Pub Date : 2023-09-30DOI: 10.35339/msz.2023.92.3.sss
S.S. Sas
Тhe article analyzes the prevalence of coronary heart disease (CHD) and its surgical treatment by performing coronary bypass surgery off-pump. The purpose of the study was to investigate echocardiography parameters in patients with CHD after off-pump coronary bypass surgery, depending on the number of shunts and their origin. The study included 521 people (416 men, 105 women), their average age was (64.2±3.4). All study participants underwent coronary bypass surgery off-pump. The article analyzes single-, two- and multi-vessel lesions of coronary arteries, paying attention to the origin of shunts. What were used during the provision of coronary bypass surgery off-pump. Attention is paid to echocardiography indicators, which are indicators of heart failure – left ventricular ejection fraction and end-diastolic volume. It has been established that coronary bypass surgery off-pump allows for the elimination of structural features (left ventricular ejection fraction, end-diastolic volume) and there are no restrictions on the number of applied shunts (distal anastomoses). Coronary bypass surgery off-pump is possible in severe clinical conditions of the patient, presence of concomitant pathology and is performed only if the operating surgeon has extensive operational experience. His assistants and the entire hearth team. Thus, it is extremely important to substantiate the indications for performing coronary bypass surgery on a working heart, taking into account the patient's personal characteristics, his age, the number of affected vessels, the structural features of the vascular bed, the functional state of the cardiovascular system and other body systems, which will allow to increase the efficiency surgical treatment of coronary heart disease, extend the duration and improve the quality of life of patients. Keywords: perforation, bleeding, stenosis, penetration, vagotomy, gastric resection.
{"title":"Analysis of predictors of the development of chronic heart failure in pa-tients after coronary bypass on a working heart","authors":"S.S. Sas","doi":"10.35339/msz.2023.92.3.sss","DOIUrl":"https://doi.org/10.35339/msz.2023.92.3.sss","url":null,"abstract":"Тhe article analyzes the prevalence of coronary heart disease (CHD) and its surgical treatment by performing coronary bypass surgery off-pump. The purpose of the study was to investigate echocardiography parameters in patients with CHD after off-pump coronary bypass surgery, depending on the number of shunts and their origin. The study included 521 people (416 men, 105 women), their average age was (64.2±3.4). All study participants underwent coronary bypass surgery off-pump. The article analyzes single-, two- and multi-vessel lesions of coronary arteries, paying attention to the origin of shunts. What were used during the provision of coronary bypass surgery off-pump. Attention is paid to echocardiography indicators, which are indicators of heart failure – left ventricular ejection fraction and end-diastolic volume. It has been established that coronary bypass surgery off-pump allows for the elimination of structural features (left ventricular ejection fraction, end-diastolic volume) and there are no restrictions on the number of applied shunts (distal anastomoses). Coronary bypass surgery off-pump is possible in severe clinical conditions of the patient, presence of concomitant pathology and is performed only if the operating surgeon has extensive operational experience. His assistants and the entire hearth team. Thus, it is extremely important to substantiate the indications for performing coronary bypass surgery on a working heart, taking into account the patient's personal characteristics, his age, the number of affected vessels, the structural features of the vascular bed, the functional state of the cardiovascular system and other body systems, which will allow to increase the efficiency surgical treatment of coronary heart disease, extend the duration and improve the quality of life of patients. Keywords: perforation, bleeding, stenosis, penetration, vagotomy, gastric resection.","PeriodicalId":404961,"journal":{"name":"Медицина сьогодні і завтра","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135126638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.35339/msz.2023.92.2.bak
A.D. Barkovska
The aim of the study was to determine how well Ukrainian women perceive and understand information provided at the dentist’s depending on educational level, to assess the role of vocabulary on dental-patient communication. Data for analysis were collected by questionnaire from 358 women aged 18–75 years from Poltava and Zaporizhzhia regions. The questionnaire consisted of 19 questions, 5 of which were taken from the Modified Scale of Dental Anxiety, the others were determined by the authors. The obtained results were statistically processed. The respondents’ characteristics in this study are as follows: with higher education (65.6%), with special secondary (25%) and upper secondary education (9.4%). It was found that 6% of the respondents’ have dentophobia; 12% – high anxiety, and 21% – moderate anxiety; 62% – low anxiety. The impact of medical vocabulary on communication is assessed by respondents as "negative" by 30% and "positive" by 28% of respondents. Unfamiliar words cause "more trust" in 60%, 40%, 36% of the participants, "more anxiety" in 38%, 53%, and 56% of women with upper secondary, special secondary, higher education respectively. The level of availability of the words "endodontic treatment" naturally increases with increasing level of education: the option `do not understand` in groups upper secondary, special secondary, higher education has chosen 88%, 76%, 61% of respondents, respectively. To conclude, high dental anxiety level and dentophobia are more prevalent among respondents with special secondary and higher education. Dentists should minimize the presence of medical terms during their conversations with patients, especially low educational patients. These steps should positively affect dentist-patient communication and psychological aspects of dental treatment in total. Keywords: dental care, medication adherence, psychometrics, surveys and questionnaires.
