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Characterizing Prescribing Patterns of Diabetes Medications at an Adult Medicine Clinic: A Focus on Glucagon-Like Peptide 1 Receptor Agonists and Sodium–Glucose Cotransporter 2 Inhibitors 描述一家成人内科诊所的糖尿病药物处方模式:聚焦胰高血糖素样肽 1 受体激动剂和钠-葡萄糖共转运体 2 抑制剂
Q3 Medicine Pub Date : 2024-01-05 DOI: 10.2337/ds22-0095
Ashley N. Shtoyko, Meaghan B. Murphy, Jenna L. Harris, Caitlin Toomey, Elizabeth M. Phillips
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引用次数: 0
Using Community Engagement Methods to Guide Study Protocol Decisions for School-Aged Children With Type 1 Diabetes. 利用社区参与方法指导1型糖尿病学龄儿童的研究方案决策
Q3 Medicine Pub Date : 2024-01-01 Epub Date: 2023-09-08 DOI: 10.2337/ds23-0018
Fayo Abadula, Lori C Jordan, Lauren LeStourgeon, Sarah S Jaser

Introduction: Many challenges exist in developing multisite protocols for newly diagnosed children with type 1 diabetes. Our research team engaged community members to increase the likelihood of study success during a planning grant for a longitudinal study aimed at understanding risk and protective factors for neurocognitive function in school-aged children newly diagnosed with type 1 diabetes.

Methods: Two methods were used to obtain caregiver input into study protocol decisions. The first was a survey given to caregivers of children with diabetes (n = 21) about which aspects of the study protocol would make families more or less likely to participate. The second was a Community Engagement (CE) Studio to obtain recommendations from a diverse group of caregivers of children with diabetes (n = 7) on key aspects of recruitment and enrollment.

Results: Results from both the survey and the CE Studio indicated that caregivers were interested and willing to participate in a longitudinal study of this nature. Both methods resulted in similar preferences for the type and amount of compensation, convenient study visits, flexible scheduling options, and receipt of neurocognitive test results. Recommendations from the CE Studio included additional strategies to minimize participant burden and enhance communication around study participation.

Conclusion: Both the feasibility survey and the CE Studio were useful mechanisms to obtain caregiver input during the study's planning and design phase. Uniquely, the CE Studio approach offers researchers the ability to gain valuable community member input with minimal staff effort.

为新诊断的1型糖尿病儿童制定多站点方案存在许多挑战。我们的研究团队在一项纵向研究的规划拨款期间,让社区成员参与进来,以增加研究成功的可能性,该研究旨在了解新诊断为1型糖尿病的学龄儿童神经认知功能的风险和保护因素。两种方法用于获得护理人员对研究方案决策的投入。第一项是对糖尿病儿童(n=21)的照顾者进行的调查,了解研究方案的哪些方面会使家庭或多或少地参与其中。第二个是社区参与(CE)工作室,从糖尿病儿童(n=7)的不同照顾者那里获得关于招募和登记的关键方面的建议。调查和CE工作室的结果表明,护理人员有兴趣并愿意参与这种性质的纵向研究。这两种方法在补偿类型和金额、方便的研究访问、灵活的日程安排选择以及神经认知测试结果的接收方面都有相似的偏好。CE工作室的建议包括额外的策略,以尽量减少参与者的负担,并加强围绕研究参与的沟通。可行性调查和CE工作室都是在研究的规划和设计阶段获得护理人员意见的有用机制。独特的是,CE Studio方法为研究人员提供了用最少的工作人员努力获得有价值的社区成员投入的能力。
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引用次数: 0
Liraglutide and Robust A1C Reductions Among People With Type 2 Diabetes Requiring Appetite Control: A Review of Two Cases 利拉鲁肽和需要控制食欲的 2 型糖尿病患者的 A1C 显著降低:两个病例的回顾
Q3 Medicine Pub Date : 2023-12-14 DOI: 10.2337/ds23-0052
Mason A. Pitts, Ryanne H. Griggs, Macey R. Hall, McKinley S. Tankersley, Jeremy L. Johnson
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引用次数: 0
A Pragmatic Rethinking of Glucose Monitoring for the Incarcerated 务实地反思对被监禁者的血糖监测
Q3 Medicine Pub Date : 2023-12-05 DOI: 10.2337/ds23-0036
Rebecca E. Luethy, Renee C. Lipinski, Jennifer L. West
Using continuous glucose monitoring (CGM) improves diabetes-related outcomes in the community, yet the fingerstick blood glucose monitoring (BGM) method is the norm in prisons. The purpose of this study was to investigate the safety and patient perceptions of CGM in the carcerate environment, quantify changes in A1C after initiating CGM, and investigate rates of emergency department (ED) visits for diabetes-related complications comparing CGM users to patients using BGM. This pragmatic longitudinal analysis was conducted in two parts. A pilot program was carried out at a single women’s prison. A CGM program was initiated at men’s facilities within a single U.S. state, where A1C change and ED visit rates were investigated. Interested patients at an appropriate security level were invited to use CGM. Pre- and post-CGM surveys of glucose monitoring perceptions were administered during the pilot program. Security and perceptions were analyzed descriptively. A1C change was assessed using a t test. Fisher exact test, Barnard exact test, and post-hoc power analysis were applied to ED visits. Security was not disrupted. Patient perceptions of glucose monitoring improved with CGM use (n = 6). A1C declined by 0.60% with a medium effect size (Cohen’s d −0.45, n = 42). Power to detect a difference in ED visits was low; however, no CGM patients had an ED visit (n = 758). It is safe and efficacious to replace BGM with CGM in prisons when patients are engaged in their care and are at a security level allowing CGM devices in their cells.
