Pub Date : 2018-09-12DOI: 10.19163/2307-9266-2018-6-4-318-339
E. G. Sannikova, O. Popova, E. V. Kompantseva
One of the most promising plants for expanding the range of medicines having astringent and anti-inflammatory effects are various species of willow, which have been used in folk medicine for a long time and now arewidely appliedin the composition of various biologically active additives to food both abroad and in Russia. Currently, in medical practice, white willow (Salix alba L.) is mainly used. Numerous species of willow that grow and are widely cultivated in the Russian Federation have not yet been widely used in medicine.The aim of the studyis to summarize the literary data about the expansion habitat, the content of biologically active substances and the possibility of harvesting raw materials of willow triandra (Salix triandra L.) and its use in medicine and pharmacy.Materials and methods.The object of the study is willow triandra (S. triandra L.) widespread in the Russian Federation. The study was conducted using search and information and library databases (eLibrary, PubMed, CyberLeninka, ResearchGate).Results and discussion.Willow triandra (Salix triandra L.) is a perennial dioecious plant, belonging to the Salicaceae family (Willow), Amygdalinae section. The natural habitat of willow triandra is predominantly forest and forest-steppe zones of the European and Asian continents. Eastern Europe is the geographical center of the growth of willow triandra, where it occurs throughout the territory. In Russia, willow triandra occupies almost the whole of its European part, in the North extends as far as the Petrozavodsk-Vologda-Kirov line, and the North Caucasus, it can be found on the territory of Western and Central Siberia. This suggests the idea that plant resources of willow triandra are significant. The possibility of cultivation of willow triandra in various edaphic-phytocenotic conditions is noted, since it is most easily subjected to vegetative propagation. It has been pointed out that willow triandra, like other willow species, contains a rich complex of polyphenolic compounds, which causes its anti-inflammatory effect. It has been revealed that in efficiency, the branches are not inferior to the bark of the species under study, which makes it possible to use branches of various willow speciesas a medicinal plant material.Conclusion.The prospect of research of branches of various willow species, including willow triandra, as a medicinal plant raw material showing anti-inflammatory properties, is confirmed.
各种柳树是最有希望扩大具有收敛和抗炎作用的药物范围的植物之一，它们在民间医学中使用了很长时间，现在在国外和俄罗斯被广泛应用于各种生物活性食品添加剂的组成中。目前，在医疗实践中，主要使用白柳(Salix alba L.)。在俄罗斯联邦生长和广泛种植的许多柳树品种尚未广泛用于医学。摘要综述了国内外有关三棱柳(Salix triandra L.)扩展生境、生物活性物质含量、原料采收可能性及药用价值的文献资料。材料和方法。本研究的对象是分布在俄罗斯联邦的柳柳(S. triandra L.)。这项研究是通过检索和信息以及图书馆数据库(图书馆、PubMed、CyberLeninka、ResearchGate)进行的。结果和讨论。柳(Salix triandra L.)是一种多年生雌雄异株植物，属于水杨科(柳)，苦杏仁科。三柳的自然栖息地主要是欧洲和亚洲大陆的森林和森林草原地带。东欧是柳树生长的地理中心，在那里它遍布整个领土。在俄罗斯，柳树几乎占据了整个欧洲部分，在北部延伸到彼得罗扎沃茨克-沃洛格达-基洛夫线，在北高加索，它可以在西伯利亚西部和中部的领土上找到。这表明三棱柳的植物资源是重要的。注意到在各种土壤-植物生长条件下种植柳柳的可能性，因为它最容易进行无性繁殖。有人指出，与其他柳树种类一样，三柳含有丰富的多酚化合物复合物，这使其具有抗炎作用。研究表明，其枝条的功效不低于所研究树种的树皮，这为利用不同柳树枝条作为药用植物原料提供了可能。结论:确定了包括三棱柳在内的不同柳树枝条作为具有抗炎作用的药用植物原料的研究前景。
{"title":"WILLOW TRIANDRA (SALIX TRIANDRA L.): PROSPECTS AND OPPORTUNITIES FOR USE IN MEDICINE AND PHARMACY","authors":"E. G. Sannikova, O. Popova, E. V. Kompantseva","doi":"10.19163/2307-9266-2018-6-4-318-339","DOIUrl":"https://doi.org/10.19163/2307-9266-2018-6-4-318-339","url":null,"abstract":"One of the most promising plants for expanding the range of medicines having astringent and anti-inflammatory effects are various species of willow, which have been used in folk medicine for a long time and now arewidely appliedin the composition of various biologically active additives to food both abroad and in Russia. Currently, in medical practice, white willow (Salix alba L.) is mainly used. Numerous species of willow that grow and are widely cultivated in the Russian Federation have not yet been widely used in medicine.The aim of the studyis to summarize the literary data about the expansion habitat, the content of biologically active substances and the possibility of harvesting raw