Pub Date : 2022-11-23DOI: 10.1080/23772484.2022.2146586
M. Pilmane, Nityanand Jain, Elīna Nadziņa, P. Fedirko, G. Sumeraga
Abstract Cleft lip and palate are the most common congenital malformations which require early primary cleft surgery in all infants. The surgical treatment of cleft lip and palate deformities results in the formation of scar tissue. However, the scarred tissue has sparsely been immunohistochemically evaluated to date. Herein, we report the differences in the cellular expression of various proteins in the scar and nearby healthy tissue of a 35-year-old patient who underwent cleft correction surgery during infancy. The scar tissue showed basal cell proliferation, prominent cysts, and fibrotic connective tissue. An increased expression of both interleukin 1α (IL-1α) and IL-10 in the scar tissue was noted, although the balance favored an anti-inflammatory environment. No differences in the expression of matrix metallopeptidase-2 (MMP-2) and TIMP-2 were found whilst an increased expression of PAX-9 and MSX-1 was observed in the scar tissue, which co-localized with RYK expression. Temporal studies like the present one can aid in advancing our understanding of the longitudinal processes governing wound healing morpho-pathogenesis in cleft-affected patients.
{"title":"Immunohistochemical evaluation of the cleft-affected scar tissue three decades post-corrective surgery: A rare case report","authors":"M. Pilmane, Nityanand Jain, Elīna Nadziņa, P. Fedirko, G. Sumeraga","doi":"10.1080/23772484.2022.2146586","DOIUrl":"https://doi.org/10.1080/23772484.2022.2146586","url":null,"abstract":"Abstract Cleft lip and palate are the most common congenital malformations which require early primary cleft surgery in all infants. The surgical treatment of cleft lip and palate deformities results in the formation of scar tissue. However, the scarred tissue has sparsely been immunohistochemically evaluated to date. Herein, we report the differences in the cellular expression of various proteins in the scar and nearby healthy tissue of a 35-year-old patient who underwent cleft correction surgery during infancy. The scar tissue showed basal cell proliferation, prominent cysts, and fibrotic connective tissue. An increased expression of both interleukin 1α (IL-1α) and IL-10 in the scar tissue was noted, although the balance favored an anti-inflammatory environment. No differences in the expression of matrix metallopeptidase-2 (MMP-2) and TIMP-2 were found whilst an increased expression of PAX-9 and MSX-1 was observed in the scar tissue, which co-localized with RYK expression. Temporal studies like the present one can aid in advancing our understanding of the longitudinal processes governing wound healing morpho-pathogenesis in cleft-affected patients.","PeriodicalId":40723,"journal":{"name":"Acta Oto-Laryngologica Case Reports","volume":"7 1","pages":"52 - 58"},"PeriodicalIF":0.1,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43042211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-16DOI: 10.1080/23772484.2022.2139704
Akihisa Tanaka, Taeko Ito, Takahiro Kimura, T. Kitahara
Abstract Von Willebrand disease (VWD), which causes mucocutaneous haemorrhage, is the most common heritable bleeding disorder. However, a lack of awareness regarding VWD results in underdiagnosis and nontreatment. This study describes the first reported case of VWD diagnosed during the treatment of a deep neck abscess (DNA). A 55-year-old man underwent emergency surgery for DNA, which is a life-threatening disease, with subsequent difficulty in haemostasis both intraoperatively and postoperatively. Hence, coagulopathy was suspected, and VWD was eventually diagnosed. Administration of blood products helped control bleeding. Coagulopathies, including VWD, should be suspected in patients with refractory bleeding. This is especially important for otolaryngologists, who often treat mucocutaneous bleeding, such as epistaxis and oral mucosal bleeding.
