Pub Date : 2022-06-27DOI: 10.33533/jrpps.v1i1.4250
A. Septama, Eldiza Puji Rahmi, M.Sc
Streptococcus pyogenes and Staphylococcus epidermidis are major problem of human health and may generate antibacterial resistance problem. Flavonoid has been used for the treatment of several ailments including bacterial infection. Artocarpus heterophyllus is a potential source of flavonoid compounds such as artocarpin and cyanomaclurin. The study was conducted to observe synergistic effects between flavonoid compounds against S. pyogenes and S. epidermidis. The antibacterial activity of combination of artocarpin and cyanomaclurin isolated from A. heterophyllus heartwoods were evaluated against S. pyogenes and S. epidermidis using broth microdilution methods. Interaction between two compounds in combination was determined using checkerboard assay. Artocarpin showed strong antibacterial activity with MIC value of 1.9 µg/mL. Cyanomaclurin only exhibited moderate activity with MIC value of 15.6 µg/mL. The mixture of compounds in several ratios tended to increase antibacterial activities of cyanomaclurin. There is no antagonistic effect when compounds used together. It can be concluded that flavonoid compounds in combination may enhance antibacterial activity to prevent development of antibacterial resistance.
{"title":"SYNERGISTIC EFFECT OF COMBINATION BETWEEN CYANOMACLURIN AND ARTOCARPIN FROM ARTOCARPUS HETEROPHYLLUS HEARTWOODS AGAINSTS STREPTOCOCCUS PYOGENES AND STAPHYLOCOCCUS EPIDERMIDIS","authors":"A. Septama, Eldiza Puji Rahmi, M.Sc","doi":"10.33533/jrpps.v1i1.4250","DOIUrl":"https://doi.org/10.33533/jrpps.v1i1.4250","url":null,"abstract":"Streptococcus pyogenes and Staphylococcus epidermidis are major problem of human health and may generate antibacterial resistance problem. Flavonoid has been used for the treatment of several ailments including bacterial infection. Artocarpus heterophyllus is a potential source of flavonoid compounds such as artocarpin and cyanomaclurin. The study was conducted to observe synergistic effects between flavonoid compounds against S. pyogenes and S. epidermidis. The antibacterial activity of combination of artocarpin and cyanomaclurin isolated from A. heterophyllus heartwoods were evaluated against S. pyogenes and S. epidermidis using broth microdilution methods. Interaction between two compounds in combination was determined using checkerboard assay. Artocarpin showed strong antibacterial activity with MIC value of 1.9 µg/mL. Cyanomaclurin only exhibited moderate activity with MIC value of 15.6 µg/mL. The mixture of compounds in several ratios tended to increase antibacterial activities of cyanomaclurin. There is no antagonistic effect when compounds used together. It can be concluded that flavonoid compounds in combination may enhance antibacterial activity to prevent development of antibacterial resistance.","PeriodicalId":398630,"journal":{"name":"Journal of Research in Pharmacy and Pharmaceutical Sciences","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131519503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-27DOI: 10.33533/jrpps.v1i1.4460
Gladys Imanda Sapoetri, R. Revina, A. Muti
Antibiotic resistance is a global health problem that has severe implications for morbidity, mortality, and health costs. Based on the Antimicrobial Resistant in Indonesia (AMRIN-Study), it was reported that there were bacteria that were resistant to antibiotics, including Escherichia coli, which is resistant to ampicillin trimethoprim-sulfamethoxazole and ciprofloxacin; and Staphylococcus aureus which is resistant to oxacillin, vancomycin, clindamycin, and levofloxacin. In Indonesia, Syzygium polyanthum (Wight) Walp. Bay leaf is one of the plants that is often used as spices. Its bay leaf contains secondary metabolites that have an antibacterial function. This study analyzed the antibacterial activities of bay leaf extract against Staphylococcus aureus and Escherichia coli. This research used a systematic literature review with a literature search strategy using Google Scholar and PubMed. The literature discusses bay leaf extract, Staphylococcus aureus, Escherichia coli, and antibacterial activity. From this study, 14 research articles described the antibacterial activity of bay leaf extract by inhibiting the growth of Staphylococcus aureus and Escherichia coli in the medium, strong, and very strong categories. Bay leaf extract can inhibit the growth of Staphylococcus aureus and Escherichia coli because it contains phytochemical compounds with antibacterial properties, including alkaloids, flavonoids, steroids/ triterpenoids, saponins, tannins, phenols, essential oils, and carbohydrate.