在社区中,使用连续血糖监测(CGM)可以改善糖尿病相关的预后,但手指血糖监测(BGM)方法在监狱中仍是常态。本研究的目的是调查在碳化环境中CGM的安全性和患者的认知,量化启动CGM后A1C的变化,并调查CGM使用者与BGM患者的糖尿病相关并发症急诊(ED)就诊率。本文的语用纵向分析分为两部分。在一所女子监狱开展了一项试点方案。一项CGM计划在美国一个州的男性医院启动,调查了A1C变化和ED就诊率。邀请有兴趣且安全等级适当的患者使用CGM。在试点项目中,对cgm前后的血糖监测感知进行了调查。对安全性和感知进行描述性分析。采用t检验评估A1C变化。Fisher精确检验、Barnard精确检验和事后功效分析应用于急诊科就诊。安全没有受到干扰。使用CGM后,患者对血糖监测的感知得到改善(n = 6)。A1C下降0.60%,效果中等(Cohen’s d = - 0.45, n = 42)。在急诊科就诊中发现差异的能力很低;然而,没有CGM患者有ED就诊(n = 758)。在监狱中,当病人正在接受治疗并且处于允许在其牢房中使用CGM装置的安全级别时,用CGM代替BGM是安全有效的。
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引用次数: 0
Nondisclosure of Type 1 Diabetes in Adolescence: A Single-Center Experience 青春期未披露 1 型糖尿病:单中心经验
Q3 Medicine Pub Date : 2023-12-05 DOI: 10.2337/ds23-0006
Judith Nir, A. Liberman, M. Yackobovitch-Gavan, Drora Fraser, Moshe Phillip, Tal Oron
The aim of this study was to assess the extent of nondisclosure of type 1 diabetes in adolescents and investigate its association with several psychosocial parameters and clinical outcomes. This was a cross-sectional study based on data collected from 69 adolescents with type 1 diabetes who were 12–18 years of age and followed at our diabetes clinic. The degree of disclosure, demographics, diabetes management, and psychosocial issues were assessed via questionnaires. Clinical parameters were derived from medical records. Associations between nondisclosure status and clinical and psychosocial study variables were assessed. Fifty-three participants (77%) reported some extent of nondisclosure. Nondisclosure was associated with low self-esteem, reduced friend support, and increased diabetes-related worries. Nondisclosure was also found to be associated with diminished self-care behaviors related to insulin administration and with elevated A1C. Our results demonstrate that nondisclosure of type 1 diabetes in adolescents may be more common than initially recognized and is likely associated with unfavorable psychological outcomes and reduced self-care and diabetes management. Our results emphasize the importance of social interactions and disclosure in adolescents and may serve as a potential stepping stone to address other social barriers hindering diabetes management.