{"title":"Diagnosis of von Willebrand disease during the management of deep neck abscess: A case report","authors":"Akihisa Tanaka, Taeko Ito, Takahiro Kimura, T. Kitahara","doi":"10.1080/23772484.2022.2139704","DOIUrl":"https://doi.org/10.1080/23772484.2022.2139704","url":null,"abstract":"Abstract Von Willebrand disease (VWD), which causes mucocutaneous haemorrhage, is the most common heritable bleeding disorder. However, a lack of awareness regarding VWD results in underdiagnosis and nontreatment. This study describes the first reported case of VWD diagnosed during the treatment of a deep neck abscess (DNA). A 55-year-old man underwent emergency surgery for DNA, which is a life-threatening disease, with subsequent difficulty in haemostasis both intraoperatively and postoperatively. Hence, coagulopathy was suspected, and VWD was eventually diagnosed. Administration of blood products helped control bleeding. Coagulopathies, including VWD, should be suspected in patients with refractory bleeding. This is especially important for otolaryngologists, who often treat mucocutaneous bleeding, such as epistaxis and oral mucosal bleeding.","PeriodicalId":40723,"journal":{"name":"Acta Oto-Laryngologica Case Reports","volume":"7 1","pages":"44 - 47"},"PeriodicalIF":0.1,"publicationDate":"2022-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47210216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-15DOI: 10.1080/23772484.2022.2143364
Jonas Bruneau, C. Talani, Johan S. Nilsson
Abstract Ectopic thyroid is a rare condition most often found at the base of the tongue, lingual thyroid (LT). The majority of patients are asymptomatic. Recently, transoral robotic surgery (TORS) has emerged as an option for definitive treatment. Here, we present a 20-year-old patient with symptomatic LT, treated with TORS-assisted surgery without adverse events and with depletion of symptoms. We advocate TORS as a very promising means to be considered when encountering the rare condition of symptomatic LT.
{"title":"Exstirpation of symptomatic lingual thyroid with transoral robotic surgery (TORS): A promising novel treatment option","authors":"Jonas Bruneau, C. Talani, Johan S. Nilsson","doi":"10.1080/23772484.2022.2143364","DOIUrl":"https://doi.org/10.1080/23772484.2022.2143364","url":null,"abstract":"Abstract Ectopic thyroid is a rare condition most often found at the base of the tongue, lingual thyroid (LT). The majority of patients are asymptomatic. Recently, transoral robotic surgery (TORS) has emerged as an option for definitive treatment. Here, we present a 20-year-old patient with symptomatic LT, treated with TORS-assisted surgery without adverse events and with depletion of symptoms. We advocate TORS as a very promising means to be considered when encountering the rare condition of symptomatic LT.","PeriodicalId":40723,"journal":{"name":"Acta Oto-Laryngologica Case Reports","volume":"7 1","pages":"48 - 51"},"PeriodicalIF":0.1,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48560182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-31DOI: 10.1080/23772484.2022.2115915
Karin Hallin, H. Rask-Andersen
Abstract We present a pitch discrimination test performed by five experienced adult auditory brainstem implant (ABI) users with neurofibromatosis type 2 (NF2). The ability to discriminate frequency/pitch from different channels on the implant may be an important factor in improving speech performance. The pitch discrimination ability was evaluated by using a triangle test compared to adjacent contacts and the speech perception was measured by the Swedish three-digit test. The test was easy to perform, and all patients were able to answer reliably, even though it cannot be ruled out that patients used attributes other than pitch to differentiate between sounds. Due to the limited number of patients and small variation in results, no conclusive correlations could be made regarding pitch discrimination and auditory outcome. There was a tendency for poorer ability to discriminate pitch (discrimination of tonotopically adjacent electrodes) at testing to result in poorer speech results.