materials of willow triandra (Salix triandra L.) and its use in medicine and pharmacy.Materials and methods.The object of the study is willow triandra (S. triandra L.) widespread in the Russian Federation. The study was conducted using search and information and library databases (eLibrary, PubMed, CyberLeninka, ResearchGate).Results and discussion.Willow triandra (Salix triandra L.) is a perennial dioecious plant, belonging to the Salicaceae family (Willow), Amygdalinae section. The natural habitat of willow triandra is predominantly forest and forest-steppe zones of the European and Asian continents. Eastern Europe is the geographical center of the growth of willow triandra, where it occurs throughout the territory. In Russia, willow triandra occupies almost the whole of its European part, in the North extends as far as the Petrozavodsk-Vologda-Kirov line, and the North Caucasus, it can be found on the territory of Western and Central Siberia. This suggests the idea that plant resources of willow triandra are significant. The possibility of cultivation of willow triandra in various edaphic-phytocenotic conditions is noted, since it is most easily subjected to vegetative propagation. It has been pointed out that willow triandra, like other willow species, contains a rich complex of polyphenolic compounds, which causes its anti-inflammatory effect. It has been revealed that in efficiency, the branches are not inferior to the bark of the species under study, which makes it possible to use branches of various willow speciesas a medicinal plant material.Conclusion.The prospect of research of branches of various willow species, including willow triandra, as a medicinal plant raw material showing anti-inflammatory properties, is confirmed.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":"1 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2018-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67826936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the main tasks of modern pharmacology is the development of new methods for correcting various stress-induced states. An essential role in solving this problem can be played by herbal medicinal products. A special interest is represented by Astragalus vulpinus Willd - a plant of a large Astragalus genus of the legume family (Fabaceae), growing in the Astrakhan Region. The aim of the study is to investigate the effect of the Astragalus vulpinus Willd extract on the psychoemotional state of animals against the background of informational overload (IО). Materials and methods. The experiment was performed on nonlinear male rats. All the manipulations with the animals were carried out according to the rules and principles of work with laboratory animals. The animals were divided into groups: Group 1 - control rats; Group 2 – the animals exposed to IО for 20 days; Group 3 – the animals treated with intragastric liquid extract of Astragalus vulpinus Willd in the dose of 50 mg / kg /a day for 14 days and exposed to IО; Group 4 – the animals treated with the comparative drug of Phenibut in the dose of 25 mg / kg for 14 days against the background of informational overload. The IO model was a multi-alternative labyrinth in which food-producing skills were formed. The psychoemotional state of rats was studied in the “Suok-test” (ST), which is a complex of several classical behavioral models. Results and discussion. The study of laboratory animals’ behavior in the “Suok-test” against the background of informational overload showed the formation of the state of increased anxiety, which was manifested by a decrease in the motor and research activity of white rats. It was established that the Astragalus vulpinus Willd extract has an anxiolytic and antidepressant effect, eliminating manifestations of an anxiety-depressive state developing against the background of informational overload. Conclusion. Estimating the influence of the Astragalus vulpinus Willd extract in comparison with the activity of Phenibutum, it can be concluded that the investigated drugs eliminate the changes in the psychoemotional state of the anxiety-depressive character, demonstrating a practically comparable anxiolytic and antidepressant effect.