{"title":"Influence of educational level on dental anxiety and understanding special medical vocabulary in women","authors":"A.D. Barkovska","doi":"10.35339/msz.2023.92.2.bak","DOIUrl":"https://doi.org/10.35339/msz.2023.92.2.bak","url":null,"abstract":"The aim of the study was to determine how well Ukrainian women perceive and understand information provided at the dentist’s depending on educational level, to assess the role of vocabulary on dental-patient communication. Data for analysis were collected by questionnaire from 358 women aged 18–75 years from Poltava and Zaporizhzhia regions. The questionnaire consisted of 19 questions, 5 of which were taken from the Modified Scale of Dental Anxiety, the others were determined by the authors. The obtained results were statistically processed. The respondents’ characteristics in this study are as follows: with higher education (65.6%), with special secondary (25%) and upper secondary education (9.4%). It was found that 6% of the respondents’ have dentophobia; 12% – high anxiety, and 21% – moderate anxiety; 62% – low anxiety. The impact of medical vocabulary on communication is assessed by respondents as \"negative\" by 30% and \"positive\" by 28% of respondents. Unfamiliar words cause \"more trust\" in 60%, 40%, 36% of the participants, \"more anxiety\" in 38%, 53%, and 56% of women with upper secondary, special secondary, higher education respectively. The level of availability of the words \"endodontic treatment\" naturally increases with increasing level of education: the option `do not understand` in groups upper secondary, special secondary, higher education has chosen 88%, 76%, 61% of respondents, respectively. To conclude, high dental anxiety level and dentophobia are more prevalent among respondents with special secondary and higher education. Dentists should minimize the presence of medical terms during their conversations with patients, especially low educational patients. These steps should positively affect dentist-patient communication and psychological aspects of dental treatment in total. Keywords: dental care, medication adherence, psychometrics, surveys and questionnaires.","PeriodicalId":404961,"journal":{"name":"Медицина сьогодні і завтра","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.35339/msz.2023.92.2.aky
K.Yu. Andrienko
Successful dental rehabilitation of a patient with complete removable dentures depends not only on a number of features of the selected design and clinical conditions of the patient's prosthetic area. Also on the manufacturing technology of the materials used for its manufacture. The purpose of our study was a comparative assessment of the physical and mechanical properties of doped packing materials for removable denture structures using an improved method. An alloyed packing material based on gypsum and supergypsum, modified with nitrile rubber latexes and organosilicon emulsion, was developed. The selected modifiers differ in their structure, group polarity and lyophilicity. The comparative analysis of the quality of auxiliary dental materials included a generalization of the results of a laboratory study of the physical and mechanical properties of various types of plaster. In the system of qualitative assessment of plasters, the indicative properties of auxiliary materials were investigated: "ORTHOGYPS", "Gypsum highness type 10", "Base Stone", provided by ISO 6873, which are divided by us into technological (defining features of the material packaging process) and physical and mechanical (total working time, structuring time, relative expansion during structuring, relative expansion after structuring, compressive strength, linear shrinkage). As a result, it was determined that the developed modified components of the alloy packing material, in turn, provided acceptable accuracy of the base of the removable dentures, which corresponded to the working model due to the improvement of the physical and mechanical properties of the packing material and, as a result, improved manufacturability of removable orthopedic structures of dental prostheses. Keywords: orthopedic treatment, physical and mechanical properties, complete removable dentures, modifier, gypsum mixture.
