Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3314
A. Reimelt, D. Vasilescu, R. Beare, L. Knudsen, R. Grothausmann
{"title":"Effects of Linear Deformations on the 3D Alveolar Shape","authors":"A. Reimelt, D. Vasilescu, R. Beare, L. Knudsen, R. Grothausmann","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3314","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3314","url":null,"abstract":"","PeriodicalId":406969,"journal":{"name":"B64. NEW INSIGHTS FROM LUNG IMAGING","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126046157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3320
T. Achekzai, K. Ruppert, L. Loza, F. Amzajerdian, S. Kadlecek, R. Rizi
{"title":"Introducing a Correction Method for TP and RBC Separation in XTC Imaging","authors":"T. Achekzai, K. Ruppert, L. Loza, F. Amzajerdian, S. Kadlecek, R. Rizi","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3320","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3320","url":null,"abstract":"","PeriodicalId":406969,"journal":{"name":"B64. NEW INSIGHTS FROM LUNG IMAGING","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133810400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3313
L. Loza, T. Achekzai, S. Kadlecek, H. Hamedani, I. Duncan, R. Rizi
{"title":"Comparison of Discrete Acquisition Techniques for Measuring Fractional Ventilation Using Hyperpolarized 129Xe MRI","authors":"L. Loza, T. Achekzai, S. Kadlecek, H. Hamedani, I. Duncan, R. Rizi","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3313","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3313","url":null,"abstract":"","PeriodicalId":406969,"journal":{"name":"B64. NEW INSIGHTS FROM LUNG IMAGING","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131389325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3309
P. Niedbalski, R. Rawlings, C. Hall, M. Castro
Hyperpolarized 129Xe MRI (Xe-MRI) is eliciting increasing interest as an outcome measure in clinical trials, and, with FDA approval expected in 2022, for clinical application. This technique can provide 3D images of pulmonary structure and function non-invasively and with no ionizing radiation. In particular, Xe-MRI can be used to map regional ventilation and gas exchange, both of which have proven effective at identifying structure and function abnormalities in a variety of pulmonary diseases. However, multiple breath-holds are required to collect ventilation and gas exchange images, which increases patient burden and the time/cost of imaging. Building on recent advances to Xe-MRI, namely 3D spiral imaging and flip angle/TR equivalence, we have developed an imaging sequence that can acquire high quality ventilation and gas exchange images within a single, clinically feasible (∼10 s) breath-hold. This sequence uses an interleaved 3D spiral/3D radial 1- point Dixon approach to simultaneously acquire ventilation and gas exchange images. In postprocessing, images are generated of ventilation (voxel size 4 x 4 x 4 mm3) and gas exchange, including xenon dissolved in tissues (“Barrier”) and red blood cells (RBCs) (voxel size 6.25 x 6.25 x 6.25 mm3). This sequence has been used to acquire images in 8 subjects, including 4 healthy volunteers, 1 patient with scleroderma associated ILD (SSc-ILD), and 3 patients experiencing respiratory post-acute sequelae of COVID-19 (PASC). Of these, 7 subjects had a dedicated breath-hold for imaging ventilation, and 5 subjects had a dedicated gas exchange image. In all cases, image signal to noise ratio was equal or superior to dedicated breath-hold images. Qualitative agreement between ventilation/gas exchange images in dedicated breath-holds (Figure A, B) and single-breath images (Figure C) was excellent, and quantitative biomarkers, including ventilation defect percentage (VDP) (ICC = 0.90, p = 0.006), mean barrier signal (ICC = .99, p = 0.001), mean RBC signal (ICC = 0.93, p < 0.001), global RBC oscillation (ICC = 0.984, p = 0.001), percent of the lungs with low barrier (ICC = .98, p = 0.001), and percent with low RBC signal (ICC = 0.92, p = 0.006) were closely correlated. Single-breath imaging was able to identify ventilation defects (Figure C), elevated barrier (in SSc-ILD), and RBC defects (in SSc-ILD, PASC). These data show that hyperpolarized 129Xe ventilation and gas exchange images can effectively be acquired within a single, clinically manageable breath-hold, which may help to pave the way for increased clinical utilization of hyperpolarized 129Xe MRI. (Figure Presented).
超极化129Xe MRI (Xe-MRI)作为临床试验的结果指标引起了越来越多的兴趣，预计FDA将于2022年批准其临床应用。该技术可以无创、无电离辐射地提供肺部结构和功能的三维图像。特别是，x - mri可用于绘制区域通风和气体交换图，这两者已被证明在识别各种肺部疾病的结构和功能异常方面是有效的。然而，需要多次屏气来收集通气和气体交换图像，这增加了患者的负担和成像的时间/成本。基于x - mri的最新进展，即3D螺旋成像和翻转角度/TR等效，我们开发了一种成像序列，可以在单次临床可行的屏气(~ 10秒)内获得高质量的通气和气体交换图像。该序列使用交错的3D螺旋/3D径向1点Dixon方法同时获取通风和气体交换图像。在后处理中，生成通风(体素大小为4 x 4 x 4 mm3)和气体交换的图像，包括溶解在组织(“屏障”)和红细胞(红细胞)中的氙(体素大小为6.25 x 6.25 x 6.25 mm3)。该序列已用于获取8名受试者的图像，包括4名健康志愿者、1名硬皮病相关ILD (SSc-ILD)患者和3名COVID-19急性后呼吸道后遗症(PASC)患者。其中，7名受试者有专门的屏气成像通气，5名受试者有专门的气体交换成像。在所有情况下，图像信噪比等于或优于专用屏气图像。定性协议专用通风/气体交换图片之间的屏息(图A, B)和次呼吸图像(图C)非常好,和定量生物标记,包括通风缺陷百分比(VDP) (ICC = 0.90, p = 0.006),意味着障碍信号(ICC = 0, p = 0.001),平均红细胞信号(ICC = 0.93, p < 0.001),红细胞全球振荡(ICC = 0.984, p = 0.001),肺壁垒较低的百分比(ICC = .98, p = 0.001),红细胞和百分比低信号(ICC = 0.92,P = 0.006)密切相关。单次呼吸成像能够识别通气缺陷(图C)、屏障升高(SSc-ILD)和红细胞缺陷(SSc-ILD、PASC)。这些数据表明，超极化129Xe通气和气体交换图像可以在一次临床可管理的屏气中有效地获得，这可能有助于为增加超极化129Xe MRI的临床应用铺平道路。(图)。
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