现代药理学的主要任务之一是开发新的方法来纠正各种应激诱导的状态。草药产品可以在解决这一问题方面发挥重要作用。一个特别感兴趣的代表是野生黄芪-豆科(豆科)的大型黄芪属植物，生长在阿斯特拉罕地区。本研究旨在探讨在信息过载的背景下，黄芪提取物对动物心理情绪状态的影响(IО)。材料和方法。实验在非线性雄性大鼠身上进行。所有对动物的操作都按照实验动物工作的规则和原则进行。实验动物分为两组:第一组为对照大鼠;第二组:接触IО 20天的动物;3组:以50 mg / kg / d灌胃黄耆液体提取物，连续14 d，并暴露于IО;第4组:在信息过载背景下，以25mg / kg剂量给药，连续14天。IO模型是一个多种选择的迷宫，在其中形成了粮食生产技能。大鼠的心理情绪状态通过“suok测试”(ST)进行研究，该测试是几种经典行为模型的复合体。结果和讨论。在信息过载背景下对实验动物“suok测试”行为的研究表明，焦虑状态的增加形成，表现为大鼠的运动和研究活动减少。结果表明，黄芪提取物具有抗焦虑和抗抑郁作用，消除了信息过载背景下产生的焦虑抑郁状态的表现。结论。通过对黄芪提取物与苯butum活性的比较，可以得出结论，所研究的药物消除了焦虑-抑郁特征的心理情绪状态的变化，显示出几乎相当的抗焦虑和抗抑郁作用。
{"title":"Изучение психомодулирующих свойств экстракта травы Астрагала лисьего (Astragalus vulpinus Willd) в условиях информационного стресса","authors":"Марина Александровна Самотруева, Мариям Утежановна Сергалиева","doi":"10.19163/2307-9266-2018-6-3-255-268","DOIUrl":"https://doi.org/10.19163/2307-9266-2018-6-3-255-268","url":null,"abstract":"One of the main tasks of modern pharmacology is the development of new methods for correcting various stress-induced states. An essential role in solving this problem can be played by herbal medicinal products. A special interest is represented by Astragalus vulpinus Willd - a plant of a large Astragalus genus of the legume family (Fabaceae), growing in the Astrakhan Region. The aim of the study is to investigate the effect of the Astragalus vulpinus Willd extract on the psychoemotional state of animals against the background of informational overload (IО). Materials and methods. The experiment was performed on nonlinear male rats. All the manipulations with the animals were carried out according to the rules and principles of work with laboratory animals. The animals were divided into groups: Group 1 - control rats; Group 2 – the animals exposed to IО for 20 days; Group 3 – the animals treated with intragastric liquid extract of Astragalus vulpinus Willd in the dose of 50 mg / kg /a day for 14 days and exposed to IО; Group 4 – the animals treated with the comparative drug of Phenibut in the dose of 25 mg / kg for 14 days against the background of informational overload. The IO model was a multi-alternative labyrinth in which food-producing skills were formed. The psychoemotional state of rats was studied in the “Suok-test” (ST), which is a complex of several classical behavioral models. Results and discussion. The study of laboratory animals’ behavior in the “Suok-test” against the background of informational overload showed the formation of the state of increased anxiety, which was manifested by a decrease in the motor and research activity of white rats. It was established that the Astragalus vulpinus Willd extract has an anxiolytic and antidepressant effect, eliminating manifestations of an anxiety-depressive state developing against the background of informational overload. Conclusion. Estimating the influence of the Astragalus vulpinus Willd extract in comparison with the activity of Phenibutum, it can be concluded that the investigated drugs eliminate the changes in the psychoemotional state of the anxiety-depressive character, demonstrating a practically comparable anxiolytic and antidepressant effect.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":"6 1","pages":"255-268"},"PeriodicalIF":0.6,"publicationDate":"2018-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67825930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-31DOI: 10.19163/2307-9266-2017-5-5-487-503
А. А. Глушко, А. С. Чиряпкин, В. С. Чиряпкин, А. М. Муртузалиева, Юлия Александровна Полковникова
Nowadays cardiovascular diseases are the main cause of death among the population around the word. The development of new drugs, giving a possibility to normalize blood pressure, is a promising direction in the field of pharmacy and medicine. Now inhibitors of angiotensinconverting enzyme (ACE) are widely adopted for the treatment of hypertension and chronic heart failure. The principle of action of ACE inhibitors is based on blocking the conversion of angiotensin I into angiotensin II, which mediates vasodilation. The aim of the work is a selection of methods of lisinopril interaction with the active center of angiotensin-converting enzyme by molecular dynamics methods. Materials and methods . Lisinopril molecule was used as a ligand; the charges of that ligand were calculated with the density functional theory (DFT) and ub3lyp method with the basis sets 6-31G* and 6-311G**. Simulation of 75 ns of molecular dynamics of lisinopril interaction with the active center of ACE was carried out in the Bioevrica program. As a result of molecular dynamics simulation, the trajectory of the “lisinopril-ACE” system was obtained. After that a comparison of ligand conformations at different points in simulation time with the experimental conformation of the value of standard deviation of coordinates of atoms was made. Results and discussion. The results of simulation have showed that lisinopril with the charges corresponding to basis set 6-311G** behaves consistent with the x-ray data in the active center of the ACE, in contrast to lisinopril with the charges calculated by basis set 6-31G*. Conclusion. The methods of lisinopril interaction modeling with the active center of angiotensin-converting enzyme has been selected. The obtained technique can be used for studying the interaction of substances, similar in structure to lisinopril with the active center of the enzyme (ACE).
