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Hematology and Digital Image Processing: Watershed Transform-Based Methodology for Blood Cell Counting Using the WT-MO Algorithm 血液学和数字图像处理:使用WT-MO算法的基于分水岭变换的血细胞计数方法
Pub Date : 2020-12-07 DOI: 10.26415/2572-004x-vol4iss3p576-576
Ana Carolina Borges Monteiro
Background: Most diseases can be detected by routine examination, even if they are in the initial phase. Currently, one of the most requested medical laboratory tests is that which allows detecting from bacterial infections until leukemias. However, for less favored populations, this examination can be seen as having a high cost. Methods: Thus, this study introduces an algorithm of segmentation of images capable of detecting and counting red blood cells and leukocytes present in digital images of blood smear. The methodology was named by WT-MO, once it relies on the concepts of Watershed Transform and Morphological Operations. The experiments were conducted in the MATLAB software simulation environment, where 25 images were used in order to evaluate the accuracy, processing time, and execution time of the WT-MO algorithm. Results: The results show that the WT-MO methodology presents high accuracy, reaching 96% and 92% in the red blood cell and leukocyte counts, respectively; reliability and low processing time, reaching an average processing time and execution time, achieving from 0.74 to 2.17 seconds. Therefore, the WT-MO algorithm can be seen as the first step in making laboratory tests more accessible to populations in underdeveloped and developing countries. Conclusion: The WT-MO methodology helps not only disadvantaged populations gain access to low-cost, high-reliability tests but also has excellent potential for use in laboratories in developed countries.
背景:大多数疾病可以通过常规检查发现,即使它们处于初期阶段。目前,最需要的医学实验室检测之一是从细菌感染到白血病的检测。然而,对于不太受青睐的人群来说,这种检查的成本很高。因此,本研究引入了一种能够检测和计数血液涂片数字图像中存在的红细胞和白细胞的图像分割算法。该方法曾以分水岭变换和形态运算的概念为基础,被命名为WT-MO。实验在MATLAB软件仿真环境下进行,共使用25张图像,对WT-MO算法的精度、处理时间和执行时间进行评价。结果:WT-MO方法具有较高的准确性,红细胞和白细胞计数分别达到96%和92%;可靠性和低处理时间,达到平均处理时间和执行时间,从0.74秒到2.17秒不等。因此,WT-MO算法可被视为使不发达国家和发展中国家人口更容易获得实验室检测的第一步。结论:WT-MO方法不仅有助于弱势群体获得低成本、高可靠性的检测,而且在发达国家的实验室中也具有极好的使用潜力。
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引用次数: 1
SDR-Based High-Definition Video Transmission for Biomedical Engineering 基于sdr的生物医学工程高清视频传输
Pub Date : 2020-12-07 DOI: 10.26415/2572-004x-vol4iss3p584-585
Vania V. Estrela
Background: Software-Defined Radio (SDR) frameworks from cellular telephone base stations, e.g., Multiservice Distributed Access System (MDAS) and small cells, employ extensively integrated RF agile transceivers. The Internet of Medical Things (IoMT) is the collection of medical devices and applications that connect to healthcare IT systems through online computer networks. Medical devices equipped with Wi-Fi allow M2M communication, which is the backbone of IoMT and associated devices linked to cloud platforms containing stored data to be analyzed. Examples of IoMT include remote patient monitoring of people with chronic or long-term conditions, tracking patient medication orders and the location of patients admitted to hospitals, and patients' wearables to send info to caregivers. Infusion pumps connected to dashboards and hospital beds rigged with sensors measuring patients' vital signs are medical devices that can be converted to or deployed as IoMT technology. Methods: This work proposes an SDR architecture to allow wireless High-Definition (HD) video broadcast for biomedical applications. This text examines a Wideband Wireless Video (WWV) signal chain implementation using the transceivers, the data transmitted volume, the matching occupied RF bandwidth, the communication distance, the transmitter’s power, and the implementation of the PHY layer as Orthogonal Frequency Division Multiplexing (OFDM) with test results to evade RF interference. Results: As the IoMT grows, the amount of possible IoMT uses increases. Many mobile devices employ Near Field Communication (NFC) Radio Frequency Identification (RFID) tags allowing them to share data with IT systems. RFID tags in medical equipment and supplies allow hospital staff can remain aware of the quantities they have in stock. The practice of using IoMT devices to observe patients in their homes remotely is also known as telemedicine. This kind of treatment spares patients from traveling to healthcare facilities whenever they have a medical question or change in their condition. Conclusion: An SDR-based HD biomedical video transmission is proposed, with its benefits and disadvantages for biomedical WWV are discussed. The security of IoMT sensitive data is a developing concern for healthcare providers.