本研究的目的是评估青少年1型糖尿病的保密程度,并调查其与几个社会心理参数和临床结果的关系。这是一项横断面研究,收集了69名12-18岁的1型糖尿病青少年的数据,并在我们的糖尿病诊所进行了随访。通过问卷调查评估披露程度、人口统计、糖尿病管理和社会心理问题。临床参数来源于医疗记录。评估不披露状态与临床和社会心理研究变量之间的关系。53名参与者(77%)表示有一定程度的保密行为。隐瞒与低自尊、减少朋友支持和增加与糖尿病相关的担忧有关。研究还发现,不披露与胰岛素治疗相关的自我护理行为减少和糖化血红蛋白升高有关。我们的研究结果表明,1型糖尿病的隐瞒在青少年中可能比最初认识到的更常见,并且可能与不利的心理结果、自我保健和糖尿病管理的减少有关。我们的研究结果强调了社会互动和披露在青少年中的重要性,并可能作为解决其他阻碍糖尿病管理的社会障碍的潜在垫脚石。
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引用次数: 0
Novel Pharmacy Model: Pharmacy Diabetes Clinic in Abdominal Transplant Recipients 新颖的药房模式:腹部移植受者的糖尿病药房门诊
Q3 Medicine Pub Date : 2023-11-29 DOI: 10.2337/ds23-0025
Helen Sweiss, Reed Hall, Suverta Bhayana, Rupal Patel, Marcus Flores, Christina Long
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引用次数: 0
What Do Adolescents With Type 1 Diabetes Need to Thrive: Perspective of a 16-Year-Old With 4 Years of Experience Living With Type 1 Diabetes 患有 1 型糖尿病的青少年需要怎样才能茁壮成长?一位拥有 4 年 1 型糖尿病生活经验的 16 岁青少年的观点
Q3 Medicine Pub Date : 2023-11-16 DOI: 10.2337/ds23-0024
Nathan J. Bekelman
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引用次数: 0
About Richard M. Bergenstal: Guest Editor 关于Richard M. Bergenstal:客座编辑
Q3 Medicine Pub Date : 2023-11-01 DOI: 10.2337/ds23-ge04
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引用次数: 0
Electronic Health Interventions for Type 2 Diabetes and Obesity in Hispanic or Latino Adults: A Systematic Review of English and Spanish Studies 西班牙或拉丁裔成人2型糖尿病和肥胖的电子健康干预:英语和西班牙语研究的系统回顾
Q3 Medicine Pub Date : 2023-10-16 DOI: 10.2337/ds22-0083
Elizabeth Lorenzo, Alicia Lynn O’Neal, Lisbeth Cantu Garcia, Kenny Mendoza, Rebecca E. Lee
Objective The objective of this study was to synthesize English and Spanish literature to determine whether electronic health interventions (EHIs) such as telehealth, telemedicine, digital health, and mobile health (mHealth) improve A1C, blood glucose, BMI, and/or weight among Hispanic/Latino adults with type 2 diabetes or overweight/obesity in the Americas. Design and methods Searches were conducted in June 2021 using the Scientific Electronic Library Online, Cumulative Index of Nursing and Allied Health Literature, PubMed, and PsycInfo literature databases. Studies were identified that investigated the effect of an EHI on A1C, blood glucose, BMI, or weight in populations that were ≥12% Hispanic/Latino adults with type 2 diabetes or overweight/obesity, were conducted in the Americas, and were published in English or Spanish. Study quality was determined using the Quality Index Score. Data were extracted and synthesized, and themes were identified. Results Twenty-five studies met inclusion criteria, including 23 in English (from the United States) and two in Spanish (from Chile). A total of 22 investigated type 2 diabetes, and three investigated overweight/obesity. The studies encompassed 6,230 participants, including 3,413 Hispanic/Latino adults. Sixty-three percent of studies demonstrated significant improvements in A1C or blood glucose and 67% in weight. Thirteen studies offered an EHI in both English and Spanish, six offered the intervention in either English or Spanish alone. All EHIs involving mHealth exclusively and most (90%) involving more than one electronic modality demonstrated a higher number of significant findings compared with those having only one EHI modality, especially telehealth (44.4%). EHIs lasting ≤12 months had more significant findings (72.7%) than those lasting &gt;12 months (50%). Six studies had industry-related funding, with 83.3% of those demonstrating significant improvements in outcomes. Conclusion EHIs improved A1C and weight in adults (n = 4,355), including 45.5% Hispanic/Latino adults. mHealth and EHIs using more than one electronic modality and those lasting ≤12 months were especially effective. However, overall study quality was modest. Future research should be conducted in Spanish-speaking countries in Latin America and should compare the effectiveness of different EHI modalities.