{"title":"Comparative assessment of physical and mechanical indicators of packing materials of complete removable dentures","authors":"K.Yu. Andrienko","doi":"10.35339/msz.2023.92.2.aky","DOIUrl":"https://doi.org/10.35339/msz.2023.92.2.aky","url":null,"abstract":"Successful dental rehabilitation of a patient with complete removable dentures depends not only on a number of features of the selected design and clinical conditions of the patient's prosthetic area. Also on the manufacturing technology of the materials used for its manufacture. The purpose of our study was a comparative assessment of the physical and mechanical properties of doped packing materials for removable denture structures using an improved method. An alloyed packing material based on gypsum and supergypsum, modified with nitrile rubber latexes and organosilicon emulsion, was developed. The selected modifiers differ in their structure, group polarity and lyophilicity. The comparative analysis of the quality of auxiliary dental materials included a generalization of the results of a laboratory study of the physical and mechanical properties of various types of plaster. In the system of qualitative assessment of plasters, the indicative properties of auxiliary materials were investigated: \"ORTHOGYPS\", \"Gypsum highness type 10\", \"Base Stone\", provided by ISO 6873, which are divided by us into technological (defining features of the material packaging process) and physical and mechanical (total working time, structuring time, relative expansion during structuring, relative expansion after structuring, compressive strength, linear shrinkage). As a result, it was determined that the developed modified components of the alloy packing material, in turn, provided acceptable accuracy of the base of the removable dentures, which corresponded to the working model due to the improvement of the physical and mechanical properties of the packing material and, as a result, improved manufacturability of removable orthopedic structures of dental prostheses. Keywords: orthopedic treatment, physical and mechanical properties, complete removable dentures, modifier, gypsum mixture.","PeriodicalId":404961,"journal":{"name":"Медицина сьогодні і завтра","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136370539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.35339/msz.2023.92.2.mkd
O. Mytchenok, Yu. Kilmukhametova, I. Drozda, O. Soltys, M. Mytchenok
The educational process is a significant part of specialists' formation in medicine, including dentistry. Seekers of medical education in universities need the support and guidance of highly specialized teachers for their future realization as professionals. However, it is equally important for the students to be interested in successfully mastering the disciplines in different ways, from classroom work to independent projects. On the difficult student path of becoming a dentist, a teacher who can direct their ward in the right direction in the field of dental practice play a considerable role. Additionally, it is important to provide students with a high-quality theoretical base in university departments, modern clinical equipment for polishing professional practical skills, and constant support in the form of consultations, lectures, and master classes from leading specialists of the higher education institution. General medical disciplines are also a significant component of the educational program of dental students, as these subjects provide basic medical knowledge. Without mastering the materials of these disciplines, it will be difficult for the future dentist to integrate into the general field of medical practice. To fully understand and assimilate the material and topics during the lectures and classes, students need to be interested in learning more than what is prescribed in the curriculum of the educational program of the dental specialty; since this area of medicine is undergoing rapid development today. Therefore, such a type of activity as independent work is introduced in the student's curriculum. This type of work for students majorly contributes to improving discipline on the one hand and increases the ability of clinical thinking of future dentists on the other. The article is written in the form of a short scientific report. Keywords: clinical practice, independent work, practical skills, education seeker, practical classes.
