Pub Date : 2018-09-12DOI: 10.19163/2307-9266-2018-6-4-318-339
E. G. Sannikova, O. Popova, E. V. Kompantseva
One of the most promising plants for expanding the range of medicines having astringent and anti-inflammatory effects are various species of willow, which have been used in folk medicine for a long time and now arewidely appliedin the composition of various biologically active additives to food both abroad and in Russia. Currently, in medical practice, white willow (Salix alba L.) is mainly used. Numerous species of willow that grow and are widely cultivated in the Russian Federation have not yet been widely used in medicine.The aim of the studyis to summarize the literary data about the expansion habitat, the content of biologically active substances and the possibility of harvesting raw materials of willow triandra (Salix triandra L.) and its use in medicine and pharmacy.Materials and methods.The object of the study is willow triandra (S. triandra L.) widespread in the Russian Federation. The study was conducted using search and information and library databases (eLibrary, PubMed, CyberLeninka, ResearchGate).Results and discussion.Willow triandra (Salix triandra L.) is a perennial dioecious plant, belonging to the Salicaceae family (Willow), Amygdalinae section. The natural habitat of willow triandra is predominantly forest and forest-steppe zones of the European and Asian continents. Eastern Europe is the geographical center of the growth of willow triandra, where it occurs throughout the territory. In Russia, willow triandra occupies almost the whole of its European part, in the North extends as far as the Petrozavodsk-Vologda-Kirov line, and the North Caucasus, it can be found on the territory of Western and Central Siberia. This suggests the idea that plant resources of willow triandra are significant. The possibility of cultivation of willow triandra in various edaphic-phytocenotic conditions is noted, since it is most easily subjected to vegetative propagation. It has been pointed out that willow triandra, like other willow species, contains a rich complex of polyphenolic compounds, which causes its anti-inflammatory effect. It has been revealed that in efficiency, the branches are not inferior to the bark of the species under study, which makes it possible to use branches of various willow speciesas a medicinal plant material.Conclusion.The prospect of research of branches of various willow species, including willow triandra, as a medicinal plant raw material showing anti-inflammatory properties, is confirmed.
各种柳树是最有希望扩大具有收敛和抗炎作用的药物范围的植物之一，它们在民间医学中使用了很长时间，现在在国外和俄罗斯被广泛应用于各种生物活性食品添加剂的组成中。目前，在医疗实践中，主要使用白柳(Salix alba L.)。在俄罗斯联邦生长和广泛种植的许多柳树品种尚未广泛用于医学。摘要综述了国内外有关三棱柳(Salix triandra L.)扩展生境、生物活性物质含量、原料采收可能性及药用价值的文献资料。材料和方法。本研究的对象是分布在俄罗斯联邦的柳柳(S. triandra L.)。这项研究是通过检索和信息以及图书馆数据库(图书馆、PubMed、CyberLeninka、ResearchGate)进行的。结果和讨论。柳(Salix triandra L.)是一种多年生雌雄异株植物，属于水杨科(柳)，苦杏仁科。三柳的自然栖息地主要是欧洲和亚洲大陆的森林和森林草原地带。东欧是柳树生长的地理中心，在那里它遍布整个领土。在俄罗斯，柳树几乎占据了整个欧洲部分，在北部延伸到彼得罗扎沃茨克-沃洛格达-基洛夫线，在北高加索，它可以在西伯利亚西部和中部的领土上找到。这表明三棱柳的植物资源是重要的。注意到在各种土壤-植物生长条件下种植柳柳的可能性，因为它最容易进行无性繁殖。有人指出，与其他柳树种类一样，三柳含有丰富的多酚化合物复合物，这使其具有抗炎作用。研究表明，其枝条的功效不低于所研究树种的树皮，这为利用不同柳树枝条作为药用植物原料提供了可能。结论:确定了包括三棱柳在内的不同柳树枝条作为具有抗炎作用的药用植物原料的研究前景。
{"title":"WILLOW TRIANDRA (SALIX TRIANDRA L.): PROSPECTS AND OPPORTUNITIES FOR USE IN MEDICINE AND PHARMACY","authors":"E. G. Sannikova, O. Popova, E. V. Kompantseva","doi":"10.19163/2307-9266-2018-6-4-318-339","DOIUrl":"https://doi.org/10.19163/2307-9266-2018-6-4-318-339","url":null,"abstract":"One of the most promising plants for expanding the range of medicines having astringent and anti-inflammatory effects are various species of willow, which have been used in folk medicine for a long time and now arewidely appliedin the composition of various biologically active additives to food both abroad and in Russia. Currently, in medical practice, white willow (Salix alba L.) is mainly used. Numerous species of willow that grow and are widely cultivated in the Russian Federation have not yet been widely used in medicine.The aim of the studyis to summarize the