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An Innovative Surgical Technique to Obtain an Adipose-Derived Stromal Cell-Rich Graft for the Treatment of Osteoarthritis: Technical Note 获得脂肪来源的富含基质细胞移植物治疗骨关节炎的创新外科技术:技术说明
Pub Date : 2023-03-25 DOI: 10.3390/std12020005
L. Ambrosio, F. Russo, Simone Catapano, G. Papalia, G. Vadalà, R. Papalia, V. Denaro
Osteoarthritis (OA) is one of the main causes of disability worldwide and is caused by the progressive degeneration of joint tissues, ultimately leading to chronic pain and loss of function. Intraarticular delivery of mesenchymal stromal cells, such as adipose-derived stromal cells (ASCs), is being actively investigated due to their trophic properties observed in both preclinical and clinical studies. However, cell expansion and handling involve costly and time-consuming processes that limit their application. Recently, several devices and kits have been developed to isolate and process the stromal vascular fraction (SVF), a high biologically active compound of the adipose tissue, right at the patient’s bedside. In this study, we introduce a novel technique to obtain an SVF graft with a high content of ASCs for intraarticular injection directly from liposuction and with minimal equipment. In this technical note, we describe in detail the steps of the surgical technique as well as strategies to avoid common pitfalls and complications.
骨关节炎(OA)是世界范围内致残的主要原因之一,是由关节组织的渐进性退化引起的,最终导致慢性疼痛和功能丧失。由于在临床前和临床研究中观察到间充质基质细胞(如脂肪来源的基质细胞(ASCs))的营养特性,因此正在积极研究其关节内递送。然而,细胞扩增和处理涉及成本高昂且耗时的过程,这限制了它们的应用。最近,已经开发了几种设备和试剂盒来分离和处理基质血管部分(SVF),这是一种高生物活性的脂肪组织化合物,就在患者床边。在本研究中,我们介绍了一种新的技术,通过抽脂和最少的设备直接获得具有高含量ASCs的SVF移植物,用于关节内注射。在本技术说明中,我们详细描述了手术技术的步骤以及避免常见陷阱和并发症的策略。
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引用次数: 0
Lacrimal Gland Prolapse: Case Report 泪腺脱垂1例
Pub Date : 2023-03-08 DOI: 10.3390/std12010004
Ei Ei Naing, Khin Thandar Myint, R. Roddi
Lacrimal gland prolapse is an important diagnosis to consider in patients with lateral upper eyelid fullness. Prolapse of the lacrimal gland is the descent of the lacrimal gland into the upper eyelid. It can result in blepharoptosis and a bulging “frog-eyed” appearance. This is a case report of lacrimal gland prolapse in a 19-year-old female patient treated by suture repositioning of the glands in an outpatient surgical setting. We report on non-recognition of the prolapse and in the absence of essential surgical correction, in addition to the aesthetic disorders often reported, worsening of functional symptoms such as epiphora with major discomfort. Prolapse in young patients has not been reported in the international literature consulted, E&OE.