{"title":"Practical training of the 5th-year students in clinical departments","authors":"O. Mytchenok, Yu. Kilmukhametova, I. Drozda, O. Soltys, M. Mytchenok","doi":"10.35339/msz.2023.92.2.mkd","DOIUrl":"https://doi.org/10.35339/msz.2023.92.2.mkd","url":null,"abstract":"The educational process is a significant part of specialists' formation in medicine, including dentistry. Seekers of medical education in universities need the support and guidance of highly specialized teachers for their future realization as professionals. However, it is equally important for the students to be interested in successfully mastering the disciplines in different ways, from classroom work to independent projects. On the difficult student path of becoming a dentist, a teacher who can direct their ward in the right direction in the field of dental practice play a considerable role. Additionally, it is important to provide students with a high-quality theoretical base in university departments, modern clinical equipment for polishing professional practical skills, and constant support in the form of consultations, lectures, and master classes from leading specialists of the higher education institution. General medical disciplines are also a significant component of the educational program of dental students, as these subjects provide basic medical knowledge. Without mastering the materials of these disciplines, it will be difficult for the future dentist to integrate into the general field of medical practice. To fully understand and assimilate the material and topics during the lectures and classes, students need to be interested in learning more than what is prescribed in the curriculum of the educational program of the dental specialty; since this area of medicine is undergoing rapid development today. Therefore, such a type of activity as independent work is introduced in the student's curriculum. This type of work for students majorly contributes to improving discipline on the one hand and increases the ability of clinical thinking of future dentists on the other. The article is written in the form of a short scientific report.\u0000\u0000Keywords: clinical practice, independent work, practical skills, education seeker, practical classes.","PeriodicalId":404961,"journal":{"name":"Медицина сьогодні і завтра","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.35339/msz.2023.92.2.zab
I.I. Zabolotna
In press Biofilm is a predominant growth form of a greater number of microorganisms in the oral cavity that has the differences in physiology and genetics compared to planktonic forms. It requires a review of methods of the diagnostics and management of patients with the diseases caused by dental biofilms. The literature review was conducted with the aim of summarizing modern scientific information related to the control of its formation and evaluation of means for disorganization and regulation that are used in clinical dentistry. Based on the results of these studies a close relationship between the level of hygiene and the microbiological state of the oral cavity has been justified. Carrying out individual and professional hygiene is an important component in the comprehensive treatment of dental patients. It has been proven that the pathogenicity of the dental biofilm can be significantly reduced by breaking the integrity of its structure and restoring the normal microflora with the help of high-quality professional hygiene. But long-term uncontrolled use of personal hygiene products can cause some changes in the quality of the microbiome of the oral cavity. Modern research is aimed at disorganization of the biofilm matrix by pharmaceutical and non-pharmacological means. But its destruction can lead to the release of living microorganisms and the dissemination of the pathogen. The presented results of the use of different groups of means for normalizing the microflora of the oral cavity have both advantages and disadvantages that requires further discussion. Qualitative control over the development of dental biofilm will permit to anticipate the course of teeth diseases and periodontal tissues, and objectively assess the effectiveness of the prescribed treatment. Conducting a microbiological study of the biocenosis of the oral cavity will be the basis for choosing personal hygiene products and implementing timely measures. All this will further contribute to increase in the efficiency of prevention and management of pathology of the teeth. Keywords: microorganisms, оral cavity, biofilm, hygiene.