{"title":"Разработка методики моделирования взаимодействия биологически активных веществ с активным центром ангиотензин-превращающего фермента","authors":"А. А. Глушко, А. С. Чиряпкин, В. С. Чиряпкин, А. М. Муртузалиева, Юлия Александровна Полковникова","doi":"10.19163/2307-9266-2017-5-5-487-503","DOIUrl":"https://doi.org/10.19163/2307-9266-2017-5-5-487-503","url":null,"abstract":"Nowadays cardiovascular diseases are the main cause of death among the population around the word. The development of new drugs, giving a possibility to normalize blood pressure, is a promising direction in the field of pharmacy and medicine. Now inhibitors of angiotensinconverting enzyme (ACE) are widely adopted for the treatment of hypertension and chronic heart failure. The principle of action of ACE inhibitors is based on blocking the conversion of angiotensin I into angiotensin II, which mediates vasodilation. The aim of the work is a selection of methods of lisinopril interaction with the active center of angiotensin-converting enzyme by molecular dynamics methods. Materials and methods . Lisinopril molecule was used as a ligand; the charges of that ligand were calculated with the density functional theory (DFT) and ub3lyp method with the basis sets 6-31G* and 6-311G**. Simulation of 75 ns of molecular dynamics of lisinopril interaction with the active center of ACE was carried out in the Bioevrica program. As a result of molecular dynamics simulation, the trajectory of the “lisinopril-ACE” system was obtained. After that a comparison of ligand conformations at different points in simulation time with the experimental conformation of the value of standard deviation of coordinates of atoms was made. Results and discussion. The results of simulation have showed that lisinopril with the charges corresponding to basis set 6-311G** behaves consistent with the x-ray data in the active center of the ACE, in contrast to lisinopril with the charges calculated by basis set 6-31G*. Conclusion. The methods of lisinopril interaction modeling with the active center of angiotensin-converting enzyme has been selected. The obtained technique can be used for studying the interaction of substances, similar in structure to lisinopril with the active center of the enzyme (ACE).","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":"5 1","pages":"487-503"},"PeriodicalIF":0.6,"publicationDate":"2017-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67826266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-09-22DOI: 10.19163/2307-9266-2017-5-4-368-379
Ju. V. Miroshnichenko, V. N. Kononov, E. O. Rodionov, O. Z. Mustaev, E. Soldatov, M. L. Chuvashev, I. V. Klochkova
The experience of the medical evacuation activities in armed conflicts shows that the Arctic special medical and geographical conditions have expressed mainly negative impact on the methods of conducting military operations and medical care of the wounded and sick, including the Russian Federation Military Forces operational and combat units` medical logistics. The aim of the study was to identify the ways to improve the equipment of medical units of interspecific group of troops (forces) in the Russian Federation Arctic zone. Materials and methods . The theoretical and methodological basis of the research was the works of Russian scientists in the field of improving the order of rendering medical assistance and performing other medical measures in conditions of low ambient temperature. The study used such methods as retrospective; logical; structural and functional analyses and others. Results and discussion . In the course of the study special medical and geographic factors of the Arctic were identified, and their influence on the operational and combat units’ medical logistics was established. The measures to preserve the quality of medicines and medical products in the Arctic are considered, the order of their use is determined, and the requirements for their transportation are established. Prospective means of deploying medical units in the Arctic have been identified. The impact analysis results of the Russian Federation Arctic zone conditions on the need of Military Forces operational and combat units in medical property are given. Conclusion. Based on the results of the study, the most relevant areas for the development and improvement of the organization of Russian Federation Military Forces operational and combat units` medical logistics in the Arctic Zone have been established.