背景:来自蜂窝电话基站的软件定义无线电(SDR)框架,例如,多业务分布式接入系统(MDAS)和小型蜂窝,采用广泛集成的射频敏捷收发器。医疗物联网(IoMT)是通过在线计算机网络连接到医疗IT系统的医疗设备和应用程序的集合。配备Wi-Fi的医疗设备允许作为IoMT骨干的M2M通信,以及与包含存储数据的云平台相连的相关设备进行分析。IoMT的例子包括对患有慢性或长期疾病的人进行远程患者监测,跟踪患者的药物订单和住院患者的位置,以及患者的可穿戴设备向护理人员发送信息。连接到仪表板上的输液泵和装有测量患者生命体征传感器的病床,都是可以转换为或部署为IoMT技术的医疗设备。方法:本工作提出了一种SDR架构,允许无线高清(HD)视频广播用于生物医学应用。本文研究了一个宽带无线视频(WWV)信号链的实现,使用收发器,数据传输量,匹配占用的射频带宽,通信距离,发射机功率,以及将物理层作为正交频分复用(OFDM)的实现,并通过测试结果避免射频干扰。结果:随着IoMT的增加,可能的IoMT使用量增加。许多移动设备采用近场通信(NFC)射频识别(RFID)标签,允许它们与IT系统共享数据。医疗设备和用品中的RFID标签使医院工作人员可以随时了解他们的库存数量。使用IoMT设备在家中远程观察患者的做法也被称为远程医疗。这种治疗方法使患者在有医疗问题或病情发生变化时不必前往医疗机构。结论:提出了一种基于sdr的高清生物医学视频传输方式,并讨论了其在生物医学视频传输中的优缺点。IoMT敏感数据的安全性是医疗保健提供商日益关注的问题。
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引用次数: 2
Removal of Copper from Industrial Wastewater and its Relationship with Wilson's Disease 工业废水中铜的去除及其与威尔森氏病的关系
Pub Date : 2020-06-17 DOI: 10.26415/2572-004x-vol4iss1p504-514
Keniche Assia
Background:Wilson’s illness, or hepatolenticular degeneration, is an autosomal passive issue that outcomes from an accumulation of copper prevalently in the liver and brain. The aggregation is happen because of imperfect biliary discharge of copper. Current information demonstrates that grown-up people need to ingest about 0.75 mg of copper every day to continue a parity. Because of a hereditary imperfection, people with Wilson’s ailment can't discharge the abundance copper, bringing about a progressive develop of copper in the body. Substantial metals are the most hurtful of the concoction toxins and are of specific worry because of their poison levels to people. From this poisonous metal copper, which has impacts in drinking water on the gastrointestinal tract, yet there is some with respect to the drawn out impacts of copper on delicate populaces, for example, bearers of the quality for Wilson’smalady and other metabolic issue of copper homeostasis. Method:We picked as a characteristic adsorbent in this work the Moringa Oleifera Seeds (MOSs) from Mali assortment, which could be a practical and earth safe strategy for water sanitization. All examinations were directed at room temperature, andafter being permitted to represent two hours, the examples were broke down utilizing the Atomic Absorption Spectrophotometer (AAS). The seeds of Moringawere set up by taking around 1 g of the seed squashed and blending it in with around 20 cm3 of water to be decontaminated in three distinct measuring utensils. Result:The different arrangements after filtration, indicated an expanded thickness in the amount of copper, which demonstrates the viability of the cleansing intensity of the seeds of MO. The best consequences of adsorption were for 30 min of contact time. We had half copper evacuation. The impact of contact time is significant in biosorption investigations to decide the harmony time required for the take-up of metal particles by the MOSs. Conclusion:In this investigation, the MOS from Mali were demonstrated to be a proficient regular adsorbent material of copper from fluid arrangements. The limit of the MOS to evacuate copper relies upon numerous models as; plant assortment and states of examinations. Our examination is going on the investigation of evacuation parameters, for example, contact time, pH, temperature, molecule size, sorbent portion, and introductory metal fixation.