literary data about the expansion habitat, the content of biologically active substances and the possibility of harvesting raw materials of willow triandra (Salix triandra L.) and its use in medicine and pharmacy.Materials and methods.The object of the study is willow triandra (S. triandra L.) widespread in the Russian Federation. The study was conducted using search and information and library databases (eLibrary, PubMed, CyberLeninka, ResearchGate).Results and discussion.Willow triandra (Salix triandra L.) is a perennial dioecious plant, belonging to the Salicaceae family (Willow), Amygdalinae section. The natural habitat of willow triandra is predominantly forest and forest-steppe zones of the European and Asian continents. Eastern Europe is the geographical center of the growth of willow triandra, where it occurs throughout the territory. In Russia, willow triandra occupies almost the whole of its European part, in the North extends as far as the Petrozavodsk-Vologda-Kirov line, and the North Caucasus, it can be found on the territory of Western and Central Siberia. This suggests the idea that plant resources of willow triandra are significant. The possibility of cultivation of willow triandra in various edaphic-phytocenotic conditions is noted, since it is most easily subjected to vegetative propagation. It has been pointed out that willow triandra, like other willow species, contains a rich complex of polyphenolic compounds, which causes its anti-inflammatory effect. It has been revealed that in efficiency, the branches are not inferior to the bark of the species under study, which makes it possible to use branches of various willow speciesas a medicinal plant material.Conclusion.The prospect of research of branches of various willow species, including willow triandra, as a medicinal plant raw material showing anti-inflammatory properties, is confirmed.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2018-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67826936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-31DOI: 10.19163/2307-9266-2017-5-5-487-503
А. А. Глушко, А. С. Чиряпкин, В. С. Чиряпкин, А. М. Муртузалиева, Юлия Александровна Полковникова
Nowadays cardiovascular diseases are the main cause of death among the population around the word. The development of new drugs, giving a possibility to normalize blood pressure, is a promising direction in the field of pharmacy and medicine. Now inhibitors of angiotensinconverting enzyme (ACE) are widely adopted for the treatment of hypertension and chronic heart failure. The principle of action of ACE inhibitors is based on blocking the conversion of angiotensin I into angiotensin II, which mediates vasodilation. The aim of the work is a selection of methods of lisinopril interaction with the active center of angiotensin-converting enzyme by molecular dynamics methods. Materials and methods . Lisinopril molecule was used as a ligand; the charges of that ligand were calculated with the density functional theory (DFT) and ub3lyp method with the basis sets 6-31G* and 6-311G**. Simulation of 75 ns of molecular dynamics of lisinopril interaction with the active center of ACE was carried out in the Bioevrica program. As a result of molecular dynamics simulation, the trajectory of the “lisinopril-ACE” system was obtained. After that a comparison of ligand conformations at different points in simulation time with the experimental conformation of the value of standard deviation of coordinates of atoms was made. Results and discussion. The results of simulation have showed that lisinopril with the charges corresponding to basis set 6-311G** behaves consistent with the x-ray data in the active center of the ACE, in contrast to lisinopril with the charges calculated by basis set 6-31G*. Conclusion. The methods of lisinopril interaction modeling with the active center of angiotensin-converting enzyme has been selected. The obtained technique can be used for studying the interaction of substances, similar in structure to lisinopril with the active center of the enzyme (ACE).