{"title":"Auditory brainstem implant pitch discrimination and auditory outcome","authors":"Karin Hallin, H. Rask-Andersen","doi":"10.1080/23772484.2022.2115915","DOIUrl":"https://doi.org/10.1080/23772484.2022.2115915","url":null,"abstract":"Abstract We present a pitch discrimination test performed by five experienced adult auditory brainstem implant (ABI) users with neurofibromatosis type 2 (NF2). The ability to discriminate frequency/pitch from different channels on the implant may be an important factor in improving speech performance. The pitch discrimination ability was evaluated by using a triangle test compared to adjacent contacts and the speech perception was measured by the Swedish three-digit test. The test was easy to perform, and all patients were able to answer reliably, even though it cannot be ruled out that patients used attributes other than pitch to differentiate between sounds. Due to the limited number of patients and small variation in results, no conclusive correlations could be made regarding pitch discrimination and auditory outcome. There was a tendency for poorer ability to discriminate pitch (discrimination of tonotopically adjacent electrodes) at testing to result in poorer speech results.","PeriodicalId":40723,"journal":{"name":"Acta Oto-Laryngologica Case Reports","volume":"7 1","pages":"39 - 43"},"PeriodicalIF":0.1,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46115108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-29DOI: 10.1080/23772484.2022.2077206
Arun Panwar, V. Keluskar, Shivayogi Charantimath, L. Kumar S., S. M, J. T
Abstract Eagle’s syndrome refers to unilateral or bilateral elongation of the styloid process or calcified stylohyoid ligament, along with other symptoms, such as dysphagia, otalgia, tinnitus, and globus pharyngeus. A styloid process is considered elongated or abnormal when it exceeds a normal length of 25-27 mm. However, elongation of the ossified styloid ligament is insufficient for diagnosing Eagle’s syndrome. Instead, a constellation of symptoms in history, as mentioned above, and physical and radiographic examinations contribute to diagnosis. This disorder has long been a diagnostic challenge for clinicians. Hence, it is essential for dentists to have a superior knowledge of this relatively rare entity and its anatomic base. This report presents a case of classical Eagle’s syndrome in a 47-year-old woman with symptomatic bilateral elongation of the styloid process. The lengths of the right and left styloid processes were 60.5 mm and 70.74 mm, respectively, which is one of the longest ever reported.
{"title":"Bilateral elongated styloid process (Eagle’s syndrome) - a case report and short review","authors":"Arun Panwar, V. Keluskar, Shivayogi Charantimath, L. Kumar S., S. M, J. T","doi":"10.1080/23772484.2022.2077206","DOIUrl":"https://doi.org/10.1080/23772484.2022.2077206","url":null,"abstract":"Abstract Eagle’s syndrome refers to unilateral or bilateral elongation of the styloid process or calcified stylohyoid ligament, along with other symptoms, such as dysphagia, otalgia, tinnitus, and globus pharyngeus. A styloid process is considered elongated or abnormal when it exceeds a normal length of 25-27 mm. However, elongation of the ossified styloid ligament is insufficient for diagnosing Eagle’s syndrome. Instead, a constellation of symptoms in history, as mentioned above, and physical and radiographic examinations contribute to diagnosis. This disorder has long been a diagnostic challenge for clinicians. Hence, it is essential for dentists to have a superior knowledge of this relatively rare entity and its anatomic base. This report presents a case of classical Eagle’s syndrome in a 47-year-old woman with symptomatic bilateral elongation of the styloid process. The lengths of the right and left styloid processes were 60.5 mm and 70.74 mm, respectively, which is one of the longest ever reported.","PeriodicalId":40723,"journal":{"name":"Acta Oto-Laryngologica Case Reports","volume":"7 1","pages":"33 - 38"},"PeriodicalIF":0.1,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48761558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-29DOI: 10.1080/23772484.2022.2063129
Yuki Irifune, Takashi Mukaigawa, M. Fukaya, Yuko Kakuda, N. Hato
Abstract Malignant lymphoma (ML) and papillary thyroid carcinoma (PTC) are the most common hematological and endocrine malignancies. However, ML originating from the intratracheal region is rare, with few reported cases in the literature. We report a case of a 57-year-old woman with double primary cancer, consisting of ML of the intratracheal region and PTC in the isthmus. She complained of hoarseness and exertional dyspnea. Adjacent tumors through the anterior tracheal wall were initially considered as tracheal invasion of the thyroid carcinoma. However, MRI and PET-CT suggested that these tumors had different radiological signs. We performed thyroidectomy and biopsy of the intratracheal tumor with a tracheostomy. Pathological examination revealed PTC and CD-5-positive B-cell indolent intratracheal lymphoma. She received weekly infusions of rituximab for eight weeks after surgery. The intratracheal ML showed complete response, and the tracheocutaneous fistula was closed six months after the initial surgery.
