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Neuropsychological correlates underlying verbal fluency deficits in schizophrenia: The role of attention and executive function 精神分裂症中潜在的语言流畅性缺陷的神经心理学相关性:注意力和执行功能的作用
Pub Date : 1900-01-01 DOI: 10.17234/9789531758314.04
Anna Rosenkranz, T. Kircher, A. Nagels
Verbal fluency deficits are commonly observed in patients with schizophrenia. The role of executive functions is still a topic of critical debate, although other neuropsychological domains, e.g. attention, working memory and verbal intelligence, may also influence verbal fluency task performance. Furthermore, some studies report semantic fluency dysfunctions suggesting particular semantic access deficits, while others report regular patterns of verbal fluency task performance, with better performance in semantic fluency as compared to lexical fluency, suggesting general retrieval difficulties. In addition, formal thought disorder symptomatology is often associated with reduced verbal fluency performance. To further address these issues of verbal fluency deficits in schizophrenia, patients with schizophrenia (n=50) as well as a healthy control group (n=36) were recruited and tested according to the aforementioned neuropsychological parameters and both semantic and lexical fluency. Results indicate that executive dysfunctions are associated with verbal fluency performance particularly in the lexical fluency domain. Furthermore, a strong relationship was found between sustained-attention deficits and both semantic and lexical fluency, indicating that verbal fluency deficits in general are mainly driven by attention dysfunctions rather than aberrations in the executive domain. Results showed that patients with schizophrenia did not perform differently for letter vs. semantic fluency. Furthermore, controlling for attention, the results suggest that formal thought disorder symptomatology is unrelated to performance on verbal fluency. Taken together, impaired attention drives the decreased performance in verbal fluency tasks in patients with schizophrenia.
言语流畅性缺陷在精神分裂症患者中很常见。尽管其他神经心理学领域,如注意力、工作记忆和言语智力,也可能影响言语流畅性任务的表现,但执行功能的作用仍然是一个关键的争论话题。此外,一些研究报告了语义流畅功能障碍,表明特定的语义获取缺陷,而另一些研究报告了语言流畅任务表现的规律,语义流畅表现优于词汇流畅,表明一般检索困难。此外,形式思维障碍的症状通常与语言流畅性下降有关。为了进一步解决精神分裂症患者的语言流畅性缺陷问题,我们招募了50名精神分裂症患者(n=50)和健康对照组(n=36),并根据上述神经心理学参数以及语义和词汇流畅性进行了测试。结果表明,执行功能障碍与语言流畅性表现有关,特别是在词汇流畅性领域。此外,研究还发现持续注意缺陷与语义和词汇流畅性之间存在密切关系,这表明言语流畅性缺陷主要是由注意力功能障碍而不是执行领域的异常引起的。结果显示,精神分裂症患者在字母流畅性和语义流畅性方面的表现没有差异。此外,在控制注意力的情况下,结果表明形式思维障碍的症状与语言流畅性的表现无关。综上所述,注意力受损导致精神分裂症患者在语言流畅性任务中的表现下降。
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引用次数: 5
The role of imageability and frequency in language production and comprehension in first-episode and early-course psychosis 可想象性和频率在首发和早期精神病的语言产生和理解中的作用
Pub Date : 1900-01-01 DOI: 10.17234/9789531758314.07
I. Kuzina, Vlasta Erdeljac, M. Sovic, N. Mimica, D. Ostojić, A. Savic
This study is an overview of language production and the comprehension of associations depending on the lexical-semantic imageability and frequency features in subjects with first-episode and early-course psychosis. Concepts with low values of lexical-semantic feature imageability, unlike those with high imageability, demand greater cognitive effort in the creation of their mental image and their activation in the semantic memory. This study included two tests, a forced-choice language comprehension test and an elicited association production test, which were constructed for the purpose of the study on the basis of an existing database of psycholinguistic lexical-semantic features (Erdeljac et al., 2018). Twelve subjects diagnosed with first-episode early-course psychosis were recruited, as well as 12 healthy subjects as a control group. It was confirmed that the target group, the subjects with first-episode and early-course psychosis, processes language differently with regards to the imageability feature in the production test. The patient group had longer reaction times on both imageability conditions in relation to the control group, but while the control group had shorter reaction times on highly imageable words, the patient group’s reaction times did not differ on account of the imageability condition. In the comprehension test, the patient group had overall longer reaction times independently of the imageability condition. Furthermore, in the comprehension test, both groups statistically more often chose associations that were of high and medium frequency, when compared to low frequency words, and the target group had longer reaction times on highand medium-frequency words than on low-frequency words. The results analysis was conducted according to current psycholinguistic theories and further validate the theory that subjects with schizophrenia have increased activation and decreased inhibition in the spreading of activation in the semantic memory during language processing.