{"title":"Разработка методики моделирования взаимодействия биологически активных веществ с активным центром ангиотензин-превращающего фермента","authors":"А. А. Глушко, А. С. Чиряпкин, В. С. Чиряпкин, А. М. Муртузалиева, Юлия Александровна Полковникова","doi":"10.19163/2307-9266-2017-5-5-487-503","DOIUrl":"https://doi.org/10.19163/2307-9266-2017-5-5-487-503","url":null,"abstract":"Nowadays cardiovascular diseases are the main cause of death among the population around the word. The development of new drugs, giving a possibility to normalize blood pressure, is a promising direction in the field of pharmacy and medicine. Now inhibitors of angiotensinconverting enzyme (ACE) are widely adopted for the treatment of hypertension and chronic heart failure. The principle of action of ACE inhibitors is based on blocking the conversion of angiotensin I into angiotensin II, which mediates vasodilation. The aim of the work is a selection of methods of lisinopril interaction with the active center of angiotensin-converting enzyme by molecular dynamics methods. Materials and methods . Lisinopril molecule was used as a ligand; the charges of that ligand were calculated with the density functional theory (DFT) and ub3lyp method with the basis sets 6-31G* and 6-311G**. Simulation of 75 ns of molecular dynamics of lisinopril interaction with the active center of ACE was carried out in the Bioevrica program. As a result of molecular dynamics simulation, the trajectory of the “lisinopril-ACE” system was obtained. After that a comparison of ligand conformations at different points in simulation time with the experimental conformation of the value of standard deviation of coordinates of atoms was made. Results and discussion. The results of simulation have showed that lisinopril with the charges corresponding to basis set 6-311G** behaves consistent with the x-ray data in the active center of the ACE, in contrast to lisinopril with the charges calculated by basis set 6-31G*. Conclusion. The methods of lisinopril interaction modeling with the active center of angiotensin-converting enzyme has been selected. The obtained technique can be used for studying the interaction of substances, similar in structure to lisinopril with the active center of the enzyme (ACE).","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2017-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67826266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-09-22DOI: 10.19163/2307-9266-2017-5-4-368-379
Ju. V. Miroshnichenko, V. N. Kononov, E. O. Rodionov, O. Z. Mustaev, E. Soldatov, M. L. Chuvashev, I. V. Klochkova
The experience of the medical evacuation activities in armed conflicts shows that the Arctic special medical and geographical conditions have expressed mainly negative impact on the methods of conducting military operations and medical care of the wounded and sick, including the Russian Federation Military Forces operational and combat units` medical logistics. The aim of the study was to identify the ways to improve the equipment of medical units of interspecific group of troops (forces) in the Russian Federation Arctic zone. Materials and methods . The theoretical and methodological basis of the research was the works of Russian scientists in the field of improving the order of rendering medical assistance and performing other medical measures in conditions of low ambient temperature. The study used such methods as retrospective; logical; structural and functional analyses and others. Results and discussion . In the course of the study special medical and geographic factors of the Arctic were identified, and their influence on the operational and combat units’ medical logistics was established. The measures to preserve the quality of medicines and medical products in the Arctic are considered, the order of their use is determined, and the requirements for their transportation are established. Prospective means of deploying medical units in the Arctic have been identified. The impact analysis results of the Russian Federation Arctic zone conditions on the need of Military Forces operational and combat units in medical property are given. Conclusion. Based on the results of the study, the most relevant areas for the development and improvement of the organization of Russian Federation Military Forces operational and combat units` medical logistics in the Arctic Zone have been established.