{"title":"ВЛИЯНИЕ ОСОБЫХ МЕДИКО-ГЕОГРАФИЧЕСКИХ УСЛОВИЙ АРКТИКИ НА ОБЕСПЕЧЕНИЕ СОЕДИНЕНИЙ И ВОИНСКИХ ЧАСТЕЙ МЕДИЦИНСКИМ ИМУЩЕСТВОМ","authors":"Ju. V. Miroshnichenko, V. N. Kononov, E. O. Rodionov, O. Z. Mustaev, E. Soldatov, M. L. Chuvashev, I. V. Klochkova","doi":"10.19163/2307-9266-2017-5-4-368-379","DOIUrl":"https://doi.org/10.19163/2307-9266-2017-5-4-368-379","url":null,"abstract":"The experience of the medical evacuation activities in armed conflicts shows that the Arctic special medical and geographical conditions have expressed mainly negative impact on the methods of conducting military operations and medical care of the wounded and sick, including the Russian Federation Military Forces operational and combat units` medical logistics. The aim of the study was to identify the ways to improve the equipment of medical units of interspecific group of troops (forces) in the Russian Federation Arctic zone. Materials and methods . The theoretical and methodological basis of the research was the works of Russian scientists in the field of improving the order of rendering medical assistance and performing other medical measures in conditions of low ambient temperature. The study used such methods as retrospective; logical; structural and functional analyses and others. Results and discussion . In the course of the study special medical and geographic factors of the Arctic were identified, and their influence on the operational and combat units’ medical logistics was established. The measures to preserve the quality of medicines and medical products in the Arctic are considered, the order of their use is determined, and the requirements for their transportation are established. Prospective means of deploying medical units in the Arctic have been identified. The impact analysis results of the Russian Federation Arctic zone conditions on the need of Military Forces operational and combat units in medical property are given. Conclusion. Based on the results of the study, the most relevant areas for the development and improvement of the organization of Russian Federation Military Forces operational and combat units` medical logistics in the Arctic Zone have been established.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":"5 1","pages":"368-379"},"PeriodicalIF":0.6,"publicationDate":"2017-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67826165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-04DOI: 10.19163/2307-9266-2017-5-1-12-22
Анна Степановна Саушкина, Любовь Николаевна Зинчук, Михаил Андреевич Денисов, Владислав Александрович Шокуров, Д. В. Гончаров
A serious threat to the health of the population is falsified medicines. In a number of cases, they are identified in the process of incoming quality control for compliance with the requirements of regulatory documents for indicators “Description”, “Packaging”, “Marking”. However, in order to identify sophisticated counterfeits, only a visual assessment of the drug is not enough. Purpose screening evaluation of potentially counterfeited or poor-quality drugs using the IR spectrometry along the total spectrum. Materials and methods. The objects of research were available in freely available commercially available tablets produced by domestic and foreign manufacturers “Paracetamol Extratab”, “Solpadein fast”, “Citrapac”, “Citramon P”, “Ascofen-P”, corresponding to the requirements of the current regulatory documents. The studies were carried out on a Fourier-Spectrophotometer infrared “FSM 1201”. Results and discussion. On the example of the tablets “Citramon P”, “Ascophen-P”, “Citrapac”, “Paracetamol Extratab”, “Solpadein Fast” the possibility of using the total IR spectra as a primary screening index of authenticity is shown. It was established that the total IR spectra of medicines of similar composition reflect the similarity of serial samples of the products of one manufacturer and the difference in serial samples of products of different manufacturers.