背景:Wilson病,或称肝豆状核变性,是一种常染色体被动疾病,由肝脏和大脑中普遍存在的铜积累引起。聚集的发生是由于胆内铜的排出不完全所致。目前的信息表明,成年人每天需要摄入约0.75毫克的铜来维持一个平价。由于遗传缺陷,患有威尔逊病的人不能排出体内丰富的铜,导致体内铜的逐渐增多。大量金属是混合毒素中最有害的,由于它们对人体的毒性水平,因此特别令人担忧。这种有毒的金属铜,在饮用水中对胃肠道有影响,但也有一些关于铜对脆弱人群的长期影响,例如,对威尔森病的质量和铜体内平衡的其他代谢问题的携带者。方法:选用马里品种辣木籽(Moringa Oleifera Seeds, MOSs)作为吸附剂,可作为一种实用且对土壤安全的水处理策略。所有的检查都在室温下进行,允许代表两小时后,使用原子吸收分光光度计(AAS)分解样品。辣木种子的制作方法是,取约1克压碎的辣木种子,将其与约20立方厘米的水混合,在三种不同的测量器具中进行净化。结果:不同的排列方式过滤后,铜量的厚度增加,表明了MO种子净化强度的可行性,吸附效果最好的是接触时间为30 min。我们排出了一半的铜。在生物吸附研究中,接触时间的影响是重要的,以决定苔藓吸收金属颗粒所需的和谐时间。结论:在本研究中,来自马里的MOS被证明是一种熟练的从流体排列中吸附铜的规则材料。MOS抽离铜的极限取决于许多模型,如;植物分类和检验状态。我们的研究正在进行的疏散参数的调查,例如,接触时间,pH值,温度,分子大小,吸附剂的比例,和介绍性金属固定。
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引用次数: 0
Detection of Biofilm Formation of Klebsiella Pneumoniae Isolated from Medical Devices at the University Hospital of Tlemcen, Algeria 阿尔及利亚特莱姆森大学医院医疗器械分离肺炎克雷伯菌生物膜形成的检测
Pub Date : 2020-06-05 DOI: 10.26415/2572-004X-VOL4ISS1P518-519
S. Bellifa
Background: Klebsiella pneumoniae is a major cause of community-acquired and nosocomial infections. This germ is responsible for acute and chronic infections, most of which are due to its ability to adhere to medical implants and form a biofilm. The objective of this work is to study the interaction between clinical isolates of K. pneumoniae and abiotic surfaces (medical devices) and some factors influencing biofilm formation. Methods: Over a period of 2 years, 115 strains of K. pneumoniae were isolated from medical devices CHU Tlemcen, most of which had a high level of resistance to cephalosporins 1st, 2nd, and 3rd generation.  Their capacity to form biofilm was assessed using two 3 techniques: TCP, TP, and RCA.  We determined in vitro the effects of three antimicrobial agents against planktonic and biofilm forms of K. pneumoniae. The presence of MrkD genes was detected by polymerase chain reaction (PCR). Results: According to the studied (TCP, TP, RCA) strains of K .pneumoniae isolated from urinary catheters have proved very good, forming the biofilm to those isolated from other medical devices. 24 of 115 isolated strains showed a clear difference in antibiotic susceptibility between planktonic populations and biofilm populations. They were 10-20 times higher. All strains presented a highly hydrophilic character and adhesion 2-10 times greater in PVC with respect to glass support. The MrkD gene (detected by PCR) responsible for biofilm formation was found in 22 strains of K. pneumoniae, which may explain their adhesion and therefore their pathogenicity. Conclusion: Our results show the great ability of K.pneumoniae strains to form a biofilm on medical devices, and the isolates were at least 10 times more resistant than their planktonic counterparts. In addition, we showed that the presence of type 3-encoding gene mrkD was associated with high adhesion indexes.