{"title":"ВЛИЯНИЕ ОСОБЫХ МЕДИКО-ГЕОГРАФИЧЕСКИХ УСЛОВИЙ АРКТИКИ НА ОБЕСПЕЧЕНИЕ СОЕДИНЕНИЙ И ВОИНСКИХ ЧАСТЕЙ МЕДИЦИНСКИМ ИМУЩЕСТВОМ","authors":"Ju. V. Miroshnichenko, V. N. Kononov, E. O. Rodionov, O. Z. Mustaev, E. Soldatov, M. L. Chuvashev, I. V. Klochkova","doi":"10.19163/2307-9266-2017-5-4-368-379","DOIUrl":"https://doi.org/10.19163/2307-9266-2017-5-4-368-379","url":null,"abstract":"The experience of the medical evacuation activities in armed conflicts shows that the Arctic special medical and geographical conditions have expressed mainly negative impact on the methods of conducting military operations and medical care of the wounded and sick, including the Russian Federation Military Forces operational and combat units` medical logistics. The aim of the study was to identify the ways to improve the equipment of medical units of interspecific group of troops (forces) in the Russian Federation Arctic zone. Materials and methods . The theoretical and methodological basis of the research was the works of Russian scientists in the field of improving the order of rendering medical assistance and performing other medical measures in conditions of low ambient temperature. The study used such methods as retrospective; logical; structural and functional analyses and others. Results and discussion . In the course of the study special medical and geographic factors of the Arctic were identified, and their influence on the operational and combat units’ medical logistics was established. The measures to preserve the quality of medicines and medical products in the Arctic are considered, the order of their use is determined, and the requirements for their transportation are established. Prospective means of deploying medical units in the Arctic have been identified. The impact analysis results of the Russian Federation Arctic zone conditions on the need of Military Forces operational and combat units in medical property are given. Conclusion. Based on the results of the study, the most relevant areas for the development and improvement of the organization of Russian Federation Military Forces operational and combat units` medical logistics in the Arctic Zone have been established.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2017-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67826165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-04DOI: 10.19163/2307-9266-2017-5-1-12-22
Анна Степановна Саушкина, Любовь Николаевна Зинчук, Михаил Андреевич Денисов, Владислав Александрович Шокуров, Д. В. Гончаров
A serious threat to the health of the population is falsified medicines. In a number of cases, they are identified in the process of incoming quality control for compliance with the requirements of regulatory documents for indicators “Description”, “Packaging”, “Marking”. However, in order to identify sophisticated counterfeits, only a visual assessment of the drug is not enough. Purpose screening evaluation of potentially counterfeited or poor-quality drugs using the IR spectrometry along the total spectrum. Materials and methods. The objects of research were available in freely available commercially available tablets produced by domestic and foreign manufacturers “Paracetamol Extratab”, “Solpadein fast”, “Citrapac”, “Citramon P”, “Ascofen-P”, corresponding to the requirements of the current regulatory documents. The studies were carried out on a Fourier-Spectrophotometer infrared “FSM 1201”. Results and discussion. On the example of the tablets “Citramon P”, “Ascophen-P”, “Citrapac”, “Paracetamol Extratab”, “Solpadein Fast” the possibility of using the total IR spectra as a primary screening index of authenticity is shown. It was established that the total IR spectra of medicines of similar composition reflect the similarity of serial samples of the products of one manufacturer and the difference in serial samples of products of different manufacturers.
{"title":"ИДЕНТИФИКАЦИЯ НЕКОТОРЫХ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ СЛОЖНОГО СОСТАВА, СОДЕРЖАЩИХ ПАРАЦЕТАМОЛ, МЕТОДОМ ИК-СПЕКТРОМЕТРИИ","authors":"Анна Степановна Саушкина, Любовь Николаевна Зинчук, Михаил Андреевич Денисов, Владислав Александрович Шокуров, Д. В. Гончаров","doi":"10.19163/2307-9266-2017-5-1-12-22","DOIUrl":"https://doi.org/10.19163/2307-9266-2017-5-1-12-22","url":null,"abstract":"A serious threat to the health of the population is falsified medicines. In a number of cases, they are identified in the process of incoming quality control for compliance with the requirements of regulatory documents for indicators “Description”, “Packaging”, “Marking”. However, in order to identify sophisticated counterfeits, only a visual assessment of the drug is not enough. Purpose screening evaluation of potentially counterfeited or poor-quality drugs using the IR spectrometry along the total spectrum. Materials and methods. The objects of research were available in freely available commercially available tablets produced by domestic and foreign manufacturers “Paracetamol Extratab”, “Solpadein fast”, “Citrapac”, “Citramon P”, “Ascofen-P”, corresponding to the requirements of the current regulatory documents. The studies were carried out on a Fourier-Spectrophotometer infrared “FSM 1201”. Results and discussion. On the example of the tablets “Citramon P”, “Ascophen-P”, “Citrapac”, “Paracetamol Extratab”, “Solpadein Fast” the possibility of using the total IR spectra as a primary screening index of authenticity is shown. It was established that the total IR spectra of medicines of similar composition reflect the similarity of serial samples of the products of one manufacturer and the difference in serial samples of products of different manufacturers.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2017-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47103381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-09-02DOI: 10.19163/2307-9266-2016-4-2(15)-41-59
Ольга Олеговна Фролова, Евгени Владимировна Компанцева, Т. М. Дементьева
The review systematizes data about chemical composition of bark, leaves, inflorescences, and sprouts of different species of Salix L. The closest attention is payed to investigations of Salix, which has been recently carried out in our country and abroad. For every group of biologically active substances described in Salix there are data about suppressed types of pharmacological activity.