本研究概述了首发和早期精神病患者的语言产生和联想理解依赖于词汇语义可想象性和频率特征。词汇-语义特征可想象性值低的概念,与可想象性值高的概念不同,其心理意象的形成和语义记忆的激活需要更大的认知努力。本研究包括两个测试,一个是强迫选择语言理解测试,另一个是诱发联想产生测试,这两个测试是基于现有的心理语言学词汇语义特征数据库构建的(Erdeljac et al., 2018)。本研究招募了12名诊断为首发早期病程精神病的受试者,以及12名健康受试者作为对照组。结果表明,首发精神病患者和病程早期精神病患者在产生性测试的可想象性特征上对语言的加工存在差异。与对照组相比,患者组在两种可想象条件下的反应时间都更长,而对照组在高可想象条件下的反应时间更短,而患者组的反应时间并没有因为可想象条件而有所不同。在理解测试中,患者组的整体反应时间较长,与可想象性条件无关。此外,在理解测试中,与低频词相比,两组在统计上更多地选择高频和中频的联想,目标组在高频和中频词上的反应时间比低频词长。根据现有的心理语言学理论对结果进行分析,进一步验证了精神分裂症被试在语言加工过程中语义记忆激活扩散的激活增强和抑制减弱的理论。
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引用次数: 0
Glossary 术语表
Pub Date : 1900-01-01 DOI: 10.17234/9789531758314.10
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引用次数: 0
Modality-specific sensory norms: a new window into semantic organization 模态特定的感官规范:一个进入语义组织的新窗口
Pub Date : 1900-01-01 DOI: 10.17234/9789531758314.09
Dušica Filipović Đurđević, Milica Popović Stijačić
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引用次数: 0
The influence of the typicality feature in the production of language associations in schizophrenia 典型特征对精神分裂症语言联想产生的影响
Pub Date : 1900-01-01 DOI: 10.17234/9789531758314.08
Petra Dominik, I. Kuzina, Vlasta Erdeljac, M. Sekulić Sović, N. Mimica, D. Ostojić, A. Savic
Language deficits in schizophrenia are hypothesized to be a result of increased spreading of activation in the semantic memory during language processing. The spreading of activation is determined by the features of concepts activated in search and retrieval processes. One of the features thought to have a great influence on processing is the typicality feature (Holmes & Ellis, 2006). The aim of this study was to establish whether there are differences in language processing in schizophrenia subjects compared to a healthy control group in a verbal fluency task based upon the typicality feature. Specifically, the analysis was limited to the first cluster of the verbal fluency task because it requires the least effort in terms of task restrictions (Venneri et al., 2008). The study included 8 patients diagnosed with schizophrenia from the University Psychiatric Hospital Vrapče and 8 healthy control subjects. A category semantic fluency task was conducted on both groups, and the healthy control group was given a typicality rating task consisting of exemplars produced by both groups in the first cluster of the former task. Results analysis showed no differences in the typicality ratings of exemplars between the groups in any of the categories except the animals category. These results also indicate differences in the language processing of the animals category and could suggest differences in the processing of animacy features. Additionally, the results show that there are no differences in language processing of the typicality feature in other semantic categories in first-episode psychosis subjects in relation to the healthy control group. Future studies should additionally analyze the processing of animacy features and typicality in schizo-phrenia-spectrum disorders across different illness phases.
精神分裂症的语言缺陷被认为是语言加工过程中语义记忆激活扩散增加的结果。激活的扩散是由搜索和检索过程中激活的概念的特征决定的。典型特征被认为对加工有很大影响(Holmes & Ellis, 2006)。本研究的目的是确定精神分裂症受试者与健康对照组相比,在基于典型特征的语言流畅性任务中,语言加工是否存在差异。具体来说,该分析仅限于言语流畅性任务的第一组,因为它在任务限制方面需要的努力最少(Venneri et al., 2008)。该研究包括8名来自vrape大学精神病院诊断为精神分裂症的患者和8名健康对照者。对两组进行类别语义流畅性任务,健康对照组在前者任务的第一簇中由两组产生的范例组成典型评定任务。结果分析显示,除动物类别外,各组间样本的典型性评分均无差异。这些结果也表明了动物类别在语言处理上的差异,并可能表明动物特征处理上的差异。此外,首发精神病患者在其他语义类别的典型特征的语言加工上与健康对照组没有差异。未来的研究应进一步分析精神分裂症谱系障碍在不同疾病阶段的动物性特征和典型性的处理。
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引用次数: 0
Acknowledgments 致谢
Pub Date : 1900-01-01 DOI: 10.17234/9789531758314.01
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引用次数: 0
Semantic and pragmatic relations in categorization in early-course psychosis 早期精神病分类中的语义和语用关系
Pub Date : 1900-01-01 DOI: 10.17234/9789531758314.05
Vlasta Erdeljac, I. Kuzina, M. Vandek, M. Sovic, N. Mimica, D. Ostojić, A. Savic
