Journal of Clinical Neuromuscular Disease最新文献

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A Study on the Epidemiology of COVID-19-Related Guillain-Barré Syndrome in the United States. 美国 COVID-19 相关格林-巴利综合征流行病学研究》。

Q3 Medicine

Journal of Clinical Neuromuscular Disease

Pub Date : 2024-06-01 DOI: 10.1097/CND.0000000000000480

Aditya Sharma, Aditi Sharma, Ayman O Soubani

Introduction: Several neurological complications have been reported with COVID-19, including Guillain-Barré syndrome (GBS). We looked at incidence, baseline characteristics, and in-hospital outcomes of COVID-19-associated GBS in the United States.

Study design and methods: We conducted a retrospective analysis using the US National Inpatient Sample database to identify hospitalizations for COVID-19 and GBS, using International Classification of Disease, 10th Revision, codes G610 and G650 for GBS and U071 for COVID-19. The codes used in this study are listed in Supplemental Digital Content 1 (see e Appendix, http://links.lww.com/JCND/A69).

Results: In total, 13,705 GBS admissions were recorded nationwide in 2020; of these, 1155 (8.43%) were associated with COVID-19. The frequency of GBS in COVID-19 admissions was 0.07%, compared with 0.08% in non-COVID-19 admissions (P = 0.8166). COVID-19 cohort with GBS had higher utilization of invasive mechanical ventilation (20.8% vs. 11.8%, P < 0.001) in comparison with COVID-19 cohort without GBS. GBS admissions with COVID-19 exhibited significantly higher inpatient mortality (12.2% vs. 3%, P < 0.001) compared with GBS admissions without COVID-19.

Interpretation: Our findings underscore GBS as a rare yet severe complication of COVID-19, highlighting a significant difference in mortality when compared with GBS not associated with COVID-19.

简介据报道，COVID-19可引起多种神经系统并发症，包括吉兰-巴雷综合征（GBS）。我们调查了美国 COVID-19 相关 GBS 的发病率、基线特征和住院结果：我们使用美国全国住院病人抽样数据库进行了一项回顾性分析，以确定 COVID-19 和 GBS 的住院情况，GBS 使用《国际疾病分类》第 10 次修订版中的代码 G610 和 G650，COVID-19 使用 U071。本研究使用的代码列于补充数字内容 1（见电子附录，http://links.lww.com/JCND/A69）。结果：2020年全国共记录了13705例GBS入院病例，其中1155例（8.43%）与COVID-19有关。COVID-19 入院患者中 GBS 的发生率为 0.07%，而非 COVID-19 入院患者中 GBS 的发生率为 0.08%（P = 0.8166）。与未患 GBS 的 COVID-19 入院患者相比，患 GBS 的 COVID-19 入院患者使用有创机械通气的比例更高（20.8% 对 11.8%，P < 0.001）。与无COVID-19的GBS住院患者相比，COVID-19的GBS住院患者死亡率明显更高（12.2% vs. 3%，P < 0.001）：我们的研究结果表明，GBS 是 COVID-19 罕见但严重的并发症，与 COVID-19 无关的 GBS 相比，死亡率差异显著。

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引用次数: 0

MuSK Antibody-Positive Myasthenia Gravis With SARS CoV-2 Infection: A Case Report and Literature Review. MuSK抗体阳性的肌无力伴SARS CoV-2感染：病例报告与文献综述

Q3 Medicine

Journal of Clinical Neuromuscular Disease

Pub Date : 2024-06-01 DOI: 10.1097/CND.0000000000000491

Shreyashi Jha, Santosh Kumar Pendyala

引用次数: 0

Myopathy With Crescent of Nuclei: A Novel Histopathologic Finding in Desminopathy. 伴有新月形细胞核的肌病：脱髓鞘病的新组织病理学发现

Q3 Medicine

Journal of Clinical Neuromuscular Disease

Pub Date : 2024-06-01 DOI: 10.1097/CND.0000000000000493

Andre Granger, Eric J Sorenson, Duygu Selcen, Teerin Liewluck

引用次数: 0

Scleroderma-Polymyositis Overlap Syndrome as a Potential Bulbar Amyotrophic Lateral Sclerosis Mimic. 硬皮病-多发性肌炎重叠综合征是一种潜在的球部肌萎缩性脊髓侧索硬化症模拟病。

Q3 Medicine

Journal of Clinical Neuromuscular Disease

Pub Date : 2024-06-01 DOI: 10.1097/CND.0000000000000467

Alessandra Maccabeo, Emanuela Salustro, Mauro Sanna, Pietro Garau, Maria Antonietta Maioli, Roberta Coa, Monica Puligheddu, Giuseppe Borghero

引用次数: 0

Flail Leg Phenotype in Familial Amyotrophic Lateral Sclerosis: Think of a Cause With Something to Offer. 家族性肌萎缩侧索硬化症的崴脚表型：想想有价值的事业。