背景:肺炎克雷伯菌是社区获得性和医院感染的主要原因。这种细菌是造成急性和慢性感染的原因,其中大多数是由于它能够附着在医疗植入物上并形成生物膜。本研究旨在研究临床分离的肺炎克雷伯菌与非生物表面(医疗器械)的相互作用以及影响生物膜形成的一些因素。方法:在2年的时间里,从医疗器械中分离出115株肺炎克雷伯菌,其中大部分对第1代、第2代和第3代头孢菌素具有较高的耐药水平。采用TCP、TP和RCA两种技术评估其形成生物膜的能力。我们在体外测定了三种抗菌剂对浮游和生物膜形式肺炎克雷伯菌的作用。采用聚合酶链反应(PCR)检测MrkD基因的存在。结果:所研究的从导尿管中分离出的肺炎克雷伯菌(TCP、TP、RCA)与从其他医疗器械中分离出的肺炎克雷伯菌形成的生物膜较好。115株分离菌株中有24株在浮游菌群和生物膜菌群之间表现出明显的抗生素敏感性差异。它们是10-20倍。所有菌株都表现出高度亲水性,在PVC上的附着力比玻璃支架大2-10倍。在22株肺炎克雷伯菌中发现了与生物膜形成有关的MrkD基因(通过PCR检测),这可能解释了它们的粘附性和致病性。结论:肺炎克雷伯菌具有很强的在医疗器械上形成生物膜的能力,其耐药性是浮游克雷伯菌的10倍以上。此外,我们发现3型编码基因mrkD的存在与高粘附指数相关。
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引用次数: 24
Data-Based Risk Assessment of Cancer Diseases for Life insurance 基于数据的人寿保险癌症疾病风险评估
Pub Date : 2019-10-20 DOI: 10.26415/2572-004x-vol3iss3p454-454
R. Lohse
Using US cancer registry data of SEER (Surveillance, Epidemiology, and End Results Program), data based analyses of prevalence, incidence, and survival rates are able for the medical risk assessment in life insurance. Statistical analyses of cancer patients and base population were performed using SEER*Stat from the US National Cancer Institute. The system provides multivariate restrictions of patient groups and subdivisions of outcomes. The lecture focuses on survival time analyses and additional calculations for the outcome of extra mortality rates of cancer patients in relation to base population. Based on these extra mortality rates, principles of underwriting decisions in life insurance will be presented.