{"title":"Biologically Active Substances of Plants from Sali x L. Genus","authors":"Ольга Олеговна Фролова, Евгени Владимировна Компанцева, Т. М. Дементьева","doi":"10.19163/2307-9266-2016-4-2(15)-41-59","DOIUrl":"https://doi.org/10.19163/2307-9266-2016-4-2(15)-41-59","url":null,"abstract":"The review systematizes data about chemical composition of bark, leaves, inflorescences, and sprouts of different species of Salix L. The closest attention is payed to investigations of Salix, which has been recently carried out in our country and abroad. For every group of biologically active substances described in Salix there are data about suppressed types of pharmacological activity.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2016-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67824671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.19163/2307-9266-2016-4-3-56-67
Г. Санникова, О. И. Попова, Ольга Олеговна Фролова, E. G. Sannikova, O. Popova, O. O. Frolova, A. Airapetova
{"title":"Россия DETERMINATION OF FLAVONOIDS OF WILLOW TRIANDRA ( SALIX TRIANDRA L . ) , GROWING IN THE NORTH CAUCASUS","authors":"Г. Санникова, О. И. Попова, Ольга Олеговна Фролова, E. G. Sannikova, O. Popova, O. O. Frolova, A. Airapetova","doi":"10.19163/2307-9266-2016-4-3-56-67","DOIUrl":"https://doi.org/10.19163/2307-9266-2016-4-3-56-67","url":null,"abstract":"","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67825958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-04DOI: 10.19163/2307-9266-2015-3-5(12)-60-63
Н. М. Сергеева, Е. В. Репринцева
Strategy of pharmaceutical goods (PG) promotion is a working out of methods of goods realization stimulation. To make PG promotion maximum effective, and to receive a sufficient result for pharmaceutical organization (PO) it is necessary to conduct marketing studies (MS), to work out a marketing plan for PG promotion and to offer marketing strategies for goods promotion. To resolve these problems we have formed a concept of marketing promotion of PG system for one of big retail PO of Kursk and Kursk oblast (code name “A”). With this purpose we have identified a problem of PG promotion organization, studied an influence of external and internal environment on the PO “A” activity, determined strong and weak sides of PO activity. We have systematized the results in SWOT-analysis, and formed the strategies of PO for the improvement of work efficiency on the market. On the basis of the results received we have worked out the recommendations for the marketing strategies of PG promotion for the certain PO.