泪腺脱垂是上眼睑外侧丰满患者需要考虑的重要诊断。泪腺脱垂是指泪腺下降到上眼睑。它会导致上睑下垂和凸起的“蛙眼”外观。这是一例19岁女性患者泪腺脱垂的病例报告,该患者在门诊手术中通过泪腺缝合复位进行治疗。我们报告了脱垂未被识别,在没有必要的手术矫正的情况下,除了经常报告的美学障碍外,功能症状恶化,如口溢和严重不适。在查阅的国际文献、E&OE中,尚未报道年轻患者的脱垂。
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引用次数: 0
Hyperbaric Oxygen Therapy in Plastic, Aesthetic, and Reconstructive Surgery: Systematic Review 高压氧在整形、美容和重建手术中的应用:系统综述
Pub Date : 2023-02-20 DOI: 10.3390/std12010003
Mariana Ríos-Gómez, Viviana Gómez-Ortega, Cesar Cardona, J. A. de la Hoz-Valle
Introduction: Hyperbaric oxygen therapy (HBOT) has been used over the past six decades to treat multiple conditions. This systematic review aims to identify and evaluate the clinical outcomes of hyperbaric oxygen therapy in the field of plastic, reconstructive, and aesthetic surgery, found in the literature from the year 2000 to the present. Methods: A systematic review of the literature focused on the conceptual and methodological aspects of the PRISMA Declaration. The search for clinical trials focused on the results of hyperbaric therapy in plastic, reconstructive, and cosmetic surgery. The Newcastle–Ottawa scale suggested by the Cochrane manual was applied to each study. The study was carried out with a defined protocol and was registered in PROSPERO, with code CRD42022301261. Results: From the 170 articles identified, 6 were selected. Five of them showed that hyperbaric oxygen therapy favored the reduction of the size of skin ulcers and increased the formation of granulation tissue (two trials; p < 0.05), increased the partial pressure of transcutaneous oxygen in patients with free flaps (one trial; p < 0.001), reduced perfusion in keloid scarring disorder (one trial; p < 0.01), and accelerated both the fading of melanin pigmentation and the decrease in age spot size (one trial; p < 0.05). The methodological quality was moderate in all cases because there was no blinding method reported. One study failed to find differences in flap survival, time to resolution of venous congestion, resolution of edema, and postoperative recovery period (p > 0.05). Conclusions: Hyperbaric oxygen therapy has been increasingly used in the field of plastic and reconstructive surgery, and has shown potential benefits in promoting wound healing, reducing the risk of infection, and improving the survival of tissues used in reconstructive procedures. Further research with more rigorous clinical trials is needed to fully understand the efficacy and optimal use of this therapy in the field of plastic and reconstructive surgery.
简介:高压氧治疗(HBOT)在过去的60年里一直被用于治疗多种疾病。本系统综述旨在确定和评估2000年至今文献中高压氧治疗在整形、重建和美容外科领域的临床结果。方法:对文献进行系统回顾,重点关注PRISMA宣言的概念和方法方面。临床试验的搜索集中在整形、重建和美容手术中高压治疗的结果上。Cochrane手册建议的Newcastle–Ottawa量表应用于每项研究。该研究按照规定的方案进行,并在PROSPERO注册,代码CRD42022301261。结果:从已鉴定的170篇文章中,选出6篇。其中5项研究表明,高压氧治疗有利于缩小皮肤溃疡的大小并增加肉芽组织的形成(两项试验;p<0.05),增加游离皮瓣患者的经皮氧分压(一项试验;p<0.001),减少瘢痕疙瘩疤痕障碍的灌注(一项试验;p<0.01),并加速黑色素沉着的消退和年龄斑大小的减小(一项试验;p<0.05)。由于没有盲法报告,所有病例的方法质量都是中等的。一项研究未能发现皮瓣存活率、静脉充血消退时间、水肿消退时间和术后恢复期的差异(p>0.05)。结论:高压氧治疗在整形外科和重建外科领域的应用越来越多,在促进伤口愈合、降低感染风险方面显示出潜在的益处,以及提高重建手术中使用的组织的存活率。需要通过更严格的临床试验进行进一步的研究,以充分了解这种疗法在整形外科和重建外科领域的疗效和最佳用途。
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引用次数: 0
Surgical Strategy for the Treatment of Facial Clefts 面部唇裂的外科治疗策略
Pub Date : 2023-01-25 DOI: 10.3390/std12010002
R. Roddi, Aung Oo, E. Pepe, Ei Naing, S. Sung
Craniofacial clefts have an incidence of 1/700 [...]