利用美国SEER(监测、流行病学和最终结果计划)的癌症登记数据,基于流行率、发病率和存活率的数据分析能够用于人寿保险中的医疗风险评估。使用美国国家癌症研究所的SEER*Stat对癌症患者和基础人群进行统计分析。该系统提供了患者群体和结果细分的多变量限制。讲座的重点是生存时间分析和癌症患者相对于基础人群的额外死亡率结果的额外计算。基于这些额外的死亡率,将提出人寿保险承保决策的原则。
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引用次数: 1
The Assessment of Long-Term-Care, its Quality Assurance and Results -The German Perspective- 长期护理的评估、质量保证和结果——德国视角
Pub Date : 2019-10-20 DOI: 10.26415/2572-004x-vol3iss3p453-453
W. Seger
The consequences of demographic aging caused an impulse for German politics to establish an independent Social Long-Term-Care Insurance in 1995. Since then the assessment for long-term-care became stepwise more comprehensive to cover the bio-psycho-social needs of an increasing part of the population. Nowadays, about 3.3 Million persons receive benefits from this social insurance which help to cover a great part (but not in full) of financial and material support to overcome the impacts of long-term-care. About 2.5 Million persons are assessed every year with continuously increasing tendency by nursing experts working for the Statutory Medical Service mostly performing home visits. They assess the appropriate scores for mobility, cognitive and communicative abilities, behavior, attitudes, habits and psychic problems, self-sufficiency, coping and handling of requirements due to disease and therapy, management of everyday life and maintaining social contacts, adding up to one of 5 grades, the need for technical aids, flat conversion, therapeutic procedures, rehabilitation and educative support. The assessment guidelines and the monitoring of the quality of their realization are presented as well as the outcome for the Long-Term-Care Insurance on the federal level. Twenty-five years of Long-Term-Care Insurance have led to a well established and steadfast insurance but with increasing expenses as well as rising social security contributions to face the challenges of a human and dignified evening of life for an increasing part of the population.
人口老龄化的后果促使德国政界在1995年建立了独立的社会长期护理保险。从那时起,长期护理的评估逐步变得更加全面,以涵盖越来越多的人口的生物、心理和社会需求。如今,约有330万人从这种社会保险中受益,这有助于支付很大一部分(但不是全部)财政和物质支助,以克服长期照料的影响。每年约有250万人接受法定医疗服务机构的护理专家的评估,这一数字呈持续增长的趋势,这些专家主要进行家访。他们评估活动能力、认知和沟通能力、行为、态度、习惯和心理问题、自给自足、应对和处理因疾病和治疗引起的要求、日常生活管理和保持社会联系等方面的适当分数,加起来达到5个等级中的一个,对技术援助的需求、平面转换、治疗程序、康复和教育支持。在联邦一级介绍了长期护理保险的评估准则和实施质量监测以及结果。25年的长期护理保险已经建立了一个完善和稳定的保险,但随着费用的增加以及社会保障缴款的增加,越来越多的人口面临着人类和有尊严的生活的挑战。
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引用次数: 1
Why Software-Defined Radio (SDR) Matters in Healthcare? 为什么软件定义无线电(SDR)在医疗保健中很重要?
Pub Date : 2019-10-20 DOI: 10.26415/2572-004x-vol3iss3p421-429
Vania V. Estrela
Background: Wireless Body Area Networks (WBANs) have been drawing noteworthy academic and industrial attention. A WBAN states a network dedicated to acquire personal biomedical data via cutting-edge sensors and to transmit healthcare-related commands to particular types of actuators intended for health purposes. Still, different proprietary designs exist, which may lead to biased assessments. This paper studies the role of Software-Defined Radio (SDR) in a WBAN system for inpatient and outpatient monitoring and explains to health professionals the importance of the SDR within WBANs. Methods: A concern related to all wireless networks is their dependence on hardware, which limits reprogramming or reconfiguration alternatives. If an error happens in the equipment, firmware, or software, then, typically, there will be no way to fix system vulnerabilities. SDR solves many fixed-hardware problems with other benefits. Results: SDR entails more healthcare domain dynamics with more network convergence in agreement with the stakeholders involved. Then the SDR perspective can bring in innovation to the healthcare subsystems’ interoperability with recombination/reprogramming of their parts, updating, and malleability. Conclusion: SDR technology has many utilizations in radio environments and is becoming progressively more widespread among all kinds of users. Nowadays, there are many frameworks to manipulate radio signals only with a computer and an inexpensive SDR arrangement. Moreover, providing a very cheap radio receiver/transmitter equipment, SDR devices can be merged with free software to simplify the spectrum analyses, provide interferences detection, deliver efficient frequency distribution assignments, test repeaters' operation while measuring their parameters, identify spectrum intruders and characterize noise according to frequency bands.