{"title":"МАРКЕТИНГОВЫЕ СТРАТЕГИИ ФАРМАЦЕВТИЧЕСКОЙ ОРГАНИЗАЦИИ","authors":"Н. М. Сергеева, Е. В. Репринцева","doi":"10.19163/2307-9266-2015-3-5(12)-60-63","DOIUrl":"https://doi.org/10.19163/2307-9266-2015-3-5(12)-60-63","url":null,"abstract":"Strategy of pharmaceutical goods (PG) promotion is a working out of methods of goods realization stimulation. To make PG promotion maximum effective, and to receive a sufficient result for pharmaceutical organization (PO) it is necessary to conduct marketing studies (MS), to work out a marketing plan for PG promotion and to offer marketing strategies for goods promotion. To resolve these problems we have formed a concept of marketing promotion of PG system for one of big retail PO of Kursk and Kursk oblast (code name “A”). With this purpose we have identified a problem of PG promotion organization, studied an influence of external and internal environment on the PO “A” activity, determined strong and weak sides of PO activity. We have systematized the results in SWOT-analysis, and formed the strategies of PO for the improvement of work efficiency on the market. On the basis of the results received we have worked out the recommendations for the marketing strategies of PG promotion for the certain PO.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2015-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67824918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-10-14DOI: 10.19163/2307-9266-2015-3-4(11)-25-30
Андрей Владиславович Воронков, Ирина Николаевна Дьякова, Дмитрий Игоревич Поздняков, Н. А. Муравьева
24 Время растворения суппозиториев, приготовленных на основе ПЭГ400:ПЭГ1500:ПЭГ 4000 (10:70:20), превысило допустимые нормы (табл. 1). На основании предварительных фармакотехнологических и биофармацевтических исследований, при изготовлении суппозиториев, содержащих масляный экстракт рябины обыкновенной и экстракт каштана конского жидкий, разработан состав двухслойных суппозиториев, содержащих данные растительные объекты. Внешний слой таких суппозиториев (оболочка) приготавливается методом выливания массы в охлажденную форму и последующим погружением в каждую форму металлических стержней для образования полости. После охлаждения в полости заливали суппозиторную массу для формования внутреннего слоя (ядра). В качестве внешнего слоя (оболочки) использована следующая суппозиторная композиция: 1. Масляный экстракт рябины обыкновенной 0,5г. 2. Основа: твёрдый жир тип А (Т.плавления = 33,11±1,17%) достаточное количество для получения суппозиториев массой 2,0г. В качестве внутреннего слоя (ядра) была использована суппозиторная композиция, следующего состава: 1. Экстракт каштана конского жидкий 0,5. 2. Основа: твёрдый жир кондитерский тип В (Т.плавления = 36,41±0,3%), достаточное количество для получения суппозиториев массой 2,0. Для изготовления суппозиториев по предлагаемой прописи предварительно охлажденные компоненты основы измельчали, отвешивали на весах, отвешивали масляный экстракт рябины обыкновенной, экстракт каштана конского жидкий отмеривали с помощью пипетки.
{"title":"ОЦЕНКА СТЕПЕНИ ВЛИЯНИЯ ФЛОРИДЗИНА И ИКАРИИНА НА УРОВЕНЬ РАБОТОСПОСОБНОСТИ И НЕВРОЛОГИЧЕСКИЙ СТАТУС ЖИВОТНЫХ В УСЛОВИЯХ ДЛИТЕЛЬНЫХ ИСТОЩАЮЩИХ ФИЗИЧЕСКИХ И ПСИХОЭМОЦИОНАЛЬНЫХ НАГРУЗОК","authors":"Андрей Владиславович Воронков, Ирина Николаевна Дьякова, Дмитрий Игоревич Поздняков, Н. А. Муравьева","doi":"10.19163/2307-9266-2015-3-4(11)-25-30","DOIUrl":"https://doi.org/10.19163/2307-9266-2015-3-4(11)-25-30","url":null,"abstract":"24 Время растворения суппозиториев, приготовленных на основе ПЭГ400:ПЭГ1500:ПЭГ 4000 (10:70:20), превысило допустимые нормы (табл. 1). На основании предварительных фармакотехнологических и биофармацевтических исследований, при изготовлении суппозиториев, содержащих масляный экстракт рябины обыкновенной и экстракт каштана конского жидкий, разработан состав двухслойных суппозиториев, содержащих данные растительные объекты. Внешний слой таких суппозиториев (оболочка) приготавливается методом выливания массы в охлажденную форму и последующим погружением в каждую форму металлических стержней для образования полости. После охлаждения в полости заливали суппозиторную массу для формования внутреннего слоя (ядра). В качестве внешнего слоя (оболочки) использована следующая суппозиторная композиция: 1. Масляный экстракт рябины обыкновенной 0,5г. 2. Основа: твёрдый жир тип А (Т.плавления = 33,11±1,17%) достаточное количество для получения суппозиториев массой 2,0г. В качестве внутреннего слоя (ядра) была использована суппозиторная композиция, следующего состава: 1. Экстракт каштана конского жидкий 0,5. 2. Основа: твёрдый жир кондитерский тип В (Т.плавления = 36,41±0,3%), достаточное количество для получения суппозиториев массой 2,0. Для изготовления суппозиториев по предлагаемой прописи предварительно охлажденные компоненты основы измельчали, отвешивали на весах, отвешивали масляный экстракт рябины обыкновенной, экстракт каштана конского жидкий отмеривали с помощью пипетки.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2015-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67825083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-14DOI: 10.19163/2307-9266-2014-2-5(6)-17-23
И. Л. Абисалова, Елена Петровна Федорова, Е. А. Масловская
Cosmetics with the ability to neutralize harmful influence of ultraviolet rays on skin are quite in demand. UV filters in creams composition are divided into two groups: physical and chemical. Antioxidants are used as chemical UV filters. The article presents the results of ferulic acid testing as UV filter in ointment bases with lipophile, hydrophile and lipophilic and hydrophilic properties. The dependence of ferulic acid efficiency from the base type where it was applied was established. The results received are correlated with data about release rate of ferulic acid received in vitro. Ointment bases with such emulsifiers as cetyl alcohol, base emulsifier and Olivem 1000 have the most signified UV protective effect of ferulic acid.