颅面裂的发生率为1/700[…]
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引用次数: 0
Upper-Abdominal Cytoreduction for Advanced Ovarian Cancer—Therapeutic Rationale, Surgical Anatomy and Techniques of Cytoreduction 晚期卵巢癌的上腹部细胞减灭术——细胞减灭的治疗原理、手术解剖和技术
Pub Date : 2022-12-21 DOI: 10.3390/std12010001
G. Bhandoria, A. Bhatt, S. Mehta, O. Glehen
Cytoreductive surgery (CRS) is the cornerstone of treating advanced ovarian cancer. Approximately 60–70% of patients with advanced ovarian cancer will have involvement in the upper abdomen or the supracolic compartment of the abdominal cavity. Though the involvement of this region results in poorer survival compared, complete cytoreduction benefits overall survival, making upper-abdominal cytoreduction an essential component of CRS for advanced ovarian cancer. The upper abdomen constitutes several vital organs and large blood vessels draped with the parietal or visceral peritoneum, common sites of disease in ovarian cancer. A surgeon treating advanced ovarian cancer should be well versed in upper-abdominal cytoreduction techniques, including diaphragmatic peritonectomy and diaphragm resection, lesser omentectomy, splenectomy with or without distal pancreatectomy, liver resection, cholecystectomy, and suprarenal retroperitoneal lymphadenectomy. Other procedures such as clearance of the periportal region, Glisson’s capsulectomy, clearance of the superior recess of the lesser sac, and Morrison’s pouch are essential as these regions are often involved in ovarian cancer. This manuscript covers the surgical anatomy of the upper abdomen, the techniques and therapeutic rationale of upper-abdominal cytoreduction, and specific measures for perioperative management of these patients. The main focus is the description of various peritonectomies and regional lymphadenectomies.
细胞减灭术(CRS)是治疗晚期癌症的基石。大约60-70%的晚期癌症患者会累及上腹部或腹腔上腔。尽管与此相比,该区域的受累导致生存率较低,但完全的细胞减少有利于总体生存,使上支配细胞减少成为晚期卵巢癌症CRS的重要组成部分。上腹部由几个重要器官和覆盖着顶腹膜或内脏腹膜的大血管组成,这是癌症常见的发病部位。治疗晚期癌症的外科医生应精通上消化道细胞减少技术,包括膈腹膜切除术和膈切除术、小网膜切除术、脾切除术(包括或不包括远端胰切除术)、肝切除术、胆囊切除术和肾上腹膜后淋巴结切除术。其他程序,如清除门周区域、Glisson囊切除术、清除小囊上隐窝和Morrison囊是必不可少的,因为这些区域通常涉及卵巢癌症。本文涵盖了上腹部的外科解剖,上腹部细胞减少的技术和治疗原理,以及这些患者围手术期管理的具体措施。主要关注的是各种腹膜切除术和区域淋巴结切除术的描述。
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引用次数: 1
The Outcomes of Three Surgical Approaches for Acromioclavicular Dislocation Treatment: Findings from Vietnam 三种手术入路治疗肩锁关节脱位的疗效:来自越南的发现
Pub Date : 2022-11-15 DOI: 10.3390/std11030010
N. X. Thủy, N. M. Tien, Vu Truong Thinh, P. V. Hieu, H. Phan, Dam Minh Duc, Bui Tuan Nghia, Tran Minh Long Trieu, Duong Ngoc Le Mai
Background: Acromioclavicular (AC) dislocation, one of the most common shoulder joint injuries, can be treated by several surgical methods. However, there are still few records about the treatment quality. This study aims to describe the outcomes of three surgical methods for acromioclavicular dislocation treatment at Viet Duc University Hospital, Vietnam. Methods: A cross-sectional study was conducted on 80 patients diagnosed with AC. We retrospectively collected data in the medical records and re-examined the patients. Results: There was no difference between the three groups of surgical approaches relating to the patient’s characteristics, except for the time from the accident to hospital admission. The median length of stay after surgery was highest in the Hook plate group (median (IQR) = 5(2) days), while it was lowest in the K-wire group (median (IQR) = 3(1) days) (p < 0.05). There is statistical significance in the difference of coracoclavicular distance between pre and post-operation in all three surgical method groups (p < 0.001). Conclusion: All of the methods—Hook plate, K-wire, and TightRope—were associated with optimistic outcomes and restored initial anatomy. While the three surgical methods are both safe and effective, the K-wire method is associated with a shorter length of stay and might be economical.