{"title":"ИДЕНТИФИКАЦИЯ НЕКОТОРЫХ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ СЛОЖНОГО СОСТАВА, СОДЕРЖАЩИХ ПАРАЦЕТАМОЛ, МЕТОДОМ ИК-СПЕКТРОМЕТРИИ","authors":"Анна Степановна Саушкина, Любовь Николаевна Зинчук, Михаил Андреевич Денисов, Владислав Александрович Шокуров, Д. В. Гончаров","doi":"10.19163/2307-9266-2017-5-1-12-22","DOIUrl":"https://doi.org/10.19163/2307-9266-2017-5-1-12-22","url":null,"abstract":"A serious threat to the health of the population is falsified medicines. In a number of cases, they are identified in the process of incoming quality control for compliance with the requirements of regulatory documents for indicators “Description”, “Packaging”, “Marking”. However, in order to identify sophisticated counterfeits, only a visual assessment of the drug is not enough. Purpose screening evaluation of potentially counterfeited or poor-quality drugs using the IR spectrometry along the total spectrum. Materials and methods. The objects of research were available in freely available commercially available tablets produced by domestic and foreign manufacturers “Paracetamol Extratab”, “Solpadein fast”, “Citrapac”, “Citramon P”, “Ascofen-P”, corresponding to the requirements of the current regulatory documents. The studies were carried out on a Fourier-Spectrophotometer infrared “FSM 1201”. Results and discussion. On the example of the tablets “Citramon P”, “Ascophen-P”, “Citrapac”, “Paracetamol Extratab”, “Solpadein Fast” the possibility of using the total IR spectra as a primary screening index of authenticity is shown. It was established that the total IR spectra of medicines of similar composition reflect the similarity of serial samples of the products of one manufacturer and the difference in serial samples of products of different manufacturers.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":"5 1","pages":"12-22"},"PeriodicalIF":0.6,"publicationDate":"2017-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47103381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-29DOI: 10.19163/2307-9266-2016-4-5-81-89
Андрей Владиславович Воронков, А. Ю. Терехов, Ирина Николаевна Дьякова, Н. С. Авраменко, Светлана Анатольевна Кулешова, Е. Е. Зацепина, Дмитрий Игоревич Поздняков
Contemporary therapeutic approaches offer a wide range of laxative agents, which are often used without a control, exceeding the regime recommended. Therefore, the comparative study for subchronic toxicity of both drugs from this group (Vaseline oil and Glycelax) appears interesting. The aim of the study was the comparison of a toxic influence of 14-days application of the drugs under study. Methods. The drugs were studied in two doses: higher therapeutic, and toxic, which 10 times exceeds therapeutic dose. We used “Polispektr-8/B” electrocardiograph, BC 2800vet (Mindray) hematologic veterinary analyzer, BS-380 (Mindray) biochemical analyzer, CL-50 urine analyzer. After the animals autopsy we determined organs’ coefficient (heart, lungs, spleen, liver, stomach, kidneys, adrenals). Results. While studying the ECG of female rats, amplitude of R wave increased after they got Glycelax in both doses. Female rats who got Vaseline oil this index decreased at minimum dose and increased at maximum dose. After Glycelax application, male rats had an increased activity of alanine aminotransferase. After Vaseline oil application at maximum dose, female rats had alkaline phosphatase activity lowered. Female rats, which got a maximum dose of Vaseline oil had a total protein lowered. Glycelax at maximum dose increased the content of bilirubin and its fractions in male and female rats, while Vaseline oil application at maximum dose increased the content of bilirubin in female rats. Male rats which got Glycelax had hemoglobin and hematocrit level increased. Conclusion. At long-term application of Vaseline oil, animals of both genders had heart disorders with possible development of arrhythmia, hepatotoxic effect, lipid exchange dysfunction. After excessive use of Glycelax the above mentioned is added with possible hemoglobin and rheological blood properties level decrease.