{"title":"Primary tracheal lymphoma with thyroid carcinoma","authors":"Yuki Irifune, Takashi Mukaigawa, M. Fukaya, Yuko Kakuda, N. Hato","doi":"10.1080/23772484.2022.2063129","DOIUrl":"https://doi.org/10.1080/23772484.2022.2063129","url":null,"abstract":"Abstract Malignant lymphoma (ML) and papillary thyroid carcinoma (PTC) are the most common hematological and endocrine malignancies. However, ML originating from the intratracheal region is rare, with few reported cases in the literature. We report a case of a 57-year-old woman with double primary cancer, consisting of ML of the intratracheal region and PTC in the isthmus. She complained of hoarseness and exertional dyspnea. Adjacent tumors through the anterior tracheal wall were initially considered as tracheal invasion of the thyroid carcinoma. However, MRI and PET-CT suggested that these tumors had different radiological signs. We performed thyroidectomy and biopsy of the intratracheal tumor with a tracheostomy. Pathological examination revealed PTC and CD-5-positive B-cell indolent intratracheal lymphoma. She received weekly infusions of rituximab for eight weeks after surgery. The intratracheal ML showed complete response, and the tracheocutaneous fistula was closed six months after the initial surgery.","PeriodicalId":40723,"journal":{"name":"Acta Oto-Laryngologica Case Reports","volume":"7 1","pages":"22 - 25"},"PeriodicalIF":0.1,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48208669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-29DOI: 10.1080/23772484.2022.2067544
Salla Kellberg, G. Kurdo, M. Kontro, S. Sinkkonen
Abstract Multiple myeloma (MM), the most common plasmacell neoplasm, manifests relatively often in the head and neck region, but rarely in the ear. We present a patient with fluctuating hearing loss, otalgia, persistent otitis externa and occipital swelling. CT imaging showed a large mass of cranium and the initial radiological diagnosis was plasmacytoma. Multiple osteolytic bone lesions, monoclonal serum protein with serum M component concentration of 35.2 g/L and bone marrow biopsy with abnormal, clonal plasma cells population confirmed the diagnosis of multiple myeloma. Although a rare manifestation in the external ear canal and its surroundings, plasmacytoma or multiple myeloma should be considered as a possible diagnosis in the presence of a scalp mass or a treatment resistant swelling of the external ear canal.