背景:肩锁关节脱位是最常见的肩关节损伤之一,可以通过多种手术方法进行治疗。然而,关于治疗质量的记录仍然很少。本研究旨在描述越南越南杜克大学医院三种治疗肩锁关节脱位的手术方法的结果。方法:对80例确诊为AC的患者进行横断面研究。我们回顾性地收集医疗记录中的数据,并对患者进行复查。结果:除了从事故发生到入院的时间外,三组手术方法与患者的特点无关。钩板组术后中位停留时间最高(中位(IQR)=5(2)天),而K线组术后最低(中位IQR)=3(1)天)(p<0.05),和TightRope——与乐观的结果和恢复的初始解剖结构有关。虽然这三种手术方法都是安全有效的,但K线法的住院时间更短,可能更经济。
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引用次数: 0
Custom-Made 3D Titanium Plate for Mandibular Reconstruction in Surgery of Ameloblastoma: A Novel Case Report 定制三维钛板用于成釉细胞瘤下颌骨重建:一例新报告
Pub Date : 2022-10-31 DOI: 10.3390/std11030009
Somangshu Chakraborty, R. Guha, Sukanya Naskar, R. Banerjee
Ameloblastoma is a benign yet locally invasive odontogenic neoplasm, characterised by slow growth and painless swelling. The treatment for ameloblastoma varies from curettage to en bloc resection, with recurrence commonly occurring. The safety margin of resection is hence essential to avoid recurrence. Understanding the three-dimensional anatomy for reconstruction of mandibular defects after tumour resection often poses problems for head and neck surgeons. Historically, various autografts and alloplastic materials have been used in the reconstruction of these types of defects. Over time, advances in technology with computed tomography scanners and three-dimensional images enhance the surgical planning and management of maxillofacial tumours. The development of new prototyping systems provides accurate 3D biomodels on which surgery can be simulated, especially in cases of ameloblastoma, in which the safety margin is vital for the clinical outcome. The objective of this paper was to report a clinical case of employing these methodologies for reconstruction after an extensive mandibular resection. The clinical outcomes were observed. A case of follicular ameloblastoma of the mandible is depicted in the following paper, where a 3D biomodel was used throughout the surgery. A 3D printed patient-specific titanium implant was manufactured and placed intraoperatively for reconstruction. The treatment had satisfactory postoperative results without complications. Titanium implants being bioinert, customisable and easily workable, especially with the help of 3D virtual planning techniques, can be considered as ideal alloplastic materials for mandibular reconstruction.
成釉细胞瘤是一种良性但局部侵袭性的牙源性肿瘤,其特征是生长缓慢和无痛肿胀。成釉细胞瘤的治疗方法多种多样,从刮宫到整体切除,复发很常见。因此,切除术的安全范围对于避免复发至关重要。了解肿瘤切除后下颌骨缺损重建的三维解剖结构经常给头颈外科医生带来问题。历史上,各种自体移植物和同种异体移植物材料已被用于重建这些类型的缺陷。随着时间的推移,计算机断层扫描扫描仪和三维图像技术的进步增强了颌面肿瘤的手术计划和管理。新原型系统的开发提供了精确的3D生物模型,可以在其上模拟手术,特别是在成釉细胞瘤的情况下,其中安全边际对临床结果至关重要。本文的目的是报告一个应用这些方法在下颌大面积切除术后重建的临床病例。观察临床结果。以下论文描述了一例下颌骨滤泡性成釉细胞瘤,在整个手术过程中使用了3D生物模型。制作了3D打印的患者专用钛植入物,并在术中进行重建。术后治疗效果满意,无并发症。钛植入物具有生物惰性、可定制性和易操作性,特别是在3D虚拟规划技术的帮助下,可以被认为是下颌骨重建的理想同种异体材料。
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引用次数: 2
Clinical Application of 3D Visualization Technology in Pancreatoduodenectomy 三维可视化技术在胰十二指肠切除术中的临床应用
Pub Date : 2022-09-24 DOI: 10.3390/std11030008
Yubo Zhang, Gang Yang, Peng Lei, Dan Zhang