{"title":"ANTIBACTERIAL ACTIVITY TEST OF BAY LEAF EXTRACTS (SYZYGIUM POLYANTHUM (WIGHT) WALP.) AGAINST STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI: SYSTEMATIC LITERATURE REVIEW","authors":"Gladys Imanda Sapoetri, R. Revina, A. Muti","doi":"10.33533/jrpps.v1i1.4460","DOIUrl":"https://doi.org/10.33533/jrpps.v1i1.4460","url":null,"abstract":"Antibiotic resistance is a global health problem that has severe implications for morbidity, mortality, and health costs. Based on the Antimicrobial Resistant in Indonesia (AMRIN-Study), it was reported that there were bacteria that were resistant to antibiotics, including Escherichia coli, which is resistant to ampicillin trimethoprim-sulfamethoxazole and ciprofloxacin; and Staphylococcus aureus which is resistant to oxacillin, vancomycin, clindamycin, and levofloxacin. In Indonesia, Syzygium polyanthum (Wight) Walp. Bay leaf is one of the plants that is often used as spices. Its bay leaf contains secondary metabolites that have an antibacterial function. This study analyzed the antibacterial activities of bay leaf extract against Staphylococcus aureus and Escherichia coli. This research used a systematic literature review with a literature search strategy using Google Scholar and PubMed. The literature discusses bay leaf extract, Staphylococcus aureus, Escherichia coli, and antibacterial activity. From this study, 14 research articles described the antibacterial activity of bay leaf extract by inhibiting the growth of Staphylococcus aureus and Escherichia coli in the medium, strong, and very strong categories. Bay leaf extract can inhibit the growth of Staphylococcus aureus and Escherichia coli because it contains phytochemical compounds with antibacterial properties, including alkaloids, flavonoids, steroids/ triterpenoids, saponins, tannins, phenols, essential oils, and carbohydrate.","PeriodicalId":398630,"journal":{"name":"Journal of Research in Pharmacy and Pharmaceutical Sciences","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117132577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-27DOI: 10.33533/jrpps.v1i1.4046
Kezia Ivana, D. C. Pradana, Citra Ayu Aprilia
Diabetes Mellitus requires long-term management at a considerable cost. Therefore, a cost-Effectiveness analysis was used to assess several health interventions. Biguanide and Sulfonylurea provided the best results at the cheapest cost in this study. This study aims to gain a supporting theoretical foundation regarding the cost-effectiveness of using oral antidiabetic drugs biguanide and sulfonylureas in patients with type 2 diabetes mellitus. The method used in this study is a Narrative Review using literature that discusses the cost-effectiveness of oral antidiabetic drugs biguanide and sulfonylureas in patients with type 2 diabetes mellitus. Based on the results of this study, the age range of the occurrence of Type 2 Diabetes Mellitus is 45-65 years, with more percentage of male patients than women and a common complication is hypertension. In this study, the use of the biguanide drug (Metformin) was shown to provide a significant reduction in blood sugar levels at a reasonably low cost. The ICER results showed that combination drugs increased additional costs, but their use was more effective in healing and improving patients' quality of life. In conclusion to this study, the use of biguanide and sulfonylurea groups proved cost-effective compared to other antidiabetic drugs.
{"title":"NARRATIVE REVIEW: COST-EFFECTIVENESS ANALYSIS OF THE USE OF ORAL ANTIDIABETIC DRUGS BIGUANIDE AND SULFONYLUREA GROUP IN PATIENTS WITH TYPE 2 DIABETES MELLITUS","authors":"Kezia Ivana, D. C. Pradana, Citra Ayu Aprilia","doi":"10.33533/jrpps.v1i1.4046","DOIUrl":"https://doi.org/10.33533/jrpps.v1i1.4046","url":null,"abstract":"Diabetes Mellitus requires long-term management at a considerable cost. Therefore, a cost-Effectiveness analysis was used to assess several health interventions. Biguanide and Sulfonylurea provided the best results at the cheapest cost in this study. This study aims to gain a supporting theoretical foundation regarding the cost-effectiveness of using oral antidiabetic drugs biguanide and sulfonylureas in patients with type 2 diabetes mellitus. The method used in this study is a Narrative Review using literature that discusses the cost-effectiveness of oral antidiabetic drugs biguanide and sulfonylureas in patients with type 2 diabetes mellitus. Based on the results of this study, the age range of the occurrence of Type 2 Diabetes Mellitus is 45-65 years, with more percentage of male patients than women and a common complication is hypertension. In this study, the use of the biguanide drug (Metformin) was shown to provide a significant reduction in blood sugar levels at a reasonably low cost. The ICER results showed that combination drugs increased additional costs, but their use was more effective in healing and improving patients' quality of life. In conclusion to this study, the use of biguanide and sulfonylurea groups proved cost-effective compared to other antidiabetic drugs.","PeriodicalId":398630,"journal":{"name":"Journal of Research in Pharmacy and Pharmaceutical Sciences","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132474374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-27DOI: 10.33533/jrpps.v1i1.4441
Theodora Putri Simanjaya, Erna Harfiani, Mila Citrawati
Dyspepsia is a disease with one or more symptoms relating to abnormalities in gastroduodenal. One of the factors that influence dyspepsia is Helicobacter pylori (H. pylori). Clarithromycin-based triple therapy is recommended as first line eradication treatment. Resistance towards clarithromycin is increasing and causing eradication rates in Clarithromycin-based triple therapy to decrease. The purpose of this study was to determine the effectiveness of triple therapy variation on dyspepsia with H. pylori infection. Data was collected through literature searches on two different databases using the preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) 2020. This systematic review included all relevant articles from 2011-2021. Six studies met the inclusion criteria. The results showed that metronidazole-based triple therapy is effective in eradicating H. pylori due to its eradication rate surpassing the target rate of 80%. The highest eradication rates in intention-to-treat (ITT) and per-protocol (PP) were 94.3% and 93.5%, respectively. The best triple therapy composition is metronidazole-based triple therapy with 7 days of duration.
