Alessandra Consolati, Maria Paola Farinelli, Paolo Serravalle, Christine Rollandin, L. Apprato, Salvatore Bongiorno
Background RSV is the leading cause of hospitalization for respiratory infections in infants, such as bronchiolitis. In the epidemic season 2023-2024, in Valle D’Aosta Region of Italy (VdA) a universal prevention program against RSV was implemented to protect all infants aged less than 6 months with Nirsevimab. Here we present preliminary data as of 15Feb/2023 regarding coverage rate and effectiveness of nirsevimab. Methods Written consent to the administration of Nirsevimab and the processing of health data was obtained from parents. Nirsevimab administration data were extrapolated from electronic health records managed by Health Authority of VdA, while hospitalizations data for RSV bronchiolitis were extrapolated from hospital discharge records of the same VdA. Results Nirsevimab was available for all infants from 20/Dec/2023. Coverage rates were 65% (292/448) for infants born from 1/May/2023 to 18/Dec/2023, and 86% (77/89) for infants born from 20/Dec/2023 to 15/Feb/2024. There have been 29 hospitalizations for RSV bronchiolitis, 18 in infants born after 1/May/2023. In the past epidemic season 2022/2023, on the same date, the number of hospitalizations was 61, of which 47 in children born after 1/May/2022. The prevalence of RSV bronchiolitis hospitalization in infants who did not receive Nirsevimab was 8.3% (14/168), while there were no hospitalizations due to RSV bronchiolitis in infants who received Nirsevimab (0/369), p<0.001 (Fisher’s exact test). Conclusions The high coverage rate and the solid effectiveness results of Nirsevimab in VdA, as already demonstrated in other countries such as US, Spain, France, Luxemburg, may support Italian policy makers in the implementation of RSV prevention program among the entire country in the next year. Further data on safety and effectiveness on full epidemic season will better explain the potential of this prevention programme.
{"title":"Il nirsevimab nella prevenzione della bronchiolite da virus respiratorio sinciziale","authors":"Alessandra Consolati, Maria Paola Farinelli, Paolo Serravalle, Christine Rollandin, L. Apprato, Salvatore Bongiorno","doi":"10.53126/meb43239","DOIUrl":"https://doi.org/10.53126/meb43239","url":null,"abstract":"Background RSV is the leading cause of hospitalization for respiratory infections in infants, such as bronchiolitis. In the epidemic season 2023-2024, in Valle D’Aosta Region of Italy (VdA) a universal prevention program against RSV was implemented to protect all infants aged less than 6 months with Nirsevimab. Here we present preliminary data as of 15Feb/2023 regarding coverage rate and effectiveness of nirsevimab. Methods Written consent to the administration of Nirsevimab and the processing of health data was obtained from parents. Nirsevimab administration data were extrapolated from electronic health records managed by Health Authority of VdA, while hospitalizations data for RSV bronchiolitis were extrapolated from hospital discharge records of the same VdA. Results Nirsevimab was available for all infants from 20/Dec/2023. Coverage rates were 65% (292/448) for infants born from 1/May/2023 to 18/Dec/2023, and 86% (77/89) for infants born from 20/Dec/2023 to 15/Feb/2024. There have been 29 hospitalizations for RSV bronchiolitis, 18 in infants born after 1/May/2023. In the past epidemic season 2022/2023, on the same date, the number of hospitalizations was 61, of which 47 in children born after 1/May/2022. The prevalence of RSV bronchiolitis hospitalization in infants who did not receive Nirsevimab was 8.3% (14/168), while there were no hospitalizations due to RSV bronchiolitis in infants who received Nirsevimab (0/369), p<0.001 (Fisher’s exact test). Conclusions The high coverage rate and the solid effectiveness results of Nirsevimab in VdA, as already demonstrated in other countries such as US, Spain, France, Luxemburg, may support Italian policy makers in the implementation of RSV prevention program among the entire country in the next year. Further data on safety and effectiveness on full epidemic season will better explain the potential of this prevention programme.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"92 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Confrontarsi con l’incertezza a partire dagli originali criteri per adottare uno screening che sono quelli del 1968 di Wilson e Jungner.