Objective: To explore the surgical effect of three-dimensional (3D) image reconstruction technology in pancreatoduodenectomy. Methods: The clinical records of 47 cases who underwent pancreatoduodenectomy between January 2018 and December 2019 at the department of hepatobiliary surgery of the General Hospital of Ningxia Medical University were retrospectively examined, including 23 males and 24 females, with an average age of 55.00 ± 10.06 years. All patients underwent enhanced computed tomography (CT), and the 3D images were reconstructed by uploading the CT imaging data. The pre-operation evaluation and treatment strategy were planned according to CT imaging and 3D data, respectively. The change of treatment strategy based on 3D evaluation, actual surgical procedure, tumor volume measured by 3D model, actual tumor volume, variants of hepatic artery, operation time, intraoperative blood loss, post-operation hospital stay and post-operation complications was recorded. Results: The treatment strategies were changed after 3D visualization in 10 (21.3%) out of 47 patients because of blood vessel and organ invasion by tumor. The surgical procedure was changed in three cases, and the surgical procedure was optimized and improved in seven cases. All surgical plans based on 3D visualization technology were matched with the actual surgical procedures. Tumor volume measured by 3D model was 19.69 ± 23.47 mL, post-operation actual tumor volume was 17.07 ± 20.29 mL, with no significant difference between them (t = 0.54, p = 0.59). Pearson’s correlation analysis showed statistical significance (r = 0.766, p = 0.00). The average operation time was 4.85 ± 1.75 h, median blood loss volume was 447.05 (50–5000) mL, and post-operation hospital stay was 26.13 ± 11.13 days. Six cases had pancreatic fistula, two cases had biliary leakage, and four cases had delayed gastric emptying. Ascites and pleural effusion was observed in three cases. Conclusions: 3D visualization technology can offer a precise and individualized surgical plan before operation, which might improve the safety of pancreatoduodenectomy, and has application value in preoperative planning.
目的:探讨三维图像重建技术在胰十二指肠切除术中的应用效果。方法:回顾性分析2018年1月至2019年12月在宁夏医科大学总医院肝胆外科接受胰十二指肠切除术的47例患者的临床记录,其中男性23例,女性24例,平均年龄55.00±10.06岁。所有患者都接受了增强型计算机断层扫描(CT),并通过上传CT成像数据重建3D图像。术前评估和治疗策略分别根据CT成像和3D数据进行规划。记录基于3D评估的治疗策略的变化、实际手术过程、3D模型测量的肿瘤体积、实际肿瘤体积、肝动脉变异、手术时间、术中失血、术后住院时间和术后并发症。结果:47例患者中,有10例(21.3%)因肿瘤侵犯血管和器官而改变了治疗策略。3例改变了手术方式,7例优化和改进了手术方式。所有基于三维可视化技术的手术计划都与实际手术程序相匹配。3D模型测量的肿瘤体积为19.69±23.47mL,术后实际肿瘤体积为17.07±20.29mL,两者之间无显著差异(t=0.54,p=0.59)。Pearson相关分析显示具有统计学意义(r=0.766,p=0.00)。平均手术时间为4.85±1.75h,中位失血量为447.05(50-5000)mL,术后住院时间为26.13±11.13天。胰瘘6例,胆漏2例,胃排空延迟4例。腹水和胸腔积液3例。结论:三维可视化技术可以在术前提供精确、个性化的手术方案,提高胰十二指肠切除术的安全性,在术前计划中具有应用价值。
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引用次数: 1
Technical Note on Unilateral Biportal Lumbar Endoscopic Interbody Fusion 单侧双门腰椎内窥镜椎间融合术技术要点
Pub Date : 2022-08-15 DOI: 10.3390/std11020007
Eugene Tze-Chun Lau, P. Wu
Unilateral biportal lumbar endoscopic interbody fusion is a relatively new technique in the field of minimally invasive spine surgery. It combines the benefits of preservation of the normal anatomy of the spine with direct visualization of the decompression of neural elements and endplate preparation for fusion. This results in high union rates and excellent outcomes for patients with back pain and lumbar spinal stenosis from spondylolisthesis while reducing the risk of injuries to the neural elements, endplate fractures and the theoretical rate of adjacent segment disease from disruption of the musculature. In this paper, we describe the steps and technical pearls pertaining to this technique and methods to avoid common pitfalls and complications. In conclusion, this technique would be a good tool in the armamentarium of a spinal surgeon specializing in minimally invasive spinal surgery.