Q3 Medicine

Journal of Clinical Neuromuscular Disease

Pub Date : 2024-03-01 DOI: 10.1097/CND.0000000000000471

Saranya B Gomathy, Animesh Das, Achal Kumar Srivastava

引用次数: 0

Sensory-Predominant Trigeminal Neuropathy Secondary to a Cosmetic Liquid Nitrogen Procedure. 继发于液氮美容手术的以感觉为主的三叉神经病变

Q3 Medicine

Journal of Clinical Neuromuscular Disease

Pub Date : 2024-03-01 DOI: 10.1097/CND.0000000000000462

James B Meiling, Nicholas J Miller, Rachana K Gandhi Mehta

引用次数: 0

What Is in the Literature. 文献中的内容

Q3 Medicine

Journal of Clinical Neuromuscular Disease

Pub Date : 2024-03-01 DOI: 10.1097/CND.0000000000000473

Mark B Bromberg

Abstract: This issue of What is in the Literature focuses on the Guillain-Barré syndrome. Guillain-Barré syndrome is a monophasic illness, and there is new information about precipitating factors, changes in nerve conduction studies over time, potential biomarkers, optimal treatment, and features in uncommon patient populations.

摘要：本期《文献综述》聚焦吉兰-巴雷综合征。吉兰-巴雷综合征是一种单相性疾病，关于诱发因素、神经传导研究随时间的变化、潜在的生物标志物、最佳治疗方法以及不常见患者群体的特征等方面都有新的信息。

引用次数: 0

Before SARS-CoV-2 Vaccine is Held Responsible for Guillain-Barre Syndrome, Other Causes Must be Removed From the Table. 在认定 SARS-CoV-2 疫苗是格林-巴利综合征的罪魁祸首之前，必须剔除其他病因。

Q3 Medicine

Journal of Clinical Neuromuscular Disease

Pub Date : 2024-03-01 DOI: 10.1097/CND.0000000000000476

Josef Finsterer

引用次数: 0

Whether Clenbuterol Is Beneficial in Sporadic ALS Can Only Be Answered Through Appropriately Designed Studies. 盐酸克仑特罗是否有益于偶发性渐进性肌萎缩性脊髓侧索硬化症，只有通过适当设计的研究才能得出答案。

Q3 Medicine

Journal of Clinical Neuromuscular Disease

Pub Date : 2024-03-01 DOI: 10.1097/CND.0000000000000475

Josef Finsterer

引用次数: 0

Late Onset of Severe Demyelinating Peripheral Neuropathy in a 62-Year-Old African American Woman. 一名 62 岁非裔美国妇女晚期患上严重脱髓鞘性周围神经病

Q3 Medicine

Journal of Clinical Neuromuscular Disease

Pub Date : 2024-03-01 DOI: 10.1097/CND.0000000000000481

Sasha A Zivkovic, Daniel DiCapua

Abstract: Hereditary neuropathies are typically associated with an early onset of symptoms, but same types of neuropathies may also manifest late, after the age 50 years. A 62-year-old African American woman presented with a 6-year history of gait unsteadiness and has been using a walker since the age 57 years after an unwitnessed fall. Gradual worsening of walking difficulties was later followed by decreased dexterity. The family history was negative for neuromuscular disorders, including neuropathy. On examination, the patient had both distal and proximal weakness with distal sensory loss to all modalities and hyporeflexia. Charcot Marie Tooth Examination Score was 12. Previous electrodiagnostic testing at the age 60 years showed severe sensorimotor demyelinating polyneuropathy with bilateral severe carpal tunnel syndrome. Genetic testing showed a homozygous pathogenic mutation in SH3TC2 gene (c.2860C>T; p.Arg954*), associated with CMT4C. CMT4C is the most common recessive demyelinating sensorimotor polyneuropathy and overall comprises 0.4%-1.7% of all patients with Charcot-Marie-Tooth disease. It is more common in French Canadians and Spanish Roma and in recent natural history study; only 1 of 56 patients was African American. This report demonstrates sporadic occurrence of CMT4C in other ethnic groups as well.

摘要：遗传性神经病通常发病较早，但同样类型的神经病也可能在50岁以后才出现症状。一名 62 岁的非裔美国妇女在一次无目击的跌倒后，出现步态不稳的症状长达 6 年，并从 57 岁开始使用助行器。行走困难逐渐加重，随后出现灵活性下降。家族病史中没有神经肌肉疾病，包括神经病。经检查，患者有远端和近端无力，远端各种感觉缺失，反射减弱。夏科-玛丽牙检查评分为 12 分。之前在 60 岁时进行的电诊断测试显示，患者患有严重的感觉运动脱髓鞘性多发性神经病，并伴有双侧严重的腕管综合征。基因检测显示，SH3TC2 基因存在同卵致病突变（c.2860C>T; p.Arg954*），与 CMT4C 有关。CMT4C 是最常见的隐性脱髓鞘感觉运动性多发性神经病，占所有夏科-玛丽-牙病患者的 0.4%-1.7%。该病在法裔加拿大人和西班牙裔罗姆人中更为常见，在最近的自然史研究中，56 名患者中只有 1 人是非裔美国人。这份报告表明，CMT4C 在其他族裔群体中也有零星发生。

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