In schizophrenia, language processing indicates an over-inclusiveness (Chen, 1994; Brebi-on, 2010) in category (hypernymy and hyponymy) relations. The aim of this study was to examine the preservation of category relations of semantic memory in first-episode and ear-ly-course schizophrenia-spectrum psychosis as it offers an insight to foundations of schizophrenia language deficits. The study was conducted in cooperation with the University Psychiatric Hospital Vrapče on 17 patients. The patients’ results were correlated with those of a matched control group. The test that was used to conduct the experiment was constructed for the intent of this study, and it consisted of 10 categories, each of which was tested over 5 trials. For each trial, participants had to choose a member of a presented category. Possible answers included the target word (a category member such as hobotnica ‘octopus’), a pragmatic-semantically related distractor (e.g. more ‘sea’), a lexical-semantically related distractor (e.g. krak ‘tentacle’), and an unrelated distractor (e.g. truba ‘trumpet’). None of the unrelated distractors in either group were selected as category members. Although both pragmatic-semantically related and lexical-semantically related distractors were classified as category members more often in the patient group, pragmatic-semantically related distractors were chosen more often than lexical-semantically related distractors. While the results support the theory that concept representations in the semantic memory are not completely lost, the question remains whether the representations are degraded or whether there is a difference in search and retrieval processes in patients with first episode psychosis (FEP) when compared to a healthy control group.
在精神分裂症中,语言加工表现出过度包容(Chen, 1994;Brebi-on, 2010)在范畴(上义和下义)关系。本研究的目的是研究语义记忆的类别关系在首发和早期病程的精神分裂症谱系精神病中的保存,因为它提供了对精神分裂症语言缺陷的基础的见解。该研究是与大学精神病医院vrape合作对17名患者进行的。患者的结果与匹配对照组的结果相关。用于进行实验的测试是为了本研究的目的而构建的,它由10个类别组成,每个类别都经过5个试验的测试。在每次试验中,参与者必须从给定的类别中选择一个成员。可能的答案包括目标词(一个类别成员,如hobotnica的“章鱼”),一个语用语义相关的干扰物(如more的“海”),一个词汇语义相关的干扰物(如krak的“触手”),和一个不相关的干扰物(如truba的“喇叭”)。两组不相关干扰物均未被选为类别成员。虽然在病人组中,语用语义相关和词汇语义相关的干扰物被更多地归类为类别成员,但语用语义相关的干扰物比词汇语义相关的干扰物被更多地选择。虽然结果支持语义记忆中的概念表征并未完全丧失的理论,但问题仍然存在,即首次发作精神病(FEP)患者的表征是否退化,或者与健康对照组相比,在搜索和检索过程中是否存在差异。
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引用次数: 1
The effect of age on language in adults with intellectual disabilities: A comparison of passives in Down syndrome and Williams syndrome 年龄对智力残疾成人语言的影响:唐氏综合征和威廉姆斯综合征被动语态的比较
Pub Date : 1900-01-01 DOI: 10.17234/9789531758314.03
A. Perovic, K. Wexler
Individuals with intellectual disabilities often show limitations in language functioning, commonly linked to their overall poor cognitive skills. However, despite the intellectual impairments and language delays, it is well established that language is more vulnerable in some populations, e.g. Down syndrome (DS), and relatively preserved in others, e.g. Williams syndrome (WS). Individuals with DS are also known to be at increased risk of cognitive decline due to the earlier onset of Alzheimer’s dementia, although little is known about how aging affects language skills in this population. Individuals with WS, though with relatively developed language, are reported to never acquire some grammatical structures that appear late in typically developing (TD) individuals, such as passives of psychological verbs. In an attempt to better understand how linguistic deficits in individuals with intellectual disabilities can be teased apart from the effects of general language delays, chronological age, and overall intellectual impairment, we compare the comprehension of passives in adults with DS (mean age: 38) and WS (mean age: 30). Passives are known to develop late in typical development and present difficulties for individuals with developmental disorders. This has been observed especially in their generally poorer performance on passives of psychological verbs than on passives of actional verbs. Our results reveal divergent patterns of performance in our participants. Adults with WS performed no different from younger TD controls on actives and passives of both actional and psychological verbs. In contrast, adults with DS showed exceptionally poor performance on all sentence types, even on actives of actional verbs, considerably poorer than observed in the TD and WS groups. While the good performance of adults with WS might be due to individual variation, rather than continuous language development, we argue that the poor performance of participants with DS is due to an age-related decline of cognitive and language abilities, possibly linked to Alzheimer’s-type dementia.