单侧双门腰椎内窥镜椎间融合术是微创脊柱外科领域中一项相对较新的技术。它结合了保存脊柱正常解剖结构的好处,以及神经元件减压和终板融合准备的直接可视化。这为脊椎滑脱引起的背痛和腰椎管狭窄症患者带来了高的愈合率和良好的结果,同时降低了神经元件损伤、终板骨折的风险,以及肌肉组织破坏引起的邻近节段疾病的理论发生率。在本文中,我们描述了与该技术相关的步骤和技术要点,以及避免常见陷阱和复杂性的方法。总之,对于专门从事微创脊柱手术的脊柱外科医生来说,这项技术将是一种很好的工具。
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引用次数: 0
Surgical Ostioplasty of the Left Main Coronary Artery: An Alternative to Coronary Artery Bypass Grafting in the Treatment of Left Main Stem Isolated Ostial Stenosis—A Case Series 左冠状动脉主干外科骨成形术:一种替代冠状动脉旁路移植术治疗左主干孤立性骨狭窄的病例系列
Pub Date : 2022-07-20 DOI: 10.3390/std11020006
Álvaro M. Perazzo, Pedro Rafael Vieira de Oliveira Salerno, Mariana Ferreira Paulino, Vitoria de Ataide Caliari, Isabella Martins Ribeiro, R. Lorusso, Ricardo de Carvalho Lima, P. Salerno
This study aims to demonstrate the use of surgical ostioplasty of the left main coronary artery as an alternative technique to the conventional use of coronary artery bypass grafting for the treatment of left main stem-isolated ostial stenosis. From 2002 to 2021, five patients—three women (60%) and two men (40%)—presented with a history of angina pectoris and were diagnosed with isolated stenosis of the coronary ostia associated with normal distal coronary arteries. Pre-operative cardiac catheterization and echocardiography were performed to aid in the diagnosis. The patients were submitted to surgical ostioplasty with a posterior approach using a saphenous patch. There were no hospital deaths or myocardial infarctions during the post-operative period. The mean cardiopulmonary bypass time was 82 min (range, 70–95 min), and the mean aortic-clamp time was 62 min (range, 55–75 min). The average time of hospitalization was 6.2 days (range, 4–18 days). Patients with isolated stenosis of the coronary ostia associated with normal distal coronary arteries may be submitted to left main coronary artery ostioplasty as an alternative to coronary artery bypass grafting, the traditional surgical technique for this pathology.
本研究旨在证明使用左主干冠状动脉手术成形术作为传统冠状动脉旁路移植术治疗左主干分离性口狭窄的替代技术。从2002年到2021年,5名患者(3名女性(60%)和2名男性(40%))表现出心绞痛病史,并被诊断为与正常远端冠状动脉相关的孤立性冠状动脉口狭窄。术前行心导管检查及超声心动图辅助诊断。患者接受手术成形术,采用后路隐静脉补片。术后无院内死亡或心肌梗死。平均体外循环时间为82分钟(范围70 ~ 95分钟),平均主动脉夹持时间为62分钟(范围55 ~ 75分钟)。平均住院时间6.2天(范围4 ~ 18天)。与正常远端冠状动脉相关的孤立性冠状动脉开口狭窄的患者可以接受左主干冠状动脉成形术,作为冠状动脉旁路移植术的替代方法,这是治疗这种病理的传统手术技术。
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引用次数: 0
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