{"title":"Сравнительное исследование субхронической токсичности Вазелинового масла и Глицелакса","authors":"Андрей Владиславович Воронков, А. Ю. Терехов, Ирина Николаевна Дьякова, Н. С. Авраменко, Светлана Анатольевна Кулешова, Е. Е. Зацепина, Дмитрий Игоревич Поздняков","doi":"10.19163/2307-9266-2016-4-5-81-89","DOIUrl":"https://doi.org/10.19163/2307-9266-2016-4-5-81-89","url":null,"abstract":"Contemporary therapeutic approaches offer a wide range of laxative agents, which are often used without a control, exceeding the regime recommended. Therefore, the comparative study for subchronic toxicity of both drugs from this group (Vaseline oil and Glycelax) appears interesting. The aim of the study was the comparison of a toxic influence of 14-days application of the drugs under study. Methods. The drugs were studied in two doses: higher therapeutic, and toxic, which 10 times exceeds therapeutic dose. We used “Polispektr-8/B” electrocardiograph, BC 2800vet (Mindray) hematologic veterinary analyzer, BS-380 (Mindray) biochemical analyzer, CL-50 urine analyzer. After the animals autopsy we determined organs’ coefficient (heart, lungs, spleen, liver, stomach, kidneys, adrenals). Results. While studying the ECG of female rats, amplitude of R wave increased after they got Glycelax in both doses. Female rats who got Vaseline oil this index decreased at minimum dose and increased at maximum dose. After Glycelax application, male rats had an increased activity of alanine aminotransferase. After Vaseline oil application at maximum dose, female rats had alkaline phosphatase activity lowered. Female rats, which got a maximum dose of Vaseline oil had a total protein lowered. Glycelax at maximum dose increased the content of bilirubin and its fractions in male and female rats, while Vaseline oil application at maximum dose increased the content of bilirubin in female rats. Male rats which got Glycelax had hemoglobin and hematocrit level increased. Conclusion. At long-term application of Vaseline oil, animals of both genders had heart disorders with possible development of arrhythmia, hepatotoxic effect, lipid exchange dysfunction. After excessive use of Glycelax the above mentioned is added with possible hemoglobin and rheological blood properties level decrease.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":"4 1","pages":"81-89"},"PeriodicalIF":0.6,"publicationDate":"2016-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67826144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-09-03DOI: 10.19163/2307-9266-2016-4-3-4-37
С. Б. Евсеева, Б. Б. Сысуев
In contemporary pharmaceutical practice extracts are used as a separate cosmetic product and as an intermediate for external medicinal forms (ointments, gels, liniments) and cosmetic forms. Their range is highly diverse. The aim is an overview of the scientific and technical information concerning plant raw materials extracts using in the external drug and cosmetic products. Methods. To describe the range of extracts proposed for external use the analysis of the proposals of Russian and foreign producers submitted their official websites and online trading platforms was used. The specificity of extraction of biologically active substances of plant extracting agents: water, ethyl alcohol, glycols, vegetable oils, carbon dioxide used to obtain extracts was described on the basis of available scientific literature (eLIBRARY, PubMed, Cyberleninca, Google Books). Results. Examples of external drugs and cosmetic products based on plant raw materials extracts from a range of pharmaceutical organizations are given. It was found that from the extracting solvent used the range is presented by hydrophilic, such as glycol (propylene glycol, glycerin), water, alcoholic extracts; lipophilic (oil, CO2-extracts), and two-phase (caprylic/caprate triglyceride/water extracts). The main features of the extracting solvent used for this category of extracts: the specifics of the use in cosmetics (the skin specific effect), in particular selectivity to groups of biologically active plant substances, microbiological purity, are noted. Results of research data on the study of the prospects for the use of cosmetic ingredients – silicones, caprylic/ capric triglyceride, isopropyl myristate both solvents. The extraction techniques: classical (maceration, percolation) and intensified (electro-plasma dynamic extraction, vacuum extraction circulation, CO2 supercritical extraction) used in industry to produce cosmetic extracts are described. Conclusion : in this way, the range of extracts for use in exterior cosmetics is very diverse and is characterized by the use of different solvents, performing the function of the components in cosmetics, and extraction methods.