背景:无线体域网络(wban)已经引起了学术界和工业界的广泛关注。无线宽带网络规定了一个专门通过尖端传感器获取个人生物医学数据的网络,并将与医疗保健有关的命令传输给用于健康目的的特定类型的执行器。尽管如此,不同的专利设计仍然存在,这可能会导致有偏见的评估。本文研究了软件定义无线电(SDR)在WBAN系统中用于住院和门诊监测的作用,并向卫生专业人员解释了SDR在WBAN系统中的重要性。方法:与所有无线网络相关的一个问题是它们对硬件的依赖,这限制了重新编程或重新配置的选择。如果在设备、固件或软件中发生错误,那么通常没有办法修复系统漏洞。SDR解决了许多固定硬件问题,并具有其他优点。结果:SDR需要更多的医疗保健领域动态和更多的网络融合,与相关利益相关者达成一致。然后,SDR视角可以通过对医疗保健子系统部件的重组/重新编程、更新和延展性,为其互操作性带来创新。结论:SDR技术在无线电环境中具有多种用途,并在各类用户中日益普及。目前,有许多框架仅使用计算机和廉价的SDR安排来操纵无线电信号。此外,作为一种非常便宜的无线电接收/发射设备,SDR设备可以与免费软件合并,以简化频谱分析,提供干扰检测,提供有效的频率分配分配,在测量中继器参数时测试其运行,识别频谱入侵者并根据频段表征噪声。
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引用次数: 13
Access to Opioids in Palliative Care in Low-and Middle-Income Countries : The Case of Burkina-Faso -How Can Blockchain and Internet of Things Assist? – 低收入和中等收入国家在姑息治疗中获得阿片类药物:布基纳法索的案例——区块链和物联网如何提供帮助?- - - - - -
Pub Date : 2019-10-20 DOI: 10.26415/2572-004x-vol3iss3p430-442
T. Edoh, Martin Lankoandé
Background: People requesting palliative care or suffering from pain are subjected to adhere to opioid-based treatment in order to alleviate their pain. Commonly, access to opioids is strictly controlled. Access to Healthcare delivery services remains challenging in Low-and Middle-Income Countries (LMIC). In Burkina-Faso (BF), a Sub-Saharan African (SSA) country, patients requiring palliative care (PC) are especially facing poor access to pain drugs such as morphine. Facing poor access to pain-alleviating medicine can severely impact the daily quality of life (QoL). On one hand, patients are experiencing poor opioids access. On another hand opioids abuse, leading to drug addiction is noticed. The question arising here is how can they face poor access and at the same time abuse the given drug? One plausible answer is the counterfeit chain, which provides illegal drugs. Beyond the counterfeit issues faced, the public health care system is also facing, amongst others, prescription falsification, fraud in the distribution, and stock shortage. Method & Design:  Mixed-Method-Design was applied to this study. National stipulations, regulations, and the state-of-the-art in the field of palliative care in BF were investigated and analyzed. Based on the investigation‘s outcomes and following the paradigm of design science research, and information system based improvement solution is proposed to tackle the poor access to opioids, improve the supply and distribution chain as well as to efficiently monitor the consumption of opioids in BF, and prevent patients from any health issues, drug addiction, and death. Objectives: The main objectives are to fight against opioid addiction, counterfeits, a stock shortage, and prevent related health safety issues. The main aim is to enable the traceability of any opioids prescription, secure the supply and distribution, and thus early detect any fraud in the system. This editorial paper would, therefore, focus on investigating the reasons underlying the poor