{"title":"Dental biofilm: control of formation, disorganization and means of regulation","authors":"I.I. Zabolotna","doi":"10.35339/msz.2023.92.2.zab","DOIUrl":"https://doi.org/10.35339/msz.2023.92.2.zab","url":null,"abstract":"In press Biofilm is a predominant growth form of a greater number of microorganisms in the oral cavity that has the differences in physiology and genetics compared to planktonic forms. It requires a review of methods of the diagnostics and management of patients with the diseases caused by dental biofilms. The literature review was conducted with the aim of summarizing modern scientific information related to the control of its formation and evaluation of means for disorganization and regulation that are used in clinical dentistry. Based on the results of these studies a close relationship between the level of hygiene and the microbiological state of the oral cavity has been justified. Carrying out individual and professional hygiene is an important component in the comprehensive treatment of dental patients. It has been proven that the pathogenicity of the dental biofilm can be significantly reduced by breaking the integrity of its structure and restoring the normal microflora with the help of high-quality professional hygiene. But long-term uncontrolled use of personal hygiene products can cause some changes in the quality of the microbiome of the oral cavity. Modern research is aimed at disorganization of the biofilm matrix by pharmaceutical and non-pharmacological means. But its destruction can lead to the release of living microorganisms and the dissemination of the pathogen. The presented results of the use of different groups of means for normalizing the microflora of the oral cavity have both advantages and disadvantages that requires further discussion. Qualitative control over the development of dental biofilm will permit to anticipate the course of teeth diseases and periodontal tissues, and objectively assess the effectiveness of the prescribed treatment. Conducting a microbiological study of the biocenosis of the oral cavity will be the basis for choosing personal hygiene products and implementing timely measures. All this will further contribute to increase in the efficiency of prevention and management of pathology of the teeth. Keywords: microorganisms, оral cavity, biofilm, hygiene.","PeriodicalId":404961,"journal":{"name":"Медицина сьогодні і завтра","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the study is to assess the possibility of applying the calliperometric method to assess the physical development of children of primary school age who have chronic diseases in the stage of compensation. The research was carried out during 2017–2022 on the basis of the clinical units of the ONMedU. 120 children of primary school age were examined, including 30 – practically healthy (control group), 30 – from the group of frequently and long-term patients (Group I), 30 – from the number of children with congenital heart defects without signs of heart failure (Group II), and 30 – with signs of alimentary and constitutional obesity (III group). The physical development of children of primary school age was evaluated based on the results of anthroposcopic, anthropometric and physiometric indicators according to national standards of physical development. The assessment of body composition components (fat and lean body mass) was carried out according to Saunders R. in the modification of Velichko V.I., etc. The research was carried out in compliance with modern bioethical requirements, the children's parents signed a voluntary consent for the children's participation in the research. Statistical processing was carried out by methods of variance analysis using MS Excel software. It has been shown that obese primary school-age children have a body fat mass of (18.8±0.8)% for boys and (19.7±0.9)% for girls. In children of primary school age with normal body weight, in the presence of chronic diseases, body fat decreases by (10–15)%. Caliperometric method can be used to assess the physical development of children of primary school age who have chronic diseases in the stage of compensation. Keywords: prevention, primary school age, body weight, assessment of fat deposition, chronic diseases.
{"title":"Caliperometry as a tool for assessing children's physical development","authors":"O.L. Plakida, R.S. Vastyanov, O.V. Goroshkov, K.V. Ostapchuk, Ph.M. Matyushenko","doi":"10.35339/msz.2023.92.2.pvg","DOIUrl":"https://doi.org/10.35339/msz.2023.92.2.pvg","url":null,"abstract":"The purpose of the study is to assess the possibility of applying the calliperometric method to assess the physical development of children of primary school age who have chronic diseases in the stage of compensation. The research was carried out during 2017–2022 on the basis of the clinical units of the ONMedU. 120 children of primary school age were examined, including 30 – practically healthy (control group), 30 – from the group of frequently and long-term patients (Group I), 30 – from the number of children with congenital heart defects without signs of heart failure (Group II), and 30 – with signs of alimentary and constitutional obesity (III group). The physical development of children of primary school age was evaluated based on the results of anthroposcopic, anthropometric and physiometric indicators according to national standards of physical development. The assessment of body composition components (fat and lean body mass) was carried out according to Saunders R. in the modification of Velichko V.I., etc. The research was carried out in compliance with modern bioethical requirements, the children's parents signed a voluntary consent for the children's participation in the research. Statistical processing was carried out by methods of variance analysis using MS Excel software. It has been shown that obese primary school-age children have a body fat mass of (18.8±0.8)% for boys and (19.7±0.9)% for girls. In children of primary school age with normal body weight, in the presence of chronic diseases, body fat decreases by (10–15)%. Caliperometric method can be used to assess the physical development of children of primary school age who have chronic diseases in the stage of compensation. Keywords: prevention, primary school age, body weight, assessment of fat deposition, chronic diseases.","PeriodicalId":404961,"journal":{"name":"Медицина сьогодні і завтра","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.35339/msz.2019.85.04.05
