examine the effect of initial cell density on fold increase. We used both our previous clinical data and our current experimental data to predict the yields of synovial MSCs in nine cases within the range of clinical studies.Results In the clinical studies, collected serum ranged between 87 and 186 ml, harvested nucleated cells ranged between 6.2 and 23 million, and the top five total MSC yields were obtained from donors when the initial plating cell density ranged from 919 to 1905 cells/cm2. Experimentally, fold increase significantly decreased between 700 and 1,900 cells/cm2. In cases where the cell number was low and the serum volume was high, the estimated yield/donor decreased along with the initial density, while in cases where the cell number was high and the serum volume was low, the estimated yield/donor increased along with the initial density. In cases both where some nucleated cells were discarded at low density and no cells were discarded at high density, the maximum yield/donor were obtained when the initial density was the lowest density that does not discard cells.Conclusions There was an optimal initial density that yields the highest number of primary MSCs in a clinical setting when cell numbers and human serum volumes are limited.","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"68 1","pages":"17-26"},"PeriodicalIF":0.0,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47575540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinicopathological parameters derived from initial transurethral resection of bladder tumor (TUR-Bt) have limitations in predicting tumor progression in bladder cancer. Reduced folate carrier 1 (RFC1) and equilibrative nucleoside transporter 1 (ENT1) are solute carrier (SLC) transporters supporting cellular uptake of endogenous bioactive substances and anti-cancer drugs. The aim of this study was to elucidate the role of SLC transporters in bladder cancer and investigate the potential of RFC1 and ENT1 expression as immunohistochemical markers for high-grade malignancy. We compared T-stage with the immunohistochemical expression of RFC1 and ENT1 and other clinicopathological parameters; moreover, we also used multiple logistic regression model to assess relative contributions for T-stage in bladder cancer (n=130). Concurrently, 57 TUR-Bt-derived imprint cytological samples were stained to evaluate the implication of cytological analysis. Elevated expression levels of RFC1 and ENT1 were significantly correlated with higher T-stage (p < .0001) and efficiently predicted tumor progres sion, compared with other clinicopathological parameters (RFC1, p = .0325; ENT1, p = .0171). Indepen dent variables of optimal model for predicting T-stage were gender, age, histological grade, expression levels of RFC1 and ENT1. Cytological analysis was consistent with immunostained-tissue data. We reveal RFC1 and ENT1 as potential immunohistocytochemical markers for high-grade malignancy in bladder cancer.
{"title":"Solute carrier transporters, reduced folate carrier 1 and equilibrative nucleoside transporter 1, as immunohistochemical markers for high-grade malignancy in bladder cancer","authors":"Denda Tamami, Kamoshida Shingo, Kuwao Sadahito, Kawamura Jumpei, Ota Yasunori, Soejima Yurie, Akiyama Masako, Sawabe Motoji","doi":"10.11480/JMDS.670002","DOIUrl":"https://doi.org/10.11480/JMDS.670002","url":null,"abstract":"Clinicopathological parameters derived from initial transurethral resection of bladder tumor (TUR-Bt) have limitations in predicting tumor progression in bladder cancer. Reduced folate carrier 1 (RFC1) and equilibrative nucleoside transporter 1 (ENT1) are solute carrier (SLC) transporters supporting cellular uptake of endogenous bioactive substances and anti-cancer drugs. The aim of this study was to elucidate the role of SLC transporters in bladder cancer and investigate the potential of RFC1 and ENT1 expression as immunohistochemical markers for high-grade malignancy. We compared T-stage with the immunohistochemical expression of RFC1 and ENT1 and other clinicopathological parameters; moreover, we also used multiple logistic regression model to assess relative contributions for T-stage in bladder cancer (n=130). Concurrently, 57 TUR-Bt-derived imprint cytological samples were stained to evaluate the implication of cytological analysis. Elevated expression levels of RFC1 and ENT1 were significantly correlated with higher T-stage (p < .0001) and efficiently predicted tumor progres sion, compared with other clinicopathological parameters (RFC1, p = .0325; ENT1, p = .0171). Indepen dent variables of optimal model for predicting T-stage were gender, age, histological grade, expression levels of RFC1 and ENT1. Cytological analysis was consistent with immunostained-tissue data. We reveal RFC1 and ENT1 as potential immunohistocytochemical markers for high-grade malignancy in bladder cancer.","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"67 1","pages":"11-20"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11480/JMDS.670002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46595120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Horiguchi, Takashi Umezawa, Miyaka Umemori, S. Ito, Sachiko Tsuchiya, S. Hirooka, T. Kiyokawa, M. Ikegami, Hiroyuki Takahashi, Yurie Soejima, M. Sawabe
Objective: To analyze the mismatched cases between liquid-based cytology (LBC) and cell block in effusion cytology and to confirm the utility of cell block. Methods: One hundred eighty-two samples of effusions were examined. Cell blocks were prepared from residual samples after LBC preparation, and the details about the diagnostic concordance and difference in cytological characteristics were investigated. Cell block immunostaining was performed to predict the histological type and the primary site of the carcinoma in 32 cases. ALK rearrangement and EGFR mutation were also analyzed using the cell block. Results: The diagnostic concordance rate between LBC and cell block was 97.3%. Diagnoses using LBC and cell block were mismatched in five cases. By immunostaining, the histological type was determined in 91.0% of carcinomas, and primary sites were identified in 76.5% of adenocarcinomas. ALK rearrangement was examined in two cases of lung carcinoma and EGFR mutation was examined in four cases of lung carcinoma. Conclusion: A high concordance rate between LBC and cell block in effusion cytology was found. The main cause of the mismatched diagnosis was the small amount of atypical cells in LBC or cell block. We also showed the utility of cell block in immunostaining and DNA analysis. Key word: cell block, liquid-based cytology, pleural effusion, peritoneal effusion, immunohistochemistry.