access to opioids in palliative care in BF and make suggestions for improvement. A blockchain (BC) and the Internet of Things (IoT) based system to secure and improve opioids supply, distribution, and prescription will be proposed. Results: The contribution analysis reveals the potential of the proposed model to assist in many ways to improve access to opioids and to secure this access. The model could contribute to preventing drug abuse, overprescription, supporting off-label-use of opioids and thus providing a knowledge database for off-label use of opioids. This model shows promise to deliver accurate data and information about the exact opioid’s needs and consumption atlas. This will assist to better distribute the product in the entire country. A proof-of-concept of the proposed model is required. This is ongoing and will be presented in a forthcoming paper. Conclusion: This editorial paper investigates access to opioids in Burkina Faso. It pointed out b
背景:要求姑息治疗或患有疼痛的人必须坚持以阿片类药物为基础的治疗,以减轻疼痛。通常,获得阿片类药物是受到严格控制的。在低收入和中等收入国家(LMIC),获得医疗保健服务仍然具有挑战性。在撒哈拉以南非洲国家布基纳法索(BF),需要姑息治疗(PC)的患者尤其难以获得吗啡等止痛药。难以获得止痛药会严重影响日常生活质量(QoL)。一方面,患者难以获得阿片类药物。另一方面,阿片类药物滥用,导致吸毒成瘾是值得注意的。这里出现的问题是,他们如何在获得药物的同时又滥用药物?一个合理的答案是提供非法毒品的假冒连锁店。除了面临的假冒问题外,公共卫生保健系统还面临处方伪造、分发欺诈和库存短缺等问题。方法与设计:本研究采用混合方法设计。对国家有关姑息治疗领域的规定、法规和现状进行了调查和分析。根据调查结果,遵循设计科学研究的范式,提出基于信息系统的改进方案,以解决阿片类药物难以获得的问题,改善供应和分销链,有效监测BF中阿片类药物的消耗,防止患者出现任何健康问题,吸毒成瘾和死亡。目标:主要目标是打击阿片类药物成瘾、假药、库存短缺,并预防相关的健康安全问题。其主要目的是实现任何阿片类药物处方的可追溯性,确保供应和分销,从而及早发现系统中的任何欺诈行为。因此,这篇社论将侧重于调查BF姑息治疗中阿片类药物难以获得的原因,并提出改进建议。将提出一个基于区块链(BC)和物联网(IoT)的系统,以确保和改善阿片类药物的供应、分销和处方。结果:贡献分析揭示了所提出的模型在许多方面有助于改善阿片类药物的获取并确保这种获取的潜力。该模型有助于预防药物滥用、过度处方、支持阿片类药物的标签外使用,从而为阿片类药物的标签外使用提供一个知识数据库。该模型有望提供有关阿片类药物确切需求和消费图谱的准确数据和信息。这将有助于在全国更好地分销产品。需要对所建议的模型进行概念验证。这项工作正在进行中,并将在即将发表的一篇论文中提出。结论:这篇社论调查了布基纳法索阿片类药物的获取情况。通过对计算机科学视角的分析,指出了危机产生的不同原因。提供了一个上下文化的模型。需要在现场进行测试。
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引用次数: 1
Are the plants used in Algerian traditional medicine effective? : Assessment of the antibacterial, anti-inflammatory and anti-oxidative effects of three plants used in Algerian traditional medicine; Olea europaea, Glycyrrhiza glabra and Ocimum basilicum 阿尔及利亚传统医学中使用的植物有效吗?阿尔及利亚传统医药中三种植物的抗菌、抗炎和抗氧化作用的评价;油橄榄、光甘草和罗勒
Pub Date : 2019-10-20 DOI: 10.26415/2572-004x-vol3iss3p443-452
Elkolli Meriem, Elkolli Hayet
Background: Algeria has a very large vegetation biodiversity. Algerians use herbs in phytotherapy because of their easy, safe and inexpensive use. However, the consumption of these plants remains uncontrolled or regulated by the authorities, which lacks reassurances concerning their use. Objective: The purpose of this work is to confirm or refute the empirical use of the plants as well as to start adjusting the dosages for each therapeutic purpose. Methods: The present experimentation was done during the year 2017 (April-June) at the laboratory for the valorization of natural biological substances