E. Sid, O. Soloviov
One of the important problems of modern medicine is the continuous increase of cardiovascular disease. An urgent problem at the present stage is the treatment of patients with acute forms of coronary heart disease, since vascular accidents are the leading causative factors of mortality from cardiovascular disease. Recently, an increasing number of studies have determined the role of genetic markers for predicting the adverse course of various cardiovascular diseases, including acute myocardial infarction. The distribution of genes markers of systemic inflammatory responses was determined in patients with STEMI. There are riteria for inclusion in the study: male and female patients from 46 to 75 years old; for postmenopausal women, more than 1 year; the presence of STEMI in the first 12 hours of the onset of the disease; informed consent of the patient to participate in the study. DNA was isolated from leukocytes from whole blood using the Express DNA Blood Kit (Litech). In the process of DNA extraction, the recommendations given in the kit instructions were followed. SNP polymorphisms of C-reactive protein genes were determined G-3014>A, tumor necrosis factor-α G-308>A, interleukin-10 G-1082>A by real-time polymerase chain reaction using a Rotor-Gene 6000 thermocycler (Corbett Research, Australia). The structure of the primers from the standard SNP-express-PB sets (Litech) was used. It was determined, that in patients with STEMI, an increase in the proportion of homozygotes (GG) and a decrease in heterozygotes (GA) of the genotypes of the G-3014>A polymorphism of the C-reactive protein gene are determined in comparison with the Hardy–Weinberg distribution. Polymorphism G-308>A of the tumor necrosis factor-α gene among patients with STEMI had a significant discrepancy with Hardy–Weinberg equilibrium, with an increase in the proportion of homozygotes (GG) and a decrease in heterozygotes (GA) and homozygotes (AA). The distribution of G-1082>A polymorphism of the interleukin-10 gene was characterized by an increase in the proportion of homozygotes (GG) and a decrease in heterozygotes (GA) in patients with STEMI compared to the Hardy–Weinberg distribution.
{"title":"Distribution of genotypes polymorphisms of genes markers of systemic inflammatory response among patients with STEMI","authors":"E. Sid, O. Soloviov","doi":"10.35339/msz.2019.85.04.05","DOIUrl":"https://doi.org/10.35339/msz.2019.85.04.05","url":null,"abstract":"One of the important problems of modern medicine is the continuous increase of cardiovascular disease. An urgent problem at the present stage is the treatment of patients with acute forms of coronary heart disease, since vascular accidents are the leading causative factors of mortality from cardiovascular disease. Recently, an increasing number of studies have determined the role of genetic markers for predicting the adverse course of various cardiovascular diseases, including acute myocardial infarction. The distribution of genes markers of systemic inflammatory responses was determined in patients with STEMI. There are riteria for inclusion in the study: male and female patients from 46 to 75 years old; for postmenopausal women, more than 1 year; the presence of STEMI in the first 12 hours of the onset of the disease; informed consent of the patient to participate in the study. DNA was isolated from leukocytes from whole blood using the Express DNA Blood Kit (Litech). In the process of DNA extraction, the recommendations given in the kit instructions were followed. SNP polymorphisms of C-reactive protein genes were determined G-3014>A, tumor necrosis factor-α G-308>A, interleukin-10 G-1082>A by real-time polymerase chain reaction using a Rotor-Gene 6000 thermocycler (Corbett Research, Australia). The structure of the primers from the standard SNP-express-PB sets (Litech) was used. It was determined, that in patients with STEMI, an increase in the proportion of homozygotes (GG) and a decrease in heterozygotes (GA) of the genotypes of the G-3014>A polymorphism of the C-reactive protein gene are determined in comparison with the Hardy–Weinberg distribution. Polymorphism G-308>A of the tumor necrosis factor-α gene among patients with STEMI had a significant discrepancy with Hardy–Weinberg equilibrium, with an increase in the proportion of homozygotes (GG) and a decrease in heterozygotes (GA) and homozygotes (AA). The distribution of G-1082>A polymorphism of the interleukin-10 gene was characterized by an increase in the proportion of homozygotes (GG) and a decrease in heterozygotes (GA) in patients with STEMI compared to the Hardy–Weinberg distribution.","PeriodicalId":404961,"journal":{"name":"Медицина сьогодні і завтра","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129722645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.35339/msz.2019.85.04.06
S. Yarova, A. Komlev, O. Genzytska, S. Turchenenko, Y. Yarov
The results of studies of elastic cushioning materials in removable plate prostheses are presented. Negative role in the mechanism of the rapid aging of the elastic material of functional loads, causing compression, relatively higher than the reversible deformation of materials is shown. The technique of constructing elastic pads with removable plate denture prosthetics is proposed. Clinical assessment of durability of the elastic-elastic pads in the removable plate denture is carried out. In order to preserve the properties of elastic strips, dentures constructed so that the sealing materials during the function did not experience the load exceeds the value of their relatively reversible deformation. It is determined that the presence of prostheses stops deformation and elastic pads, designed to meet the functional prevent excessive contractions allow prosthesis significantly longer maintain their functional value.