从最初的筛选标准，即 1968 年威尔逊和荣格纳提出的标准出发，面对不确定性。
{"title":"Screening e comunicazione","authors":"D. Baronciani","doi":"10.53126/meb43249","DOIUrl":"https://doi.org/10.53126/meb43249","url":null,"abstract":"Confrontarsi con l’incertezza a partire dagli originali criteri per adottare uno screening che sono quelli del 1968 di Wilson e Jungner.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140660425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Italy is the first country in the world to have introduced screening on the entire pediatric population for type 1 diabetes mellitus and celiac disease which will be preceded by a preparatory pilot study in 4 regions and on approximately 5000 children aged 2, 6 and 10 years of age. In this article we will give some practical information on screening and we will try to give the reasons for screening and any doubts, keeping in mind the Wilson and Jungner screening criteria.
{"title":"Screening per diabete mellito tipo 1 e celiachia: intenzioni, pregi e difetti","authors":"G. Tornese, L. Greco","doi":"10.53126/meb43243","DOIUrl":"https://doi.org/10.53126/meb43243","url":null,"abstract":"Italy is the first country in the world to have introduced screening on the entire pediatric population for type 1 diabetes mellitus and celiac disease which will be preceded by a preparatory pilot study in 4 regions and on approximately 5000 children aged 2, 6 and 10 years of age. In this article we will give some practical information on screening and we will try to give the reasons for screening and any doubts, keeping in mind the Wilson and Jungner screening criteria.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"61 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Orsi, Giulia Bini, G. Baroncelli, A. Bonuccelli, D. Peroni
West Nile Virus infection in children may usually occur as a self-limiting febrile illness or rarely as a neuroinvasive disease with possible late neurological sequelae. Therefore, the paediatrician should take into consideration this condition in febrile children who also showed neurological signs or symptoms. Early recognition of the disease and appropriate management may result in a favorable prognosis.
{"title":"Infezione da West Nile Virus","authors":"F. Orsi, Giulia Bini, G. Baroncelli, A. Bonuccelli, D. Peroni","doi":"10.53126/meb43233","DOIUrl":"https://doi.org/10.53126/meb43233","url":null,"abstract":"West Nile Virus infection in children may usually occur as a self-limiting febrile illness or rarely as a neuroinvasive disease with possible late neurological sequelae. Therefore, the paediatrician should take into consideration this condition in febrile children who also showed neurological signs or symptoms. Early recognition of the disease and appropriate management may result in a favorable prognosis.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"62 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
“Occhio” alle sequenze di Pierre-Robin, soprattutto se “dure d’orecchio”
注意 "皮埃尔-罗宾序列，尤其是 "听力不好的人
{"title":"La sindrome di Stickler","authors":"L. Cazzaniga, Michele Abramo, A. Selicorni","doi":"10.53126/meb43251","DOIUrl":"https://doi.org/10.53126/meb43251","url":null,"abstract":"“Occhio” alle sequenze di Pierre-Robin, soprattutto se “dure d’orecchio”","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"58 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140665972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alcuni stati europei hanno introdotto la prevenzione universale con il nirsevimab con risultati favorevoli, così come dimostrerebbe l’esperienza pilota della Valle d’Aosta (pag. 239). Si tratta di definire in modo molto pratico cosa fare nel panorama “nazionale” per la prossima stagione.
{"title":"La profilassi dell'infezione da virus respiratorio sinciziale: dal dire al fare?","authors":"Federico Marchetti","doi":"10.53126/meb43211","DOIUrl":"https://doi.org/10.53126/meb43211","url":null,"abstract":"Alcuni stati europei hanno introdotto la prevenzione universale con il nirsevimab con risultati favorevoli, così come dimostrerebbe l’esperienza pilota della Valle d’Aosta (pag. 239). Si tratta di definire in modo molto pratico cosa fare nel panorama “nazionale” per la prossima stagione.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":"42 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140665871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marialetizia Fantasia, Martha Caterina Faraguna, G. Ferrari, P. Corti
Circa il 20% delle colelitiasi presenta una origine ematologica, non sempre facile da diagnosticare. Una emolisi cronica deve essere sempre ricercata in presenza di calcoli della colecisti, soprattutto in età pediatrica e tra le possibili cause la sferocitosi (spesso misconosciuta) è quella tra le più frequenti.