at the University of Setif 1. The in vitro anti-inflammatory effect of Olive and basil leaves and Licorice root aqueous extracts were evaluated against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 25923 by the disc diffusion assay. The in vitro anti-inflammatory activity was realized by the estimation of the protein denaturation of the BSA and the anti-oxidative test was done by the DPPH method. All experiments were done in triplicate and results and were reported as mean ± SD. Data were analyzed by GraphPad prism 5 software; the statistical analysis was done by the one way ANOVA. Results: Olive leaf extract (OLE) and Licorice root extract (LRE) were active on both E. coli (13.5, 10mm) and S. aureus (14, 12mm) at 200 mg/ml. While the Basil leaf extract (BLE) was inactive against all strains. The percentage of BSA denaturation was concentration-dependent by both BLE and LRE and the maximum inhibition was recorded by the OLE at 250 μg/ml, it was slightly different from BLE at P≤0.05, but not significantly different from LRE. The three extracts showed good values of IC50 with 0.65, 4.98 and 0.91 mg/ml OLE, LRE and BLE respectively, but they were inferior to that of BHT. Conclusion: These results confirm the use of these plants but under control.
背景:阿尔及利亚拥有非常大的植被生物多样性。阿尔及利亚人在植物疗法中使用草药,因为它们使用简单、安全、廉价。然而,这些植物的消费仍然不受当局控制或管制,当局对其使用缺乏保证。目的:本研究的目的是证实或反驳这些植物的经验性使用,并开始调整每种治疗目的的剂量。方法:本实验于2017年(4 - 6月)在塞提夫大学天然生物物质增值实验室完成。采用圆盘扩散法评价橄榄叶、罗勒叶和甘草根水提液对大肠杆菌ATCC 25922、铜绿假单胞菌ATCC 27853和金黄色葡萄球菌ATCC 25923的体外抗炎作用。体外抗炎活性通过测定BSA蛋白变性来实现,抗氧化活性通过DPPH法进行。所有实验均为三次重复,结果以均数±标准差报告。数据分析采用GraphPad prism 5软件;统计分析采用单因素方差分析。结果:橄榄叶提取物(OLE)和甘草根提取物(LRE)在200 mg/ml时对大肠杆菌(13.5、10mm)和金黄色葡萄球菌(14、12mm)均有活性。而罗勒叶提取物(BLE)对所有菌株均无活性。BLE和LRE对牛血清白蛋白变性率均呈浓度依赖性,在250 μg/ml时,OLE对牛血清白蛋白变性率的抑制作用最大,与BLE差异较小(P≤0.05),与LRE差异不显著。3种提取物的IC50值分别为0.65、4.98和0.91 mg/ml OLE、LRE和BLE,但均不及BHT。结论:这些结果证实了这些植物的使用,但受到控制。
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引用次数: 1
Report on the International Congress on Health Sciences and Medical Technologies 健康科学和医疗技术国际大会报告
Pub Date : 2019-07-13 DOI: 10.26415/2572-004X-VOL3ISS2P418-419
Abdeldjalil Khelassi, Vania V. Estrela
The International Congress on Health Sciences and Medical Technologies is a periodical congress. It held three times regrouping several researchers and organization active in technology and medical research. With the contribution of universities, research centers, companies and publishers the congress was established at Algerian cities (Tlemcen, Algiers). This report describes the congress achievement through these three past years and announces its’ new edition.
国际健康科学与医疗技术大会是一个定期会议。它举行了三次,重组了一些活跃于技术和医学研究的研究人员和组织。在大学、研究中心、公司和出版商的贡献下,大会在阿尔及利亚的城市(特莱姆森、阿尔及尔)成立。本报告介绍了大会过去三年的成果,并公布了新版报告。
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引用次数: 1
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Medical Technologies Journal
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