{"title":"Экстракты растительного сырья как компоненты косметических и наружных лекарственных средств: ассортимент продукции, особенности получения (обзор)","authors":"С. Б. Евсеева, Б. Б. Сысуев","doi":"10.19163/2307-9266-2016-4-3-4-37","DOIUrl":"https://doi.org/10.19163/2307-9266-2016-4-3-4-37","url":null,"abstract":"In contemporary pharmaceutical practice extracts are used as a separate cosmetic product and as an intermediate for external medicinal forms (ointments, gels, liniments) and cosmetic forms. Their range is highly diverse. The aim is an overview of the scientific and technical information concerning plant raw materials extracts using in the external drug and cosmetic products. Methods. To describe the range of extracts proposed for external use the analysis of the proposals of Russian and foreign producers submitted their official websites and online trading platforms was used. The specificity of extraction of biologically active substances of plant extracting agents: water, ethyl alcohol, glycols, vegetable oils, carbon dioxide used to obtain extracts was described on the basis of available scientific literature (eLIBRARY, PubMed, Cyberleninca, Google Books). Results. Examples of external drugs and cosmetic products based on plant raw materials extracts from a range of pharmaceutical organizations are given. It was found that from the extracting solvent used the range is presented by hydrophilic, such as glycol (propylene glycol, glycerin), water, alcoholic extracts; lipophilic (oil, CO2-extracts), and two-phase (caprylic/caprate triglyceride/water extracts). The main features of the extracting solvent used for this category of extracts: the specifics of the use in cosmetics (the skin specific effect), in particular selectivity to groups of biologically active plant substances, microbiological purity, are noted. Results of research data on the study of the prospects for the use of cosmetic ingredients – silicones, caprylic/ capric triglyceride, isopropyl myristate both solvents. The extraction techniques: classical (maceration, percolation) and intensified (electro-plasma dynamic extraction, vacuum extraction circulation, CO2 supercritical extraction) used in industry to produce cosmetic extracts are described. Conclusion : in this way, the range of extracts for use in exterior cosmetics is very diverse and is characterized by the use of different solvents, performing the function of the components in cosmetics, and extraction methods.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":"4 1","pages":"4-37"},"PeriodicalIF":0.6,"publicationDate":"2016-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67825910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-09-02DOI: 10.19163/2307-9266-2016-4-2(15)-79-87
Ф. К. Серебряная, И. И. Посевин
The article covers the results of the study for micromorphological signs of leaf, stem, petiole of Chamenerion angustifolium (L.) Scop., from Onagraceae family, which grows in the Northern Caucasus, necessary to establish raw materials authenticity.
{"title":"Morphological and anatomical investigations of Chamenerion angustifolium (L.) Scop .) growing in the Northern Caucasus region","authors":"Ф. К. Серебряная, И. И. Посевин","doi":"10.19163/2307-9266-2016-4-2(15)-79-87","DOIUrl":"https://doi.org/10.19163/2307-9266-2016-4-2(15)-79-87","url":null,"abstract":"The article covers the results of the study for micromorphological signs of leaf, stem, petiole of Chamenerion angustifolium (L.) Scop., from Onagraceae family, which grows in the Northern Caucasus, necessary to establish raw materials authenticity.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":"4 1","pages":"79-87"},"PeriodicalIF":0.6,"publicationDate":"2016-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67826120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-09-02DOI: 10.19163/2307-9266-2016-4-2(15)-41-59
Ольга Олеговна Фролова, Евгени Владимировна Компанцева, Т. М. Дементьева
The review systematizes data about chemical composition of bark, leaves, inflorescences, and sprouts of different species of Salix L. The closest attention is payed to investigations of Salix, which has been recently carried out in our country and abroad. For every group of biologically active substances described in Salix there are data about suppressed types of pharmacological activity.
{"title":"Biologically Active Substances of Plants from Sali x L. Genus","authors":"Ольга Олеговна Фролова, Евгени Владимировна Компанцева, Т. М. Дементьева","doi":"10.19163/2307-9266-2016-4-2(15)-41-59","DOIUrl":"https://doi.org/10.19163/2307-9266-2016-4-2(15)-41-59","url":null,"abstract":"The review systematizes data about chemical composition of bark, leaves, inflorescences, and sprouts of different species of Salix L. The closest attention is payed to investigations of Salix, which has been recently carried out in our country and abroad. For every group of biologically active substances described in Salix there are data about suppressed types of pharmacological activity.","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":"4 1","pages":"41-59"},"PeriodicalIF":0.6,"publicationDate":"2016-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67824671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.19163/2307-9266-2016-4-3-56-67
Г. Санникова, О. И. Попова, Ольга Олеговна Фролова, E. G. Sannikova, O. Popova, O. O. Frolova, A. Airapetova
{"title":"Россия DETERMINATION OF FLAVONOIDS OF WILLOW TRIANDRA ( SALIX TRIANDRA L . ) , GROWING IN THE NORTH CAUCASUS","authors":"Г. Санникова, О. И. Попова, Ольга Олеговна Фролова, E. G. Sannikova, O. Popova, O. O. Frolova, A. Airapetova","doi":"10.19163/2307-9266-2016-4-3-56-67","DOIUrl":"https://doi.org/10.19163/2307-9266-2016-4-3-56-67","url":null,"abstract":"","PeriodicalId":40926,"journal":{"name":"Pharmacy & Pharmacology-Farmatsiya i Farmakologiya","volume":"1 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67825958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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