{"title":"ИССЛЕДОВАНИЕ УФ-ПРОТЕКТОРНОЙ АКТИВНОСТИ КИСЛОТЫ ФЕРУЛОВОЙ В СОСТАВЕ МАЗЕВЫХ КОМПОЗИЦИЙ С РАЗЛИЧНЫМИ ФИЗИКО-ХИМИЧЕСКИМИ СВОЙСТВАМИ","authors":"И. Л. Абисалова, Елена Петровна Федорова, Е. А. Масловская","doi":"10.19163/2307-9266-2014-2-5(6)-17-23","DOIUrl":"https://doi.org/10.19163/2307-9266-2014-2-5(6)-17-23","url":null,"abstract":"Cosmetics with the ability to neutralize harmful influence of ultraviolet rays on skin are quite in demand. UV filters in creams composition are divided into two groups: physical and chemical. Antioxidants are used as chemical UV filters. The article presents the results of ferulic acid testing as UV filter in ointment bases with lipophile, hydrophile and lipophilic and hydrophilic properties. The dependence of ferulic acid efficiency from the base type where it was applied was established. The results received are correlated with data about release rate of ferulic acid received in vitro. Ointment bases with such emulsifiers as cetyl alcohol, base emulsifier and Olivem 1000 have the most signified UV protective effect of ferulic acid.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2015-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67824880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-12DOI: 10.19163/2307-9266-2014-2-4(5)-63-70
Александр Игоревич Медвецкий, Лидия Ильинична Щербакова, Владислав Алексеевич Компанцев, Л. П. Гокжаева, Т. М. Васина
Stability of microparticles of alprazolam in natural conditions was studied by the method of "accelerated aging". It was established that microparticles of alprazolam were not exposed to disruption and their appearance was not altered during the research. Expiration dates of alprazolam microparticles determination was calculated using the formula of J.H. van't Hoff. The expiration date made 2 years.
{"title":"ИЗУЧЕНИЕ СТАБИЛЬНОСТИ И УСТАНОВЛЕНИЕ СРОКОВ ГОДНОСТИ МИКРОЧАСТИЦ АЛПРАЗОЛАМА НА ОСНОВЕ ПОЛИ-D,L-ЛАКТИД-КО-ГЛИКОЛИДА","authors":"Александр Игоревич Медвецкий, Лидия Ильинична Щербакова, Владислав Алексеевич Компанцев, Л. П. Гокжаева, Т. М. Васина","doi":"10.19163/2307-9266-2014-2-4(5)-63-70","DOIUrl":"https://doi.org/10.19163/2307-9266-2014-2-4(5)-63-70","url":null,"abstract":"Stability of microparticles of alprazolam in natural conditions was studied by the method of \"accelerated aging\". It was established that microparticles of alprazolam were not exposed to disruption and their appearance was not altered during the research. Expiration dates of alprazolam microparticles determination was calculated using the formula of J.H. van't Hoff. The expiration date made 2 years.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2015-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67823961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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