{"title":"THE ELEMENTS OF RETREAT","authors":"","doi":"10.2307/j.ctv1fj84w3.16","DOIUrl":"https://doi.org/10.2307/j.ctv1fj84w3.16","url":null,"abstract":"","PeriodicalId":399045,"journal":{"name":"You Should Leave Now","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130800382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GO YOUR OWN WAY","authors":"","doi":"10.2307/j.ctv1fj84w3.15","DOIUrl":"https://doi.org/10.2307/j.ctv1fj84w3.15","url":null,"abstract":"","PeriodicalId":399045,"journal":{"name":"You Should Leave Now","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113975232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"WHAT DOES (YOUR NAME HERE) WANT?","authors":"","doi":"10.2307/j.ctv1fj84w3.17","DOIUrl":"https://doi.org/10.2307/j.ctv1fj84w3.17","url":null,"abstract":"","PeriodicalId":399045,"journal":{"name":"You Should Leave Now","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129883593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-13DOI: 10.1201/9781439801550.sec1
B. Couple-Famille-Ménages
Background • Tumors attempt to evade the immune system by upregulating CD47, a marker of self. By blocking CD47 interaction with its myeloid cell receptor SIRPα, it may be possible to enhance innate and adaptive immunity against cancer.1 • ALX148 is a fusion protein comprised of an engineered high affinity CD47 binding domain of SIRPα genetically linked to an inactive Fc region of human immunoglobulin (Figure 1).2, 3 • In non clinical models, ALX148 blocks CD47 and safely enhances the activity of several anti-cancer targeted antibodies and checkpoint inhibitors through Fc dependent and independent mechanisms, bridging innate and adaptive anti-cancer immune response.2,3 • Based upon these observations, AT148001, a first-in-human phase 1 study of ALX148 administered as a single agent (Part 1) and in combination with established anticancer antibodies (Part 2) was initiated.
{"title":"PHASE 1:","authors":"B. Couple-Famille-Ménages","doi":"10.1201/9781439801550.sec1","DOIUrl":"https://doi.org/10.1201/9781439801550.sec1","url":null,"abstract":"Background • Tumors attempt to evade the immune system by upregulating CD47, a marker of self. By blocking CD47 interaction with its myeloid cell receptor SIRPα, it may be possible to enhance innate and adaptive immunity against cancer.1 • ALX148 is a fusion protein comprised of an engineered high affinity CD47 binding domain of SIRPα genetically linked to an inactive Fc region of human immunoglobulin (Figure 1).2, 3 • In non clinical models, ALX148 blocks CD47 and safely enhances the activity of several anti-cancer targeted antibodies and checkpoint inhibitors through Fc dependent and independent mechanisms, bridging innate and adaptive anti-cancer immune response.2,3 • Based upon these observations, AT148001, a first-in-human phase 1 study of ALX148 administered as a single agent (Part 1) and in combination with established anticancer antibodies (Part 2) was initiated.","PeriodicalId":399045,"journal":{"name":"You Should Leave Now","volume":"150 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130877073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETREAT, YOUR STYLE","authors":"","doi":"10.2307/j.ctv1fj84w3.8","DOIUrl":"https://doi.org/10.2307/j.ctv1fj84w3.8","url":null,"abstract":"","PeriodicalId":399045,"journal":{"name":"You Should Leave Now","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116956319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THIS MODERN LIFE","authors":"生铁","doi":"10.3138/9781442676619-023","DOIUrl":"https://doi.org/10.3138/9781442676619-023","url":null,"abstract":"“热门软件排行榜”总不如游戏软件排行榜那么好看，很长一段时间，我都把这归罪于软件厂商想象力的匮乏。比如IE5可起名字叫《星际争霸——网际探险》，IE6．0完全可以换个名字叫《魔兽争霸——英特纳之谜》。实际上应用软件能用就好，更何况还不断有新版本的出现来强大、完善其功能。完善的意思也就是更稳定、更方便和更高效率。你不会希望在老板要你半小时内尽快处理完一些文件时对他说：别急，我昨天又换了一套新软件，我要先练习一下。","PeriodicalId":399045,"journal":{"name":"You Should Leave Now","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114999509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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