{"title":"Optimization of the designing of flexible pads in removable dental prosthetics","authors":"S. Yarova, A. Komlev, O. Genzytska, S. Turchenenko, Y. Yarov","doi":"10.35339/msz.2019.85.04.06","DOIUrl":"https://doi.org/10.35339/msz.2019.85.04.06","url":null,"abstract":"The results of studies of elastic cushioning materials in removable plate prostheses are presented. Negative role in the mechanism of the rapid aging of the elastic material of functional loads, causing compression, relatively higher than the reversible deformation of materials is shown. The technique of constructing elastic pads with removable plate denture prosthetics is proposed. Clinical assessment of durability of the elastic-elastic pads in the removable plate denture is carried out. In order to preserve the properties of elastic strips, dentures constructed so that the sealing materials during the function did not experience the load exceeds the value of their relatively reversible deformation. It is determined that the presence of prostheses stops deformation and elastic pads, designed to meet the functional prevent excessive contractions allow prosthesis significantly longer maintain their functional value.","PeriodicalId":404961,"journal":{"name":"Медицина сьогодні і завтра","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124052770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.35339/msz.2019.85.04.03
V. Lychko
The features of changes in the structural and functional characteristics of brain tissue were studied in 60 outbred male Wistar rats during modelling of acute focal cerebral ischemia (AFCI) in the dynamics of treatment with human cryopreserved cord blood serum (CCBS). Electronic and optical microscopic examination of the sensorimotor area of the cerebral cortex was performed. All animals were divided into three groups: the first (control) group consisted of intact rats without trauma and treatment; the second group consisted of animals after modelling AFCI without treatment; third group consisted of rats after modelling AFCI, which were injected by CCBS. Each group consisted of 20 animals. Material for morphological examination was taken after administration of CCBS solution to animals with the model of AFCI at 12, 24, 72 hours and 7th days after the start of the experiment. The average area of perivascular spaces, which is an indicator of vasogenic oedema in rats of group 2 was 45 times higher than in rats of group 1. In contrast, in rats of group 3 with CCBS, this figure was exceeded 37 times. The average area of pericellular spaces, indicating the degree of cytotoxic oedema, in animals of group 2 on the 7th day after AFCI was almost 23 times higher than the results of group 1. This figure in rats of group 3 was increased 20 times compared with data in group 2. Against the background of the use of this drug, there were signs of reactive changes in endothelial cells in the form of an increase in the number of ribosomes and polysomes in the cytoplasm, a decrease in the degree of perivascular oedema of brain tissue by 21.4 %. The surface area of endothelial cells in the zone of AFCI on the 7th day of the experiment in animals that additionally received CCBS was (1483.00±26.48) μm2, which indicates a positive anti-inflammatory effect of the drug. On the 7th day of the experiment in group 3 rats by optical microscopy was found to increase the density of cerebral capillaries compared with group 2, which indicates the stimulation of the restoration of the ultrastructure of damaged capillaries, increase their density, the formation of new capillaries under the components of CCBS.