智障人士通常在语言功能方面表现出局限性,这通常与他们整体认知能力低下有关。然而,尽管存在智力障碍和语言迟缓,但众所周知,语言在某些人群中更为脆弱,例如唐氏综合征(DS),而在其他人群中相对保存,例如威廉姆斯综合征(WS)。由于早发阿尔茨海默氏痴呆症,患有退行性痴呆的人认知能力下降的风险也会增加,尽管人们对衰老如何影响这一人群的语言技能知之甚少。据报道,WS患者虽然语言相对发达,但从未习得正常发育(TD)个体较晚出现的一些语法结构,如心理动词的被动态。为了更好地理解除了一般语言延迟、实足年龄和整体智力障碍的影响外,智力残疾个体的语言缺陷是如何被取笑的,我们比较了DS(平均年龄:38岁)和WS(平均年龄:30岁)成人对被动语的理解。众所周知,被动在典型发育中发展较晚,对发育障碍患者来说存在困难。这一点尤其体现在他们在心理动词被动态上的表现要比在行动动词被动态上的表现差。我们的研究结果揭示了参与者的不同表现模式。成年WS患者在动作动词和心理动词的主动和被动方面与年轻TD对照组没有差异。相比之下,患有DS的成年人在所有句子类型上都表现得异常糟糕,甚至在动作动词的主动语态上也表现得非常糟糕,比TD和WS组的表现要差得多。虽然成年WS患者的良好表现可能是由于个体差异,而不是持续的语言发展,但我们认为,DS患者的不良表现是由于与年龄相关的认知和语言能力下降,可能与阿尔茨海默氏型痴呆有关。
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引用次数: 1
The role of the psycholinguistic characteristics of words in the assessment of language processing of patients with psychosis, ultrahigh risk of psychosis, or schizophrenia 词的心理语言学特征在精神病、精神病超高风险或精神分裂症患者语言加工评估中的作用
Pub Date : 1900-01-01 DOI: 10.17234/9789531758314.02
Vlasta Erdeljac, M. Sekulić Sović, D. Ostojić, A. Savic
role of the psycholinguistic characteristics of
心理语言特征的作用
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引用次数: 0
Shared lexical-semantic features and the animacy effect in early-course psychosis 共享词汇语义特征与早期精神病的活力效应
Pub Date : 1900-01-01 DOI: 10.17234/9789531758314.06
M. Sekulić Sović, Vlasta Erdeljac, I. Kuzina, M. Vandek, N. Mimica, D. Ostojić, A. Savic
Language deficits in psychosis, and in schizophrenia, are presumed to be due to increased activation and connectivity of the semantic memory, which is determined by lexical-semantic features of concepts. The aim of this study was to analyse the influence of shared lexical-semantic features on language processing in patients with first-episode and early-course psychosis. The study included 15 Croatian-speaking patients from the University Psychiatric Hospital Vrapče, Zagreb, diagnosed with first-episode and early-course psychosis and a healthy control group. The subjects performed a lexical-semantic decision task in which the primes and the target words were either related as hypernym and hyponym or were unrelated, and in which the target words represented either animate or inanimate concepts. Two results analyses were conducted: one on the taxonomic (hyponym–hypernym) condition and one on the animacy (living/non-living stimulus) condition. The patient group was less accurate on the taxonomy condition because the taxonomy relations were dependent on their shared features. The patients’ activation of shared features was higher, and their inhibition was reduced. Consequently, the patients will have a greater number of concepts activated and not inhibited. For the inanimate concepts, a high correlation of distinctive features is characteristic, while the animate concepts have a high correlation of shared features. The presupposition is that the greater activation of shared features influenced the patients’ answers, so the distinctive features had no influence. Thus, the control group had higher accuracy for inanimate concepts.
精神病和精神分裂症的语言缺陷被认为是由于语义记忆的激活和连通性增加,这是由概念的词汇-语义特征决定的。本研究的目的是分析共同词汇语义特征对首发和早期精神病患者语言加工的影响。该研究包括来自萨格勒布vrap大学精神病医院的15名克罗地亚语患者,他们被诊断为首发和早期精神病,并作为健康对照组。被试完成一项词汇-语义决策任务,其中启动词和目标词作为上义词和下义词相关或不相关,目标词代表有生命或无生命的概念。对两项结果进行了分析:一项是对分类(上下)条件的分析,另一项是对animacy(活体/非活体刺激)条件的分析。患者组在分类条件上的准确性较低,因为分类关系依赖于他们的共同特征。患者对共同特征的激活程度较高,抑制程度降低。因此,患者会有更多的概念被激活,而不是被抑制。对于无生命的概念来说,鲜明特征的高相关性是其特征,而有生命的概念则具有共同特征的高相关性。假设是,共享特征的更大激活会影响患者的答案,因此独特特征没有影响。因此,对照组对无生命概念有更高的准确性。
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引用次数: 2
期刊
Interdisciplinary Linguistic and Psychiatric Research on Language Disorders
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