{"title":"THE EFFECTIVITY OF TRIPLE THERAPY COMPOSITION ON DYSPEPSIA WITH HELICOBACTER PYLORI INFECTION: A SYSTEMATIC REVIEW","authors":"Theodora Putri Simanjaya, Erna Harfiani, Mila Citrawati","doi":"10.33533/jrpps.v1i1.4441","DOIUrl":"https://doi.org/10.33533/jrpps.v1i1.4441","url":null,"abstract":"Dyspepsia is a disease with one or more symptoms relating to abnormalities in gastroduodenal. One of the factors that influence dyspepsia is Helicobacter pylori (H. pylori). Clarithromycin-based triple therapy is recommended as first line eradication treatment. Resistance towards clarithromycin is increasing and causing eradication rates in Clarithromycin-based triple therapy to decrease. The purpose of this study was to determine the effectiveness of triple therapy variation on dyspepsia with H. pylori infection. Data was collected through literature searches on two different databases using the preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) 2020. This systematic review included all relevant articles from 2011-2021. Six studies met the inclusion criteria. The results showed that metronidazole-based triple therapy is effective in eradicating H. pylori due to its eradication rate surpassing the target rate of 80%. The highest eradication rates in intention-to-treat (ITT) and per-protocol (PP) were 94.3% and 93.5%, respectively. The best triple therapy composition is metronidazole-based triple therapy with 7 days of duration.","PeriodicalId":398630,"journal":{"name":"Journal of Research in Pharmacy and Pharmaceutical Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116558398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-27DOI: 10.33533/jrpps.v1i1.4171
I. Prabowo, Arifa Shaliha, Oktania Sandra Puspita
Acne is a skin disease caused by Propionibacterium acnes, Staphylococcus epidermidis-, and Staphylococcus aureus-induced inflammation. Apple cider vinegar contains antibacterial compounds such as acetic acid, chlorogenic acid, polyphenols, alkaloids, flavonoids, and glycosides. This study is conducted to determine the effectiveness of antibacterial compounds contained in apple cider vinegar against the growth of S.epidermidis and P.acnes, in vitro. The study used the disc diffusion method by utilizing the Mueller Hinton Agar medium. The apple cider vinegar inhibition zone was formed at the concentration of 25%, 50%, 75%, and 100% against the growth of P.acnes, whereas the inhibition zone against S.epidermidis was formed at the concentration of 50%, 75%, and 100%. The highest inhibition zone against P. acnes was 8,825 mm and against S.epidermidis was 3,725 mm at the concentration of 75%. Test results One-way ANOVA on P.acnes and Kruskal Wallis to S.epidermidis obtained (p) <0,005. This study concludes the effectiveness of apple cider vinegar in inhibiting the growth of P. acnes and S. epidermidis, where the effectiveness against P. acnes was stronger than against S. epidermidis.
{"title":"ANTIMICROBIAL EFFECTIVENESS OF APPLE CIDER VINEGAR IN THE GROWTH OF Staphylococcus epidermidis and Propionibacterium acnes","authors":"I. Prabowo, Arifa Shaliha, Oktania Sandra Puspita","doi":"10.33533/jrpps.v1i1.4171","DOIUrl":"https://doi.org/10.33533/jrpps.v1i1.4171","url":null,"abstract":"Acne is a skin disease caused by Propionibacterium acnes, Staphylococcus epidermidis-, and Staphylococcus aureus-induced inflammation. Apple cider vinegar contains antibacterial compounds such as acetic acid, chlorogenic acid, polyphenols, alkaloids, flavonoids, and glycosides. This study is conducted to determine the effectiveness of antibacterial compounds contained in apple cider vinegar against the growth of S.epidermidis and P.acnes, in vitro. The study used the disc diffusion method by utilizing the Mueller Hinton Agar medium. The apple cider vinegar inhibition zone was formed at the concentration of 25%, 50%, 75%, and 100% against the growth of P.acnes, whereas the inhibition zone against S.epidermidis was formed at the concentration of 50%, 75%, and 100%. The highest inhibition zone against P. acnes was 8,825 mm and against S.epidermidis was 3,725 mm at the concentration of 75%. Test results One-way ANOVA on P.acnes and Kruskal Wallis to S.epidermidis obtained (p) <0,005. This study concludes the effectiveness of apple cider vinegar in inhibiting the growth of P. acnes and S. epidermidis, where the effectiveness against P. acnes was stronger than against S. epidermidis.","PeriodicalId":398630,"journal":{"name":"Journal of Research in Pharmacy and Pharmaceutical Sciences","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114493933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：