{"title":"Le colelitiasi a origine ematologica","authors":"Marialetizia Fantasia, Martha Caterina Faraguna, G. Ferrari, P. Corti","doi":"10.53126/meb43187","DOIUrl":"https://doi.org/10.53126/meb43187","url":null,"abstract":"Circa il 20% delle colelitiasi presenta una origine ematologica, non sempre facile da diagnosticare. Una emolisi cronica deve essere sempre ricercata in presenza di calcoli della colecisti, soprattutto in età pediatrica e tra le possibili cause la sferocitosi (spesso misconosciuta) è quella tra le più frequenti.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Badina, Federico Marchetti, Simone Fontijn, I. Berti
The penicillins (amoxicillin) are among the most effective and safe antibiotics for many common bacterial respiratory infections in paediatric age and should be avoided only when a true allergy is highly suspected. Severe true antibiotic allergies are rare and allergies are often overestimated. In high-income countries, 5-15% of patients report a penicillin allergy. However, in most cases (> 95%), these patients do not have a true immunologically mediated allergy and they may very likely tolerate the antibiotic upon a new exposure. All patients defined as allergic should be carefully evaluated and their levels of antibiotic allergy risk determined. In cases of suspected penicillin allergy (e.g. those with cutaneous manifestations), skin tests are not necessary before prescribing a beta-lactam antibiotic (amoxicillin) and direct oral administration can be performed in low-risk phenotypes carefully selected according to simple protocols that do not always require a specialist evaluation. The article, based on the recommendations of the WHO Aware Manual, provides current evidence and practical guidance, and fosters a correct interpretation and management of an overestimated problem that does not promote an optimal and judicious antibiotic use.
{"title":"Allergia agli antibiotici beta-lattamici: i miti da sfatare e le azioni pratiche da adottare","authors":"L. Badina, Federico Marchetti, Simone Fontijn, I. Berti","doi":"10.53126/meb43155","DOIUrl":"https://doi.org/10.53126/meb43155","url":null,"abstract":"The penicillins (amoxicillin) are among the most effective and safe antibiotics for many common bacterial respiratory infections in paediatric age and should be avoided only when a true allergy is highly suspected. Severe true antibiotic allergies are rare and allergies are often overestimated. In high-income countries, 5-15% of patients report a penicillin allergy. However, in most cases (> 95%), these patients do not have a true immunologically mediated allergy and they may very likely tolerate the antibiotic upon a new exposure. All patients defined as allergic should be carefully evaluated and their levels of antibiotic allergy risk determined. In cases of suspected penicillin allergy (e.g. those with cutaneous manifestations), skin tests are not necessary before prescribing a beta-lactam antibiotic (amoxicillin) and direct oral administration can be performed in low-risk phenotypes carefully selected according to simple protocols that do not always require a specialist evaluation. The article, based on the recommendations of the WHO Aware Manual, provides current evidence and practical guidance, and fosters a correct interpretation and management of an overestimated problem that does not promote an optimal and judicious antibiotic use.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lettere","authors":"","doi":"10.53126/meb43149","DOIUrl":"https://doi.org/10.53126/meb43149","url":null,"abstract":"","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":" 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The still culturally widespread belief that girls and women possess an innate ‘maternal instinct’ is often a source of stress and unhappiness when new mothers struggle in caring - and even feeling love - for their newborn, as they experience the burden of social expectations that they should immediately be competent and loving. There is no evidence - either from neuroscience or ethnography and anthropology - that girls and women are ‘naturally predisposed’, differently from men, to care for and love their child. When mothers and fathers (biological or not) spend the same time in caring for and bonding with their child they develop equal competence in care. It is important to support new parents and provide an environment in which they can develop as co-parents and gain confidence in their parenting skills.
{"title":"Il mito dell’istinto materno: madri (e padri) non si nasce, si diventa","authors":"B. Vatta, Annina Lubbock","doi":"10.53126/meb43171","DOIUrl":"https://doi.org/10.53126/meb43171","url":null,"abstract":"The still culturally widespread belief that girls and women possess an innate ‘maternal instinct’ is often a source of stress and unhappiness when new mothers struggle in caring - and even feeling love - for their newborn, as they experience the burden of social expectations that they should immediately be competent and loving. There is no evidence - either from neuroscience or ethnography and anthropology - that girls and women are ‘naturally predisposed’, differently from men, to care for and love their child. When mothers and fathers (biological or not) spend the same time in caring for and bonding with their child they develop equal competence in care. It is important to support new parents and provide an environment in which they can develop as co-parents and gain confidence in their parenting skills.","PeriodicalId":39695,"journal":{"name":"Medico e Bambino","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140209926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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