本研究的目的是综合英语和西班牙语文献,以确定电子健康干预(EHIs)如远程医疗、远程医疗、数字健康和移动健康(mHealth)是否能改善美洲西班牙裔/拉丁裔成人2型糖尿病或超重/肥胖患者的A1C、血糖、BMI和/或体重。设计和方法于2021年6月使用科学电子图书馆在线、护理和相关健康文献累积索引、PubMed和PsycInfo文献数据库进行检索。在美洲进行了以英语或西班牙语发表的研究,研究了EHI对≥12%患有2型糖尿病或超重/肥胖的西班牙裔/拉丁裔成年人的A1C、血糖、BMI或体重的影响。使用质量指数评分来确定研究质量。提取和综合数据,确定主题。结果25项研究符合纳入标准,其中23项为英语(来自美国),2项为西班牙语(来自智利)。共有22名研究了2型糖尿病,3名研究了超重/肥胖。这些研究包括6230名参与者,其中包括3413名西班牙裔/拉丁裔成年人。63%的研究表明糖化血红蛋白或血糖有显著改善,67%的研究表明体重有显著改善。13项研究同时提供英语和西班牙语的EHI, 6项研究只提供英语或西班牙语的干预。所有仅涉及移动医疗的EHI和大多数(90%)涉及一种以上电子模式的EHI,与只有一种EHI模式的EHI,特别是远程医疗(44.4%)相比,显示出更多的重要发现。持续≤12个月的EHIs(72.7%)比持续≤12个月的EHIs(50%)更显著。6项研究获得了与行业相关的资助,其中83.3%的研究表明结果有显著改善。结论EHIs改善了成人(n = 4355)的A1C和体重,其中包括45.5%的西班牙/拉丁裔成年人。使用一种以上电子方式的移动医疗和EHIs以及持续≤12个月的电子医疗尤其有效。然而,总体研究质量一般。未来的研究应在拉丁美洲的西班牙语国家进行,并应比较不同的EHI模式的有效性。
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引用次数: 0
Frequency and Causes of Nocturnal Alarms in Youth and Young Adults With Type 1 Diabetes Using a First-Generation Hybrid Closed-Loop System 使用第一代混合闭环系统研究青年和青年1型糖尿病患者夜间警报的频率和原因
Q3 Medicine Pub Date : 2023-09-19 DOI: 10.2337/ds23-0003
Erin C. Cobry, Tim Vigers, Cari Berget, Laurel H. Messer, R. Paul Wadwa, Laura Pyle, Gregory P. Forlenza
Background Meeting glycemic recommendations is challenging for youth with type 1 diabetes. Diabetes technology, including continuous glucose monitoring (CGM) and hybrid closed-loop (HCL) automated insulin delivery systems, significantly increase achievement of glycemic targets; however, many youth struggle to sustain use of early HCL systems. Nocturnal alarm fatigue contributes to disrupted sleep and device discontinuation. Methods We examined the frequency and causes of nocturnal (10:00 p.m. to 6:00 a.m.) alarms in pediatric patients (N = 76, median age 14.5 years [interquartile range 11.8–17.0 years, range 7–24 years]) starting on a first-generation HCL system in a prospective observational study. Device data were analyzed with linear mixed effects models to examine change across time at 3-month intervals for 12 months. Results At baseline (HCL system in nonautomated mode), participants averaged 3.3 ± 0.6 alarms per night. In the 2 weeks after starting HCL (automated) mode, alarm frequency significantly increased to 5.4 ± 0.5 time per night (P &lt;0.001). Alarm frequency decreased through the remainder of the observational period; however, CGM sensor and HCL system use also declined. The types of alarms were evenly distributed among sensor maintenance, sensor threshold, pump, and HCL-specific alarms. Conclusion These data show that HCL system nocturnal alarms are frequent and may be barriers to sleep quality and device use. Further research is needed to assess the impact of diabetes technology on sleep and to determine method to improve sleep quality with technology use.
背景:对于1型糖尿病青年患者来说,达到血糖推荐值是一项挑战。糖尿病技术,包括连续血糖监测(CGM)和混合闭环(HCL)自动胰岛素输送系统,显著提高了血糖目标的实现;然而,许多年轻人难以维持早期HCL系统的使用。夜间警报疲劳导致睡眠中断和设备中断。方法:在一项前瞻性观察研究中,研究了开始使用第一代HCL系统的儿童患者(N = 76,中位年龄14.5岁[四分位数范围11.8-17.0岁,范围7-24岁])夜间(晚上10:00至早上6:00)报警的频率和原因。使用线性混合效应模型分析设备数据,以每隔3个月检查12个月的时间变化。结果在基线(非自动化模式下的HCL系统),参与者平均每晚报警3.3±0.6次。在启动HCL(自动)模式2周后,报警频率显著增加至每晚5.4±0.5次(P <0.001)。在剩余的观测期内,报警频率下降;然而,CGM传感器和HCL系统的使用也有所下降。告警类型均匀分布在传感器维护告警、传感器阈值告警、泵告警和盐酸告警中。结论HCL系统夜间报警频繁,可能影响睡眠质量和设备使用。需要进一步的研究来评估糖尿病技术对睡眠的影响,并确定使用技术改善睡眠质量的方法。
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引用次数: 0
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Diabetes Spectrum
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