{"title":"Multiple myeloma of cranium with external ear canal swelling and occipital mass: A rare case report","authors":"Salla Kellberg, G. Kurdo, M. Kontro, S. Sinkkonen","doi":"10.1080/23772484.2022.2067544","DOIUrl":"https://doi.org/10.1080/23772484.2022.2067544","url":null,"abstract":"Abstract Multiple myeloma (MM), the most common plasmacell neoplasm, manifests relatively often in the head and neck region, but rarely in the ear. We present a patient with fluctuating hearing loss, otalgia, persistent otitis externa and occipital swelling. CT imaging showed a large mass of cranium and the initial radiological diagnosis was plasmacytoma. Multiple osteolytic bone lesions, monoclonal serum protein with serum M component concentration of 35.2 g/L and bone marrow biopsy with abnormal, clonal plasma cells population confirmed the diagnosis of multiple myeloma. Although a rare manifestation in the external ear canal and its surroundings, plasmacytoma or multiple myeloma should be considered as a possible diagnosis in the presence of a scalp mass or a treatment resistant swelling of the external ear canal.","PeriodicalId":40723,"journal":{"name":"Acta Oto-Laryngologica Case Reports","volume":"7 1","pages":"30 - 32"},"PeriodicalIF":0.1,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45534352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-25DOI: 10.1080/23772484.2022.2050374
Niloofar Sherazi Dreyer, K. G. Gregersen, K. Bork
Abstract Background: Subglottic stenosis (SGS) is the obstruction of the central airway in the region bounded superiorly by a plane below the glottis and inferiorly by the first two tracheal rings. Causes of subglottic stenosis can be congenital, acquired, or idiopathic. We present a case of possible post infectious subglottic stenosis. Case report: A 26-year-old woman was admitted to the hospital due to worsening of dyspnea for 3 years. She was initially diagnosed with asthma, but asthma medication did not have an effect. She had an endoscopic bronchoscopy that revealed a subglottic stenosis and a few hours after the bronchoscopy the patient developed stridor and was hurried to surgery. Conclusions: Subglottic stenosis is a rare condition and is possible misdiagnosed as asthma or chronic obstructive pulmonary disease (COPD). Early and correct diagnosis is essential to reduce morbidity and mortality. Diagnosis of SGS is endoscopic laryngoscopy/bronchoscopy or CT scan.
{"title":"Life-threatening idiopathic subglottic stenosis misdiagnosed as asthma","authors":"Niloofar Sherazi Dreyer, K. G. Gregersen, K. Bork","doi":"10.1080/23772484.2022.2050374","DOIUrl":"https://doi.org/10.1080/23772484.2022.2050374","url":null,"abstract":"Abstract Background: Subglottic stenosis (SGS) is the obstruction of the central airway in the region bounded superiorly by a plane below the glottis and inferiorly by the first two tracheal rings. Causes of subglottic stenosis can be congenital, acquired, or idiopathic. We present a case of possible post infectious subglottic stenosis. Case report: A 26-year-old woman was admitted to the hospital due to worsening of dyspnea for 3 years. She was initially diagnosed with asthma, but asthma medication did not have an effect. She had an endoscopic bronchoscopy that revealed a subglottic stenosis and a few hours after the bronchoscopy the patient developed stridor and was hurried to surgery. Conclusions: Subglottic stenosis is a rare condition and is possible misdiagnosed as asthma or chronic obstructive pulmonary disease (COPD). Early and correct diagnosis is essential to reduce morbidity and mortality. Diagnosis of SGS is endoscopic laryngoscopy/bronchoscopy or CT scan.","PeriodicalId":40723,"journal":{"name":"Acta Oto-Laryngologica Case Reports","volume":"7 1","pages":"26 - 29"},"PeriodicalIF":0.1,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46804504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-25DOI: 10.1080/23772484.2022.2043751
Ryutaro Onaga, Toru Sasaki, Tomohiko Yamauchi, K. Namba, A. Higaki, A. Gomi, H. Nishino
Abstract Neurofibromatosis type 1 is an inherited disease. Vascular malformation represents minor complication but the rupture is fatal. We report two cases of ruptured vascular malformation in extracranial carotid artery who survived after successful treatment. Case 1 was a 35-year-old man who presented with airway obstruction due to a mass in the pharynx. The mass was diagnosed as ruptured aneurysm of the right internal carotid artery (ICA). An emergent treatment of superficial temporal artery to middle cerebral artery (STA–MCA) bypass surgery followed by endovascular occlusion of the right ICA was conducted. Case 2 was a 55-year-old man who presented with dyspnea associated with right-side neck swelling. Angiography showed two major high-flow arteriovenous fistulas, mainly fed from the ICA and maxillary artery. The patient also underwent embolization. Early diagnoses and appropriate managements of these rare cases could save lives after the serious condition.