{"title":"Application of cell block preparation in effusion cytology: Analysis of mismatched diagnosis and utility of immunostaining","authors":"A. Horiguchi, Takashi Umezawa, Miyaka Umemori, S. Ito, Sachiko Tsuchiya, S. Hirooka, T. Kiyokawa, M. Ikegami, Hiroyuki Takahashi, Yurie Soejima, M. Sawabe","doi":"10.11480/JMDS.670003","DOIUrl":"https://doi.org/10.11480/JMDS.670003","url":null,"abstract":"Objective: To analyze the mismatched cases between liquid-based cytology (LBC) and cell block in effusion cytology and to confirm the utility of cell block. Methods: One hundred eighty-two samples of effusions were examined. Cell blocks were prepared from residual samples after LBC preparation, and the details about the diagnostic concordance and difference in cytological characteristics were investigated. Cell block immunostaining was performed to predict the histological type and the primary site of the carcinoma in 32 cases. ALK rearrangement and EGFR mutation were also analyzed using the cell block. Results: The diagnostic concordance rate between LBC and cell block was 97.3%. Diagnoses using LBC and cell block were mismatched in five cases. By immunostaining, the histological type was determined in 91.0% of carcinomas, and primary sites were identified in 76.5% of adenocarcinomas. ALK rearrangement was examined in two cases of lung carcinoma and EGFR mutation was examined in four cases of lung carcinoma. Conclusion: A high concordance rate between LBC and cell block in effusion cytology was found. The main cause of the mismatched diagnosis was the small amount of atypical cells in LBC or cell block. We also showed the utility of cell block in immunostaining and DNA analysis. Key word: cell block, liquid-based cytology, pleural effusion, peritoneal effusion, immunohistochemistry.","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"67 1","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47542841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaowei Lyu, Kumiko Morita, Hitomi Nagamine, Kay Maruyama
{"title":"Effectiveness of health education programme of primary school-aged children in the urban area of China","authors":"Xiaowei Lyu, Kumiko Morita, Hitomi Nagamine, Kay Maruyama","doi":"10.11480/JMDS.680004","DOIUrl":"https://doi.org/10.11480/JMDS.680004","url":null,"abstract":"","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"68 1","pages":"27-38"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64012190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Satomi Nomura, M. Miyao, M. Okamitsu, Satoshi Yago, N. Nagata, S. Katsumoto, K. Arai, M. Kubota, Yoshiyuki Tachibana, Takahide Omori
Parents of infants with autistic behaviors frequently face difficulties in childrearing owing to their infants’ behavioral traits. This study aimed to clarify the characteristics of parent-infant interaction, parental depressive symptoms, and parenting stress in the context of infants’ autistic behaviors. We employed a cross-sectional, case-control observational design with a case group of 52 parents and a control group of 56 parents. We measured parent-infant interaction using the Japanese version of the Nursing Child Assessment Teaching Scale, and parental depressive symptoms and parenting stress with the Japanese version of the Center for Epidemiologic Studies Depression Scale and the Japanese Parenting Stress Index Short Form, respectively. There was no significant difference between the two groups regarding parent-infant interaction. Mothers in the case group had significantly higher depressive symptoms than those in the control group (p < .05). Both fathers (p < .05) and mothers (p < .01) in the case group scored significantly higher than the control group on parenting stress. Thus, parents of infants with autistic behaviors have greater mental health problems right from infancy. We suggest that nurses should provide families with appropriate support to promote adaptive parent-infant interaction and prevent the aggravation of parental mental health problems irrespective of Autism Spectrum Disorder diagnoses.
{"title":"Characteristics of Parents and Their Infants with Autistic Behaviors: Parent-Infant Interaction, Parental Depression, and Parenting Stress","authors":"Satomi Nomura, M. Miyao, M. Okamitsu, Satoshi Yago, N. Nagata, S. Katsumoto, K. Arai, M. Kubota, Yoshiyuki Tachibana, Takahide Omori","doi":"10.11480/JMDS.670004","DOIUrl":"https://doi.org/10.11480/JMDS.670004","url":null,"abstract":"Parents of infants with autistic behaviors frequently face difficulties in childrearing owing to their infants’ behavioral traits. This study aimed to clarify the characteristics of parent-infant interaction, parental depressive symptoms, and parenting stress in the context of infants’ autistic behaviors. We employed a cross-sectional, case-control observational design with a case group of 52 parents and a control group of 56 parents. We measured parent-infant interaction using the Japanese version of the Nursing Child Assessment Teaching Scale, and parental depressive symptoms and parenting stress with the Japanese version of the Center for Epidemiologic Studies Depression Scale and the Japanese Parenting Stress Index Short Form, respectively. There was no significant difference between the two groups regarding parent-infant interaction. Mothers in the case group had significantly higher depressive symptoms than those in the control group (p < .05). Both fathers (p < .05) and mothers (p < .01) in the case group scored significantly higher than the control group on parenting stress. Thus, parents of infants with autistic behaviors have greater mental health problems right from infancy. We suggest that nurses should provide families with appropriate support to promote adaptive parent-infant interaction and prevent the aggravation of parental mental health problems irrespective of Autism Spectrum Disorder diagnoses.","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"67 1","pages":"31-39"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64012037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between combinations of pathological conditions causing cerebral palsy among mothers and infants and associated characteristics including umbilical arterial pH and parity","authors":"M. Murata, M. Sugawa, K. Kawahara","doi":"10.11480/JMDS.680001","DOIUrl":"https://doi.org/10.11480/JMDS.680001","url":null,"abstract":"","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"68 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64011588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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