{"title":"The place of neurotrophic therapy in the concept of stimulation of secondary angiogenesis in acute focal cerebral ischemia","authors":"V. Lychko","doi":"10.35339/msz.2019.85.04.03","DOIUrl":"https://doi.org/10.35339/msz.2019.85.04.03","url":null,"abstract":"The features of changes in the structural and functional characteristics of brain tissue were studied in 60 outbred male Wistar rats during modelling of acute focal cerebral ischemia (AFCI) in the dynamics of treatment with human cryopreserved cord blood serum (CCBS). Electronic and optical microscopic examination of the sensorimotor area of the cerebral cortex was performed. All animals were divided into three groups: the first (control) group consisted of intact rats without trauma and treatment; the second group consisted of animals after modelling AFCI without treatment; third group consisted of rats after modelling AFCI, which were injected by CCBS. Each group consisted of 20 animals. Material for morphological examination was taken after administration of CCBS solution to animals with the model of AFCI at 12, 24, 72 hours and 7th days after the start of the experiment. The average area of perivascular spaces, which is an indicator of vasogenic oedema in rats of group 2 was 45 times higher than in rats of group 1. In contrast, in rats of group 3 with CCBS, this figure was exceeded 37 times. The average area of pericellular spaces, indicating the degree of cytotoxic oedema, in animals of group 2 on the 7th day after AFCI was almost 23 times higher than the results of group 1. This figure in rats of group 3 was increased 20 times compared with data in group 2. Against the background of the use of this drug, there were signs of reactive changes in endothelial cells in the form of an increase in the number of ribosomes and polysomes in the cytoplasm, a decrease in the degree of perivascular oedema of brain tissue by 21.4 %. The surface area of endothelial cells in the zone of AFCI on the 7th day of the experiment in animals that additionally received CCBS was (1483.00±26.48) μm2, which indicates a positive anti-inflammatory effect of the drug. On the 7th day of the experiment in group 3 rats by optical microscopy was found to increase the density of cerebral capillaries compared with group 2, which indicates the stimulation of the restoration of the ultrastructure of damaged capillaries, increase their density, the formation of new capillaries under the components of CCBS.","PeriodicalId":404961,"journal":{"name":"Медицина сьогодні і завтра","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133804314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.35339/msz.2019.85.04.16
O. Godovanets, A. Kotelban, L.G. Grinkevich, D.G. Romanyuk
The review of the literature considers the current understanding of scientists about the risk factors for the development of diseases of hard dental tissues in children. Dental caries is an important social problem of childhood in all countries of the world. The worldwide prevalence of this disease ranges from 25 % to 72 %. While, according to the WHO, the frequency and intensity of dental caries in children have been declining in a number of countries in recent decades, in Ukraine these rates remain high and tend to increase. Caries of temporary teeth ranks tenth among the most common diseases in the world. It is a multifactorial, diet-associated dental disease manifested by foci of demineralization. The etiology and pathogenesis of dental nosology are well studied and known. Despite this, tooth caries remains an important social problem among children in all countries of the world, and is often accompanied by serious impacts on the health of children and their families.
{"title":"Factors that cause caries among children. Current state of question","authors":"O. Godovanets, A. Kotelban, L.G. Grinkevich, D.G. Romanyuk","doi":"10.35339/msz.2019.85.04.16","DOIUrl":"https://doi.org/10.35339/msz.2019.85.04.16","url":null,"abstract":"The review of the literature considers the current understanding of scientists about the risk factors for the development of diseases of hard dental tissues in children. Dental caries is an important social problem of childhood in all countries of the world. The worldwide prevalence of this disease ranges from 25 % to 72 %. While, according to the WHO, the frequency and intensity of dental caries in children have been declining in a number of countries in recent decades, in Ukraine these rates remain high and tend to increase. Caries of temporary teeth ranks tenth among the most common diseases in the world. It is a multifactorial, diet-associated dental disease manifested by foci of demineralization. The etiology and pathogenesis of dental nosology are well studied and known. Despite this, tooth caries remains an important social problem among children in all countries of the world, and is often accompanied by serious impacts on the health of children and their families.","PeriodicalId":404961,"journal":{"name":"Медицина сьогодні і завтра","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123806492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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