{"title":"Successful treatment of ruptured extracranial carotid artery aneurysm and fistula associated with neurofibromatosis type1: Report of two cases","authors":"Ryutaro Onaga, Toru Sasaki, Tomohiko Yamauchi, K. Namba, A. Higaki, A. Gomi, H. Nishino","doi":"10.1080/23772484.2022.2043751","DOIUrl":"https://doi.org/10.1080/23772484.2022.2043751","url":null,"abstract":"Abstract Neurofibromatosis type 1 is an inherited disease. Vascular malformation represents minor complication but the rupture is fatal. We report two cases of ruptured vascular malformation in extracranial carotid artery who survived after successful treatment. Case 1 was a 35-year-old man who presented with airway obstruction due to a mass in the pharynx. The mass was diagnosed as ruptured aneurysm of the right internal carotid artery (ICA). An emergent treatment of superficial temporal artery to middle cerebral artery (STA–MCA) bypass surgery followed by endovascular occlusion of the right ICA was conducted. Case 2 was a 55-year-old man who presented with dyspnea associated with right-side neck swelling. Angiography showed two major high-flow arteriovenous fistulas, mainly fed from the ICA and maxillary artery. The patient also underwent embolization. Early diagnoses and appropriate managements of these rare cases could save lives after the serious condition.","PeriodicalId":40723,"journal":{"name":"Acta Oto-Laryngologica Case Reports","volume":"7 1","pages":"14 - 18"},"PeriodicalIF":0.1,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44359726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-10DOI: 10.1080/23772484.2022.2033122
N. Nishio, Yuriko Okazaki, A. Wada, H. Tsuzuki, Miki Kambe, Y. Fujimoto, M. Sone
Abstract Bilateral squamous cell carcinoma (SCC) of the external auditory canal (EAC) is extremely rare. Here, we report the details of the history and management of a 74-year-old patient with bilateral locally advanced SCC of the EAC. The patient underwent subtotal temporal bone resection for primary SCC of the EAC in the right ear. Three years later, a biopsy revealed SCC of the contralateral ear. The patient received proton therapy for the second primary SCC of the EAC and achieved a complete response. Two years after proton therapy, a recurrence was observed in the left ear. Despite systemic chemotherapy for recurrence, the patient died of the disease. Although a second primary SCC in the contralateral ear is extremely rare, clinicians should consider the possibility of bilateral SCC of the EAC and carefully manage each of the ears during the follow-up period.
{"title":"Management of bilateral locally advanced squamous cell carcinoma of the external auditory canal","authors":"N. Nishio, Yuriko Okazaki, A. Wada, H. Tsuzuki, Miki Kambe, Y. Fujimoto, M. Sone","doi":"10.1080/23772484.2022.2033122","DOIUrl":"https://doi.org/10.1080/23772484.2022.2033122","url":null,"abstract":"Abstract Bilateral squamous cell carcinoma (SCC) of the external auditory canal (EAC) is extremely rare. Here, we report the details of the history and management of a 74-year-old patient with bilateral locally advanced SCC of the EAC. The patient underwent subtotal temporal bone resection for primary SCC of the EAC in the right ear. Three years later, a biopsy revealed SCC of the contralateral ear. The patient received proton therapy for the second primary SCC of the EAC and achieved a complete response. Two years after proton therapy, a recurrence was observed in the left ear. Despite systemic chemotherapy for recurrence, the patient died of the disease. Although a second primary SCC in the contralateral ear is extremely rare, clinicians should consider the possibility of bilateral SCC of the EAC and carefully manage each of the ears during the follow-up period.","PeriodicalId":40723,"journal":{"name":"Acta Oto-Laryngologica Case Reports","volume":"7 1","pages":"8 - 13"},"PeriodicalIF":0.1,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45258710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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